Frank Gaunitz

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Glucocorticoid induced expression of glutamine synthetase in hepatoma cells
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 296:1026-32. 2002
  2. ncbi request reprint Cloning and expression of the rat BACE1 promoter
    Christine Lange-Dohna
    Department of Neurochemistry, University of Leipzig, Leipzig, Germany
    J Neurosci Res 73:73-80. 2003
  3. ncbi request reprint Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines
    Anke Hannemann
    Institute of Biochemistry, University of Leipzig Medical Faculty, Liebigstrasse 16, D 04103 Leipzig, Germany
    Gene 345:237-47. 2005
  4. doi request reprint Carnosine and cancer: a perspective
    Frank Gaunitz
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103, Leipzig, Germany
    Amino Acids 43:135-42. 2012
  5. ncbi request reprint A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Mol Endocrinol 18:63-9. 2004
  6. ncbi request reprint HTS compatible assay for antioxidative agents using primary cultured hepatocytes
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Assay Drug Dev Technol 1:469-77. 2003
  7. ncbi request reprint An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Hepatology 41:1225-32. 2005
  8. doi request reprint Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approach
    Ansgar Asperger
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103 Leipzig, Germany, 1
    Cancer Invest 29:272-81. 2011
  9. pmc Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
  10. pmc Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
    Felicitas Merz
    Institute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, Germany
    Neuro Oncol 15:670-81. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Glucocorticoid induced expression of glutamine synthetase in hepatoma cells
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 296:1026-32. 2002
    ..However, evidence is presented that aside from a primary effect on transcription glucocorticoids mediate their effect on the expression of GS also at the posttranscriptional level...
  2. ncbi request reprint Cloning and expression of the rat BACE1 promoter
    Christine Lange-Dohna
    Department of Neurochemistry, University of Leipzig, Leipzig, Germany
    J Neurosci Res 73:73-80. 2003
    ..The BACE1 promoter sequence data and the constructs described here will be useful to identify factors that influence the expression of BACE1 in experimental paradigms in vitro...
  3. ncbi request reprint Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines
    Anke Hannemann
    Institute of Biochemistry, University of Leipzig Medical Faculty, Liebigstrasse 16, D 04103 Leipzig, Germany
    Gene 345:237-47. 2005
    ..The methylation status of the promoter region was analyzed in different neural tumor cell lines and compared with that in human leukocytes and muscle...
  4. doi request reprint Carnosine and cancer: a perspective
    Frank Gaunitz
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103, Leipzig, Germany
    Amino Acids 43:135-42. 2012
    ..Finally, alternative strategies are examined such as treatment with other dipeptides or β-alanine...
  5. ncbi request reprint A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Mol Endocrinol 18:63-9. 2004
    ..This yet unknown factor was designated GS silencer-binding protein. It is absent in FAO cells that respond to glucocorticoids with enhanced expression of GS and present in HepG2 cells that do not respond...
  6. ncbi request reprint HTS compatible assay for antioxidative agents using primary cultured hepatocytes
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Assay Drug Dev Technol 1:469-77. 2003
    ..Although the protocol is primarily designed to screen for substances with antioxidative potential, it can easily be adapted to screen for other biologically active substances...
  7. ncbi request reprint An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Hepatology 41:1225-32. 2005
    ....
  8. doi request reprint Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approach
    Ansgar Asperger
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103 Leipzig, Germany, 1
    Cancer Invest 29:272-81. 2011
    ..Finally, peptide mass fingerprinting identified the "BCL2-associated athanogene 2" and the "von Hippel-Lindau binding protein 1" among other proteins, linking the action of carnosine to protein folding and HIF-1α signalling...
  9. pmc Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
    ....
  10. pmc Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
    Felicitas Merz
    Institute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, Germany
    Neuro Oncol 15:670-81. 2013
    ..Here, we describe how glioblastoma specimens obtained from surgical biopsy material can be sectioned and transferred into cultures within minutes...
  11. pmc Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
    ..In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human cancer therapy...
  12. ncbi request reprint Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors
    Max Werth
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Hepatology 44:967-75. 2006
    ..In conclusion, the GS 5' enhancer contains elements important for GS expression in cells carrying an activated form of beta-catenin as previously shown in experimentally induced hepatocellular carcinomas...
  13. doi request reprint Hedgehog signaling in glioblastoma multiforme
    Stefanie Braun
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, Leipzig, Germany
    Cancer Biol Ther 13:487-95. 2012
    ....
  14. doi request reprint Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling
    Inge Lindner
    Institute of Biochemistry, Department of Ophthalmology, University of Leipzig, Leipzig, Germany
    Cancer Res 70:277-87. 2010
    ..Notably, LRP1 antibodies could phenocopy the effects of A2M*. Our findings suggest a pathway of tumor suppression in astrocytoma that might be tractable to therapeutic exploitation...
  15. doi request reprint Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells
    Sanja Pavlica
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Toxicol In Vitro 23:653-9. 2009
    ..In conclusion, Zn(2+)-salts could be divided into three categories with high (zinc-citrate, zinc-sulphate), moderate (zinc-orotate, zinc-acetate, zinc-chloride(,) zinc-gluconate) and low cytotoxicity (zinc-histidinate)...
  16. ncbi request reprint Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver
    Rolf Gebhardt
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Prog Histochem Cytochem 41:201-66. 2007
    ....
  17. doi request reprint Dual luciferase assay for secreted luciferases based on Gaussia and NanoLuc
    Kerstin Heise
    Institute of Biochemistry, Leipzig University Hospital, Faculty of Medicine, Leipzig University, Leipzig, Germany
    Assay Drug Dev Technol 11:244-52. 2013
    ..Since Gaussia luciferase and NanoLuc are nonhomologous reporters, the method to determine both luciferase activities may also be useful for coincidence reporter gene systems for high-throughput screening...
  18. doi request reprint Carnosine inhibits ATP production in cells from malignant glioma
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Neurol Res 32:101-5. 2010
    ..In order to understand how this effect is mediated, experiments were performed that addressed a possible influence of carnosine on energy metabolism...
  19. doi request reprint Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation
    Katrin Bigl
    Interdisciplinary Centre of Clinical Research IZKF, Faculty of Medicine, University of Leipzig, Inselstr 22, 04103, Leipzig, Germany
    J Neural Transm 115:1545-56. 2008
    ..This indicates that apoptotic events may be involved in the change of physiological parameters...
  20. ncbi request reprint 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    J Cell Mol Med 14:1276-93. 2010
    ....
  21. doi request reprint The antineoplastic effect of carnosine is accompanied by induction of PDK4 and can be mimicked by L-histidine
    Ulrike Letzien
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, Liebigstraße 20, 04103, Leipzig, Germany
    Amino Acids 46:1009-19. 2014
    ....
  22. doi request reprint Real-time RT-PCR discriminating mRNA encoding osteocalcin from unspecific targets
    Jan Karl Burkhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany
    Anal Bioanal Chem 393:1351-5. 2009
    ..It was found that the classic method that does not correct for PMF1 expression leads to overestimations as high as 70%...
  23. ncbi request reprint The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle
    Sabine Erdmann
    Institute of Anatomy, University of Leipzig, Liebigstr 13, 04103, Leipzig, Germany
    Am J Physiol Endocrinol Metab 293:E1365-77. 2007
    ..In conclusion, 1) the bovine CL is able to produce PRL and to process it into antiangiogenic fragments by Cath D activity and 2) PRL cleavage might mediate angioregression during luteolysis...
  24. ncbi request reprint Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
    Qing Lin
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20621-33. 2007
    ..We speculate that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress...
  25. ncbi request reprint Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
    Sandra Loeppen
    Institut fur Toxikologie, Universitat Tubingen, Germany
    Cancer Res 62:5685-8. 2002
    ..These data suggest that promotion of hepatocarcinogenesis by PB confers beta-catenin-mutated tumor cells with a selective advantage by up-regulation of GS expression...