T Frodl

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Neuronal correlates of emotional processing in patients with major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 10:202-8. 2009
  2. ncbi request reprint Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
  3. pmc Reduced hippocampal volume correlates with executive dysfunctioning in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    J Psychiatry Neurosci 31:316-23. 2006
  4. doi request reprint Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
  5. doi request reprint Anterior cingulate cortex does not differ between patients with major depression and healthy controls, but relatively large anterior cingulate cortex predicts a good clinical course
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 163:76-83. 2008
  6. doi request reprint Neuroimaging genetics: new perspectives in research on major depression?
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Acta Psychiatr Scand 118:363-72. 2008
  7. pmc Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study
    Thomas Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    J Psychiatry Neurosci 33:423-30. 2008
  8. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
  9. doi request reprint Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients
    G J E Schmitt
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:183-91. 2012
  10. ncbi request reprint Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:115-21. 2006

Detail Information

Publications37

  1. ncbi request reprint Neuronal correlates of emotional processing in patients with major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 10:202-8. 2009
    ..Altered activation of the prefrontal cortex and anterior cingulum during emotion processing is a key feature of major depression...
  2. ncbi request reprint Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  3. pmc Reduced hippocampal volume correlates with executive dysfunctioning in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    J Psychiatry Neurosci 31:316-23. 2006
    ..We aimed to investigate whether reduced hippocampal volumes correlate with executive dysfunctioning or memory dysfunctioning or with depression severity...
  4. doi request reprint Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
    ....
  5. doi request reprint Anterior cingulate cortex does not differ between patients with major depression and healthy controls, but relatively large anterior cingulate cortex predicts a good clinical course
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 163:76-83. 2008
    ..These findings suggest that ACC volumes are not altered in patients with major depression, but that patients with larger ACC have a better clinical outcome than patients with smaller ACC...
  6. doi request reprint Neuroimaging genetics: new perspectives in research on major depression?
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Acta Psychiatr Scand 118:363-72. 2008
    ..To enhance our understanding of both the interaction between the brain, behaviour and genetics and of biological mechanisms in mood disorders neuroimaging genetics provide a good opportunity...
  7. pmc Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study
    Thomas Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    J Psychiatry Neurosci 33:423-30. 2008
    ..We sought to examine the changes in hippocampal and amygdala volumes at baseline and at 3 years after an acute depressive episode, and the impact of reduced hippocampal volumes on the outcome...
  8. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  9. doi request reprint Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients
    G J E Schmitt
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:183-91. 2012
    ..The data obtained with the new dual-isotope SPECT technique reveal a direct effect of haloperidol at the D2 and DAT receptor level...
  10. ncbi request reprint Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:115-21. 2006
    ..Association of DAT availability and the acute psychotic syndrome is now demonstrated in a large cohort of first episode, never treated schizophrenic patients...
  11. ncbi request reprint Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naïve schizophrenic patients
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Schizophr Res 101:133-41. 2008
    ..Additionally, relations between radioligand binding to DAT and D(2) and positive symptoms were assessed...
  12. ncbi request reprint Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation
    E M Meisenzahl
    Dept of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:522-31. 2006
    ..The presented study evaluated the impact of a neuroleptic steady state treatment with quetiapine on the altered working memory activation patterns in schizophrenia...
  13. ncbi request reprint Cerebral changes and cognitive dysfunctions in medication-free schizophrenia - an fMRI study
    J Scheuerecker
    Department of Psychiatry and Psychology, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 42:469-76. 2008
    ..However, the different fMRI working memory correlates found in schizophrenic patients seem to be insufficient in terms of overall task performance...
  14. ncbi request reprint Adhesio interthalamica in male patients with schizophrenia
    E M Meisenzahl
    Department of Psychiatry and Radiology, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 157:823-5. 2000
    ..The authors investigated whether absence of the adhesio interthalamica in patients with schizophrenia constitutes a marker of early developmental neuropathological changes...
  15. ncbi request reprint Dipole localization of P300 and normal aging
    T Frodl
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Brain Topogr 13:3-9. 2000
    ..Age affected both P300 subcomponents' latencies. Therefore, the functionally different alteration of P300 subcomponents might be the reason for P300 topography changes with the P300 maximum more frontally in older age...
  16. doi request reprint Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study
    E M Meisenzahl
    Department of Psychiatry, LMU University of Munich, Munich, Germany
    Pharmacopsychiatry 41:169-75. 2008
    ..Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner...
  17. ncbi request reprint Cerebral differences in explicit and implicit emotional processing--an fMRI study
    J Scheuerecker
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 56:32-9. 2007
    ..Our data partially confirm the hypothesis of different neural substrates for the processing of implicit and explicit emotional stimuli...
  18. doi request reprint 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  19. doi request reprint Amygdala reduction in patients with ADHD compared with major depression and healthy volunteers
    T Frodl
    Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience TCIN, Trinity College, University of Dublin, Trinity Centre for Health Sciences, Trinity Academic Medical Centre The Adelaide and Meath Hospital Incorporating the National Children s Hospital AMNCH and St James s Hospital, Dublin 24, Ireland
    Acta Psychiatr Scand 121:111-8. 2010
    ..The aim of this study was to investigate whether in adult patients with ADHD hippocampal or amygdala volumes differs from that in healthy controls and patients with major depression (MD)...
  20. ncbi request reprint P300 and symptom improvement in schizophrenia
    J Gallinat
    Department of Psychiatry, Laboratory of Clinical Psychophysiology, Free University Berlin, Eschenallee 3, 14050 Berlin, Germany
    Psychopharmacology (Berl) 158:55-65. 2001
    ..A reduced amplitude of the auditory evoked P300 was interpreted as a trait marker of schizophrenia but reports about correlations between schizophrenic psychopathology and P300 amplitude indicate also a state character...
  21. ncbi request reprint The effect of the skull on event-related P300
    T Frodl
    Laboratory for Neuroimaging of Functional Psychosis, Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Clin Neurophysiol 112:1773-6. 2001
    ..The aim of the present study was to investigate this influence of skull and scalp thicknesses on event-related P300 potentials...
  22. ncbi request reprint Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, Germany
    J Psychopharmacol 16:200-6. 2002
    ..0001) and olanzapine (Pearson r = -0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t = -0.112, p = 0.911)...
  23. ncbi request reprint Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia
    T Frodl
    Department of Psychiatry, , Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 248:307-13. 1998
    ..The input-related processing stages (N100 and P200) were not altered, whereas later, the deviant and task-related processes (N200, frontal P300, parietal P300 and reaction time) were significantly prolonged in schizophrenia...
  24. ncbi request reprint Loudness dependence of auditory evoked potentials in obsessive-compulsive disorder: a pilot study
    M T Carrillo-de-la-Peña
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians Universitat, Munich, Germany
    Psychiatry Res 93:209-16. 2000
    ..These findings do not support the hypothesis of a serotonergic dysfunction in OCD patients...
  25. ncbi request reprint Digitized analysis of abnormal hand-motor performance in schizophrenic patients
    P Tigges
    Department of Psychiatry, Ludwig Maximilians University Munich, Clinical Neurophysiology Section, Nussbaumstrasse 7, D 80336, Munich, Germany
    Schizophr Res 45:133-43. 2000
    ..Our findings show NSS in schizophrenic patients, independently of neuroleptics. Further, the hypothesis of lateralization of cerebral structures generating NSS towards the right hemisphere in schizophrenia is supported...
  26. ncbi request reprint Corpus callosum and P300 in schizophrenia
    T Frodl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Schizophr Res 49:107-19. 2001
    ..The results are discussed in terms of the possibility that abnormalities in interhemispheric transfer may underlie the mechanisms of schizophrenia...
  27. doi request reprint Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study
    E M Meisenzahl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 104:44-60. 2008
    ..Furthermore, our data suggest that in the advanced stages of schizophrenia additional cortical and subcortical brain areas become involved in the disease process. Longitudinal data will be required to further test this hypothesis...
  28. doi request reprint Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects
    T Frodl
    Department of Psychiatry, Trinity College Dublin, Ireland
    Acta Psychiatr Scand 125:114-26. 2012
    ..The aim of this study was to perform a meta-analysis of MRI voxel-based morphometry (VBM) and manual tracing studies to identify the differences between adults and children with ADHD as well as between treated and untreated individuals...
  29. ncbi request reprint Thalamic volume in first-episode and chronic schizophrenic subjects: a volumetric MRI study
    U W Preuss
    Department of Psychiatry, Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Schizophr Res 73:91-101. 2005
    ....
  30. doi request reprint Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype
    A Carballedo
    Department of Psychiatry, Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 159:537-48. 2012
    ....
  31. ncbi request reprint [Treatment of vitally endangered anorexia nervosa patients based on guardianship laws]
    G Laakmann
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen
    Nervenarzt 77:35-6, 38-40, 43-9. 2006
    ..The chosen treatment is shown with the therapy courses of 25 patients treated according to this concept...
  32. ncbi request reprint Superior temporal gyrus and P300 in schizophrenia: a combined ERP/structural magnetic resonance imaging investigation
    E M Meisenzahl
    Department of Psychiatry, Psychiatrische Klinik der LMU München, Nussbaumstr 7, 80 336, Munich, Germany
    J Psychiatr Res 38:153-62. 2004
    ..No associations between the electrophysiological and structural measurements could be detected. There were also no significant reductions of ERP and MRI measurements within the subgroup of patients with pronounced negative symptoms...
  33. ncbi request reprint D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study
    E M Meisenzahl
    Departments of Psychiatry, Ludwigs Maximilians University of Munich, Germany
    J Psychopharmacol 14:364-70. 2000
    ..There were no significant differences in the presence of EPS symptoms between patients with recommended doses and those with higher doses of olanzapine...
  34. ncbi request reprint Corpus callosum size in schizophrenia--a magnetic resonance imaging analysis
    E M Meisenzahl
    Psychiatrische Klinik der LMU München
    Eur Arch Psychiatry Clin Neurosci 249:305-12. 1999
    ..In the subgroup of schizophrenic patients with a positive family history of schizophrenia, a significant reduction of the subregion corresponding to a part of the trunk of the CC was found...
  35. ncbi request reprint The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1
    G J E Schmitt
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    J Psychopharmacol 19:488-93. 2005
    ..in a comparable patient sample. [99mTc]TRODAT-1 seems to be a valuable new SPECT-ligand in the evaluation of the presynaptic site of the striatal dopaminergic synapse in schizophrenia...
  36. doi request reprint Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: a meta-analysis
    H McCarthy
    Department of Psychiatry, Integrated Neuroimaging, Trinity College Dublin, Dublin, Republic of Ireland
    Psychol Med 44:869-80. 2014
    ..To identify a consistent pattern of neural dysfunction in ADHD, a meta-analysis of fMRI studies using Go/no-go, Stop and N-back tasks was undertaken...
  37. ncbi request reprint Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study
    G Juckel
    Section of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 37:46-51. 2004
    ....