Manuela Gernert

Summary

Affiliation: University of Veterinary Medicine
Country: Germany

Publications

  1. ncbi request reprint Altered discharge pattern of basal ganglia output neurons in an animal model of idiopathic dystonia
    Manuela Gernert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, 30559 Hannover, Germany
    J Neurosci 22:7244-53. 2002
  2. ncbi request reprint Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy
    Manuela Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Eur J Neurosci 20:2377-86. 2004
  3. pmc Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures
    Marc W Nolte
    Department of Pharmacology, Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse, 67061 Ludwigshafen, Germany
    Neurobiol Dis 31:342-54. 2008
  4. doi request reprint Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity
    Saskia Kücker
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Neurobiol Dis 37:661-72. 2010
  5. ncbi request reprint Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Brain Res 1083:50-60. 2006
  6. doi request reprint The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance
    Kathrin Töllner
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, 30559 Hannover, Germany
    J Neurosci 31:16423-34. 2011
  7. ncbi request reprint Pedunculopontine neurons are involved in network changes in the kindling model of temporal lobe epilepsy
    Marc W Nolte
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Neurobiol Dis 23:206-18. 2006
  8. doi request reprint Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats
    Julia Jungnickel
    Hannover Medical School, Institute of Neuroanatomy, Hannover, Germany
    Behav Brain Res 216:129-35. 2011
  9. ncbi request reprint Effects of locally administered pentylenetetrazole on nigral single unit activity and severity of dystonia in a genetic model of paroxysmal dystonia
    Maren Fedrowitz
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Hannover, Germany
    J Neurosci Res 68:595-603. 2002
  10. doi request reprint Female Wistar rats obtained from different breeders vary in anxiety-like behavior and epileptogenesis
    Stefanie Honndorf
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 94:26-38. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Altered discharge pattern of basal ganglia output neurons in an animal model of idiopathic dystonia
    Manuela Gernert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, 30559 Hannover, Germany
    J Neurosci 22:7244-53. 2002
    ....
  2. ncbi request reprint Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy
    Manuela Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Eur J Neurosci 20:2377-86. 2004
    ....
  3. pmc Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures
    Marc W Nolte
    Department of Pharmacology, Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse, 67061 Ludwigshafen, Germany
    Neurobiol Dis 31:342-54. 2008
    ..Thus, it appears that the condition of the host brain and the production of foreign proteins by transplanted cells have to be considered in estimating the risks of rejection of transplants into the brain...
  4. doi request reprint Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity
    Saskia Kücker
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Neurobiol Dis 37:661-72. 2010
    ..The findings are relevant for a better understanding of kindling-induced network changes and might provide new targets for therapeutic manipulations in epilepsies...
  5. ncbi request reprint Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Brain Res 1083:50-60. 2006
    ....
  6. doi request reprint The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance
    Kathrin Töllner
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, 30559 Hannover, Germany
    J Neurosci 31:16423-34. 2011
    ..The data demonstrate for the first time an involvement of the SNr in pharmacoresistant experimental epilepsy and emphasize the relevance of the basal ganglia as target structures for new treatment options...
  7. ncbi request reprint Pedunculopontine neurons are involved in network changes in the kindling model of temporal lobe epilepsy
    Marc W Nolte
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Neurobiol Dis 23:206-18. 2006
    ..The underlying mechanisms are discussed. The findings are relevant for a better understanding of kindling-associated network changes and might provide new targets for therapeutic manipulations in epilepsies...
  8. doi request reprint Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats
    Julia Jungnickel
    Hannover Medical School, Institute of Neuroanatomy, Hannover, Germany
    Behav Brain Res 216:129-35. 2011
    ..These results emphasize the crucial role of graft localization for benefit of restorative cell therapy for PD...
  9. ncbi request reprint Effects of locally administered pentylenetetrazole on nigral single unit activity and severity of dystonia in a genetic model of paroxysmal dystonia
    Maren Fedrowitz
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Hannover, Germany
    J Neurosci Res 68:595-603. 2002
    ..The greater susceptibility of neurons within the SNr to PTZ suggests dysfunctions of the GABA(A) receptor in dt(sz) mutants...
  10. doi request reprint Female Wistar rats obtained from different breeders vary in anxiety-like behavior and epileptogenesis
    Stefanie Honndorf
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 94:26-38. 2011
    ..In conclusion, female Wistar outbred rats from different breeders showed variations in anxiety-like behavior and epileptogenesis. Decisions about appropriate commercial colonies used for biomedical research should be taken with caution...
  11. ncbi request reprint Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats
    Manuela Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, Hannover, Germany
    Exp Neurol 176:183-92. 2002
    ..The data demonstrate that genetically engineered cells have the potential to raise seizure thresholds when transplanted to the central PC...
  12. ncbi request reprint Comparative analysis of anxiety-like behaviors and sensorimotor functions in two rat mutants, ci2 and ci3, with lateralized rotational behavior
    Sven Lindemann
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany
    Physiol Behav 91:551-60. 2007
    ..Based on previous findings of dysfunctions of the central dopamine system in ci2 and ci3 mutant rats, we assume that alterations in dopaminergic activity are involved in the maladaptive behavior observed in the present study...
  13. ncbi request reprint Auditory and vestibular defects and behavioral alterations after neonatal administration of streptomycin to Lewis rats: Similarities and differences to the circling (ci2/ci2) Lewis rat mutant
    Marko Schirmer
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, Hannover, Germany
    Brain Res 1155:179-95. 2007
    ....
  14. doi request reprint Cell and gene therapies in epilepsy--promising avenues or blind alleys?
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Trends Neurosci 31:62-73. 2008
    ..However, several crucial issues remain to be resolved to develop cell and gene therapies into effective and safe therapies...
  15. doi request reprint Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model
    Annelie Handreck
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Cell Transplant 23:111-32. 2014
    ..The STN can be considered a highly promising target region for modulation of seizure circuits and, moreover, has the advantage of being clinically established for functional neurosurgery. ..
  16. doi request reprint Decreased density of amygdaloid parvalbumin-positive interneurons and behavioral changes in dystonic hamsters (Mesocricetus auratus)
    Melanie Hamann
    Institute of Pharmacology and Toxicology, Department of Veterinary Science, Freie Universitat Berlin, Germany
    Behav Neurosci 122:36-43. 2008
    ..Interestingly, prepulse inhibition was absent in mutant hamsters. The latter finding suggests a disturbed sensorimotor gating that can be related to alterations in both the basal ganglia nuclei and in limbic structures...
  17. ncbi request reprint Neonatal medial prefrontal cortex lesion enhances the sensitivity of the mesoaccumbal dopamine system
    Mustapha Bennay
    Department of Neuropharmacology, Brain Research Institute, University of Bremen, POB 330440, 28334 Bremen, Germany
    Eur J Neurosci 19:3277-90. 2004
    ....