Niels H Gehring

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi Disassembly of exon junction complexes by PYM
    Niels H Gehring
    University of Heidelberg and European Molecular Biology Laboratory, Germany
    Cell 137:536-48. 2009
  2. pmc The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
    Niels H Gehring
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 7:e1000120. 2009
  3. ncbi Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
    Niels H Gehring
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg 69120, Germany
    Mol Cell 20:65-75. 2005
  4. ncbi A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay
    Stephanie Boelz
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 349:186-91. 2006
  5. pmc NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins
    Bhagyashri D Burgute
    Institute of Biochemistry I, Medical Faculty, Center for Molecular Medicine Cologne CMMC, 50931 Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, 50931 Cologne, Germany and Leibniz Institute of Freshwater Ecology and Inland Fisheries, IGB, Muggelseedamm 301, 12587 Berlin, Germany
    Nucleic Acids Res 42:3177-93. 2014

Collaborators

Detail Information

Publications5

  1. doi Disassembly of exon junction complexes by PYM
    Niels H Gehring
    University of Heidelberg and European Molecular Biology Laboratory, Germany
    Cell 137:536-48. 2009
    ..In cells depleted of PYM, EJCs accumulate on spliced mRNAs and EJC protein recycling is impaired. Hence, PYM is an EJC disassembly factor that acts both in vitro and in living cells, and that antagonizes important EJC functions...
  2. pmc The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
    Niels H Gehring
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 7:e1000120. 2009
    ..Based on this systematic analysis of EJC assembly by the spliceosome, we propose a model of how a functional EJC is assembled in a strictly sequential and hierarchical fashion, including nuclear splicing-dependent and cytoplasmic steps...
  3. ncbi Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
    Niels H Gehring
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg 69120, Germany
    Mol Cell 20:65-75. 2005
    ..These results are integrated into a nonlinear model for mammalian NMD involving alternative routes of entry that converge at a common requirement of UPF1...
  4. ncbi A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay
    Stephanie Boelz
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 349:186-91. 2006
    ..Wortmannin treatment enhanced NMD reporter expression in our system in a dose-dependent way, illustrating its utility for small molecule screening...
  5. pmc NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins
    Bhagyashri D Burgute
    Institute of Biochemistry I, Medical Faculty, Center for Molecular Medicine Cologne CMMC, 50931 Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, 50931 Cologne, Germany and Leibniz Institute of Freshwater Ecology and Inland Fisheries, IGB, Muggelseedamm 301, 12587 Berlin, Germany
    Nucleic Acids Res 42:3177-93. 2014
    ..Our results reveal NKAP as nuclear speckle protein with roles in RNA splicing and processing. ..