Alexander Ghanem

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 55:1427-32. 2010
  2. doi request reprint Prognostic value of cerebral injury following transfemoral aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    EuroIntervention 8:1296-306. 2013
  3. ncbi request reprint Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiography
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Cell Transplant 20:1621-8. 2011
  4. pmc Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
    Elke Winterhager
    Institut fur Anatomie, Universitat Duisburg Essen, 45122 Essen, Germany
    BMC Dev Biol 7:26. 2007
  5. ncbi request reprint Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 34:559-66. 2008
  6. ncbi request reprint Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Mol Cell Cardiol 47:411-8. 2009
  7. ncbi request reprint The revised EuroSCORE II for the prediction of mortality in patients undergoing transcatheter aortic valve implantation
    Alexander Sedaghat
    Universitatsklinikum Bonn, Med Klinik und Poliklinik II, Rheinische Friedrich Wilhelms Universitat Bonn, 53105, Bonn, Germany
    Clin Res Cardiol 102:821-9. 2013
  8. ncbi request reprint Novel approaches for prevention of stroke related to transcatheter aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Expert Rev Cardiovasc Ther 11:1311-20. 2013
  9. doi request reprint Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    JACC Cardiovasc Interv 3:1141-9. 2010
  10. doi request reprint Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Heart J 33:1459-68. 2012

Collaborators

Detail Information

Publications34

  1. doi request reprint Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 55:1427-32. 2010
    ..The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI)...
  2. doi request reprint Prognostic value of cerebral injury following transfemoral aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    EuroIntervention 8:1296-306. 2013
    ..To evaluate the impact of serological, imaging and clinical measures of cerebral injury on patient self-sufficiency and survival after transcatheter aortic valve implantation (TAVI)...
  3. ncbi request reprint Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiography
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Cell Transplant 20:1621-8. 2011
    ..In contrast to "simple" 2D echocardiography, r3D-echo allowed the assessment of regional contractile reserve and quantification of akinetic myocardial mass as additive functional and morphological measures of LVR...
  4. pmc Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
    Elke Winterhager
    Institut fur Anatomie, Universitat Duisburg Essen, 45122 Essen, Germany
    BMC Dev Biol 7:26. 2007
    ..In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26...
  5. ncbi request reprint Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 34:559-66. 2008
    ..3DE allows precise quantitation of myocardial borderzone and identification of transmural scar tissue noninvasively. Assessment of contractile reserve improves characterization and estimation of myocardial borderzone after CMI...
  6. ncbi request reprint Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Mol Cell Cardiol 47:411-8. 2009
    ..This study provides the first evidence of the migration of MSCs across the myocardial endothelium in vivo. Hf-UMS not only improves myocardial engraftment of MSCs but also allows locoregional targeting of post-ischemic myocardium...
  7. ncbi request reprint The revised EuroSCORE II for the prediction of mortality in patients undergoing transcatheter aortic valve implantation
    Alexander Sedaghat
    Universitatsklinikum Bonn, Med Klinik und Poliklinik II, Rheinische Friedrich Wilhelms Universitat Bonn, 53105, Bonn, Germany
    Clin Res Cardiol 102:821-9. 2013
    ..Logistic EuroSCORE and STS score are currently used to estimate procedural risk and mortality for surgical and transcatheter aortic valve implantation (TAVI). The recently published EuroSCORE II might provide a helpful tool...
  8. ncbi request reprint Novel approaches for prevention of stroke related to transcatheter aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Expert Rev Cardiovasc Ther 11:1311-20. 2013
    ....
  9. doi request reprint Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    JACC Cardiovasc Interv 3:1141-9. 2010
    ..The aim of this study was to determine the influence of baseline renal function and periprocedural acute kidney injury (AKI) on prognosis after transcatheter aortic valve implantation (TAVI)...
  10. doi request reprint Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Heart J 33:1459-68. 2012
    ..We assessed the impact of a systemic inflammatory response syndrome (SIRS) on the outcome after transcatheter aortic valve implantation (TAVI)...
  11. pmc Ultrasound-mediated stimulation of microbubbles after acute myocardial infarction and reperfusion ameliorates left-ventricular remodelling in mice via improvement of borderzone vascularization
    Jonas Dörner
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    PLoS ONE 8:e56841. 2013
    ..The aim of this study was to evaluate transthoracic ultrasound-mediated microbubble stimulation (UMS) as a novel gene- and cell-free therapeutic option after acute myocardial infarction and reperfusion (AMI/R) in mice...
  12. doi request reprint Evaluation and management of paravalvular aortic regurgitation after transcatheter aortic valve replacement
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    J Am Coll Cardiol 62:11-20. 2013
    ..Every measure has to be taken to prevent or reduce PAR to provide a satisfying long-term clinical outcome. ..
  13. doi request reprint Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Mol Cell Cardiol 46:644-52. 2009
    ..We suggest that Cx30.2 and Cx40 act as counterparts in the AV-node and His-bundle, decreasing or increasing, respectively, electrical coupling and conduction velocity in these areas...
  14. doi request reprint Doppler-based renal resistance index for the detection of acute kidney injury and the non-invasive evaluation of paravalvular aortic regurgitation after transcatheter aortic valve implantation
    Jan Malte Sinning
    Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Bonn, Germany
    EuroIntervention 9:1309-16. 2014
    ....
  15. doi request reprint Aortic regurgitation index defines severity of peri-prosthetic regurgitation and predicts outcome in patients after transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Am Coll Cardiol 59:1134-41. 2012
    ....
  16. doi request reprint Decrease of pulmonary hypertension impacts on prognosis after transcatheter aortic valve replacement
    Jan Malte Sinning
    Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Bonn, Germany
    EuroIntervention 9:1042-9. 2014
    ..In cardiac surgery patients, PH is associated with less symptomatic improvement and increased late mortality. This study elucidates the impact of PH on outcome after TAVR...
  17. doi request reprint Three-dimensional speckle-tracking analysis of left ventricular function after transcatheter aortic valve implantation
    Robert Schueler
    Department of Internal Medicine, Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany
    J Am Soc Echocardiogr 25:827-834.e1. 2012
    ..The aim of this study was to determine the effect of TAVI on LV function with two-dimensional (2D) and three-dimensional (3D) speckle-tracking analysis of LV deformation capability...
  18. doi request reprint Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Interv Card Electrophysiol 26:3-10. 2009
    ..Gelsolin (gsn) is involved in the reorganization of the cytoskeleton, thereby modulating cardiomyocytal L-type Ca(2+) channels. We investigated global cardiac electrophysiological characteristics in a gsn-deficient (gsn(-/-)) mouse strain...
  19. ncbi request reprint Echocardiographic assessment of left ventricular mass in neonatal and adult mice: accuracy of different echocardiographic methods
    Alexander Ghanem
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Echocardiography 23:900-7. 2006
    ..Echocardiographic assessment of LVM is feasible in hearts weighting less than 50 mg and can be estimated best in systole. Hearts weighting more than 50 mg are estimated most accurately by means of LVM-AL at diastole...
  20. ncbi request reprint Acute Changes of Mitral Valve Geometry During Interventional Edge-to-Edge Repair With the MitraClip System Are Associated With Midterm Outcomes in Patients With Functional Valve Disease: Preliminary Results From a Prospective Single-Center Study
    Robert Schueler
    From the Departments of Medicine II R S, D M, M W, N W, C M, A G, G N, C H and Cardiovascular Surgery A W, Heart Centre Bonn, University Hospital Bonn, Bonn, Germany
    Circ Cardiovasc Interv 7:390-9. 2014
    ..We sought to assess immediate effect of TMVR on MV annular geometry with 3-dimensional (3D) transesophageal echocardiography and the association of MV diameter reduction with functional response after 6 months...
  21. doi request reprint Cognitive trajectory after transcatheter aortic valve implantation
    Alexander Ghanem
    From the Department of Medicine Cardiology A G, J K, J M S, B V B, M V, T S, M V N, C H, J O S, N W, E G, G N, Department of Psychiatry and Psychotherapy M W, S W, and Department of Radiology D T, A M, University of Bonn, Bonn, Germany and German Center for Neurodegenerative Diseases DZNE, Bonn, Germany M W, S W
    Circ Cardiovasc Interv 6:615-24. 2013
    ..Considering its increasing use, thorough longitudinal investigation of cognitive trajectory after TAVI is pivotal...
  22. pmc Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function
    Se Chan Kim
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    BMC Physiol 7:5. 2007
    ..In a chronic closed-chest model we assessed whether cardiac function is preserved in TLR4-deficient mice (C3H/HeJ) following MI/R, and whether myocardial and systemic cytokine expression differed compared to wild type (WT)...
  23. doi request reprint Transcatheter valve implantation improves central sleep apnoea in severe aortic stenosis
    Markus Linhart
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    EuroIntervention 9:923-8. 2013
    ..We sought to examine the relationship between severe aortic stenosis, sleep disordered breathing (SDB), and CSA before and after transcatheter aortic valve implantation (TAVI)...
  24. doi request reprint Functional impact of targeted closed-chest transplantation of bone marrow cells in rats with acute myocardial ischemia/reperfusion injury
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Cell Transplant 18:1289-97. 2009
    ..However, intramyocardial CTx of MNC or MSC had no influence on systolic function and contractile reserve after reperfused MI...
  25. pmc The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    Radoslaw Dobrowolski
    Institute of Genetics, University of Bonn, Germany
    Hum Mol Genet 17:539-54. 2008
    ..Our results suggest that the increased activity of ATP-releasing channels in Cx43G138R mutated cardiomyocytes may further reduce the already decreased gap junctional communication and thus aggravate arrhythmogenesis in the mouse mutant...
  26. ncbi request reprint Triggered replenishment imaging reduces variability of quantitative myocardial contrast echocardiography and allows assessment of myocardial blood flow reserve
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Echocardiography 24:149-58. 2007
    ..88x + 0.45, r = 0.83, P < 0.0001), without systematic bias. TRI significantly reduces variability of RK in quantitative MCE. Assessment of MBFR allows investigator-independent evaluation of CAD...
  27. ncbi request reprint Cardioprotective Effects of Osteopontin-1 during Development of Murine Ischemic Cardiomyopathy
    Georg D Duerr
    Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Biomed Res Int 2014:124063. 2014
    ..In conclusion, osteopontin seems to modulate expression of contractile elements, antioxidative mediators, and inflammatory response and subsequently remodel in order to protect cardiomyocytes in murine ischemic cardiomyopathy. ..
  28. doi request reprint Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury
    Ulrich M Becher
    Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Mol Cell Cardiol 50:570-7. 2011
    ..Conclusion: Inhibition of leukotriene C(4) reduces levels of oxidative stress and apoptosis and demonstrates beneficial effects on myocardial remodeling after left ventricular injury...
  29. ncbi request reprint Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart
    Georg D Duerr
    Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany Electronic address
    Life Sci 102:88-97. 2014
    ..The aim of our study was to investigate the role of cardiomyocyte specific PPAR-α overexpression in myocardial adaptation to repetitive ischemic injury without myocardial infarction...
  30. ncbi request reprint The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy
    Georg D Duerr
    Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Basic Res Cardiol 109:425. 2014
    ..Therefore, the endocannabinoid-CB2 receptor axis plays a key role in cardioprotection during the initial phase of ischemic cardiomyopathy development. ..
  31. ncbi request reprint Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair
    Sebastian Schlaweck
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Biochem Biophys Res Commun 411:627-31. 2011
    ..In all, NLRP3 plays a non-redundant role in vascular damage mediated neointima formation. Our data establish NLRP3 as a key player in the response to vascular damage, which could open new avenues to therapeutic intervention...
  32. doi request reprint An unusual cause for recurrent syncope in a female adult with LEOPARD syndrome
    Christoph Hammerstingl
    Medizinische Klinik II, Universitatsklinikum Bonn, Bonn, Germany
    Echocardiography 26:596-7. 2009
    ..This case impressively underlines the vital necessity of dynamic testing particularly in patients with symptoms during exercise even if these symptoms might be addressed to other findings...
  33. ncbi request reprint Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45
    Olaf Krüger
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, Roemerstr 164, 53117 Bonn, Germany
    J Mol Cell Cardiol 41:787-97. 2006
    ..Our findings may be particularly relevant for understanding molecular factors contributing to human congenital cardiac diseases...
  34. ncbi request reprint In vitro and in vivo studies on continuous echo-contrast application strategies using SonoVue in a newly developed rotating pump setup
    Stefan Lohmaier
    Department of Radiology, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 30:1145-51. 2004
    ..0001). The new infusion technique might thereby allow routine application of constant infusion scenarios in clinical CS...