Andreas Geier

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
  2. ncbi Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver
    Andreas Geier
    Department of Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Aachen, Germany
    Liver Int 27:1056-65. 2007
  3. ncbi Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver
    Andreas Geier
    Dept of Internal Medicine III, Division of Gastroenterology and Hepatology, Aachen Univ, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G831-41. 2005
  4. ncbi Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    World J Gastroenterol 9:2681-5. 2003
  5. ncbi Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
    Andreas Geier
    Department of Gastroenterology, Aachen University RWTH, Aachen, Germany
    J Hepatol 43:1021-30. 2005
  6. ncbi Profuse rectal bleeding of no visible cause
    Andreas Geier
    Department of Internal Medicine III, Aachen University, University Hospital, D 52074 Aachen, Germany
    Lancet 369:1664. 2007
  7. ncbi Magnetic resonance imaging and magnetic resonance cholangiopancreaticography for diagnosis and pre-interventional evaluation of a fluid thoracic mass
    Andreas Geier
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Technology Aachen, Germany
    Eur J Gastroenterol Hepatol 15:429-31. 2003
  8. ncbi Occult celiac disease prevents penetrance of hemochromatosis
    Andreas Geier
    Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    World J Gastroenterol 11:3323-6. 2005
  9. ncbi Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    Andreas Geier
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochim Biophys Acta 1773:283-308. 2007
  10. ncbi Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    Hepatology 38:345-54. 2003

Detail Information

Publications50

  1. ncbi Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
    ..Maintained binding activity of RXRalpha:RARalpha may explain differences in Mrp2 expression...
  2. ncbi Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver
    Andreas Geier
    Department of Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Aachen, Germany
    Liver Int 27:1056-65. 2007
    ....
  3. ncbi Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver
    Andreas Geier
    Dept of Internal Medicine III, Division of Gastroenterology and Hepatology, Aachen Univ, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G831-41. 2005
    ..Activity of HNF-1alpha as regulator of mNtcp is suppressed by both cytokines. Decreased binding activities of nuclear receptor heterodimers may be explained by a reduction of the ubiquitous heterodimerization partner RXR-alpha...
  4. ncbi Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    World J Gastroenterol 9:2681-5. 2003
    ..To investigate the systemic availability of budesonide in a patient with Child A cirrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma, who developed serious side effects...
  5. ncbi Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
    Andreas Geier
    Department of Gastroenterology, Aachen University RWTH, Aachen, Germany
    J Hepatol 43:1021-30. 2005
    ..Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults...
  6. ncbi Profuse rectal bleeding of no visible cause
    Andreas Geier
    Department of Internal Medicine III, Aachen University, University Hospital, D 52074 Aachen, Germany
    Lancet 369:1664. 2007
  7. ncbi Magnetic resonance imaging and magnetic resonance cholangiopancreaticography for diagnosis and pre-interventional evaluation of a fluid thoracic mass
    Andreas Geier
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Technology Aachen, Germany
    Eur J Gastroenterol Hepatol 15:429-31. 2003
    ..However, after 3 weeks of successful percutaneous drainage, infectious complications necessitated surgical intervention...
  8. ncbi Occult celiac disease prevents penetrance of hemochromatosis
    Andreas Geier
    Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    World J Gastroenterol 11:3323-6. 2005
    ..To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon gluten-free diet...
  9. ncbi Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    Andreas Geier
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochim Biophys Acta 1773:283-308. 2007
    ..Moreover, the potential therapeutic role of nuclear receptor agonists for the management of liver diseases is highlighted...
  10. ncbi Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    Hepatology 38:345-54. 2003
    ..In contrast to in vitro studies, HNF1 and RXR/RAR-independent mechanisms appear to be more important in regulation of Mrp2 and Ntcp gene expression in endotoxemia...
  11. ncbi Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha
    Christoph G Dietrich
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, University Hospital Aachen, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G585-90. 2007
    ..We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway...
  12. ncbi Cytokine-independent repression of rodent Ntcp in obstructive cholestasis
    Andreas Geier
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Hepatology 41:470-7. 2005
    ..In conclusion, during obstructive cholestasis accumulating bile acids per se, without major contribution of cytokines, leads to downregulation of Ntcp via repression of HNF-1alpha and HNF-4alpha...
  13. ncbi Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005
    ....
  14. ncbi Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Hepatology 40:327-34. 2004
    ..In conclusion, RANTES haplotypes might contribute to the polygenic interaction between HCV and the host immune system and could help to risk stratify patients prior to antiviral therapy...
  15. ncbi Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury
    Martin Roderfeld
    Department of Gastroenterology Medical Clinic 11, University Hospital, Justus Liebig University, Giessen, Germany
    Liver Int 26:579-86. 2006
    ....
  16. ncbi Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2
    Christoph G Dietrich
    Department of Internal Medicine III, Aachen University, Germany
    Gastroenterology 126:1044-53. 2004
    ....
  17. ncbi Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C
    Andreas Geier
    Department of Medicine III, University Hospital Aachen, Aachen University RWTH, Germany
    Liver Int 24:285-94. 2004
    ..Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in German hepatitis C patients...
  18. doi Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen
    Christoph G Dietrich
    Department of Gastroenterology and Hepatology, Aachen University, Aachen, Germany
    Int J Cancer 129:546-52. 2011
    ..This might promote the adenoma-carcinoma sequence by higher genotoxic effects. The results indicate a possible role of transporter deficiencies in susceptibility for colon carcinoma...
  19. ncbi Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
    Sonja Hillebrandt
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Nat Genet 37:835-43. 2005
    ..Thus, the mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species...
  20. ncbi Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Biochim Biophys Acta 1609:87-94. 2003
    ..In addition, known transactivators of Oatp2 and Ntcp were studied to further characterize transcriptional regulation of these transporter genes...
  21. ncbi Interleukin-6 regulates hepatic transporters during acute-phase response
    Elmar Siewert
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochem Biophys Res Commun 322:232-8. 2004
    ..IL-6 is required for transporter down-regulation during aseptic inflammation. Furthermore, IL-6 also contributes to transporter regulation during LPS-induced cholestasis at more delayed time points...
  22. ncbi Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis
    Andreas Geier
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Aachen University, Germany
    Nat Clin Pract Gastroenterol Hepatol 3:574-85. 2006
    ..Patients with progressive sclerosing cholangitis should be considered for orthotopic liver transplantation...
  23. ncbi Enlarged cervical lymph nodes and elevated liver chemistry tests: a therapeutic dilemma
    Christoph G Dietrich
    Department of Medicine III, Aachen University, 52074 Aachen, Germany
    Ann Hepatol 3:118-20. 2004
    ..Liver involvement of tuberculosis can have many facets and may be treated by gradual dosing of standard drugs...
  24. ncbi Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis
    Frank Lammert
    Department of Medicine III, University Hospital Aachen and Aachen University, Aachen, Germany
    Hepatology 39:117-28. 2004
    ..The mouse model supports the concept that this gene is a monogenic risk factor for cholesterol gallstones and a target for novel therapeutic strategies...
  25. ncbi Lessons from a patient with an unusual hepatic overlap syndrome
    Leif E Sander
    Department of Internal Medicine III, Aachen University Hospital, Aachen, Germany
    Nat Clin Pract Gastroenterol Hepatol 4:635-40. 2007
    ....
  26. doi Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis
    Lars P Bechmann
    Department of Gastroenterology and Hepatology, University Hospital, University Duisburg Essen, Essen, Germany
    Hepatology 57:1394-406. 2013
    ..In line with the NAS score, adiponectin levels were reversely correlated with BA levels. Adiponectin correlated with NTCP and affects Cyp7A1 expression both in vivo and in vitro...
  27. doi Multikinase inhibitor sorafenib transiently promotes necrosis after radiofrequency ablation in rat liver but activates growth signals
    Joachim C Mertens
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Eur J Radiol 81:1601-6. 2012
    ..Radiofrequency ablation is combined with the multi-tyrosinkinase-inhibitor sorafenib in ongoing clinical trials. Whether this combination treatment affects liver tissue repair is unknown...
  28. pmc The presence of non-organ-specific autoantibodies is associated with a negative response to combination therapy with interferon and ribavirin for chronic hepatitis C
    Hermann E Wasmuth
    Department of Internal Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Aachen, Germany
    BMC Infect Dis 4:4. 2004
    ..Previous studies investigated the clinical relevance of these antibodies in patients treated with interferon monotherapy, but not combination therapies...
  29. ncbi [Regulation of hepatobiliary transporters in cholestatic liver disease]
    Andreas Geier
    Medizinische Klinik III, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Med Klin (Munich) 99:7-17. 2004
    ..Understanding of these regulatory pathways represents a mandatory prerequisite for any future therapeutic intervention in acute or chronic liver diseases...
  30. doi Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage
    Steven Dooley
    Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    Gastroenterology 135:642-59. 2008
    ..The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis...
  31. doi Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice
    Ina V Martin
    Department of Internal Medicine III, University Hospital Aachen, Germany
    Biol Chem 391:1441-9. 2010
    ..Differences between intestinal and hepatic FXR could explain apparent contradictory information regarding its effects on fatty liver disease...
  32. ncbi Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, D 52074, Aachen, Germany
    J Hepatol 36:718-24. 2002
    ..Since down-regulation of hepatocellular organic anion transporters is implicated in the molecular pathogenesis of cholestasis, expression of these transporters was determined in a novel rat model, which closely resembles human PSC...
  33. doi Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers
    Oliver Goetze
    Division of Gastroenterology and Hepatology, University Hospital Zurich, Switzerland Division of Hepatology, Department of Medicine II, University Hospital Wurzburg, Germany
    Hepatology 58:2153-62. 2013
    ..001). Plasma CRP increased on MG2 and MG4, while IL-6 only increased on MG2 (P < 0.001). Serum hepcidin levels decreased at high altitude on MG2 and MG4 (P < 0.001)...
  34. ncbi Patients with acute on chronic liver failure display "sepsis-like" immune paralysis
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Hepatol 42:195-201. 2005
    ..The aim of the present study was to directly compare functional immune parameters in patients with acute on chronic liver failure (ACLF), severe sepsis, and non-decompensated cirrhosis...
  35. ncbi CC chemokine receptor 5 delta32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Mol Med (Berl) 82:64-9. 2004
    ....
  36. ncbi Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids
    Edmund Purucker
    Department of Internal Medicine III, Medical Faculty, Aachen University of Technology, D 52057 Aachen, Germany
    Am J Physiol Renal Physiol 283:F1281-9. 2002
    ..The increase in GSH consumption despite reduced gamma-GCS activity indicates a decreased GSH turnover tentatively due to reduced renal GSH efflux by competition with organic anions at membrane transport proteins...
  37. doi A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease
    Rika Iwata
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Zurich USZ, CH 8091 Zurich, Switzerland
    Clin Sci (Lond) 120:287-96. 2011
    ..The common ABCB11 1331CC genotype, which is present in 40% of HCV patients and renders the carrier susceptible to increased bile acid levels, is associated with cirrhosis...
  38. doi Current diagnosis and management of primary sclerosing cholangitis
    Jens J W Tischendorf
    Medical Department III Gastroenterology, Hepatology, and Metabolic Diseases, University Hospital Aachen, Aachen, Germany
    Liver Transpl 14:735-46. 2008
    ..Therefore, endoscopic techniques such as cholangioscopy and/or intraductal ultrasound may be useful diagnostic tools in patients with stenoses suspicious for malignancy...
  39. ncbi Functional analysis of the rat bile salt export pump gene promoter
    Thomas Gerloff
    Institute of Clinical Pharmacology, Charite University Medical Center, Humboldt University, Berlin, Germany
    Eur J Biochem 269:3495-503. 2002
    ..FXR was a major regulatory factor, mediating bile acid feed-back stimulation of Bsep transcription...
  40. ncbi [Diagnosis of cholestatic disorders]
    Andreas Geier
    Universitätsklinikum der RWTH Aachen
    Med Klin (Munich) 98:499-509. 2003
    ..This review summarizes our current knowledge in the diagnosis of cholestatic disorders...
  41. ncbi Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
    Timo Rath
    Department of Internal Medicine III, University Hospital RWTH, Aachen, Germany
    Inflamm Bowel Dis 12:1025-35. 2006
    ..In APs, increased expression of MMP-7 and MMP-13 may serve as an early indicator for colorectal carcinogenesis...
  42. ncbi Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes
    Ruth Schiffer
    Department of Dermatology, University Clinic, RWTH Aachen, Germany
    J Invest Dermatol 120:285-91. 2003
    ....
  43. pmc Hepatocyte nuclear factor-4alpha is a central transactivator of the mouse Ntcp gene
    Andreas Geier
    Dept of Internal Medicine, Div of Gastroenterology and Hepatology, Univ Hospital Zurich USZ Rämistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 295:G226-33. 2008
    ..Using Hepa 1-6 cells, HNF-4alpha-knockdown resulted in a significant 95% reduction in NTCP mRNA. In conclusion, mouse Ntcp is regulated by HNF-4alpha via a conserved distal cis-element independently of HNF-1alpha...
  44. doi Endoscopy for repeatedly ingested sharp foreign bodies in patients with borderline personality disorder: an international survey
    Cornelia M Frei-Lanter
    Department of Surgery, Kantonsspital Winterthur, Switzerland
    Eur J Gastroenterol Hepatol 24:793-7. 2012
    ..The aim of this survey was to collect data on experience and opinions on the management of FBs in psychiatric patients with BPD and to review the relevant literature...
  45. doi Rat Mrp2 gene expression is regulated by an interleukin-1β-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1
    Peter R Mertens
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University, Magdeburg, Germany
    Eur J Cell Biol 91:533-41. 2012
    ..Previously we have shown that YB-1 down-regulates Mrp2 expression in vitro. Therefore we investigated the potential role of YB-1 as regulator of hepatic acute phase genes...
  46. ncbi Hepatitis B e Antigen and the Risk of Hepatocellular Carcinoma
    Andreas Geier
    N Engl J Med 347:1721-2; author reply 1721-2. 2002
  47. ncbi Multidrug resistance and response to antiretroviral treatment
    Christoph G Dietrich
    Lancet 359:2114; author reply 2214-5. 2002
  48. ncbi It takes more than one--is a single UGT polymorphism enough to bother detoxification?
    Christoph G Dietrich
    Hepatology 42:1462; author reply 1463. 2005
  49. ncbi Antiviral therapy in HBe-Ag-positive hepatitis B with normal aminotransferase levels
    Andreas Geier
    Hepatology 37:712-3; author reply 713. 2003
  50. ncbi Bosentan for pulmonary hypertension
    Christoph G Dietrich
    N Engl J Med 347:292-4; author reply 292-4. 2002