Research Topics
Genomes and Genes | Hartmut GeigerSummaryAffiliation: University of Ulm Country: Germany Publications
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Publications
Aging in the lympho-hematopoietic stem cell compartmentHartmut Geiger
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Trends Immunol 30:360-5. 2009..Reverting or ameliorating aging of HSCs might be a crucial step to restoring immuno-competence in the elderly...
Targeting erythroblast-specific apoptosis in experimental anemiaAbhinav Diwan
Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
Apoptosis 13:1022-30. 2008..These results support the concept of targeting erythroblast apoptosis to maximize erythrocyte production in acute anemia, which may be of value in erythropoietin resistance...- Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationMarnie A Ryan
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
Nat Med 16:1141-6. 2010..Our findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provide a new pharmacological approach for improving HSPC mobilization and thereby transplantation outcomes... - Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleenTheodosia A Kalfa
Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
Haematologica 95:27-35. 2010..The role of these Rac GTPases in erythropoiesis has not yet been fully elucidated... - Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potentialHaiming Xu
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
Blood 114:3557-66. 2009..Our study defines p190-B as a critical transducer element of HSC self-renewal activity and long-term engraftment, thus suggesting that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype... - R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilizationXun Shang
Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Biol Chem 286:24068-78. 2011..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization... - Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationAmitava Sengupta
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 108:9957-62. 2011.... - Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrowLinda Yang
Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 104:5091-6. 2007..Thus, Cdc42 is a critical coordinator of HSC quiescence maintenance and interaction with the BM niche... - Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potentialJon P Williams
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Cell Stem Cell 3:658-69. 2008..We suggest that expansion of an EGFR-expressing early glial progenitor contributes to neurofibroma formation... - Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicityHartmut Geiger
Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Nat Med 18:1123-9. 2012..These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd or aPC might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation... 
Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell agingHartmut Geiger
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Cell Cycle 6:884-7. 2007....- Quantification of genomic mutations in murine hematopoietic cellsHartmut Geiger
Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
Methods Mol Biol 506:423-36. 2009.... - Regulation of hematopoietic stem cell aging in vivo by a distinct genetic elementHartmut Geiger
Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 102:5102-7. 2005.... - The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stressDeidre Daria
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA
Blood 111:1894-902. 2008..In summary, Rb is critical for hematopoietic stem and progenitor cell function, localization, and differentiation... - TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cellsJune Li
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 117:3283-95. 2007..We conclude that TNF-alpha exposure creates an environment in which somatically mutated preleukemic stem cell clones are selected and from which unaltered TNF-alpha-hypersensitive Fancc-/- stem cells are purged... - The impact of altered p53 dosage on hematopoietic stem cell dynamics during agingMelissa Dumble
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH, USA
Blood 109:1736-42. 2007..Thus, alteration of p53 activity affects stem-cell numbers, proliferation potential, and hematopoiesis in older organisms, supporting a model in which aging is caused in part by a decline in tissue stem cell regenerative function... - Increased hematopoietic stem cell mobilization in aged miceZhenlan Xing
Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 108:2190-7. 2006..These results might indicate that stroma-stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age... - Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cellsMichael D Milsom
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Cancer Res 68:6171-80. 2008..These studies have direct translational relevance to ongoing clinical gene therapy studies using MGMT(P140K), whereas the novel mechanistic findings are relevant to the basic understanding of DNA repair by MGMT... - Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesisAbhinav Diwan
Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 104:6794-9. 2007..These results suggest that physiological codependence and coordinated regulation of pro- and antiapoptotic Bcl2 family members may represent a general regulatory paradigm in hematopoiesis... - Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemiaDeepika Bhatla
Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Br J Haematol 144:388-94. 2009..59 +/- 12% AA and 55 +/- 14% AC; P = 0.40). These data indicate that children with a low activity CDA genotype are at increased risk of TRM with ara-C based therapy for AML... - p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathOndrej Krejci
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA
Blood 111:2190-9. 2008..It is possible that the superior outcome of t(8;21) patients is partly due to an activated p53 pathway, and that loss of the p53 response pathway is associated with disease progression...