Affiliation: University of Mainz
- Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorderChristian Geber
Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Ther Drug Monit 35:279-82. 2013..The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 due to a genetic deficit and (2) inhibition of CYP2C9 by cotrimoxazole...
- Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked painChristian Geber
Klinik und Poliklinik für Neurologie der Universität Mainz, Germany
J Pain 8:503-14. 2007..We describe differences, similarities, and reproducibility of these human pain models. These data might help to interpret past and future results of human pain studies using experimental pain...
- Numbness in clinical and experimental pain--a cross-sectional study exploring the mechanisms of reduced tactile functionChristian Geber
Neurologische Universitatsklinik, Johannes Gutenberg Universitat, Mainz, Germany
Pain 139:73-81. 2008..Hypaesthesia (numbness) often encountered in clinical pain can be reproduced by experimental nociceptive stimulation. The time course of effects suggests a mechanism involving central plasticity...
- Comparison of LEP and QST and their contribution to standard sensory diagnostic assessment of spinal lesions: a pilot studyChristian Geber
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Langenbeckstrasse 1, 55131 Mainz, Germany
Neurol Sci 32:401-10. 2011..LEP detected more deficits than any single QST parameter or their combination but additional QST allows the detection of positive sensory signs. The diagnostic gain of SEP was limited...
- Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre studyChristian Geber
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
Pain 152:548-56. 2011....
- Do intensity ratings and skin conductance responses reliably discriminate between different stimulus intensities in experimentally induced pain?Markus Breimhorst
Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz, Germany
J Pain 12:61-70. 2011..Further studies are needed to reveal the reason for this lack of accuracy for SCRs when applying electrical pain stimuli...
- Revised definition of neuropathic pain and its grading system: an open case series illustrating its use in clinical practiceChristian Geber
Department of Neurology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Am J Med 122:S3-12. 2009..Its clinical use should be further validated in prospective studies...
- Evolving understandings about complex regional pain syndrome and its treatmentMarcel Fechir
Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, Mainz, Germany
Curr Pain Headache Rep 12:186-91. 2008..The common therapeutic aim is to maintain or restore normal function of the affected extremity. Beyond highlighting pathophysiologic concepts, this article describes recent therapeutic approaches...
- A pathway in the brainstem for roll-tilt of the subjective visual vertical: evidence from a lesion-behavior mapping studyBernhard Baier
Department of Neurology, University of Mainz, 55131 Mainz, Germany, and Department of Neurology and Integrated Center For Research and Treatment of Vertigo Balance and Ocular Motor Disorders, Ludwig Maximillians University, 80539 Munich, Germany
J Neurosci 32:14854-8. 2012..Present data indicate that graviceptive otolith signals present a predominant role in the multisensory system of verticality perception...
- Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestineChristian Geber
Institut fur Pharmakologie, Universitat Mainz, 55131, Mainz, Germany
Naunyn Schmiedebergs Arch Pharmacol 372:277-83. 2006..The facilitatory effect is indirect and involves tachykinin release and excitation of NK1 and NK3 receptors on cholinergic neurons. The inhibition of acetylcholine release may be due to a decrease of Ca2+ influx into cholinergic neurons...