Research Topics
Genomes and GenesSpecies | Alexander GhanemSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imagingAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
J Am Coll Cardiol 55:1427-32. 2010..The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI)...- Prognostic value of cerebral injury following transfemoral aortic valve implantationAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
EuroIntervention 8:1296-306. 2013..To evaluate the impact of serological, imaging and clinical measures of cerebral injury on patient self-sufficiency and survival after transcatheter aortic valve implantation (TAVI)... - Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiographyAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Cell Transplant 20:1621-8. 2011..In contrast to "simple" 2D echocardiography, r3D-echo allowed the assessment of regional contractile reserve and quantification of akinetic myocardial mass as additive functional and morphological measures of LVR... 
Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heartElke Winterhager
Institut fur Anatomie, Universitat Duisburg Essen, 45122 Essen, Germany
BMC Dev Biol 7:26. 2007..In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26...- Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarctionAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
J Mol Cell Cardiol 47:411-8. 2009..This study provides the first evidence of the migration of MSCs across the myocardial endothelium in vivo. Hf-UMS not only improves myocardial engraftment of MSCs but also allows locoregional targeting of post-ischemic myocardium... 
Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamineAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Ultrasound Med Biol 34:559-66. 2008..3DE allows precise quantitation of myocardial borderzone and identification of transmural scar tissue noninvasively. Assessment of contractile reserve improves characterization and estimation of myocardial borderzone after CMI...- Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantationJan Malte Sinning
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Eur Heart J 33:1459-68. 2012..We assessed the impact of a systemic inflammatory response syndrome (SIRS) on the outcome after transcatheter aortic valve implantation (TAVI)... - Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient miceJan W Schrickel
Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
J Mol Cell Cardiol 46:644-52. 2009..We suggest that Cx30.2 and Cx40 act as counterparts in the AV-node and His-bundle, decreasing or increasing, respectively, electrical coupling and conduction velocity in these areas... - Aortic regurgitation index defines severity of peri-prosthetic regurgitation and predicts outcome in patients after transcatheter aortic valve implantationJan Malte Sinning
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, Bonn, Germany
J Am Coll Cardiol 59:1134-41. 2012.... - Three-dimensional speckle-tracking analysis of left ventricular function after transcatheter aortic valve implantationRobert Schueler
Department of Internal Medicine, Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany
J Am Soc Echocardiogr 25:827-834.e1. 2012..The aim of this study was to determine the effect of TAVI on LV function with two-dimensional (2D) and three-dimensional (3D) speckle-tracking analysis of LV deformation capability... - Echocardiographic assessment of left ventricular mass in neonatal and adult mice: accuracy of different echocardiographic methodsAlexander Ghanem
Medizinische Klinik und Poliklinik II, , Bonn, Germany
Echocardiography 23:900-7. 2006..Echocardiographic assessment of LVM is feasible in hearts weighting less than 50 mg and can be estimated best in systole. Hearts weighting more than 50 mg are estimated most accurately by means of LVM-AL at diastole... - Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heartJan Wilko Schrickel
Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
J Interv Card Electrophysiol 26:3-10. 2009..Gelsolin (gsn) is involved in the reorganization of the cytoskeleton, thereby modulating cardiomyocytal L-type Ca(2+) channels. We investigated global cardiac electrophysiological characteristics in a gsn-deficient (gsn(-/-)) mouse strain... - Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantationJan Malte Sinning
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
JACC Cardiovasc Interv 3:1141-9. 2010..The aim of this study was to determine the influence of baseline renal function and periprocedural acute kidney injury (AKI) on prognosis after transcatheter aortic valve implantation (TAVI)... - The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humansRadoslaw Dobrowolski
Institute of Genetics, University of Bonn, Germany
Hum Mol Genet 17:539-54. 2008..Our results suggest that the increased activity of ATP-releasing channels in Cx43G138R mutated cardiomyocytes may further reduce the already decreased gap junctional communication and thus aggravate arrhythmogenesis in the mouse mutant... - Functional impact of targeted closed-chest transplantation of bone marrow cells in rats with acute myocardial ischemia/reperfusion injuryAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Cell Transplant 18:1289-97. 2009..However, intramyocardial CTx of MNC or MSC had no influence on systolic function and contractile reserve after reperfused MI... - Toll-like receptor 4 deficiency: smaller infarcts, but no gain in functionSe Chan Kim
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
BMC Physiol 7:5. 2007..In a chronic closed-chest model we assessed whether cardiac function is preserved in TLR4-deficient mice (C3H/HeJ) following MI/R, and whether myocardial and systemic cytokine expression differed compared to wild type (WT)... - Ultrasound-mediated stimulation of microbubbles after acute myocardial infarction and reperfusion ameliorates left-ventricular remodelling in mice via improvement of borderzone vascularizationJonas Dörner
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
PLoS ONE 8:e56841. 2013..The aim of this study was to evaluate transthoracic ultrasound-mediated microbubble stimulation (UMS) as a novel gene- and cell-free therapeutic option after acute myocardial infarction and reperfusion (AMI/R) in mice... - Triggered replenishment imaging reduces variability of quantitative myocardial contrast echocardiography and allows assessment of myocardial blood flow reserveAlexander Ghanem
Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Echocardiography 24:149-58. 2007..88x + 0.45, r = 0.83, P < 0.0001), without systematic bias. TRI significantly reduces variability of RK in quantitative MCE. Assessment of MBFR allows investigator-independent evaluation of CAD... - Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injuryUlrich M Becher
Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
J Mol Cell Cardiol 50:570-7. 2011..Conclusion: Inhibition of leukotriene C(4) reduces levels of oxidative stress and apoptosis and demonstrates beneficial effects on myocardial remodeling after left ventricular injury... - An unusual cause for recurrent syncope in a female adult with LEOPARD syndromeChristoph Hammerstingl
Medizinische Klinik II, Universitatsklinikum Bonn, Bonn, Germany
Echocardiography 26:596-7. 2009..This case impressively underlines the vital necessity of dynamic testing particularly in patients with symptoms during exercise even if these symptoms might be addressed to other findings... - Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repairSebastian Schlaweck
Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Biochem Biophys Res Commun 411:627-31. 2011..In all, NLRP3 plays a non-redundant role in vascular damage mediated neointima formation. Our data establish NLRP3 as a key player in the response to vascular damage, which could open new avenues to therapeutic intervention... - Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45Olaf Krüger
Institute of Genetics, Division of Molecular Genetics, University of Bonn, Roemerstr 164, 53117 Bonn, Germany
J Mol Cell Cardiol 41:787-97. 2006..Our findings may be particularly relevant for understanding molecular factors contributing to human congenital cardiac diseases... - In vitro and in vivo studies on continuous echo-contrast application strategies using SonoVue in a newly developed rotating pump setupStefan Lohmaier
Department of Radiology, University of Bonn, Bonn, Germany
Ultrasound Med Biol 30:1145-51. 2004..0001). The new infusion technique might thereby allow routine application of constant infusion scenarios in clinical CS...