Joachim Geyer

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. request reprint
    Geyer J, Döring B, Meerkamp K, Ugele B, Bakhiya N, Fernandes C, et al. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J Biol Chem. 2007;282:19728-41 pubmed
    ..Among these inhibitors, 2- and 4-sulfooxymethylpyrene were competitive inhibitors of SOAT, with apparent K(i) values of 4.3 and 5.5 microm, respectively, and they were also transported by SOAT-HEK293 cells. ..
  2. Kranz J, Hessel S, Aretz J, Seidel A, Petzinger E, Geyer J, et al. The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice. Chem Biol Interact. 2014;224:36-41 pubmed publisher
    ..Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis. ..
  3. Fietz D, Markmann M, Lang D, Konrad L, Geyer J, Kliesch S, et al. Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation. BMC Mol Biol. 2015;16:23 pubmed publisher
    ..Studies using AR-transfected cells, subsequently stimulated, should consider alterations in AR-dependent gene expression as off-target effects of the AR transfection itself. ..
  4. Grosser G, Baringhaus K, Döring B, Kramer W, Petzinger E, Geyer J. Identification of novel inhibitors of the steroid sulfate carrier 'sodium-dependent organic anion transporter' SOAT (SLC10A6) by pharmacophore modelling. Mol Cell Endocrinol. 2016;428:133-41 pubmed publisher
    ..This value was confirmed by cell-based transport assays. Therefore, the developed SOAT pharmacophore model demonstrated its suitability in predicting novel SOAT inhibitors. ..
  5. request reprint
    Geyer J, Wilke T, Petzinger E. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch Pharmacol. 2006;372:413-31 pubmed
  6. Geyer J, Fernandes C, Doring B, Burger S, Godoy J, Rafalzik S, et al. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. Neuroscience. 2008;152:990-1005 pubmed publisher
    ..Although the functional properties of Slc10a4 could not be elucidated in this study, Slc10a4 is regarded as a new marker protein for cholinergic neurons in the rat CNS. ..
  7. Geyer J, Gavrilova O, Petzinger E. Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice. J Vet Pharmacol Ther. 2009;32:87-96 pubmed publisher
    ..This indicates that Bcrp is not a relevant efflux carrier for these macrocyclic lactone compounds in vivo at the blood-brain barrier...
  8. Schmidt S, Moncada M, Burger S, Geyer J. Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes. BMC Neurosci. 2015;16:35 pubmed publisher
  9. Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, et al. The role of sulfated steroid hormones in reproductive processes. J Steroid Biochem Mol Biol. 2017;172:207-221 pubmed publisher
    ..This review and concept paper presents key findings from all these projects and provides a broad overview over the current research on sulfated steroid hormones in the field of reproduction. ..

More Information

Publications13

  1. Bennien J, Fischer T, Geyer J. Rare genetic variants in the sodium-dependent organic anion transporter SOAT (SLC10A6): Effects on transport function and membrane expression. J Steroid Biochem Mol Biol. 2018;179:26-35 pubmed publisher
    ..If these loss-of-function SOAT variants are more frequent in men with impaired spermatogenesis or infertility needs further investigation. ..
  2. Bakhaus K, Fietz D, Kliesch S, Weidner W, Bergmann M, Geyer J. The polymorphism L204F affects transport and membrane expression of the sodium-dependent organic anion transporter SOAT (SLC10A6). J Steroid Biochem Mol Biol. 2018;179:36-44 pubmed publisher
    ..Both groups showed nearly identical distributions of the SOAT-L204F polymorphism (∼10% heterozygous and ∼5% homozygous), indicating that this polymorphism seems not be causative for hypospermatogenesis. ..
  3. Grosser G, Bennien J, Sánchez Guijo A, Bakhaus K, Döring B, Hartmann M, et al. Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6). J Steroid Biochem Mol Biol. 2018;179:20-25 pubmed publisher
  4. Bakhaus K, Bennien J, Fietz D, Sánchez Guijo A, Hartmann M, Serafini R, et al. Sodium-dependent organic anion transporter (Slc10a6-/-) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. J Steroid Biochem Mol Biol. 2018;179:45-54 pubmed publisher
    ..As cholesterol sulfate has a broader impact apart from the testis, further analysis of this phenotype will include other organs such as skin and lung, which also show high Soat expression in the mouse. ..