Hans Christoph Friederich
Affiliation: University of Heidelberg
- Differential motivational responses to food and pleasurable cues in anorexia and bulimia nervosa: a startle reflex paradigmHans Christoph Friederich
Eating Disorders Unit, Institute of Psychiatry, King s College London, London, UK
Psychol Med 36:1327-35. 2006..SEM was used because it is sensitive to motivational states of approach (appetitive response) and withdrawal (aversive response), which are independent of conscious intentional control...
- INTERBED: internet-based guided self-help for overweight and obese patients with full or subsyndromal binge eating disorder. A multicenter randomized controlled trialMartina de Zwaan
Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany
Trials 13:220. 2012....
- Neurocircuit function in eating disordersHans Christoph Friederich
Department of General Internal Medicine and Psychosomatics, Medical University of Heidelberg, Heidelberg, Germany
Int J Eat Disord 46:425-32. 2013..Inadequate response to current therapeutic interventions constitutes a challenging clinical problem. A better understanding of the underlying neurobiological mechanisms could improve psychotherapeutic and drug treatment strategies...
- Cognitive-behavioral flexibility in anorexia nervosaHans Christoph Friederich
Department of General Internal Medicine and Psychosomatics Im Neuenheimer Felds 410, Medical Hospital, University of Heidelberg, Germany
Curr Top Behav Neurosci 6:111-23. 2011..The conceptualization of AN as a neurodevelopmental striatocortical disorder may help to develop new promising treatment approaches for this severe disorder...
- Neural correlates of body dissatisfaction in anorexia nervosaHans Christoph Friederich
Eating Disorders Unit, Institute of Psychiatry, King s College London, DeCrespigny Park, SE5 8AF London, UK
Neuropsychologia 48:2878-85. 2010..Insula hyperactivation along with ACC hypoactivation may be critical for altered interoceptive awareness to body self-comparison and/or for altered implicit motivation to thin-idealized body images in AN patients...
- Interpersonal motives in anorexia nervosa: the fear of losing one's autonomyTimo Brockmeyer
University Hospital Heidelberg, Department of General Internal Medicine and Psychosomatics, Germany
J Clin Psychol 69:278-89. 2013..This study examined the widely held but insufficiently studied hypothesis of autonomy disturbances in anorexia nervosa...
- Specific emotion regulation impairments in major depression and anorexia nervosaTimo Brockmeyer
University Hospital Heidelberg, Department of General Internal Medicine and Psychosomatics, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Psychiatry Res 200:550-3. 2012..These findings support the notion of ER difficulties as transdiagnostic phenomena, and suggest that depression may be characterized by broader and greater ER difficulties than anorexia nervosa...
- Response inhibition or salience detection in the right ventrolateral prefrontal cortex?Stephan Walther
Department of Psychiatry, Section of Experimental Psychopathology and Neurophysiology, University of Heidelberg, Heidelberg, Germany
Neuroreport 22:778-82. 2011..This reflects a more general salience-detection mechanism, which is not specific for response-inhibition tasks...
- Functional neuroanatomy of body shape perception in healthy and eating-disordered womenRudolf Uher
Institute of Psychiatry, King s College London, London
Biol Psychiatry 58:990-7. 2005..Abnormalities in perception and evaluation of body shape are a hallmark of eating disorders...
- I'm not as slim as that girl: neural bases of body shape self-comparison to media imagesHans Christoph Friederich
Eating Disorders Unit, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
Neuroimage 37:674-81. 2007..Brain networks associated with anxiety induced by self-comparison to slim images may be involved in the genesis of body dissatisfaction and hence with vulnerability to eating disorders...
- Grey matter abnormalities within cortico-limbic-striatal circuits in acute and weight-restored anorexia nervosa patientsHans Christoph Friederich
Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
Neuroimage 59:1106-13. 2012..The findings of the study suggest that structural abnormalities of the ACC and SMA were independent of the disease stage, whereas subcortical limbic-striatal changes were state dependent...
- A graphical vector autoregressive modelling approach to the analysis of electronic diary dataBeate Wild
Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
BMC Med Res Methodol 10:28. 2010..To model dynamic dependence structures and feedback mechanisms between symptom-relevant variables, a multivariate time series method has to be applied...
- Neural reward processing is modulated by approach- and avoidance-related personality traitsJoe J Simon
Section of Experimental Psychopathology, Department of Psychiatry, University of Heidelberg, Germany
Neuroimage 49:1868-74. 2010....
- Treatment outcome in people with subthreshold compared with full-syndrome binge eating disorderHans Christoph Friederich
Department of Psychosomatic and General Internal Medicine, University of Heidelberg, Heidelberg, Germany
Obesity (Silver Spring) 15:283-7. 2007..This study was designed to compare eating-related and general psychopathology at baseline and in response to a multimodal treatment program in obese people with subBED compared with BED...
- [Multilevel modelling applied to the analysis of diary data of obese patients with and without binge eating disorder]Beate Wild
Klinik für Psychosomatische und Allgemeine Klinische Medizin, Universitatsklinikum Heidelberg
Psychother Psychosom Med Psychol 58:295-302. 2008..Significant differences in the development of the eating behaviour over time were found for the subgroups of patients with and without BED...
- Starvation and emotion regulation in anorexia nervosaTimo Brockmeyer
Department of General Internal Medicine and Psychosomatics, Centre for Psychosocial Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Compr Psychiatry 53:496-501. 2012..The findings are consistent with the hypothesis that self-starvation with accompanying low body weight serves as a dysfunctional behavior to regulate aversive emotions in AN...
- TaqIA polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patientsJulia K Winkler
Department of Medicine I and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany
Nutrition 28:996-1001. 2012..However, the effect of the polymorphism on the success in weight loss and/or weight maintenance during weight-loss programs has not been evaluated thus far...
- Immunogenicity and safety of H1N1 vaccination in anorexia nervosa--results from a pilot studyArne Zastrow
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Int J Eat Disord 45:146-9. 2012..Currently, no recommendation can be given on the safety and immunogenicity of indicated vaccinations in this malnourished population...
- Sustained effects of a mindfulness-based stress-reduction intervention in type 2 diabetic patients: design and first results of a randomized controlled trial (the Heidelberger Diabetes and Stress-study)Mechthild Hartmann
Department of Medicine II and Psychosomatics, University of Heidelberg, Heidelberg, Germany
Diabetes Care 35:945-7. 2012..e., depression, psychosocial stress) and the progression of nephropathy (i.e., albuminuria) and for improving the subjective health status of patients with type 2 diabetes...
- Elevated myocardial enzymes and natriuretic peptides in anorexia nervosa: prototypic condition for the pathophysiology of cachexia?Arne Zastrow
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Heidelberg, Germany
Cardiology 118:256-9. 2011..A review of the available literature is provided. Further research is required to explain the pathophysiological meaning of the abnormal laboratory findings...
- The ANTOP study: focal psychodynamic psychotherapy, cognitive-behavioural therapy, and treatment-as-usual in outpatients with anorexia nervosa--a randomized controlled trialBeate Wild
Department of Psychosomatic and General Internal Medicine, Medical University Hospital, Heidelberg, Germany
Trials 10:23. 2009..Each therapeutic approach is compared to a "treatment-as-usual" control group...
- Intra-individual reaction time variability in schizophrenia, depression and borderline personality disorderStefan Kaiser
University of Heidelberg, Department of Psychiatry, Section Experimental Psychopathology, Voss Strasse 4, 69115 Heidelberg, Germany
Brain Cogn 66:73-82. 2008..These results are discussed with respect to common versus disorder-specific neural mechanisms underlying increased IIV...
- Quantitative sensory testing profiles in chronic back pain are distinct from those in fibromyalgiaKlaus Blumenstiel
Department of General Internal Medicine and Psychosomatics, Medical Hospital, Ruprecht Karls University Heidelberg, Germany
Clin J Pain 27:682-90. 2011..The aim of this study was to disclose commonalities and differences in the pathophysiology of FMS and CBP...