Reinhard E Friedrich

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Osteochondroma of the mandibular condyle. Report of a case with 5-year follow-up
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 32:4553-6. 2012
  2. ncbi request reprint Small peripheral developing odontoma of the maxilla in a 3-year-old patient depicted on cone-beam tomograms
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf Medical Center, University of Hamburg, Martinist 52 D 20246 Hamburg
    In Vivo 24:895-8. 2010
  3. ncbi request reprint Desmoid-type infantile fibromatosis of the mandible: case report with long-term follow-up
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 24:877-81. 2010
  4. ncbi request reprint Atypical plexiform neurofibroma in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 24:871-6. 2010
  5. ncbi request reprint Adenomatoid odontogenic tumor (AOT) of maxillary sinus: case report with respect to immunohistochemical findings
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf Medical Center, University of Hamburg, Germany
    In Vivo 23:111-6. 2009
  6. ncbi request reprint Long-term follow-up control of pedunculated orbital floor osteoma becoming symptomatic by atypical facial pain
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf Medical Center, University of Hamburg, Germany
    In Vivo 23:117-21. 2009
  7. ncbi request reprint Appendices of the nipple and areola of the breast in Neurofibromatosis type 1 patients are neurofibromas
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1815-7. 2010
  8. ncbi request reprint Ameloblastoma of the maxillary sinus 11 years after extirpation of extensive dentigerous cysts and dystopic wisdom tooth
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinist 52, D 20246 Hamburg, Germany
    In Vivo 24:567-70. 2010
  9. ncbi request reprint Multiple distant metastases of hepatocellular carcinoma to the oral cavity
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    In Vivo 24:211-4. 2010
  10. ncbi request reprint Immunohistochemical study on an epithelial-myoepithelial intercalated duct carcinoma transplanted to the nude mouse
    Reinhard E Friedrich
    Department Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1565-8. 2010

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Osteochondroma of the mandibular condyle. Report of a case with 5-year follow-up
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 32:4553-6. 2012
    ..The tumour did not express insulin-like growth factor-1 receptor. Five years following the surgical intervention, there has been no local recurrence and dental occlusion was re-established, without further treatment...
  2. ncbi request reprint Small peripheral developing odontoma of the maxilla in a 3-year-old patient depicted on cone-beam tomograms
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf Medical Center, University of Hamburg, Martinist 52 D 20246 Hamburg
    In Vivo 24:895-8. 2010
    ..Cone-beam tomography was a valuable pre-operative diagnostic tool to assess the lesion as being composed in part of hard tissue...
  3. ncbi request reprint Desmoid-type infantile fibromatosis of the mandible: case report with long-term follow-up
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 24:877-81. 2010
    ..Especially in children, caution should be exercised in the treatment of benign lesions that resemble malignant conditions derived from connective tissue, with special reference to long-term follow-up...
  4. ncbi request reprint Atypical plexiform neurofibroma in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 24:871-6. 2010
    ..It appears likely that subtypes of Schwann cells express podoplanin. This marker may be useful in distinguishing different Schwann cell populations in neurofibromas...
  5. ncbi request reprint Adenomatoid odontogenic tumor (AOT) of maxillary sinus: case report with respect to immunohistochemical findings
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf Medical Center, University of Hamburg, Germany
    In Vivo 23:111-6. 2009
    ..The tumor showed immunoreactivity for certain types of cytokeratins, vimentin and p63, and was focally immunoreactive for alpha smooth muscle actin and epithelial membrane antigen...
  6. ncbi request reprint Long-term follow-up control of pedunculated orbital floor osteoma becoming symptomatic by atypical facial pain
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf Medical Center, University of Hamburg, Germany
    In Vivo 23:117-21. 2009
    ..A radiograph of the midfacial region was taken that depicted a mushroom-like tumor of the orbital floor. The tumor was surgically removed. The follow-up over a period of 13 years revealed no recurrence of the osteoma...
  7. ncbi request reprint Appendices of the nipple and areola of the breast in Neurofibromatosis type 1 patients are neurofibromas
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1815-7. 2010
    ..Tumours arising in the areola and nipple area and mimicking an accessory nipple were all neurofibromas. Local excision of neurofibromas was adequate to relief patients from an often unsightly appearance...
  8. ncbi request reprint Ameloblastoma of the maxillary sinus 11 years after extirpation of extensive dentigerous cysts and dystopic wisdom tooth
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinist 52, D 20246 Hamburg, Germany
    In Vivo 24:567-70. 2010
    ..Localization and extension of both cyst and neoplasm support the assumption that both entities arose from the same area. Long-term follow-up is recommended in the treatment of odontogenic cysts...
  9. ncbi request reprint Multiple distant metastases of hepatocellular carcinoma to the oral cavity
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    In Vivo 24:211-4. 2010
    ..Oral metastases from hepatocellular carcinoma appear to occur more frequently than formerly supposed...
  10. ncbi request reprint Immunohistochemical study on an epithelial-myoepithelial intercalated duct carcinoma transplanted to the nude mouse
    Reinhard E Friedrich
    Department Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1565-8. 2010
    ..These findings in EMC transplanted to the nude mouse demonstrate the feasibility of growing EMC in vivo...
  11. ncbi request reprint Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1793-7. 2010
    ..A long lasting history of cylindroma and evidence for bone destruction, not associated with a malignant transformation, is extremely rare in Brooke-Spiegler's syndrome...
  12. ncbi request reprint Adenomatoid odontogenic tumour of the mandible
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf Medical Center, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1787-92. 2010
    ..Differential diagnosis of AOT to other odontogenic tumours, such as ameloblastoma, is crucial for therapy. Exact morphological diagnosis avoids extensive ablative surgery...
  13. ncbi request reprint Simulation of scattering effects of irradiation on surroundings using the example of titanium dental implants: a Monte Carlo approach
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf Medical Center, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1727-30. 2010
    ..Therapists involved in radiation planning should consider the impact of dental implants on the radiation beam as a putative cause of osteoradionecrosis...
  14. ncbi request reprint Insulin-like growth factor-1 receptor (IGF-1R) in primary and metastatic undifferentiated carcinoma of the head and neck: a possible target of immunotherapy
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1641-3. 2010
    ..Targeting IGF-1R is a current topic of cancer research. The aim of this study was to identify IGF-1R in undifferentiated carcinomas of the head and neck...
  15. ncbi request reprint Expression of proteases in giant cell lesions of the jaws, tendon sheath and salivary glands
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1645-52. 2010
    ..The aim of this study was to: (a) better define the cellular compartments of the lesion and (b) compare the protease expression-profile in GC lesions of the jaws to GC lesions of other sites...
  16. ncbi request reprint Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1819-21. 2010
    ..The cause of a numb chin needs to be clarified further, and the syndrome should be seriously considered, using thorough diagnosis, including the surgical revision of the affected nerve...
  17. ncbi request reprint Expression of neuron-specific enolase in irradiated salivary glands of the rat: a pilot study
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1569-71. 2010
    ..The increased immunoreactivity for NSE in shielded glands might be useful as a marker of irradiation in salivary glands, even for scattered radiation effects in major salivary glands...
  18. ncbi request reprint Calcifying epithelial odontogenic tumour of the maxilla: a case report with respect to immunohistochemical findings
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 25:259-64. 2011
    ....
  19. ncbi request reprint Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma
    Artun Atac
    DMD, Department of Oral Maxillofacial Surgery, Building O10, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 34:235-8. 2014
    ..Data regarding the predictive and prognostic value of the CCND1 G870A polymorphism in tumors are controversial. We aimed to examine this polymorphism in patients with oral carcinoma...
  20. ncbi request reprint Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model
    Maria Demestre
    Department of Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neurooncol 98:11-9. 2010
    ..001). We demonstrated that grafting human PNF tumour fragments into nude mice provides an adequate in vivo model for drug testing. Our results provide in vivo and in vitro evidence for efficacy of imatinib mesylate for PNF...
  21. ncbi request reprint Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up
    Reinhard E Friedrich
    Department of Oral and Cranio Maxillofacial, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anticancer Res 32:4547-51. 2012
    ..This marker may be useful in distinguishing different Schwann cell populations in NF1...
  22. ncbi request reprint Dysplasia of the orbit and adjacent bone associated with plexiform neurofibroma and ocular disease in 42 NF-1 patients
    Reinhard E Friedrich
    Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1751-64. 2010
    ..Several factors constitute the individual orbital dysplasia, including the growth of the invasive PNF...
  23. ncbi request reprint Intraoperative efficiency of fluorescence imaging by Visually Enhanced Lesion Scope (VELscope(®)) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ)
    Alexandre T Assaf
    Department of Oral and Maxillofacial Surgery Head Professor Max Heiland MD, DMD, PhD, University Medical Center Hamburg Eppendorf, University of Hamburg, 20246 Hamburg, Germany Electronic address
    J Craniomaxillofac Surg 42:e157-64. 2014
    ..The purpose of this study was to determine the potential of tissue fluorescence imaging by using Visually Enhanced Lesion Scope (VELscope(®)) for the detection of osteonecrosis of the jaw induced by bisphosphonates (BRONJ)...
  24. ncbi request reprint Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies
    Alexandre T Assaf
    DMD, Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Anticancer Res 33:3917-24. 2013
    ..Recently, attempts have been made, to identify co-factors which might promote the development of BRONJ...
  25. ncbi request reprint Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    J Neurooncol 82:187-92. 2007
    ..Our findings indicate the necessity for a separate grading scheme which takes into account the genetic background in NF1 patients...
  26. ncbi request reprint 18F-FDG PET/CT for detection of malignant peripheral nerve sheath tumours in neurofibromatosis type 1: tumour-to-liver ratio is superior to an SUVmax cut-off
    Johannes Salamon
    Department of Diagnostic and Interventional Radiology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Radiol 24:405-12. 2014
    ..5...
  27. doi request reprint Hyaluronan in intra-operative edema of NF1-associated neurofibromas
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuropathology 32:406-14. 2012
    ..Fibroblasts produced less hyaluronan than Schwann cells. The findings support the view that hyaluronan plays an important role in intra-operative swelling in neurofibroma surgery...
  28. ncbi request reprint Scattering effects of irradiation on surroundings calculated for a small dental implant
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf Medical Center, University of Hamburg, Martinist 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2043-6. 2012
    ..All therapists involved in the therapy of cancer patients undergoing head and neck radiotherapy should consider the impact of dental implants on the radiation beam as a catalyst of osteoradionecrosis...
  29. doi request reprint Internal tumor burden in neurofibromatosis Type I patients with large NF1 deletions
    Lan Kluwe
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Genes Chromosomes Cancer 51:447-51. 2012
    ..However, deletion patients can frequently have extremely large internal tumors and thus demand special attention...
  30. ncbi request reprint Radiographic findings of odontogenic myxomas on conventional radiographs
    Reinhard E Friedrich
    Oral and Cranio Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2173-7. 2012
    ..The aim of this study was to analyse the radiographic appearance of OM on conventional radiographs. This type of radiographic diagnosis is typically used by dental practitioners...
  31. ncbi request reprint Rapidly progressive and metastatic mucoepidermoid carcinoma: application of serological tumor markers
    Reinhard E Friedrich
    Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 27:2099-100. 2007
    ..We describe the rapid fatal outcome of a patient with MEC in order to emphasize the malignant characteristics of this tumor and the possible application of tumor markers for the diagnosis of metastasizing MEC...
  32. ncbi request reprint Vascular endothelial growth factor (VEGF) in sera of oral and oropharyngeal squamous cell carcinoma patients
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1765-6. 2010
    ..VEGF serum levels varied considerably and showed no correlation to tumour size or locoregional spread. The wide variety of VEGF serum levels make this marker difficult to handle for initial diagnostics or monitoring of therapy...
  33. ncbi request reprint Reduced thalamic 18F-flurodeoxyglucose retention in adults with neurofibromatosis type 1
    Ralph Buchert
    Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nucl Med Commun 29:17-26. 2008
    ..18F-Flurodeoxyglucose positron emission tomography (FDG PET) might be used to investigate putative functional correlates in the brain...
  34. doi request reprint Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1
    Johannes Salamon
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur J Nucl Med Mol Imaging 40:685-92. 2013
    ....
  35. doi request reprint Comparative effectiveness of 18F-FDG PET/CT versus whole-body MRI for detection of malignant peripheral nerve sheath tumors in neurofibromatosis type 1
    Thorsten Derlin
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Nucl Med 38:e19-25. 2013
    ....
  36. ncbi request reprint Expression of podoplanin in primary and metastatic poorly differentiated and undifferentiated carcinomas of the head and neck
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinist 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2019-22. 2012
    ..The invasive growth properties of head and neck carcinoma can be determined by proteins associated with cellular motility. Podoplanin is a recently identified protein associated with motility of cells...
  37. doi request reprint Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: an immunohistochemical study
    Jozef Zustin
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany
    J Oral Pathol Med 39:115-20. 2010
    ..Podoplanin expression was described in mouse tooth germ and apical bud cells. The aim of this study was to analyse the podoplanin expression of human tooth germ tissues, adult teeth and odontogenic lesions immunohistochemically...
  38. doi request reprint Podoplanin and CD34 in peripheral nerve sheath tumours: focus on neurofibromatosis 1-associated atypical neurofibroma
    Urs Naber
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 103:239-45. 2011
    ..Podoplanin expression in atypical neurofibroma was not associated with tumour progression towards MPNST...
  39. doi request reprint Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity
    Alexander Gröbe
    Authors Affiliations Departments of Oral and Maxillofacial Surgery, Medical Biometry and Epidemiology, and Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 20:425-33. 2014
    ....
  40. doi request reprint Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro
    Wei Jiang
    Laboratory for Tumor Genetics, Department of Neurology, University Medical Center Hamburg Eppendorf, Building O48, 4th Floor, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 116:231-6. 2014
    ....
  41. ncbi request reprint Cone beam computed tomography in the differential diagnosis of mental neuropathy (numb chin syndrome) in metastatic colon cancer
    Reinhard E Friedrich
    Oral and Cranio Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg
    Anticancer Res 33:1757-60. 2013
    ....
  42. ncbi request reprint Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients
    Silke Frahm
    Laboratory of Brain Tumor Biology, Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Neurobiol Dis 16:85-91. 2004
    ..These verified MPNST cells are valuable for further investigations of the biology and pathogenesis of this malignancy as well as for in vitro pharmacologic studies essential for the development of new therapies...
  43. ncbi request reprint An unilateral basal bone defect of the mandible occupied by fatty tissue: Stafne's cavity
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    In Vivo 26:1045-8. 2012
    ..The pathogenesis of Stafne's cavity is still obscure. Differential diagnosis of mandibular lesions is essential in adequate treatment planning...
  44. ncbi request reprint Jaw malformations plus displacement and numerical aberrations of teeth in neurofibromatosis type 1: a descriptive analysis of 48 patients based on panoramic radiographs and oral findings
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
    J Craniomaxillofac Surg 31:1-9. 2003
    ..The aim of this study was to analyse jaw malformations and tooth displacement in patients with neurofibromatosis type 1 (NF1)...
  45. ncbi request reprint Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinist 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2125-7. 2012
    ..Recently, we reported podoplanin expression in sporadic cases of KCOT. We intended to investigate the podoplanin expression in KCOTs associated with NBCCS...
  46. ncbi request reprint Size of tooth crowns and position of teeth concerning the extension of facial plexiform neurofibroma in patients with neurofibromatosis type 1
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, Martinistr 52, 20246 Hamburg, Germany
    Anticancer Res 32:2207-14. 2012
    ..PNF pose many problems in reconstructive and oral surgery. This study was undertaken to describe oral findings related to PNFs and to investigate the size and position of teeth in these tumours...
  47. ncbi request reprint Nasolabial cyst: case report with respect to immunohistochemical findings
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 26:453-8. 2012
    ..Nasolabial cysts are developmental cysts that can be cured by adequate surgical techniques. The expression pattern of podoplanin in this entity points to an association of this protein expression with inflammatory reactions to the cyst...
  48. ncbi request reprint Odontogenic myxomas are not associated with GNAS1 mutations
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2169-72. 2012
    ....
  49. ncbi request reprint Morphometrics of the facial nerve following fractionated external irradiation: an experimental study in rats
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
    Anticancer Res 30:1625-32. 2010
    ..A total of 54 animals were investigated and 11,193 measurements were obtained. The computer-assisted image analysing system CUE-3 Color Image Analyzer (Olympus, Japan) was used. Facial nerves from untreated animals served as controls...
  50. ncbi request reprint Immunohistochemical long-term evaluation of laminin expression in microvascular anastomoses of the carotid artery in the Wistar rat
    Arnd Bartnick
    Department of Oral and Maxillofacial Surgery, Nordwestdeutsche Kieferklinik, Hamburg, Germany
    J Craniomaxillofac Surg 32:247-50. 2004
    ..A long-term animal experiment was used to obtain new information on the distribution of laminin in anastomoses...
  51. ncbi request reprint Loss of heterozygosity in tumor cells of a recurrent mandibular giant cell granuloma in neurofibromatosis type 1
    Reinhard E Friedrich
    Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 27:2079-83. 2007
    ..Genetic analysis of the tumor sample (GCG) and blood using 7 microsatellite markers revealed LOH of the NF1 gene in both sources. Inactivation of the NF1 gene may thus contribute to the development of GCG...
  52. ncbi request reprint Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1605-12. 2010
    ..This virus is supposed to be an aetiological factor in this entity. The aim of this study was to analyse the HPV infection status in different entities of oral neoplasms or dysplasias with basaloid differentiation of epithelial cells...
  53. ncbi request reprint Enhanced podoplanin expression in chronic maxillary sinusitis
    Jozef Zustin
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    In Vivo 27:551-4. 2013
    ..We suggest that podoplanin is involved in the pathogenesis of chronic rhinosinusitis, particularly in the intraepithelial migration of inflammatory infiltrates. ..
  54. ncbi request reprint Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw
    Jozef Zustin
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 28:125-31. 2014
    ..We discuss the current and possible future roles of surgical pathologists in diagnosing morphological changes associated with the development and therapy of BRONJ lesions. ..
  55. ncbi request reprint B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice
    Jacob Gleiss
    DMD, Building O 10, Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 27:723-7. 2013
    ..Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultrasound biomicroscopy for monitoring such grafts in vivo...
  56. doi request reprint Craniofacial fibrous dysplasia (CFD) of the maxilla in an 11-year old boy: a case report
    Alexandre T Assaf
    Department of Oral and Cranio Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    J Craniomaxillofac Surg 40:788-92. 2012
    ..Cone beam tomography was a valuable tool in determining the re-ossification of bone at the affected side. Local resection can be curative in limited disease...
  57. ncbi request reprint Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, University Hospital Hamburg Eppendorf, Germany
    J Craniomaxillofac Surg 33:55-60. 2005
    ..It has been previously shown that magnetic resonance tomography can distinguish the growth patterns of plexiform neurofibromas into three different categories: superficial, displacing and invasive...
  58. ncbi request reprint Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene
    Lan Kluwe
    Laboratory for Tumor Biology and Development Disorders, Department of Maxillofacial Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Mutat 23:111-6. 2004
    ..4% of the 500 unselected NF1 patients. Genotyping using multiple microsatellite markers may provide a simple, inexpensive, and efficient strategy for screening deletions of the NF1 gene, and can as well be applied for other large genes...
  59. ncbi request reprint Extensive sublingual epidermoid cyst--diagnosis by immunohistological analysis and proof by podoplanin
    Alexandre T Assaf
    Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    In Vivo 26:323-6. 2012
    ..The incidence of oral dermoid or epidermoid cysts is about 1.6%; most occur at the mouth floor but they nevertheless are very rare...
  60. ncbi request reprint Analysis of orbital plain radiographs for orbital deformities in neurofibromatosis type 1 patients, with special reference to alterations of the orbital rim as indicators of adjacent plexiform neurofibroma
    Reinhard E Friedrich
    DMD, NF Laboratory, Lottestr 55, D 22529 Hamburg, Germany
    Anticancer Res 33:1081-90. 2013
    ..The aim of this study was to reveal whether alterations of the orbital rim visible on plain radiographs may indicate the presence of a plexiform neurofibroma (PNF), a tumour almost exclusively diagnosed in NF1...
  61. ncbi request reprint Anterior lingual mandibular bone depression in an 11-year-old child
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    In Vivo 26:1103-7. 2012
    ..This entity is very rarely diagnosed and even more extremely rarely seen in children. We present some characteristic findings depicted on images provided by different sources and briefly address current hypotheses on its pathogenesis...
  62. ncbi request reprint Prognostic relevance of FDG PET in patients with neurofibromatosis type-1 and malignant peripheral nerve sheath tumours
    Winfried Brenner
    Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Eur J Nucl Med Mol Imaging 33:428-32. 2006
    ..Since histopathology and tumour grading are not well correlated with prognosis, we aimed to evaluate the potential of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) for prediction of patient outcome in MPNST...
  63. ncbi request reprint Pleomorphic adenoma of the salivary glands: analysis of 94 patients
    Reinhard E Friedrich
    Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 25:1703-5. 2005
    ..The aim of this study was to analyse the outcome of patients with pleomorphic adenoma from salivary glands in order to evaluate the surgical strategy of a single institution...
  64. ncbi request reprint Distant metastases and malignant cellular neoplasms encountered in the oral and maxillofacial region: analysis of 92 patients treated at a single institution
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1843-8. 2010
    ..The aim of this study was to analyse the types of tumour, the treatment modalities and the outcome of patients who experienced a malignant disease in the OMF region under these conditions...
  65. ncbi request reprint Bilateral intraosseous lymphoepithelial cyst of the mandible
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 25:451-4. 2011
    ..LEC are rarely diagnosed in oral tissues and usually located in the soft tissues. This report details the clinical, radiological and morphological findings of intraosseous LEC of the mandible...
  66. ncbi request reprint Toxicity assessment of mouthwashes in the pollen tube growth test
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
    Anticancer Res 23:941-7. 2003
    ..In addition, mouthwashes have been accused of causing oral cancer. The aim of this study was to analyse the acute toxicity of mouthwashes in an in vitro testing system, the pollen tube growth test (PTG test)...
  67. ncbi request reprint Diagnosis and treatment of patients with nevoid basal cell carcinoma syndrome [Gorlin-Goltz syndrome (GGS)]
    Reinhard E Friedrich
    Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 27:1783-7. 2007
    ..The aim of this study was to determine the diagnostic findings and the therapy for patients with NBCC...
  68. ncbi request reprint Oral Langerhans cell histiocytosis
    Arnd Bartnick
    Department of Oral and Maxillofacial Surgery, Nordwestdeutsche Kieferklinik, Germany
    J Craniomaxillofac Surg 30:91-6. 2002
    ..A classification based on clinical and immunohistochemical data is proposed and a grading for the severity of the disease is proposed...
  69. ncbi request reprint NF1 mutations in neurofibromatosis 1 patients with plexiform neurofibromas
    Lan Kluwe
    Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg Eppendorf, Germany
    Hum Mutat 19:309. 2002
    ..No correlation was found between the type or location of the NF1 mutations and size, location or feature of the PNFs, suggesting that many types of NF1 mutations can lead to development of PNFs...
  70. ncbi request reprint Vascular wall cells contribute to tumourigenesis in cutaneous neurofibromas of patients with neurofibromatosis type 1. A comparative histological, ultrastructural and immunohistochemical study
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 32:2139-58. 2012
    ..The local control of tumour growth in NF1 is poorly understood. Identification of cell markers could provide new information on the processes that are involved in tumour growth...
  71. ncbi request reprint Squamous cell carcinoma of the sole of the foot in neurofibromatosis type 1
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany
    Anticancer Res 32:2165-8. 2012
    ..To the best of our knowledge, this is the first report on an SCC of the sole diagnosed in NF1. Vacuum dressing as an adjunct to surgery allowed reduced reconstructive measures...
  72. ncbi request reprint Delay in diagnosis and referral patterns of 646 patients with oral and maxillofacial cancer: a report from a single institution in Hamburg, Germany
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1833-6. 2010
    ..This study performed an analysis of the delays between symptom onset and time taken for patients to seek medical advice and then their subsequent specialist referral to the Department of OMF Surgery at Eppendorf University Hospital...
  73. pmc Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2
    Victor Felix Mautner
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neuro Oncol 12:14-8. 2010
    ..Bevacizumab therapy may thus provide an effective treatment for progressive vestibular schwannomas in patients with NF2...
  74. ncbi request reprint Adenoid cystic carcinoma of salivary and lacrimal gland origin: localization, classification, clinical pathological correlation, treatment results and long-term follow-up control in 84 patients
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 23:931-40. 2003
    ..The aim of this study was to determine the outcome of patients with ACC in the maxillofacial region classified according to an internationally accepted staging system...
  75. ncbi request reprint Primary and second primary cancer in 649 patients with malignancies of the maxillofacial region
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery Nordwestdeutsche Kieferklinik, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 27:1805-18. 2007
    ..The aim of this study was to analyse the outcome of patients with oral and maxillofacial (OMF) cancer. The emphasis was to evaluate the outcome of patients with second primary cancer...
  76. ncbi request reprint Malignant peripheral nerve sheath tumors (MPNST) in neurofibromatosis type 1 (NF1): diagnostic findings on magnetic resonance images and mutation analysis of the NF1 gene
    Reinhard E Friedrich
    Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Germany
    Anticancer Res 25:1699-702. 2005
    ..Our objective was to establish magnetic resonance imaging (MRI) criteria for MPNST, and to test their usefulness in detecting early malignant changes in PNF and to correlate the findings with the mutations of the NF1 gene...
  77. ncbi request reprint Chromosomal rearrangements in PLAG1 of myoepithelial salivary gland tumours
    Reinhard E Friedrich
    Oral and Cranio Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Anticancer Res 32:1977-81. 2012
    ..Evidence for myoepithelial cells in PA raises the question whether the very rare entity of pure myoepithelial salivary gland tumours shows chromosomal translocations and rearrangements and whether activation of PLAG1 can be detected...
  78. ncbi request reprint Oral Langerhans cell histiocytosis: antigen-Ki-67 as a indicator for local tumor behaviour
    Arnd Bartnick
    Department of Oral and Maxillofacial Surgery, Nordwestdeutsche Kieferklinik, Martinistr 52, 20246 Hamburg, Germany
    Anticancer Res 23:921-6. 2003
    ..A classification based on clinical and immunohistochemical data is proposed and a grading for disease severity is provided...
  79. ncbi request reprint Late metastasis of gastrointestinal stromal tumour to the oral cavity
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:4283-8. 2010
    ..GIST metastases to the head and neck region are very rare. Two recent case reports about head and neck metastases of GIST showed a predilection for bone. This metastasis was solely located in the oral soft tissues...
  80. ncbi request reprint Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    Med Microbiol Immunol 192:141-4. 2003
    ..In summary, undifferentiated NPC are strongly associated with EBV. The cytoskeleton of undifferentiated NPC reveals no specific pattern of CK expression...
  81. ncbi request reprint The effect of external fractionated irradiation on the distribution pattern of extracellular matrix proteins in submandibular salivary glands of the rat
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany
    J Craniomaxillofac Surg 30:246-54. 2002
    ....
  82. ncbi request reprint Reconstruction of the sphenoid wing in a case of neurofibromatosis type 1 and complex unilateral orbital dysplasia with pulsating exophthalmos
    Reinhard E Friedrich
    Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 25:287-90. 2011
    ..An intraoperative computed cone-beam computed tomography system (3D C-arm system) was used as a prompt and feasible technique to check the positioning of the titanium mesh in an anatomic region that is sensitive to mechanical stress...
  83. ncbi request reprint Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions
    Udo Kristen
    Institute of General Botany, University of Hamburg, Hamburg, Germany
    Braz Dent J 17:58-62. 2006
    ..However, at least 4 of the mouthwashes evaluated in this study could probably irritate the oral mucosa acutely if used undiluted (original concentration)...
  84. ncbi request reprint Coxsackie adenovirus receptor expression in carcinomas of the head and neck
    Tina Wunder
    Department of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Hospital Hamburg Eppendorf, Martinistrase 52, D 20246 Hamburg, Germany
    Anticancer Res 32:1057-62. 2012
    ..Thus CAR expression in HNSCC was evaluated in the current study...
  85. ncbi request reprint Proliferation of the synovial lining cell layer in suggested metal hypersensitivity
    Andreas Burkandt
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 25:679-86. 2011
    ..Despite some important study limitations, the present observation adds to the evidence that metal hypersensitivity shares characteristic morphological features with autoimmune diseases of the joints...
  86. ncbi request reprint The influence of wisdom tooth impaction on root formation
    Reinhard E Friedrich
    Klinik für Zahn, Mund, Kiefer und Gesichtschirurgie Nordwestdeutsche Kieferklinik, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Ann Anat 185:481-92. 2003
    ..This thesis could have bearing on age estimations in teenagers and young adults and the timing of dental treatment. The aim of this study was to determine whether the impaction of wisdom teeth influences the velocity of root formation...
  87. ncbi request reprint Avascular mandibular osteonecrosis in association with bisphosphonate therapy: a report on four patients
    Reinhard E Friedrich
    Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany
    Anticancer Res 27:1841-5. 2007
    ..Due to the importance of this presumed side-effect of bisphosphonates for the dentist and the maxillofacial surgeon, we report four cases...
  88. ncbi request reprint Mandibular augmentation with vascularized fibula transplantation in a patient with systemic lupus erythematosus
    Lei Li
    Department of Oral and Maxillofacial Surgery, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Oral Maxillofac Surg 62:497-9. 2004
  89. ncbi request reprint Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors
    Lan Kluwe
    Department of Maxillofacial Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Mutat 22:420. 2003
    ..3044T>C (p.Leu1015Pro), c.2497delT, and c.6020_6027dup. The proportion of megabase deletions of the NF1 gene found in patients with MPNST (17%=4/24) was higher than that in a group of unselected NF1 patients (5.4%=27/500)...
  90. ncbi request reprint Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions of twenty brands
    Udo Kristen
    Institute of General Botany, University of Hamburg, Ohnhorstrasse 18, D 22609 Hamburg, Germany
    In Vivo 18:803-7. 2004
    ..However, 4 to 5 of the mouthwashes could probably irritate the oral mucosa acutely, when used in the form of the original producer concentrations...
  91. ncbi request reprint Presymptomatic diagnosis for children of sporadic neurofibromatosis 2 patients: a method based on tumor analysis
    Lan Kluwe
    Laboratory of Brain Tumor Biology, Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Genet Med 4:27-30. 2002
    ..To provide presymptomatic diagnosis for children of sporadic neurofibromatosis 2 patients in whom no NF2-mutations were found by screening their blood-DNA...