M Fries

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs
    Michael Fries
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 40:1297-303. 2012
  2. pmc Propofol: neuroprotection in an in vitro model of traumatic brain injury
    Jan Rossaint
    Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R61. 2009
  3. pmc Minimal instructions improve the performance of laypersons in the use of semiautomatic and automatic external defibrillators
    Stefan Beckers
    Department of Anaesthesiology, University Hospital Aachen, Aachen, Germany
    Crit Care 9:R110-6. 2005
  4. pmc Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study
    Matthias Derwall
    Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R58. 2009
  5. pmc Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
    Philip D Loetscher
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    Crit Care 13:R206. 2009
  6. pmc The intuitive use of laryngeal airway tools by first year medical students
    Johannes Bickenbach
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Germany
    BMC Emerg Med 9:18. 2009
  7. doi request reprint Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:1886-91. 2008
  8. doi request reprint Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:2420-6. 2008
  9. doi request reprint Influence of mild therapeutic hypothermia on the inflammatory response after successful resuscitation from cardiac arrest
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, 52074 Aachen, Germany
    J Crit Care 24:453-7. 2009
  10. ncbi request reprint S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury
    Michael Fries
    Department of Anesthesiology, University Hospital of Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesthesiology 102:761-7. 2005

Detail Information

Publications45

  1. doi request reprint Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs
    Michael Fries
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 40:1297-303. 2012
    ..Administering xenon may confer an additional neuroprotective effect after successful cardiopulmonary resuscitation due to its ability to stabilize cellular calcium homeostasis via N-methyl-D-aspartate-receptor antagonism...
  2. pmc Propofol: neuroprotection in an in vitro model of traumatic brain injury
    Jan Rossaint
    Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R61. 2009
    ..We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  3. pmc Minimal instructions improve the performance of laypersons in the use of semiautomatic and automatic external defibrillators
    Stefan Beckers
    Department of Anaesthesiology, University Hospital Aachen, Aachen, Germany
    Crit Care 9:R110-6. 2005
    ..In this study we examined the use of semiautomatic or automatic AEDs by laypersons who had received no training (intuitive use) and the effects of minimal general theoretical instructions on their performance...
  4. pmc Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study
    Matthias Derwall
    Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R58. 2009
    ..This study aimed to investigate the effects of mild therapeutic hypothermia on the release of the astroglial protein S-100 after cardiopulmonary resuscitation (CPR) in survivors of out-of-hospital cardiac arrest...
  5. pmc Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
    Philip D Loetscher
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    Crit Care 13:R206. 2009
    ..Since traumatic brain injury and stroke are widespread and generate an enormous economic and social burden, we investigated the possible neuroprotective effect in in vitro models of traumatic brain injury and cerebral ischemia...
  6. pmc The intuitive use of laryngeal airway tools by first year medical students
    Johannes Bickenbach
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Germany
    BMC Emerg Med 9:18. 2009
    ..Retention of skills was re-evaluated six months thereafter...
  7. doi request reprint Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:1886-91. 2008
    ..To determine the effects of norepinephrine and levosimendan on microvascular perfusion and oxygenation in a rat model of septic shock...
  8. doi request reprint Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:2420-6. 2008
    ..Treatment options to ameliorate brain damage following cardiopulmonary resuscitation from cardiac arrest are limited...
  9. doi request reprint Influence of mild therapeutic hypothermia on the inflammatory response after successful resuscitation from cardiac arrest
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, 52074 Aachen, Germany
    J Crit Care 24:453-7. 2009
    ..Although animal studies document conflicting data on the influence of hypothermia on cytokine release in various settings, no data exist if hypothermia affects the inflammatory response after successful cardiopulmonary resuscitation...
  10. ncbi request reprint S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury
    Michael Fries
    Department of Anesthesiology, University Hospital of Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesthesiology 102:761-7. 2005
    ....
  11. ncbi request reprint Incidence of cross-border emergency care and outcomes of cardiopulmonary resuscitation in a unique European region
    Michael Fries
    Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Resuscitation 72:66-73. 2007
    ..The aim of the present study was to compare cardiopulmonary resuscitation (CPR) outcomes and characteristics in three differently organised and staffed EMS systems in close vicinity...
  12. doi request reprint Neurocognitive performance after cardiopulmonary resuscitation in pigs
    Michael Fries
    Department of Anesthesiology and Institute of Neuropathology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:842-7. 2008
    ..Furthermore, to characterize the influence of different durations of cardiac arrest on cognitive performance and the accompanying neurohistopathological changes...
  13. doi request reprint Early administration of xenon or isoflurane may not improve functional outcome and cerebral alterations in a porcine model of cardiac arrest
    Michael Fries
    Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Resuscitation 80:584-90. 2009
    ..Xenon (Xe) is neuroprotective when given 1h after cardiopulmonary resuscitation (CPR). Here, we investigated if an earlier administration of Xe or isoflurane (Iso) would also reduce neurological dysfunction...
  14. ncbi request reprint [Neuromonitoring with S-100 protein in the intensive care unit]
    M Fries
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen
    Anaesthesist 53:959-64. 2004
    ..This article gives a review on the current knowledge, indications and limitations on the use of S-100 protein with regard to most of the acute neurological diseases an intensivist is confronted with in everyday practice...
  15. ncbi request reprint Neurological emergencies as causes of accidents
    Michael Fries
    Department of Anesthesiology, University Hospital, University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur J Emerg Med 12:151-4. 2005
    ..Neurological emergencies as the underlying cause of accidents are poorly investigated. This retrospective chart review study was performed to evaluate the incidence of such events...
  16. doi request reprint Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial
    D Rörtgen
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 104:167-74. 2010
    ..We hypothesized that the use of the shorter-acting volatile anaesthetic desflurane would be associated with less incidence of POCD when compared with sevoflurane...
  17. doi request reprint [Current developments in xenon research. Importance for anesthesia and intensive care medicine]
    A Brücken
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 59:883-95. 2010
    ..As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting...
  18. doi request reprint Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats
    A Brücken
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Br J Anaesth 110:i106-12. 2013
    ..We hypothesized argon, which is more available, might also protect central nervous tissues and allow better functional recovery in a rodent model of global cerebral ischaemia...
  19. doi request reprint A comparison of waste gas concentrations during xenon or nitrous oxide anaesthesia
    M Coburn
    University Hospital Aachen, RWTH Aachen, Department of Anaesthesiology, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur J Anaesthesiol 25:748-51. 2008
    ..The aim of this study was to compare waste gas concentrations during xenon or nitrous oxide anaesthesia...
  20. doi request reprint Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 100:787-91. 2008
    ..v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia...
  21. ncbi request reprint Xenon: recent developments and future perspectives
    M Derwall
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    Minerva Anestesiol 75:37-45. 2009
    ..Future studies will have to prove whether the high costs of xenon administration might be outweighed by its ability to substantially reduce the sequelae of myocardial and cerebral ischemia...
  22. ncbi request reprint ["Meet the AIX-PERTs." Emergency medical care at the beginning of the medical reform curriculum in Aachen]
    S Beckers
    Klinik fur Anasthesiologie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule, Aachen
    Anaesthesist 53:561-9. 2004
    ..Extensive knowledge and skills in the basics of emergency medical care are of paramount importance for every physician and should therefore be an integral part of medical education...
  23. ncbi request reprint Emergence and early cognitive function in the elderly after xenon or desflurane anaesthesia: a double-blinded randomized controlled trial
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52074 Aachen, Germany
    Br J Anaesth 98:756-62. 2007
    ..Xenon, known to be an N-methyl-d-aspartate antagonist, may be advantageous. In this study, the early cognitive function in the elderly after general anaesthesia with xenon was compared with that after desflurane...
  24. ncbi request reprint [Anaesthesiology as a compulsory subject in the new German medical school curriculum. Evaluation of a curricular model at the University Hospital Aachen]
    S K Beckers
    Klinik fur Anasthesiologie, Universitatsklinikum, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 56:571-80. 2007
    ..Therefore, existing curricular activities had to be changed from facultative courses for a small number of interested students to compulsory activities for all students...
  25. doi request reprint Positron emission tomography study of regional cerebral blood flow and flow-metabolism coupling during general anaesthesia with xenon in humans
    S Rex
    Department of Anaesthesiology, University Hospital, Technical University Aachen, Aachen, Germany
    Br J Anaesth 100:667-75. 2008
    ..The effects of xenon on regional cerebral blood flow (rCBF) are controversial. Moreover, the precise sites of action at which xenon exerts its effects in the human brain remain to be established...
  26. doi request reprint Performance of cardiac output measurement derived from arterial pressure waveform analysis in patients requiring high-dose vasopressor therapy
    S Metzelder
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 106:776-84. 2011
    ..We hypothesized that changes in vascular tone induced by high-dose vasopressor therapy affect the accuracy of APCO measurements independently of the FloTrac software version...
  27. ncbi request reprint Outcome and mortality risk factors in long-term treated ICU patients: a retrospective analysis
    J Bickenbach
    Department of Intensive Care, University Hospital Aachen, RWTH Aachen University, Germany
    Minerva Anestesiol 77:427-38. 2011
    ..The aim of this study was to examine mortality and its risk factors in patients requiring intensive care therapy for more than 30 days...
  28. ncbi request reprint [Requirements for the use of automated external defibrillators in German hospitals]
    J Bickenbach
    Klinik fur Anasthesiologie, Universitätsklinikum RWTH Aachen
    Anaesthesist 53:555-60. 2004
    ..Therefore, it seems reasonable to use AED in large hospitals. For implementation, training programmes and a nationally standardized documentation of resuscitation events should be promoted...
  29. doi request reprint Reducing the duration of 100% oxygen ventilation in the early reperfusion period after cardiopulmonary resuscitation decreases striatal brain damage
    Anne Brücken
    Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Resuscitation 81:1698-703. 2010
    ..We retrospectively analyzed data from a porcine CA model and hypothesized that prolonged hyperoxic reperfusion would be associated with increased neurohistopathological damage and impaired neurological recovery...
  30. doi request reprint Low tidal volume ventilation in a porcine model of acute lung injury improves cerebral tissue oxygenation
    Johannes Bickenbach
    Department of Surgical Intensive Care, RWTH University Hospital, Aachen, Germany
    Anesth Analg 109:847-55. 2009
    ..We hypothesized that mechanical ventilation with low tidal (LT) volumes improves cerebral tissue oxygenation and metabolism after experimentally induced ALI...
  31. doi request reprint Functional and structural response of arterialized femoral veins in a rodent AV fistula model
    Stephan Langer
    Department of Vascular Surgery, University Hospital RWTH Aachen, Germany
    Nephrol Dial Transplant 24:2201-6. 2009
    ..The aim of this study was to develop an experimental AVF model in the rat that shows typical features of fistula maturation and allows longitudinal monitoring of fistula veins by high-resolution ultrasound...
  32. ncbi request reprint Evaluation of a new approach to implement structured, evidence-based emergency medical care in undergraduate medical education in Germany
    Stefan Beckers
    Department of Anaesthesiology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Resuscitation 65:345-56. 2005
    ..The course evaluation data clearly showed acceptance of the new approach and enhances possibilities of extending implementation of relevant topics concerning emergency medical care within the Medical Reform Curriculum Aachen...
  33. ncbi request reprint CPREzy improves performance of external chest compressions in simulated cardiac arrest
    Stefan K Beckers
    Department of Aneasthesiology, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Germany
    Resuscitation 72:100-7. 2007
    ..This study investigates the effects of the CPREzy-pad on ECC performed by first year medical students during simulated cardiac arrest...
  34. ncbi request reprint Retention of skills in medical students following minimal theoretical instructions on semi and fully automated external defibrillators
    Stefan K Beckers
    Department of Anaesthesiology, University Hospital Aachen, Germany
    Resuscitation 72:444-50. 2007
    ..The aim of this prospective randomised interventional study was to evaluate long-term effects of a specific, minimal training programme on using semiautomatic and fully automatic AEDs in simulated cardiac arrest...
  35. ncbi request reprint Impact of early vs. late tracheostomy on weaning: a retrospective analysis
    J Bickenbach
    Department of Intensive Care, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Minerva Anestesiol 77:1176-83. 2011
    ..However, timing of tracheostomy is still unknown and evidence is lacking. The effects of early tracheostomy compared with intermediate and late tracheostomy were assessed in critically ill patients...
  36. ncbi request reprint Procalcitonin serum levels after out-of-hospital cardiac arrest
    Michael Fries
    Department of Anesthesiology, University Hospital of RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Resuscitation 59:105-9. 2003
    ..Based on this observation, studies on larger numbers of patients should prove the predictive value of PCT in those patients...
  37. doi request reprint Hydrogen sulfide does not increase resuscitability in a porcine model of prolonged cardiac arrest
    Matthias Derwall
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Shock 34:190-5. 2010
    ..Although animals receiving Na2S developed higher troponin T serum levels, these differences remained insignificant. In this investigation, Na2S did not improve resuscitability but significantly compromised postresuscitation hemodynamics...
  38. doi request reprint Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients
    Astrid V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Germany
    Eur J Anaesthesiol 27:906-11. 2010
    ..We evaluated the bispectral index (BIS) for monitoring depth of anaesthesia during clinically guided balanced xenon or sevoflurane anaesthesia in aged patients...
  39. ncbi request reprint Is xenon really neuroprotective after cardiac arrest?
    Michael Fries
    Anesthesiology 104:211; author reply 211-2. 2006
  40. ncbi request reprint In-hospital cardiac arrest
    Max Harry Weil
    Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
    Crit Care Med 33:2825-30. 2005
    ..Outcomes are therefore improved in critical care settings and especially in coronary care units in which patients are continuously monitored...
  41. ncbi request reprint Microvascular blood flow during cardiopulmonary resuscitation is predictive of outcome
    Michael Fries
    The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States
    Resuscitation 71:248-53. 2006
    ..82, p<0.01). Microvascular blood flow in the sublingual mucosa is therefore closely related to coronary perfusion pressure during cardiopulmonary resuscitation and both are predictive of outcome...
  42. ncbi request reprint Microcirculation during cardiac arrest and resuscitation
    Michael Fries
    Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
    Crit Care Med 34:S454-7. 2006
    ..We evaluated serial changes and the effects of epinephrine on microcirculatory blood flow in the most severe form of circulatory failure, namely, cardiac arrest...
  43. ncbi request reprint Increases in tissue Pco2 during circulatory shock reflect selective decreases in capillary blood flow
    Michael Fries
    Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
    Crit Care Med 34:446-52. 2006
    ..This study addresses simultaneous changes in gastric and buccal tissue Pco2 with changes in microcirculatory blood flow in a rat model of circulatory shock induced by cecal ligation and puncture...
  44. ncbi request reprint Buccal capnometry to guide management of massive blood loss
    Gianluca A A M Cammarata
    Weil Institute of Critical Care Medicine, 35100 Bob Hope Dr, Rancho Mirage, California 92270, USA
    J Appl Physiol 100:304-6. 2006
    ..Accordingly, P(CO2) BU) fulfills the criterion of a noninvasive and reliable measurement to guide fluid management of hemorrhagic shock...
  45. ncbi request reprint How does interruption of cardiopulmonary resuscitation affect survival from cardiac arrest?
    Michael Fries
    The Institute of Critical Care Medicine, Rancho Mirage, California 92270, USA
    Curr Opin Crit Care 11:200-3. 2005
    ....