N Friedrich

Summary

Affiliation: University of Greifswald
Country: Germany

Publications

  1. doi request reprint Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, Greifswald, Germany
    Am J Gastroenterol 104:89-95. 2009
  2. pmc Correlates of adverse outcomes in abdominally obese individuals: findings from the five-year followup of the population-based study of health in Pomerania
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Straße NK, 17475 Greifswald, Germany German Centre for Cardiovascular Research DZHK, partner site Greifswald, 13347 Berlin, Germany
    J Obes 2013:762012. 2013
  3. pmc Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample
    Kathleen Dittmann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    BMC Nephrol 13:169. 2012
  4. pmc Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania
    Anke Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    BMC Endocr Disord 13:11. 2013
  5. doi request reprint Short-term changes of the urine metabolome after bariatric surgery
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    OMICS 16:612-20. 2012
  6. doi request reprint Metabolomics in diabetes research
    Nele Friedrich
    Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    J Endocrinol 215:29-42. 2012
  7. doi request reprint Insulin-like growth factor I and anthropometric parameters in a Danish population
    N Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany
    Exp Clin Endocrinol Diabetes 120:171-4. 2012
  8. pmc The association between IGF-I and insulin resistance: a general population study in Danish adults
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Diabetes Care 35:768-73. 2012
  9. pmc Thyroid function tests in patients taking thyroid medication in Germany: Results from the population-based Study of Health in Pomerania (SHIP)
    Anke Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Ferdinand Sauerbruch Strasse, 17475 Greifswald, Germany
    BMC Res Notes 3:227. 2010
  10. doi request reprint Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Clin Chem Lab Med 48:115-20. 2010

Detail Information

Publications39

  1. doi request reprint Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, Greifswald, Germany
    Am J Gastroenterol 104:89-95. 2009
    ..The aim of the present study was to assess if different distributions of risk factors could explain the disparities in the prevalence of gallstone disease between Denmark and northeast Germany...
  2. pmc Correlates of adverse outcomes in abdominally obese individuals: findings from the five-year followup of the population-based study of health in Pomerania
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Straße NK, 17475 Greifswald, Germany German Centre for Cardiovascular Research DZHK, partner site Greifswald, 13347 Berlin, Germany
    J Obes 2013:762012. 2013
    ..However, it has not been resolved which factors predispose for the development of these adverse obesity-related outcomes in otherwise healthy individuals with abdominal obesity...
  3. pmc Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample
    Kathleen Dittmann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    BMC Nephrol 13:169. 2012
    ..The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults...
  4. pmc Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania
    Anke Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    BMC Endocr Disord 13:11. 2013
    ..Besides its role in bone formation, osteocalcin may play a role in the regulation of energy metabolism and male fertility. To interpret serum OC data, reference intervals adapted to a specific laboratory method are needed...
  5. doi request reprint Short-term changes of the urine metabolome after bariatric surgery
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    OMICS 16:612-20. 2012
    ..Whether urinary metabotypes might be used for early prediction of a successful bariatric procedure should be evaluated in long-term observations...
  6. doi request reprint Metabolomics in diabetes research
    Nele Friedrich
    Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    J Endocrinol 215:29-42. 2012
    ..This review summarises the current findings of metabolic research regarding diabetes in animal models and human investigations...
  7. doi request reprint Insulin-like growth factor I and anthropometric parameters in a Danish population
    N Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany
    Exp Clin Endocrinol Diabetes 120:171-4. 2012
    ..Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation...
  8. pmc The association between IGF-I and insulin resistance: a general population study in Danish adults
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Diabetes Care 35:768-73. 2012
    ..The aim of the current study was to evaluate the association between IGF-I level and insulin resistance in a Danish general population...
  9. pmc Thyroid function tests in patients taking thyroid medication in Germany: Results from the population-based Study of Health in Pomerania (SHIP)
    Anke Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Ferdinand Sauerbruch Strasse, 17475 Greifswald, Germany
    BMC Res Notes 3:227. 2010
    ..Using thyroid function tests, we aim to measure the proportions of subjects, who are under- or over-treated with thyroid medication in a previously iodine-deficient area...
  10. doi request reprint Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Clin Chem Lab Med 48:115-20. 2010
    ....
  11. doi request reprint Lack of association between insulin-like growth factor-1 or insulin-like growth factor-binding protein-3 and left ventricular hypertrophy: results of the Study of Health in Pomerania
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany
    J Hypertens 28:856-64. 2010
    ..The aim of the present study was to investigate the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) levels with LVH in a population-based study...
  12. ncbi request reprint No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults
    N Friedrich
    Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther Rathenau Strasse 48, Greifswald, Germany
    Eur J Clin Microbiol Infect Dis 26:887-94. 2007
    ..We conclude that there is no reduced immune response related to antibody production following immunisations against tetanus, diphtheria and hepatitis B in adults with atopic diseases...
  13. doi request reprint All-cause mortality and serum insulin-like growth factor I in primary care patients
    N Friedrich
    Institute for Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Germany
    Growth Horm IGF Res 21:102-6. 2011
    ..The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study...
  14. doi request reprint The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Clin Endocrinol (Oxf) 75:561-6. 2011
    ....
  15. doi request reprint Associations of anthropometric parameters with serum TSH, prolactin, IGF-I, and testosterone levels: results of the study of health in Pomerania (SHIP)
    N Friedrich
    1Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Exp Clin Endocrinol Diabetes 118:266-73. 2010
    ..These sex-specific differences should be noted in studies regarding hormones and obesity...
  16. ncbi request reprint Inverse association between periodontitis and respiratory allergies
    N Friedrich
    Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Clin Exp Allergy 36:495-502. 2006
    ..Periodontitis is an infection with systemic effects and a high prevalence among adults. In the aetiology of allergic diseases the hygiene hypothesis claims that infections in early infancy may protect against allergic diseases...
  17. doi request reprint Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 94:1732-9. 2009
    ..The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study...
  18. ncbi request reprint Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP)
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Growth Horm IGF Res 18:228-37. 2008
    ..96 *standard deviation method and the quantile regression method and (2) to perform a comparison of the results from both statistical methods...
  19. doi request reprint Inverse association between periodontitis and respiratory allergies in patients with type 1 diabetes mellitus
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Germany
    J Clin Periodontol 35:305-10. 2008
    ..The objective of the present study was to investigate the association between periodontitis and respiratory allergies in a type 1 diabetes mellitus population...
  20. doi request reprint Association between parity and autoimmune thyroiditis in a general female population
    Nele Friedrich
    Institute of Community Medicine Unit SHIP, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    Autoimmunity 41:174-80. 2008
    ..The objective of the present study was to analyse the association between parity and AIT by using ultrasound and serological data...
  21. doi request reprint The association between alcohol consumption and biomarkers of alcohol exposure with total serum immunoglobulin E levels
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Alcohol Clin Exp Res 32:983-90. 2008
    ..The purpose of the present study was to investigate the association of self-reported alcohol consumption and different biomarkers of alcohol exposure to total serum IgE levels in a general adult population...
  22. doi request reprint Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Steroids 77:52-8. 2012
    ..The aim of the present study was to investigate the combined influence of low IGF-I and low testosterone on all-cause mortality in men...
  23. doi request reprint Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    J Androl 29:610-7. 2008
    ..Quantile regression should be preferred to calculate reference ranges; a better concordance with original data is possible because no distribution assumption is required and the robustness against outliers is given...
  24. doi request reprint Is serum ferritin within the reference range a risk predictor of cardiovascular disease? A population-based, long-term study comprising 2874 subjects
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, D 17487, Greifswald, Germany
    Br J Nutr 102:594-600. 2009
    ..In concordance with former prospective studies, the present results do not support the hypothesis that normal body Fe stores should play a significant role in the development of CVD...
  25. doi request reprint Association of IGF-I and the IGF-I/IGFBP-3 ratio with plasma aldosterone levels in the general population
    A Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Horm Metab Res 44:228-33. 2012
    ..We conclude that, serum IGF-I and the IGF-I/IGFBP-3 ratio are associated with plasma aldosterone levels in women but not in men from the general population...
  26. doi request reprint Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies
    A Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    Eur J Endocrinol 167:7-15. 2012
    ..We further examined the frequency of positive screening results in subjects with resistant hypertension or stage III hypertension and assessed possible disparities between untreated and treated hypertensive subjects...
  27. ncbi request reprint Reference intervals for serum concentrations of three bone turnover markers for men and women
    J Michelsen
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Bone 57:399-404. 2013
    ..We aimed to determine reference intervals for serum concentrations of intact amino-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (BAP) and carboxy-terminal telopeptide of type I collagen (CTX)...
  28. doi request reprint The growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania
    D Rosskopf
    Department of Pharmacology, Center for Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Int J Obes (Lond) 35:364-72. 2011
    ..FTO is highly expressed in the hypothalamus and also in the pituitary gland. The decrease in growth hormone (GH) secretion is known to cause a decrease in lean body mass in older subjects...
  29. ncbi request reprint Reference intervals for aldosterone, renin, and the aldosterone-to-renin ratio in the population-based Study of Health in Pomerania (SHIP-1)
    A Hannemann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Ernst Moritz Arndt Universitat Greifswald, Greifswald, Germany
    Horm Metab Res 42:392-9. 2010
    ..We confirm that PAC and PRC are associated with various factors, including sex, age, intake of estrogen, and various antihypertensive medications...
  30. ncbi request reprint Occupational exposure to ionizing radiation is associated with autoimmune thyroid disease
    Henry Volzke
    Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    J Clin Endocrinol Metab 90:4587-92. 2005
    ..The thyroid gland is a potential target organ for radiation-related damage...
  31. ncbi request reprint Alcohol consumption and out-patient services utilization by abstainers and drinkers
    Sebastian E Baumeister
    Medical School, Institute of Epidemiology and Social Medicine, University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Addiction 101:1285-91. 2006
    ..It was hypothesized that abstainers utilize more health services because they have less social resources, practice more risky health behaviours, have poorer self-reported health and suffer more from chronic diseases...
  32. ncbi request reprint Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study
    Henry Volzke
    Institute of Community Medicine, University of Greifswald, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 92:4039-45. 2007
    ..The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations...
  33. doi request reprint Association between serum testosterone and sex hormone-binding globulin and exercise capacity in men: results of the Study of Health in Pomerania (SHIP)
    Beate Koch
    Medical Faculty of Ernst Moritz Arndt University, Department of Internal Medicine B, Cardiology, Pneumology, Infectious Diseases, and Intensive Care, University Hospital Ferdinand Sauerbruchstrasse, D 17475 Greifswald, Germany
    J Androl 32:135-43. 2011
    ..After adjustment for relevant influencing factors, neither total serum testosterone nor SHBG levels had any interference with peak exercise capacity, aerobic exercise capacity, or maximal power output in men...
  34. doi request reprint Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania
    Klaus Empen
    Department of Cardiology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    Eur J Endocrinol 163:617-23. 2010
    ..The aim of this study was to analyze the association between serum IGF1 as well as IGF-binding protein 3 (IGFBP3) levels and endothelial function measured by flow-mediated dilation (FMD)...
  35. doi request reprint Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania
    Joern Moock
    Institut for Community Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    Eur J Endocrinol 160:17-24. 2009
    ..Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated...
  36. doi request reprint Lung function reference values in different German populations
    Beate Koch
    Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23A, D 17475 Greifswald, Germany
    Respir Med 105:352-62. 2011
    ....
  37. doi request reprint Partial misspecification of survey design features sufficed to severely bias estimates of health-related outcomes
    Carsten Oliver Schmidt
    Institute for Community Medicine, University of Greifswald, Walther Rathenau Str 48, 17487 Greifswald, Germany
    J Clin Epidemiol 64:416-23. 2011
    ..This work uses a survey of public health to systematically illustrate the effects of incompletely accounting for strata, clustering, and weights...
  38. doi request reprint The benefit of long-term growth hormone (GH) replacement therapy in hypopituitary adults with GH deficiency: results of the German KIMS database
    Christin Spielhagen
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany
    Growth Horm IGF Res 21:1-10. 2011
    ..To evaluate the treatment effects of long-term growth hormone (GH) replacement therapy in adults with GH deficiency (GHD) who were followed in KIMS Germany (Pfizer International Metabolic Database), a national surveillance study...
  39. doi request reprint Association between serum insulin-like growth factor (IGF) I and IGF binding protein-3 and lung function
    Sven Glaser
    Department of Internal Medicine B, Pulmonary Medicine and Infectious Diseases, Ernst Moritz Arndt University Greifswald, D 17475 Greifswald, Germany
    J Clin Endocrinol Metab 94:2452-8. 2009
    ..The aim of the present study was to further clarify the impact of IGF-I and IGFBP-3 levels on lung volumes and respiratory pressures in a general adult population...