Michael Frotscher

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. doi request reprint Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, 79011 Freiburg, Germany
    Eur J Neurosci 27:559-71. 2008
  2. pmc Identification of alternatively spliced Dab1 and Fyn isoforms in pig
    Huan Long
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
    BMC Neurosci 12:17. 2011
  3. ncbi request reprint New ways of looking at synapses
    Michael Frotscher
    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr 17, 79104, Freiburg, Germany
    Histochem Cell Biol 128:91-6. 2007
  4. ncbi request reprint Role of Reelin in the development and maintenance of cortical lamination
    Michael Frotscher
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Neural Transm 116:1451-5. 2009
  5. ncbi request reprint Synapses formed by normal and abnormal hippocampal mossy fibers
    Michael Frotscher
    Institut für Anatomie und Zellbiologie und Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    Cell Tissue Res 326:361-7. 2006
  6. ncbi request reprint Development of cell and fiber layers in the dentate gyrus
    Michael Frotscher
    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Prog Brain Res 163:133-42. 2007
  7. ncbi request reprint Role for Reelin in stabilizing cortical architecture
    Michael Frotscher
    Institut für Anatomie und Zellbiologie and Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Trends Neurosci 33:407-14. 2010
  8. ncbi request reprint Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold
    Michael Frotscher
    Anatomisches Institut, Universitat Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
    Cereb Cortex 13:634-40. 2003
  9. ncbi request reprint Laminating the hippocampus
    Eckart Forster
    Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
    Nat Rev Neurosci 7:259-67. 2006
  10. pmc Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus
    Bianka Brunne
    Center of Neurosciences, University of Freiburg, Freiburg, Germany
    Glia 58:1553-69. 2010

Detail Information

Publications82

  1. doi request reprint Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, 79011 Freiburg, Germany
    Eur J Neurosci 27:559-71. 2008
    ....
  2. pmc Identification of alternatively spliced Dab1 and Fyn isoforms in pig
    Huan Long
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
    BMC Neurosci 12:17. 2011
    ..Dab1 function depends on its tyrosine phosphorylation by Src family kinases, especially Fyn...
  3. ncbi request reprint New ways of looking at synapses
    Michael Frotscher
    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr 17, 79104, Freiburg, Germany
    Histochem Cell Biol 128:91-6. 2007
    ..We expect these approaches to lead to new insights into the structure and function of central synapses...
  4. ncbi request reprint Role of Reelin in the development and maintenance of cortical lamination
    Michael Frotscher
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Neural Transm 116:1451-5. 2009
    ..Our results indicate that Reelin-induced stabilization of the neuronal cytoskeleton is an important component of Reelin's function in the development and maintenance of cortical architecture...
  5. ncbi request reprint Synapses formed by normal and abnormal hippocampal mossy fibers
    Michael Frotscher
    Institut für Anatomie und Zellbiologie und Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    Cell Tissue Res 326:361-7. 2006
    ..Together, the findings reviewed here establish mossy fiber synapses as an important component of inhibitory circuits in the hippocampus...
  6. ncbi request reprint Development of cell and fiber layers in the dentate gyrus
    Michael Frotscher
    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Prog Brain Res 163:133-42. 2007
    ..The molecular determinants controlling axonal pathfinding and target recognition of the profusely terminating cholinergic and GABAergic subcortical afferents still need to be elucidated...
  7. ncbi request reprint Role for Reelin in stabilizing cortical architecture
    Michael Frotscher
    Institut für Anatomie und Zellbiologie and Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Trends Neurosci 33:407-14. 2010
    ..This has implications for brain disorders, such as epilepsy and schizophrenia, in which deficiencies in Reelin expression occur...
  8. ncbi request reprint Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold
    Michael Frotscher
    Anatomisches Institut, Universitat Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
    Cereb Cortex 13:634-40. 2003
    ..These findings show that the Reelin signaling pathway is essential for the correct positioning of human hippocampal neurons and that a Reelin deficiency is involved in the pathological changes associated with epilepsy...
  9. ncbi request reprint Laminating the hippocampus
    Eckart Forster
    Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
    Nat Rev Neurosci 7:259-67. 2006
    ..Recently, the hippocampus, with its clearly segregated cell and fibre layers, has become a major subject of studies on cortical lamination...
  10. pmc Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus
    Bianka Brunne
    Center of Neurosciences, University of Freiburg, Freiburg, Germany
    Glia 58:1553-69. 2010
    ..Time-lapse imaging of acute hippocampal slices from hGFAP-eGFP transgenic mice provides direct evidence for such a migration mode of differentiating astroglial cells in the developing dentate gyrus...
  11. ncbi request reprint Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1
    Shanting Zhao
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 495:1-9. 2006
    ....
  12. doi request reprint Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3
    Xuejun Chai
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 29:288-99. 2009
    ..These novel findings suggest that Reelin-induced stabilization of neuronal processes anchors them to the marginal zone which appears to be required for the directional migration process...
  13. doi request reprint Role for Reelin in neurotransmitter release
    Sabine Hellwig
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Neurosci 31:2352-60. 2011
    ..Together, these novel findings suggest a role for Reelin in modulating presynaptic release mechanisms...
  14. ncbi request reprint Neurogranin is expressed by principal cells but not interneurons in the rodent and monkey neocortex and hippocampus
    Ilyas Singec
    Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 479:30-42. 2004
    ..Together these findings corroborate the idea of different calcium signaling pathways in excitatory and inhibitory cells that may contribute to different modes of synaptic plasticity in these neurons...
  15. ncbi request reprint Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice
    Karl Heinz Weiss
    Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 460:56-65. 2003
    ..Our results suggest that Reelin signaling via ApoER2, VLDLR, and Dab1 is required for the formation of a regular radial glial scaffold in the dentate gyrus...
  16. doi request reprint Exogenous reelin prevents granule cell dispersion in experimental epilepsy
    Martin C Muller
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 216:390-7. 2009
    ..Our findings highlight the crucial role of reelin for the maintenance of granule cell lamination in the dentate gyrus of adult mice and show that a reelin deficiency is causally involved in GCD development...
  17. ncbi request reprint Reelin and Notch1 cooperate in the development of the dentate gyrus
    Mirjam Sibbe
    Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 29:8578-85. 2009
    ..These results suggest that Reelin enhances Notch1 signaling, thereby contributing to the formation of the radial glial scaffold and the normal development of the dentate gyrus...
  18. doi request reprint Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning
    Stefanie Tinnes
    Experimental Epilepsy Group, Neurocenter, University Clinic Freiburg, Freiburg, Germany
    FASEB J 25:1002-13. 2011
    ..Taken together, our results strongly suggest that secretion of Reelin is activity-independent and that proteolytic processing of Reelin is required for the maintenance of granule cell lamination in the dentate gyrus...
  19. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..Our data link the observation that defects in Rho GTPases and Reelin signaling are responsible for developmental defects leading to neurological and psychiatric disorders...
  20. ncbi request reprint Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
    Iris Hack
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Development 134:3883-91. 2007
    ..We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons...
  21. pmc Reelin induces EphB activation
    Elisabeth Bouché
    Center for Neuroscience, Albert Ludwigs University, Albertstrasse 23, D 79104 Freiburg, Germany
    Cell Res 23:473-90. 2013
    ..Together, our data provide biochemical and functional evidence for signal integration between Reelin and EphB forward signaling...
  22. ncbi request reprint Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients
    Alexander Fahrner
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 203:320-32. 2007
    ....
  23. ncbi request reprint Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus
    Eckart Forster
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Eur J Neurosci 23:901-9. 2006
    ..Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system...
  24. ncbi request reprint Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy
    Carola A Haas
    Institute of Anatomy, Department of Neurosurgery, University of Freiburg, D 79001 Freiburg, Germany
    J Neurosci 22:5797-802. 2002
    ..These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy...
  25. ncbi request reprint Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin
    Shanting Zhao
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Deutschland
    Dev Neurosci 29:84-90. 2007
    ..These results indicate that adult neurogenesis is altered in the reeler dentate gyrus and that newly generated cells preferentially differentiate into astrocytes...
  26. ncbi request reprint Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column
    Marie T Krüger
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Albertstr 17, Freiburg, Germany
    Eur J Neurosci 32:1611-7. 2010
    ..The results extend our previous studies on cortical neurons in which Reelin in the marginal zone was found to stabilize the leading processes of migrating neurons and terminate the migration process...
  27. pmc Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes
    Chikako Nakajima
    Department of Medicine II, University Hospital and University of Freiburg, 79104 Freiburg, Germany
    J Biol Chem 288:21909-23. 2013
    ..These results show a role of LRP1 in the regulation and turnover of synaptic proteins, which may contribute to the reduced dendritic branching and to the neurological phenotype observed in the absence of LRP1. ..
  28. ncbi request reprint Hippocampal synapses depend on hippocampal estrogen synthesis
    Oliver Kretz
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 24:5913-21. 2004
    ..However, synaptophysin expression was upregulated under these conditions. Our results point to an essential role of endogenous hippocampal estrogen synthesis in the maintenance of hippocampal spine synapses...
  29. ncbi request reprint Proper layering is important for precisely timed activation of hippocampal mossy cells
    Janina Kowalski
    Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    Cereb Cortex 20:2043-54. 2010
    ..Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing...
  30. ncbi request reprint Reelin is a positional signal for the lamination of dentate granule cells
    Shanting Zhao
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, Albertstr 17, 79104 Freiburg, Germany
    Development 131:5117-25. 2004
    ..These results indicate a dual function of reelin in the dentate gyrus, as a differentiation factor for radial glial cells and as a positional cue for radial fiber orientation and granule cell migration...
  31. ncbi request reprint Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus
    Christophe Heinrich
    Experimental Epilepsy Group, University of Freiburg, D 79106 Freiburg, Germany
    J Neurosci 26:4701-13. 2006
    ..These results show that GCD does not result from increased neurogenesis but reflects a displacement of mature granule cells, most likely caused by a local reelin deficiency...
  32. ncbi request reprint Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice
    Alexander Drakew
    Institute of Anatomy, University of Freiburg, Albertstrasse 17, Freiburg, D 79104, Germany
    Exp Neurol 176:12-24. 2002
    ....
  33. pmc Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus
    Eckart Forster
    Anatomisches Institut, Universitat Freiburg, P O Box 111, D 79001 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:13178-83. 2002
    ..Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways...
  34. ncbi request reprint Reelin deficiency causes granule cell dispersion in epilepsy
    Carola A Haas
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Exp Brain Res 200:141-9. 2010
    ..In summary, these studies show that in epilepsy reelin dysfunction causes GCD development and that reelin is important for the maintenance of layered structures in the adult brain...
  35. doi request reprint Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus
    Mirjam Sibbe
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Eur J Neurosci 36:3643-52. 2012
    ..Furthermore, Sox2-positive cells as well as stem cell proliferation were reduced, thus pointing to a disruption of the stem cell niche in epilepsy under the present experimental conditions...
  36. ncbi request reprint Postnatal development of synaptopodin expression in the rodent hippocampus
    Kathrin Czarnecki
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 490:133-44. 2005
    ..However, no immunolabeling for synaptopodin was observed in identified interneurons, confirming that the protein is mainly present in spine-bearing principal cells...
  37. ncbi request reprint Different signals control laminar specificity of commissural and entorhinal fibers to the dentate gyrus
    Shanting Zhao
    Institute of Anatomy, University of Freiburg, D 79001 Freiburg, Germany
    J Neurosci 23:7351-7. 2003
    ..Together these results show that different mechanisms underlie the formation of commissural and entorhinal fiber layers during the development of the dentate gyrus...
  38. doi request reprint Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated action
    Claus M Gross
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Freiburg, Germany
    Hippocampus 22:409-20. 2012
    ..Taken together, these results show a sex-specific regulation of reelin gene expression by early life experience, most likely mediated by corticosterone...
  39. ncbi request reprint Neurogranin expression by cerebellar neurons in rodents and non-human primates
    Ilyas Singec
    Institute of Anatomy, University of Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 459:278-89. 2003
    ..In addition, NG expression in the primate cerebellum by brush cells, which are excitatory, showed remarkable cell type-specific and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms...
  40. ncbi request reprint Maturation and maintenance of cholinergic medial septum neurons require glucocorticoid receptor signaling
    Christian Guijarro
    Department of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    J Neurochem 97:747-58. 2006
    ..This pinpoints to plasticity of the septo-hippocampal system, that seems to compensate for the septal cell loss by sprouting of the remaining neurons...
  41. ncbi request reprint Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology
    Ilyas Singec
    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Nat Methods 3:801-6. 2006
    ..These cautions probably have implications for the use of 'cytospheres' as an assay in other organ systems and with other cell types, both normal and neoplastic...
  42. ncbi request reprint Go or stop? Divergent roles of Reelin in radial neuronal migration
    Shanting Zhao
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Neuroscientist 16:421-34. 2010
    ..Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons...
  43. ncbi request reprint Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse
    Iancu Bucurenciu
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Neuron 57:536-45. 2008
    ..Thus, tight coupling contributes to fast feedforward and feedback inhibition in the hippocampal network...
  44. ncbi request reprint Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells
    Akos Kulik
    Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, 79104 Freiburg, Germany
    J Neurosci 26:4289-97. 2006
    ..Thus, Kir3 channels, localized to different subcellular compartments of hippocampal principal cells, appear to be differentially involved in synaptic integration in pyramidal cell dendrites...
  45. ncbi request reprint Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus
    Akos Kulik
    Department of Anatomy and Cell Biology, University of Freiburg, 79104 Freiburg, Germany
    J Neurosci 23:11026-35. 2003
    ....
  46. pmc Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice
    Bianka Brunne
    Institute for Structural Neurobiology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Glia 61:1347-63. 2013
    ....
  47. ncbi request reprint Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis
    Peter Gerke
    Renal Division, University of Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 498:466-75. 2006
    ..Our results show that Neph proteins are expressed in the developing nervous system of mammals and suggest that these proteins may have a conserved function in synapse formation or neurogenesis...
  48. ncbi request reprint Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum
    Akos Kulik
    Department of Anatomy and Cell Biology, University of Freiburg, 79104 Freiburg, Germany
    Eur J Neurosci 19:2169-78. 2004
    ....
  49. ncbi request reprint Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network
    Josef Bischofberger
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104, Freiburg, Germany
    Pflugers Arch 453:361-72. 2006
    ..The characteristic properties of the hippocampal mossy fiber synapse may be important for pattern separation and information storage in the dentate gyrus-CA3 cell network...
  50. doi request reprint Structural plasticity of hippocampal mossy fiber synapses as revealed by high-pressure freezing
    Shanting Zhao
    Department for Structural Neurobiology, Center for Molecular Neurobiology Hamburg ZMNH, University of Hamburg, D 20246 Hamburg, Germany
    J Comp Neurol 520:2340-51. 2012
    ..These findings show that activation of hippocampal mossy fibers induces pre- and postsynaptic structural changes at mossy fiber synapses that can be monitored by EM...
  51. pmc Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity
    Thomas Deller
    Institute of Anatomy, University of Freiburg, P O Box 111, D 79001 Freiburg, Germany
    Proc Natl Acad Sci U S A 100:10494-9. 2003
    ..This genetic analysis points to a role of the spine apparatus in synaptic plasticity...
  52. ncbi request reprint Anterograde tracing of human hippocampus in vitro-a neuroanatomical tract tracing technique for the analysis of local fiber tracts in human brain
    Thomas M Freiman
    Department of Neurosurgery, Neurozentrum, University Clinic of Freiburg, Breisacher Strasse 64, D 79106, Freiburg, Germany
    J Neurosci Methods 120:95-103. 2002
    ..These data demonstrate that in vitro anterograde tracing can be employed to study the local connectivity of the human brain at the light and electron microscopic level...
  53. pmc Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks
    Marlene Bartos
    Physiologisches Institut and Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:13222-7. 2002
    ..In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling...
  54. doi request reprint Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy
    Desirée Loreth
    Department of Neuroanatomy, University of Freiburg, Germany
    Neurobiol Dis 47:1-12. 2012
    ....
  55. doi request reprint Fine structure of hippocampal mossy fiber synapses following rapid high-pressure freezing
    Shanting Zhao
    Department of Structural Neurobiology, Center for Molecular Neurobiology Hamburg, University of Hamburg, Martinistrasse 52, Hamburg, Germany
    Epilepsia 53:4-8. 2012
    ..Our results showed that high-pressure freezing nicely preserved ultrastructural detail of this particular synapse and allowed us to study rapid structural changes associated with synaptic plasticity...
  56. ncbi request reprint L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms
    Michael K E Schäfer
    Institut fur Anatomie und Zellbiologie, Universitat Freiburg, 79104 Freiburg, Germany
    Neurobiol Dis 40:222-37. 2010
    ..Our results indicate that L1 syndrome mutations impair neuronal L1 function at different levels, firstly by attenuating ER export and secondly by interfering with polarized neuronal trafficking...
  57. pmc Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells
    Theresa Pohlkamp
    Center for Neuroscience, Department of Neuroanatomy, Albert Ludwigs University, Freiburg, Germany Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 9:e100384. 2014
    ..In combination with reporter lines it is a useful model to analyze the development and maintenance of the cerebellar architecture including granule cell distribution, migration, and the extension of granule cell fibers in vivo. ..
  58. pmc BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
    Sandra Dieni
    Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    J Cell Biol 196:775-88. 2012
    ..They instead provide an ultrastructural basis for an anterograde mode of action of BDNF, contrasting with the long-established retrograde model derived from experiments with nerve growth factor in the peripheral nervous system...
  59. ncbi request reprint Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons
    Thomas Naumann
    Institute of Anatomy, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 22:2409-18. 2002
    ....
  60. ncbi request reprint Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 233:528-39. 2005
    ..In summary, we demonstrate that beta-catenin mediates cell-cell adhesion in the early telencephalon and is vital for maintaining the structural integrity of the neuroepithelium...
  61. ncbi request reprint Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons
    Ilyas Singec
    Department of Neuropathology, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    J Comp Neurol 452:139-53. 2002
    ..In conclusion, our data demonstrate that hippocampal principal cells and interneurons display a variety of synaptic vesicles that are likely to contribute to the functional characteristics of their output synapses...
  62. ncbi request reprint "Dormant basket cell" hypothesis revisited: relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat
    Robert S Sloviter
    Departments of Pharmacology and Neurology, University of Arizona, Tucson, Arizona 85724, USA
    J Comp Neurol 459:44-76. 2003
    ....
  63. ncbi request reprint Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 47:567-79. 2005
    ..Thus, alternative splicing of Apoer2, a novel component of the NMDA receptor complex, controls the modulation of NMDA receptor activity, synaptic neurotransmission, and memory by Reelin...
  64. ncbi request reprint Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus
    Carlos Bas Orth
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Comp Neurol 487:227-39. 2005
    ..We conclude, that this organelle is distributed in a region- and layer-specific manner in the mouse hippocampus and suggest that differences in the activity of afferent fiber systems could determine its distribution...
  65. pmc Neuronal migration in the murine rostral migratory stream requires serum response factor
    Siegfried Alberti
    Department of Molecular Biology, Institute for Cell Biology, Tubingen University, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 102:6148-53. 2005
    ..Our studies indicate that SRF-controlled gene expression directs both the structure and dynamics of the actin microfilament, thereby determining cell-autonomous neuronal migration...
  66. pmc A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A
    Vidar Jensen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
    J Physiol 553:843-56. 2003
    ..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit...
  67. ncbi request reprint Comparison of commissural sprouting in the mouse and rat fascia dentata after entorhinal cortex lesion
    Domenico Del Turco
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Hippocampus 13:685-99. 2003
    ..These data demonstrate an important species difference in the commissural/associational sprouting response between rats and mice that needs to be taken into account in future studies...
  68. ncbi request reprint Reelin signaling directly affects radial glia morphology and biochemical maturation
    Eva Hartfuss
    Max Planck Institute of Neurobiology, Neuronal Specification, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Development 130:4597-609. 2003
    ..Taken together, these results unravel a novel role of reelin signaling to radial glial cells that is crucial for the regulation of their Blbp content and characteristic morphology in a region-specific manner...
  69. ncbi request reprint Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body
    Kurt Sätzler
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 22:10567-79. 2002
    ..The geometry of the reconstructed synapse suggests that each of the hundreds of SCs is likely to contribute independently to the size and rising phase of the EPSC during a single AP...
  70. ncbi request reprint Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons
    Thomas Deller
    Department of Clinical Neuroanatomy, JW Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 453:33-44. 2002
    ..The intracellular sorting process, however, is independent of positional cues...
  71. pmc Kainic acid-induced recurrent mossy fiber innervation of dentate gyrus inhibitory interneurons: possible anatomical substrate of granule cell hyper-inhibition in chronically epileptic rats
    Robert S Sloviter
    Department of Pharmacology and the Graduate Program in Neuroscience, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Comp Neurol 494:944-60. 2006
    ..The anatomical data provide evidence of a possible anatomical substrate for the chronically hyper-inhibited state...
  72. ncbi request reprint Serum response factor controls neuronal circuit assembly in the hippocampus
    Bernd Knöll
    Interfakultäres Institut für Zellbiologie, Abt Molekularbiologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Nat Neurosci 9:195-204. 2006
    ..These data highlight essential links between SRF-mediated transcription and axon guidance and circuit formation in the hippocampus...
  73. ncbi request reprint Structural determinants of transmission at large hippocampal mossy fiber synapses
    Astrid Rollenhagen
    Institute of Neuroscience and Biophysics INB 3, Research Centre Julich, D 52425 Julich, Germany
    J Neurosci 27:10434-44. 2007
    ..Thus, the mossy fiber bouton differs fundamentally in structure and function from the calyx of Held and other central synapses...
  74. ncbi request reprint Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice
    Carlos Bas Orth
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 504:441-9. 2007
    ..Taken together, our data demonstrate that synaptopodin is an essential component of the cisternal organelle of axons and of the dendritic spine apparatus, two organelles that are structurally and molecularly related...
  75. ncbi request reprint Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice
    Carl Gebhardt
    Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 445:278-92. 2002
    ..These data provide further evidence for a role of granule cells in the laminar termination of commissural/associational afferents to the fascia dentata...
  76. ncbi request reprint A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Ann Anat 189:5-16. 2007
    ..Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity...
  77. ncbi request reprint Plasticity of synaptopodin and the spine apparatus organelle in the rat fascia dentata following entorhinal cortex lesion
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 499:471-84. 2006
    ....
  78. ncbi request reprint Hippocampal plasticity requires postsynaptic ephrinBs
    Ilona C Grunwald
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Nat Neurosci 7:33-40. 2004
    ..This work raises the intriguing possibility that depending on the type of synapse, Eph/ephrins can be involved in activity-dependent plasticity in converse ways, with ephrinBs on the pre- or the postsynaptic side...
  79. ncbi request reprint Lesion-induced axonal sprouting in the central nervous system
    Thomas Deller
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goether University, Frankfurt am Main, Germany
    Adv Exp Med Biol 557:101-21. 2006
    ..Finally, we discuss both the beneficial as well as disadvantageous functional implications of axonal sprouting for the injured organism in question...
  80. ncbi request reprint The most important recent advances in synapse research from my point of view--and what remains to be done
    Michael Frotscher
    Cell Tissue Res 326:203-4. 2006
  81. ncbi request reprint Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression
    Farima Bouzioukh
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    J Neurosci 27:11279-88. 2007
    ..Our results provide the first evidence for phosphotyrosine-dependent ephrinB reverse signaling in a neuronal network and for differential ephrinB2 reverse signaling in two forms of synaptic plasticity...
  82. pmc Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation
    Roland A Bender
    Department of Anatomy, University of California, Irvine, Irvine, California 92697 4475, USA
    J Neurosci 27:4697-706. 2007
    ..These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation...