Christof Geldmacher

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich LMU, Munich, Germany
    Trends Immunol 33:207-14. 2012
  2. ncbi Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich, Germany
    Curr Opin HIV AIDS 7:268-75. 2012
  3. ncbi Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
  4. ncbi Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
  5. ncbi Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
  6. ncbi Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania
    Elmar Saathoff
    Department of Infectious Diseases and Tropical Medicine, Ludwig Maximilians University of Munich LMU, Munich, Germany
    J Acquir Immune Defic Syndr 54:324-30. 2010
  7. ncbi Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
  8. ncbi Risk factors for HIV-1 infection in a longitudinal, prospective cohort of adults from the Mbeya Region, Tanzania
    Steffen Geis
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, LMU, Munich, Germany
    J Acquir Immune Defic Syndr 56:453-9. 2011
  9. ncbi Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania
    Inge Kroidl
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich LMU, Munich, Germany
    PLoS ONE 7:e39529. 2012
  10. ncbi SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007

Detail Information

Publications11

  1. ncbi Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich LMU, Munich, Germany
    Trends Immunol 33:207-14. 2012
    ....
  2. ncbi Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis
    Christof Geldmacher
    Division of Infectious Diseases and Tropical Medicine, Medical Center of University of Munich, Germany
    Curr Opin HIV AIDS 7:268-75. 2012
    ..Here, we discuss pathogenic mechanisms of HIV-induced CD4 T-cell depletion and their potential impact on immune control of Mycobacterium tuberculosis...
  3. ncbi Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
    ..This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection...
  4. ncbi Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
    ..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response...
  5. ncbi Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
    ....
  6. ncbi Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania
    Elmar Saathoff
    Department of Infectious Diseases and Tropical Medicine, Ludwig Maximilians University of Munich LMU, Munich, Germany
    J Acquir Immune Defic Syndr 54:324-30. 2010
    ..The viral load setpoint (VLS) is an important predictor of HIV disease progression, but there is a lack of information regarding the VLS and its possible determinants in African populations...
  7. ncbi Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
    ..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection...
  8. ncbi Risk factors for HIV-1 infection in a longitudinal, prospective cohort of adults from the Mbeya Region, Tanzania
    Steffen Geis
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, LMU, Munich, Germany
    J Acquir Immune Defic Syndr 56:453-9. 2011
    ..This study describes HIV-1 incidence and associated risk factors in a general population cohort of adults from Mbeya region, Tanzania, who participated in a vaccine preparedness study...
  9. ncbi Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania
    Inge Kroidl
    Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich LMU, Munich, Germany
    PLoS ONE 7:e39529. 2012
    ..To evaluate the diagnostic performance of two rapid detection tests (RDTs) for HIV 1/2 in plasma and in whole blood samples...
  10. ncbi SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
    ..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection...
  11. ncbi CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
    Christof Geldmacher
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 81:2440-8. 2007
    ..36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection...