Affiliation: University of Giessen
Geyer J, Döring B, Meerkamp K, Ugele B, Bakhiya N, Fernandes C, et al
. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J Biol Chem. 2007;282:19728-41 pubmed
..Among these inhibitors, 2- and 4-sulfooxymethylpyrene were competitive inhibitors of SOAT, with apparent K(i) values of 4.3 and 5.5 microm, respectively, and they were also transported by SOAT-HEK293 cells. ..
Kranz J, Hessel S, Aretz J, Seidel A, Petzinger E, Geyer J, et al
. The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice. Chem Biol Interact. 2014;224:36-41 pubmed publisher
..Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis. ..
Fietz D, Markmann M, Lang D, Konrad L, Geyer J, Kliesch S, et al
. Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation. BMC Mol Biol. 2015;16:23 pubmed publisher
..Studies using AR-transfected cells, subsequently stimulated, should consider alterations in AR-dependent gene expression as off-target effects of the AR transfection itself. ..
Grosser G, Baringhaus K, Döring B, Kramer W, Petzinger E, Geyer J. Identification of novel inhibitors of the steroid sulfate carrier 'sodium-dependent organic anion transporter' SOAT (SLC10A6) by pharmacophore modelling. Mol Cell Endocrinol. 2016;428:133-41 pubmed publisher
..This value was confirmed by cell-based transport assays. Therefore, the developed SOAT pharmacophore model demonstrated its suitability in predicting novel SOAT inhibitors. ..
Geyer J, Wilke T, Petzinger E. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch Pharmacol. 2006;372:413-31 pubmed
Geyer J, Fernandes C, Doring B, Burger S, Godoy J, Rafalzik S, et al
. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. Neuroscience. 2008;152:990-1005 pubmed publisher
..Although the functional properties of Slc10a4 could not be elucidated in this study, Slc10a4 is regarded as a new marker protein for cholinergic neurons in the rat CNS. ..
Geyer J, Gavrilova O, Petzinger E. Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice. J Vet Pharmacol Ther. 2009;32:87-96 pubmed publisher
..This indicates that Bcrp is not a relevant efflux carrier for these macrocyclic lactone compounds in vivo at the blood-brain barrier...
Schmidt S, Moncada M, Burger S, Geyer J. Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes. BMC Neurosci. 2015;16:35 pubmed publisher
Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, et al
. The role of sulfated steroid hormones in reproductive processes. J Steroid Biochem Mol Biol. 2017;172:207-221 pubmed publisher
..This review and concept paper presents key findings from all these projects and provides a broad overview over the current research on sulfated steroid hormones in the field of reproduction. ..