M Frotscher

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Evidence for the existence of non-GABAergic, cholinergic interneurons in the rodent hippocampus
    M Frotscher
    Institute of Anatomy, University of Freiburg, P O Box 111, D 79001, Freiburg, Germany
    Neuroscience 96:27-31. 2000
  2. ncbi request reprint Role of afferent innervation and neuronal activity in dendritic development and spine maturation of fascia dentata granule cells
    M Frotscher
    Institute of Anatomy, University of Freiburg, PO Box 111, D 79001 Freiburg, Germany
    Cereb Cortex 10:946-51. 2000
  3. ncbi request reprint Cajal-Retzius cells, Reelin, and the formation of layers
    M Frotscher
    Institute of Anatomy, University of Freiburg, Germany
    Curr Opin Neurobiol 8:570-5. 1998
  4. ncbi request reprint The hippocampus of the reeler mutant mouse: fiber segregation in area CA1 depends on the position of the postsynaptic target cells
    T Deller
    Institute of Anatomy, University of Freiburg, Freiburg, D 79001, Germany
    Exp Neurol 156:254-67. 1999
  5. ncbi request reprint Different primary target cells are important for fiber lamination in the fascia dentata: a lesson from reeler mutant mice
    T Deller
    Institute of Anatomy, University of Freiburg, Freiburg, D 79001, Germany
    Exp Neurol 156:239-53. 1999
  6. ncbi request reprint Differential induction of c-Fos, c-Jun and Jun B in the rat central nervous system following unilateral entorhinal cortex lesion
    C A Haas
    Institute of Anatomy, University of Freiburg, Germany
    Neuroscience 90:41-51. 1999
  7. doi request reprint Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice
    S Nullmeier
    Institute of Anatomy, University of Magdeburg, Magdeburg, Germany
    Eur J Neurosci 33:689-98. 2011
  8. ncbi request reprint Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion. Role of the extracellular matrix
    T Deller
    Institute of Anatomy, University of Freiburg, Germany
    Ann N Y Acad Sci 911:207-20. 2000
  9. ncbi request reprint The alvear pathway of the rat hippocampus
    T Deller
    Anatomisches Institut I, Universitat Freiburg, Postfach 111, D 79001 Freiburg, Germany
    Cell Tissue Res 286:293-303. 1996
  10. ncbi request reprint Retrograde and anterograde tracing combined with transmitter identification and electron microscopy
    T Deller
    Institute of Anatomy, University of Freiburg, PO Box 111, D 79001, Freiburg, Germany
    J Neurosci Methods 103:117-26. 2000

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Evidence for the existence of non-GABAergic, cholinergic interneurons in the rodent hippocampus
    M Frotscher
    Institute of Anatomy, University of Freiburg, P O Box 111, D 79001, Freiburg, Germany
    Neuroscience 96:27-31. 2000
    ..These data provide neurochemical evidence for the existence of non-GABAergic, supposedly cholinergic non-principal cells in the hippocampus...
  2. ncbi request reprint Role of afferent innervation and neuronal activity in dendritic development and spine maturation of fascia dentata granule cells
    M Frotscher
    Institute of Anatomy, University of Freiburg, PO Box 111, D 79001 Freiburg, Germany
    Cereb Cortex 10:946-51. 2000
    ..Neuronal activity is required, however, for the maturation of dendritic spines...
  3. ncbi request reprint Cajal-Retzius cells, Reelin, and the formation of layers
    M Frotscher
    Institute of Anatomy, University of Freiburg, Germany
    Curr Opin Neurobiol 8:570-5. 1998
    ..Recent studies have shed some light on the role of Cajal-Retzius cells and Reelin in the formation of cell and fiber layers in the neocortex and hippocampus...
  4. ncbi request reprint The hippocampus of the reeler mutant mouse: fiber segregation in area CA1 depends on the position of the postsynaptic target cells
    T Deller
    Institute of Anatomy, University of Freiburg, Freiburg, D 79001, Germany
    Exp Neurol 156:254-67. 1999
    ..These data suggest that the normal laminar organization of the murine hippocampus depends on positional cues presented by their target cells...
  5. ncbi request reprint Different primary target cells are important for fiber lamination in the fascia dentata: a lesson from reeler mutant mice
    T Deller
    Institute of Anatomy, University of Freiburg, Freiburg, D 79001, Germany
    Exp Neurol 156:239-53. 1999
    ....
  6. ncbi request reprint Differential induction of c-Fos, c-Jun and Jun B in the rat central nervous system following unilateral entorhinal cortex lesion
    C A Haas
    Institute of Anatomy, University of Freiburg, Germany
    Neuroscience 90:41-51. 1999
    ..Alternatively, the alterations in immediate early gene expression reported here may be due to changes in synaptic activity or postlesional seizures which occur in this lesioning paradigm...
  7. doi request reprint Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice
    S Nullmeier
    Institute of Anatomy, University of Magdeburg, Magdeburg, Germany
    Eur J Neurosci 33:689-98. 2011
    ..In summary, the reelin haploinsufficient mouse may provide a useful model for studying the interaction between reelin and hippocampal GABAergic system, its effect on dendritic spine maturation and plasticity related to schizophrenia...
  8. ncbi request reprint Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion. Role of the extracellular matrix
    T Deller
    Institute of Anatomy, University of Freiburg, Germany
    Ann N Y Acad Sci 911:207-20. 2000
    ....
  9. ncbi request reprint The alvear pathway of the rat hippocampus
    T Deller
    Anatomisches Institut I, Universitat Freiburg, Postfach 111, D 79001 Freiburg, Germany
    Cell Tissue Res 286:293-303. 1996
    ..These data indicate that the alveus is a major route by which entorhinal fibers reach their targets in CA1...
  10. ncbi request reprint Retrograde and anterograde tracing combined with transmitter identification and electron microscopy
    T Deller
    Institute of Anatomy, University of Freiburg, PO Box 111, D 79001, Freiburg, Germany
    J Neurosci Methods 103:117-26. 2000
    ....
  11. ncbi request reprint Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection
    C A Haas
    Institute of Anatomy I, University of Freiburg, PO Box 111, D 79001 Freiburg, Germany
    Eur J Neurosci 12:4233-42. 2000
    ..Because the GAP-43 gene contains an AP-1 site, we hypothesize a c-Jun-driven up-regulation of GAP-43 in lesioned medial septal neurons that may contribute to their survival and regenerative potential following axotomy...
  12. ncbi request reprint Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons
    T Deller
    Institute of Anatomy, University of Freiburg, Germany
    J Comp Neurol 418:164-81. 2000
    ..Spines lacking a spine apparatus are not immunoreactive for synaptopodin. These data suggest that synaptopodin links the spine apparatus to actin and may thus be involved in the actin-based plasticity of spines...
  13. ncbi request reprint Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion
    T Deller
    Institute of Anatomy, University of Freiburg, Germany
    Prog Neurobiol 53:687-727. 1997
    ..Finally, an involvement of sprouting processes in the formation of neuritic plaques in Alzheimer's disease is reviewed and discussed with regard to the axonal tangle-like formations observed after entorhinal cortex lesion...
  14. ncbi request reprint Dual role of Cajal-Retzius cells and reelin in cortical development
    M Frotscher
    Anatomisches Institut der Albert Ludwigs Universität Freiburg, Postfach 111, D 79001 Freiburg, Germany
    Cell Tissue Res 290:315-22. 1997
    ..It is hypothesized in this review that reelin functions as a stop signal for both migrating neurons and growing fibers in the developing central nervous system...
  15. ncbi request reprint Cholinergic innervation of mossy cells in the rat fascia dentata
    T Deller
    Institute of Anatomy, University of Freiburg, Germany
    Hippocampus 9:314-20. 1999
    ..These data demonstrate a direct innervation of hilar mossy cells by cholinergic septohippocampal afferents. This connectivity could contribute to the electrophysiological behavior of mossy cells during theta oscillations...
  16. ncbi request reprint Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus
    E Forster
    Institute of Anatomy, University of Freiburg, PO Box 111, D 79001, Freiburg, Germany
    Development 128:3029-39. 2001
    ..We conclude that hyaluronan-associated molecules play a crucial role in the formation of the lamina-specific entorhinal projection to the hippocampus...
  17. ncbi request reprint Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons
    C A Haas
    Institute of Anatomy, University of Freiburg, Germany
    Int J Dev Neurosci 16:691-703. 1998
    ..In this report, we will focus on an interaction of nerve growth factor (NGF) with the transcription factor c-Jun in intact and axotomized septohippocampal projection neurons...
  18. ncbi request reprint Basal expression, subcellular distribution, and up-regulation of the proto-oncogene c-JUN in the rat dentate gyrus after unilateral entorhinal cortex lesion
    C A Haas
    Institute of Anatomy, University of Freiburg, Germany
    Neuroscience 81:33-45. 1997
    ..A different mechanism has to be assumed for GABAergic interneurons known to receive an entorhinal innervation as well...
  19. ncbi request reprint Neurosteroid synthesis in the hippocampus: role in synaptic plasticity
    G M Rune
    Institute of Anatomy I Cellular Neurobiology, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neuroscience 136:833-42. 2005
    ..Our data provide strong evidence for estrogens being potent modulators of structural synaptic plasticity and point to a paracrine rather than endocrine mechanism of estrogen action in the hippocampus...
  20. ncbi request reprint Stereological estimates of total neuron numbers in the hippocampus of adult reeler mutant mice: Evidence for an increased survival of Cajal-Retzius cells
    C Coulin
    Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 439:19-31. 2001
    ..However, the reeler mutation does not affect mechanisms that determine total hippocampal neuron number...
  21. ncbi request reprint Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus
    M H Schwab
    Zentrum fur Molekulare Biologie, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 20:3714-24. 2000
    ..The primary developmental arrest appears to be restricted to granule cells in which an autoregulatory system involving all three neuronal bHLH genes has failed...
  22. ncbi request reprint A role for Cajal-Retzius cells and reelin in the development of hippocampal connections
    J A Del Rio
    Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Spain
    Nature 385:70-4. 1997
    ..Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections...
  23. ncbi request reprint Estrogen up-regulates estrogen receptor alpha and synaptophysin in slice cultures of rat hippocampus
    G M Rune
    Anatomisches Institut, Universitatskrankenhaus Eppendorf, Martinistrasse 52, D 25251 Hamburg, Germany
    Neuroscience 113:167-75. 2002
    ..We conclude that estradiol-induced spine formation on CA1 pyramidal cells may be mediated presynaptically, very likely by activation of ERalpha in CA3 pyramidal cells, followed by an increase in Schaffer collateral synapses...
  24. pmc Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress
    Y Chen
    Departments of Anatomy Neurobiology and Pediatrics, ZOT 4475, University of California at Irvine, Irvine, CA 92697 4475, USA
    Neuroscience 126:533-40. 2004
    ..This neuronal activation was abolished by selectively blocking the CRF1 receptor, suggesting that stress-evoked endogenous CRH release was involved in the activation of hippocampal principal cells...
  25. ncbi request reprint Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    D Zamanillo
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 284:1805-11. 1999
    ..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory...
  26. ncbi request reprint Synaptic plasticity in the hippocampus: effects of estrogen from the gonads or hippocampus?
    G M Rune
    Zentrum für Experimentelle Medizin, Institut für Anatomie I Zelluläre Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neurochem Res 31:145-55. 2006
    ..Our results point to an essential role of endogenous hippocampal estrogen in hippocampal synaptic plasticity rather than to a direct influence of estrogens derived from peripheral sources, such as the gonads...
  27. ncbi request reprint Morphological variability is a characteristic feature of granule cells in the primate fascia dentata: a combined Golgi/electron microscope study
    L Seress
    Institute of Anatomy, Johann Wolfgang Goethe University, D-6000 Frankfurt am Main 70, Federal Republic of Germany
    J Comp Neurol 293:253-67. 1990
    ..Unlike in rodents, we found a large variability of granule cells in the primate fascia dentata. This variability has to be considered in neuropathological studies of this cell type...
  28. pmc Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis
    Y Chen
    Departments of Anatomy/Neurobiology and Pediatrics, University of California at Irvine, Irvine, California 92697-4475, USA
    J Neurosci 21:7171-81. 2001
    ..These findings suggest novel, age-specific roles for CRH in regulating early developmental events in the hippocampal formation...