Lutz Frankenstein

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Association between spironolactone added to beta-blockers and ACE inhibition and survival in heart failure patients with reduced ejection fraction: a propensity score-matched cohort study
    L Frankenstein
    University of Heidelberg, Heidelberg, Germany
    Eur J Clin Pharmacol 69:1747-55. 2013
  2. doi request reprint Clinical characteristics, morbidity, and prognostic value of concomitant coronary artery disease in idiopathic dilated cardiomyopathy
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 102:771-80. 2013
  3. pmc Prevalence and prognostic significance of adrenergic escape during chronic beta-blocker therapy in chronic heart failure
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmology, University of Heidelberg, 69120 Heidelberg, Germany
    Eur J Heart Fail 11:178-84. 2009
  4. doi request reprint Reference change values and determinants of variability of NT-proANP and GDF15 in stable chronic heart failure
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Basic Res Cardiol 104:731-8. 2009
  5. doi request reprint Validity, prognostic value and optimal cutoff of respiratory muscle strength in patients with chronic heart failure changes with beta-blocker treatment
    Lutz Frankenstein
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 16:424-9. 2009
  6. doi request reprint Biological variation of high sensitive Troponin T in stable heart failure patients with ischemic or dilated cardiomyopathy
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 100:633-40. 2011
  7. doi request reprint Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status--do we need specificity for sex and beta-blockers?
    L Frankenstein
    Department of Cardiology, Angiology, Pulmonology, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 147:74-8. 2011
  8. doi request reprint The obesity paradox in stable chronic heart failure does not persist after matching for indicators of disease severity and confounders
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Eur J Heart Fail 11:1189-94. 2009
  9. doi request reprint The association between long-term longitudinal trends in guideline adherence and mortality in relation to age and sex
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 12:574-80. 2010
  10. doi request reprint Biological variation and reference change value of high-sensitivity troponin T in healthy individuals during short and intermediate follow-up periods
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Clin Chem 57:1068-71. 2011

Collaborators

Detail Information

Publications40

  1. doi request reprint Association between spironolactone added to beta-blockers and ACE inhibition and survival in heart failure patients with reduced ejection fraction: a propensity score-matched cohort study
    L Frankenstein
    University of Heidelberg, Heidelberg, Germany
    Eur J Clin Pharmacol 69:1747-55. 2013
    ..Since pharmacological properties differ between eplerenone and spironolactone, the prognostic benefit of spironolactone added to this baseline combination therapy needs clarification...
  2. doi request reprint Clinical characteristics, morbidity, and prognostic value of concomitant coronary artery disease in idiopathic dilated cardiomyopathy
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 102:771-80. 2013
    ..Clinical characteristics and prognostic implications of concomitant CAD in patients with dCMP are largely unknown...
  3. pmc Prevalence and prognostic significance of adrenergic escape during chronic beta-blocker therapy in chronic heart failure
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmology, University of Heidelberg, 69120 Heidelberg, Germany
    Eur J Heart Fail 11:178-84. 2009
    ..The aim of this study was to examine the prevalence and prognostic value of AE with respect to different beta-blocker agents and doses...
  4. doi request reprint Reference change values and determinants of variability of NT-proANP and GDF15 in stable chronic heart failure
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Basic Res Cardiol 104:731-8. 2009
    ..The extent of change in both markers is not related to baseline hormonal levels or other baseline variables. RCVs are high for NT-proANP and low for GDF15, while inter-individual variation is high in GDF15 and intermediate in NT-proANP...
  5. doi request reprint Validity, prognostic value and optimal cutoff of respiratory muscle strength in patients with chronic heart failure changes with beta-blocker treatment
    Lutz Frankenstein
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 16:424-9. 2009
    ..Furthermore, the effects of BBL, mainstay of modern chronic heart failure therapy, on respiratory muscle function remain controversial. Finally, no proper separate cutoff according to treatment exists...
  6. doi request reprint Biological variation of high sensitive Troponin T in stable heart failure patients with ischemic or dilated cardiomyopathy
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 100:633-40. 2011
    ..For these values, a difference between ischemic heart disease (IHD) and dilated cardiomyopathy (dCMP) appears conceivable...
  7. doi request reprint Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status--do we need specificity for sex and beta-blockers?
    L Frankenstein
    Department of Cardiology, Angiology, Pulmonology, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 147:74-8. 2011
    ..We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and NT-proBNP...
  8. doi request reprint The obesity paradox in stable chronic heart failure does not persist after matching for indicators of disease severity and confounders
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Eur J Heart Fail 11:1189-94. 2009
    ..To verify whether controlling for indicators of disease severity and confounders represents a solution to the obesity paradox in chronic heart failure (CHF)...
  9. doi request reprint The association between long-term longitudinal trends in guideline adherence and mortality in relation to age and sex
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 12:574-80. 2010
    ..Using a large clinical multi-site prospective chronic heart failure registry, we sought to determine (i) implementation of guidelines over time and (ii) adjusted survival benefit there from...
  10. doi request reprint Biological variation and reference change value of high-sensitivity troponin T in healthy individuals during short and intermediate follow-up periods
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Clin Chem 57:1068-71. 2011
    ....
  11. doi request reprint The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age
    L Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Heart 95:825-9. 2009
    ....
  12. ncbi request reprint Beta-blockers influence the short-term and long-term prognostic information of natriuretic peptides and catecholamines in chronic heart failure independent from specific agents
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pneumology, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 26:1033-9. 2007
    ..Data on the short-term and long-term predictive power comparing these biomarkers as well as accounting for the influence of beta-blocker treatment both on the marker or the resultant prognostic information are scarce...
  13. doi request reprint Relation of N-terminal pro-brain natriuretic peptide levels and their prognostic power in chronic stable heart failure to obesity status
    Lutz Frankenstein
    Department of Cardiology, Angiology and Pulmonology, University of Heidelberg, INF 410, Heidelberg, Germany
    Eur Heart J 29:2634-40. 2008
    ..To investigate the relationship between body mass index (BMI) and N-terminal pro-brain natriuretic peptide (NTproBNP) level and resultant prognostic capacity in chronic heart failure (CHF) controlled for known confounders...
  14. ncbi request reprint Prognostic impact of peakVO2-changes in stable CHF on chronic beta-blocker treatment
    L Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 122:125-30. 2007
    ..We therefore prospectively evaluated individual pVO2-changes at a 6-month interval in patients all receiving BBL...
  15. ncbi request reprint Gender and age related predictive value of walk test in heart failure: do anthropometrics matter in clinical practice?
    L Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 127:331-6. 2008
    ..As opposed to spiroergometry, improvement of its prognostic accuracy by correction for height, weight, age and gender has not yet been attempted comprehensively despite known influences of these parameters...
  16. doi request reprint Is there an additional benefit of serial NT-proBNP measurements in patients with stable chronic heart failure receiving individually optimized therapy?
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 100:1059-67. 2011
    ..The role of serial NT-proBNP measurements in patients suffering from chronic systolic heart failure (CHF) who already receive individually optimized pharmacotherapy is still unresolved...
  17. doi request reprint Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Apher 25:315-22. 2010
    ..The objective of this study was to investigate functional effects of immunoadsorption (IA) in patients with chronic nonfamilial dilated cardiomyopathy (DCM) regarding clinical and humoral markers of heart failure...
  18. doi request reprint Primary ICD-therapy in patients with advanced heart failure: selection strategies and future trials
    Lutz Frankenstein
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Clin Res Cardiol 97:594-600. 2008
    ..Furthermore, we sought to provide current survival data and a size-estimate for prospective trials based on real-life data for this high risk cohort...
  19. doi request reprint A decade of developments in chronic heart failure treatment: a comparison of therapy and outcome in a secondary and tertiary hospital setting
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:1-10. 2012
    ..To investigate determinants and temporal developments of treatment strategies, 5-year survival and heart transplantation rates between patients treated at secondary and tertiary hospitals...
  20. doi request reprint Sex-specific predictive power of 6-minute walk test in chronic heart failure is not enhanced using percent achieved of published reference equations
    Lutz Frankenstein
    Department of Cardiology, Angiology, and Pneumology, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 27:427-34. 2008
    ..The strong influence of height, weight, age, and sex on 6MWT distance may be accounted for by using percentage achieved of predicted value rather than uncorrected 6MWT values...
  21. doi request reprint Impact of troponin I-autoantibodies in chronic dilated and ischemic cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    Basic Res Cardiol 106:25-35. 2011
    ..This might possibly indicate a prophylactic effect of TNI-autoantibodies in this subgroup of patients, encouraging further studies into possible protective effects of antibodies against certain cardiac target structures...
  22. doi request reprint Is serial determination of inspiratory muscle strength a useful prognostic marker in chronic heart failure?
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 15:156-61. 2008
    ..Training studies, however, frequently use it as a therapeutic target and surrogate marker for prognosis. The prognostic value of changes of PImax that allow this extrapolation is unknown...
  23. doi request reprint Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:835-41. 2009
    ..Currently, no 12-month data regarding effects of the novel I(f) channel antagonist ivabradine on heart rate control, effects on left ventricular mass, tolerability, and safety are available in patients after heart transplantation (HTX)...
  24. doi request reprint Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Clin Apher 24:141-9. 2009
    ....
  25. doi request reprint Variability of N-terminal probrain natriuretic peptide in stable chronic heart failure and its relation to changes in clinical variables
    Lutz Frankenstein
    Department of Cardiology, Angiology, and Pulmonology University of Heidelberg, Heidelberg, Germany
    Clin Chem 55:923-9. 2009
    ..We investigated the variability of N-terminal probrain natriuretic peptide (NT-proBNP) and its relation to known confounding variables in patients with stable chronic heart failure who were on a stable optimized medication regimen...
  26. doi request reprint Negative pretransplant serostatus for Toxoplasma gondii is associated with impaired survival after heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 23:382-9. 2010
    ..The cause of impaired survival in Toxoplasma seronegative recipients is currently unclear; possible explanations include an alteration of immune-reactivity/-regulation or adverse effects of prophylactic medication...
  27. pmc Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1323-8. 2013
    ..However, long-term data regarding the effects of ivabradine, a novel If channel antagonist, are limited in patients after heart transplantation...
  28. pmc Conversion to generic cyclosporine A in stable chronic patients after heart transplantation
    Maximilian Kraeuter
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1421-6. 2013
    ..Available CSA products differ in the constitution of their emulsion. To compare intra-individual differences after a conversion to a generic CSA, a retrospective single-center study was initiated...
  29. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
    ....
  30. pmc Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation
    Ibrahim Gueler
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:297-303. 2013
    ..Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes...
  31. doi request reprint Epstein-Barr virus load in whole blood is associated with immunosuppression, but not with post-transplant lymphoproliferative disease in stable adult heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 21:963-71. 2008
    ..EBV DNA viral load determination does not appear to be useful for risk prediction or early diagnosis of PTLD in adults after HTX, but an association of EBV DNA load with qualitative and quantitative immunosuppression is demonstrated...
  32. pmc Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg
    Drug Des Devel Ther 6:289-95. 2012
    ..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation...
  33. doi request reprint Influence of sex on treatment and outcome in chronic heart failure
    Lutz Frankenstein
    Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Germany
    Cardiovasc Ther 30:182-92. 2012
    ....
  34. doi request reprint Panic disorder in patients with chronic heart failure
    Thomas Müller-Tasch
    Department of Psychosomatic and General Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Psychosom Res 64:299-303. 2008
    ..Our objective was to assess the prevalence of panic disorder, its influence on quality of life (QoL), and the presence of further anxiety and depressive comorbid disorders in outpatients with chronic heart failure (CHF)...
  35. doi request reprint [Chronic systolic heart failure - dosing recommendations at beginning and end of treatment]
    Christian Zugck
    Abteilung für Innere Medizin III, Universitatsklinikum Heidelberg
    Ther Umsch 65:585-92. 2008
    ..The present paper provides a comprehensive overview on medical therapeutic strategies with a particular focus of onset and discontinuation of drugs in patients with chronic systolic dysfunction...
  36. ncbi request reprint [Telemonitoring in chronic heart failure patients. Which diagnostic finding prevents hospital readmission?]
    C Zugck
    Universitatsklinikum Heidelberg, Abteilung fur Kardiologie, Angiologie und Pulmonologie, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Herzschrittmacherther Elektrophysiol 16:176-82. 2005
    ....
  37. doi request reprint Malignancies after heart transplantation: incidence, risk factors, and effects of calcineurin inhibitor withdrawal
    A O Doesch
    Department of Cardiology, University of Heidelberg, Germany
    Transplant Proc 42:3694-9. 2010
    ..Markedly fewer patients with noncutaneous malignancies died after switch to a CNI-free regimen, not quite reaching statistical significance by Kaplan-Meier analysis, however...
  38. doi request reprint Increased adherence after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation: a pre-experimental study
    A O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 42:4238-42. 2010
    ....
  39. doi request reprint Proton pump inhibitor co-medication reduces active drug exposure in heart transplant recipients receiving mycophenolate mofetil
    A O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 42:4243-6. 2010
    ....
  40. ncbi request reprint Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 84:988-96. 2007
    ....