H Frieling

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi [New options in the treatment of depression]
    H Frieling
    Psychiatrische und Psychotherapeutische Klinik, Universitatsklinikum Erlangen
    Fortschr Neurol Psychiatr 75:641-52. 2007
  2. doi Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
  3. ncbi Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlagen, Germany
    J Psychiatr Res 42:83-6. 2008
  4. doi Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
  5. doi Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
  6. doi Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
  7. ncbi Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Bad Oeynhausen, Germany
    J Neural Transm 112:1591-8. 2005
  8. ncbi Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    J Neural Transm 113:1299-304. 2006
  9. ncbi Biological markers to predict previous alcohol withdrawal seizures: a risk assessment
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 114:151-4. 2007
  10. doi Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009

Detail Information

Publications46

  1. ncbi [New options in the treatment of depression]
    H Frieling
    Psychiatrische und Psychotherapeutische Klinik, Universitatsklinikum Erlangen
    Fortschr Neurol Psychiatr 75:641-52. 2007
    ..Glutamate modulating agents such as ketamine or riluzole are another promising approach in the treatment of depression. Some advances have also been achieved in the field of HPA-axis modulation...
  2. doi Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
    ..Further investigations in patients with depression as a sole diagnosis are needed to support its role in the pathogenesis of major depression...
  3. ncbi Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlagen, Germany
    J Psychiatr Res 42:83-6. 2008
    ..8; df = 42; P = 0.008). Presence of depressive symptoms may explain elevated homocysteine levels previously reported in patients with eating disorders or vice versa. Longitudinal studies are needed to unravel this hen or egg problem...
  4. doi Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
    ..ANP mRNA expression was inversely associated with impaired impulse regulation. We conclude that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders...
  5. doi Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
    ....
  6. doi Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
    ..The endocannabinoid system is involved in the regulation of appetite, food intake and energy balance...
  7. ncbi Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Bad Oeynhausen, Germany
    J Neural Transm 112:1591-8. 2005
    ..566, OR=24.75, CI 2.89 - 212.23, P=0.003). These results indicate that under the special circumstances of eating disorders elevated homocysteine levels improve memory signaling possibly by facilitating long-term potentiation...
  8. ncbi Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    J Neural Transm 113:1299-304. 2006
    ..014). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control in these patients...
  9. ncbi Biological markers to predict previous alcohol withdrawal seizures: a risk assessment
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 114:151-4. 2007
    ..001, OR = 9.23, 95%CI = 2.36-36.05). A combination of both, homocysteine and prolactin, may help to assess the individual risk of alcohol withdrawal seizures in clinical practice...
  10. doi Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009
    ..Further studies focusing on longitudinal changes of epigenetic regulation and gene expression of both peptides are needed to clarify the pathophysiological role of these findings...
  11. ncbi The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin
    B Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 10:226-31. 2010
    ..Nevertheless future studies are needed to further explore the functionality of the androgen receptor gene in terms of craving...
  12. ncbi Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm 113:357-63. 2006
    ..68, 95% CI=0.57-0.79, p=0.004). The present results show first evidence of an association between elevated plasma homocysteine levels in alcoholics and cognition deficits in patients undergoing alcohol withdrawal...
  13. doi Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Pharmacopsychiatry 41:134-7. 2008
    ..The aim of the present study was to assess the risk of different possible influencing factors...
  14. ncbi Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 8:117-21. 2008
    ..We suggest that the disadvantageous effects of apolipoprotein E4 on alcohol-related brain volume loss are based on certain gene-environment interactions...
  15. doi Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    J Neural Transm 117:521-7. 2010
    ..These findings add further evidence to the hypothesis that homocysteine might be involved in the pathophysiology of anorexia and bulimia nervosa...
  16. ncbi Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 30:587-91. 2006
    ....
  17. ncbi Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
    ....
  18. ncbi Nicotine dependence is associated with compulsive alcohol craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addiction 101:892-7. 2006
    ..To investigate a possible association of nicotine dependence and alcohol craving...
  19. doi Polymorphism of the long polyglutamine tract in the human androgen receptor influences craving of men in alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 34:968-71. 2009
    ..In summary, the presented data points to an underestimated role of the genetic regulation of androgens in the pathogenesis of alcohol dependence and related disorders...
  20. doi Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 43:388-92. 2009
    ..Furthermore, hypermethylation of the DAT-promoter may play an important role in dopaminergic neurotransmission and is associated with decreased alcohol craving...
  21. doi NGF plasma levels increase due to alcohol intoxication and decrease during withdrawal
    Annemarie Heberlein
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 33:999-1003. 2008
    ..These results suggest that NGF plasma levels increase as part of a regulation mechanism that counteracts alcohol intoxication...
  22. doi N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
    J Neural Transm 116:615-22. 2009
    ..55; P = 0.013; daily ethanol intake: rho = -0.46; P = 0.043). These findings might explain the observation of an impact of alcohol consumption patterns on the gravity of withdrawal symptoms...
  23. doi NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    J Mol Neurosci 44:41-7. 2011
    ..The reported results may contribute to a better understanding of the molecular mechanisms linked to depressive symptoms...
  24. ncbi Androgen receptor polyglutamine length does not influence serum levels of adipocytokines in alcoholism: a preliminary retrospective analysis
    Bernd Lenz
    corresponding author
    Alcohol Alcohol 46:214-6. 2011
    ..The aim of the present preliminary retrospective study was to further elucidate whether adiponectin and resistin serum levels are regulated by this AR polymorphism as well...
  25. doi Smoking behaviour is associated with expression and phosphorylation of CREB in human buffy coat
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Int J Neuropsychopharmacol 13:207-15. 2010
    ..This kind of study may be helpful for translating findings from animal models and cell cultures...
  26. doi Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:296-9. 2008
    ..Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism...
  27. ncbi Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 42:509-12. 2007
    ..Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism...
  28. ncbi Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
    ..Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures. These preliminary results must be validated in further studies...
  29. ncbi Evidence of an association of leptin serum levels and craving in alcohol dependence
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 32:87-90. 2007
    ..160, t=5.793, p<0.001) with a power of 1.00. In contrast to previous results describing an association only in female patients, this power-based analysis shows that leptin is associated with alcohol craving in both genders...
  30. ncbi Combinations of carbohydrate-deficient transferrin, mean corpuscular erythrocyte volume, gamma-glutamyltransferase, homocysteine and folate increase the significance of biological markers in alcohol dependent patients
    Daniela Rinck
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 89:60-5. 2007
    ..This study focuses on the combination of established laboratory parameters with new meaningful biomarkers to advance the significance regarding alcohol dependence...
  31. doi Increased levels of adiponectin and resistin in alcohol dependence--possible link to craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 99:333-7. 2009
    ..Furthermore, adiponectin may be involved in the neurobiology of alcohol craving, possibly via its effects on the hypothalamic circuits...
  32. ncbi Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 31:950-4. 2007
    ..Aim of this analysis was to search for differences regarding an association between these peptides and alcohol craving with respect to different subtypes and beverage consumption patterns in patients with alcohol dependence...
  33. ncbi Homocysteine plasma levels are elevated in females with anorexia nervosa
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 112:979-85. 2005
    ....
  34. ncbi Blue light improves cognitive performance
    S Lehrl
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 114:457-60. 2007
    ..We report a longitudinal study in 44 adults, showing that a significant increase in alertness and speed of information processing could be achieved by blue light as compared to normal light...
  35. ncbi Elevated prolactin serum levels and history of alcohol withdrawal seizures
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Psychiatr Res 41:702-6. 2007
    ..Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures...
  36. ncbi An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Epilepsia 47:934-8. 2006
    ..The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in actively drinking alcoholics (n = 88) with first-onset alcohol-withdrawal seizures...
  37. ncbi Volume intake and craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:61-5. 2006
    ..The present study was undertaken to evaluate whether the daily volume intake of alcoholic beverages is associated with craving in patients undergoing alcohol withdrawal...
  38. ncbi Prolactin serum levels and alcohol craving - an analysis using Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 53:133-6. 2006
    ..Prolactin secretion is closely connected to dopaminergic transmission that is known to play a crucial role in mediating reinforcement and craving in alcoholism...
  39. ncbi Association of catecholamine-O-methyltransferase and 5-HTTLPR genotype with eating disorder-related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Psychiatr Genet 16:205-8. 2006
    ..The aim of the present study was to evaluate, whether behavioral and attitudinal traits of the disorders can serve as phenotypes with a possible association with two common functional polymorphisms of the monoaminergic pathways...
  40. doi Global DNA methylation is influenced by smoking behaviour
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Eur Neuropsychopharmacol 18:295-8. 2008
    ..68, p=0.02) and completely vanished if the offspring smoked or had ever smoked. These findings suggest an association between smoking behaviour and global DNA methylation, which may be of importance for a wide range of diseases...
  41. ncbi Decreased serum semicarbazide sensitive aminooxidase (SSAO) activity in patients with major depression
    Veit Roessner
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 30:906-9. 2006
    ..The disputable association between depression and monoamine metabolism requires further investigation, particularly with regard to SSAO activity and medication status...
  42. ncbi Alteration of prolactin serum levels during alcohol withdrawal correlates with craving in female patients
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:337-43. 2005
    ....
  43. ncbi Tranylcypromine: new perspectives on an "old" drug
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:268-73. 2006
    ..These findings implicate that the efficacy of tranylcypromine as an antidepressant may be due to its multiple actions within the human brain...
  44. ncbi Elevated prenatal homocysteine levels and the risk of schizophrenia
    Stefan Bleich
    Arch Gen Psychiatry 64:980-1. 2007
  45. ncbi Obsessive-compulsive alcohol craving is not associated with Apolipoprotein E genotype
    Thomas Hillemacher
    Psychiatr Genet 16:231-2. 2006
    ..Statistical analysis revealed no significant association between Apolipoprotein E polymorphism and obsessive-compulsive alcohol craving (analysis of variance: F=1.11, P=0.358)...
  46. ncbi Homocysteine and epigenetic DNA methylation: a biological model for depression?
    Thomas Hillemacher
    Am J Psychiatry 164:1610. 2007