Christof Geldmacher

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich LMU, Munich, Germany
    Trends Immunol 33:207-14. 2012
  2. doi request reprint Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich, Germany
    Curr Opin HIV AIDS 7:268-75. 2012
  3. pmc Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
  4. pmc Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
  5. pmc Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
  6. pmc Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania
    Elmar Saathoff
    Department of Infectious Diseases and Tropical Medicine, Ludwig Maximilians University of Munich LMU, Munich, Germany
    J Acquir Immune Defic Syndr 54:324-30. 2010
  7. pmc Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
  8. pmc Risk factors for HIV-1 infection in a longitudinal, prospective cohort of adults from the Mbeya Region, Tanzania
    Steffen Geis
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, LMU, Munich, Germany
    J Acquir Immune Defic Syndr 56:453-9. 2011
  9. pmc Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania
    Inge Kroidl
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich LMU, Munich, Germany
    PLoS ONE 7:e39529. 2012
  10. pmc SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007

Detail Information

Publications12

  1. pmc Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich LMU, Munich, Germany
    Trends Immunol 33:207-14. 2012
    ....
  2. doi request reprint Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich, Germany
    Curr Opin HIV AIDS 7:268-75. 2012
    ..Here, we discuss pathogenic mechanisms of HIV-induced CD4 T-cell depletion and their potential impact on immune control of Mycobacterium tuberculosis...
  3. pmc Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
    ....
  4. pmc Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
    ..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response...
  5. pmc Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
    ..This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection...
  6. pmc Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania
    Elmar Saathoff
    Department of Infectious Diseases and Tropical Medicine, Ludwig Maximilians University of Munich LMU, Munich, Germany
    J Acquir Immune Defic Syndr 54:324-30. 2010
    ..The viral load setpoint (VLS) is an important predictor of HIV disease progression, but there is a lack of information regarding the VLS and its possible determinants in African populations...
  7. pmc Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
    ..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection...
  8. pmc Risk factors for HIV-1 infection in a longitudinal, prospective cohort of adults from the Mbeya Region, Tanzania
    Steffen Geis
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, LMU, Munich, Germany
    J Acquir Immune Defic Syndr 56:453-9. 2011
    ..This study describes HIV-1 incidence and associated risk factors in a general population cohort of adults from Mbeya region, Tanzania, who participated in a vaccine preparedness study...
  9. pmc Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania
    Inge Kroidl
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich LMU, Munich, Germany
    PLoS ONE 7:e39529. 2012
    ..To evaluate the diagnostic performance of two rapid detection tests (RDTs) for HIV 1/2 in plasma and in whole blood samples...
  10. pmc SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
    ..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection...
  11. pmc CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
    Christof Geldmacher
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 81:2440-8. 2007
    ..36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection...
  12. pmc Hookworm infection and environmental factors in mbeya region, Tanzania: a cross-sectional, population-based study
    Helene Riess
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany Institute for Medical Bioinformatics, Biometry, and Epidemiology, Ludwig Maximilians University, Munich, Germany
    PLoS Negl Trop Dis 7:e2408. 2013
    ..Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control...