C Flotho

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies
    Christian Flotho
    Division of Paediatric Haematology Oncology, University of Freiburg, Freiburg, Germany
    Br J Haematol 138:644-50. 2007
  2. ncbi Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
    Charlotte M Niemeyer
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Nat Genet 42:794-800. 2010
  3. ncbi Is childhood MDS an epigenetic disease?
    Christian Flotho
    Leuk Res 31:743. 2007
  4. ncbi A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia
    Christian Flotho
    Departments of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 110:1271-7. 2007
  5. ncbi Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11
    C Flotho
    Division of Pediatric Hematology Oncology, University of Freiburg, Freiburg, Germany
    Oncogene 26:5816-21. 2007
  6. ncbi The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    C Flotho
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Leukemia 23:1019-28. 2009
  7. ncbi Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization
    Klaus Hämmerle
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, University Children s Hospital, Germany
    Cancer Genet Cytogenet 142:149-52. 2003
  8. ncbi Stem cell transplantation for paroxysmal nocturnal haemoglobinuria in childhood
    Christian Flotho
    Children's Hospital, University of Freiburg, Freiburg, Germany
    Br J Haematol 118:124-7. 2002
  9. ncbi Genomic assessment of pediatric acute leukemia
    Charles G Mullighan
    Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    Cancer J 11:268-82. 2005

Detail Information

Publications9

  1. ncbi AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies
    Christian Flotho
    Division of Paediatric Haematology Oncology, University of Freiburg, Freiburg, Germany
    Br J Haematol 138:644-50. 2007
    ..While AKAP12 function has not been previously linked to leukaemogenesis, our results raise the possibility that epigenetic silencing of AKAP12 is involved in myeloid malignancies...
  2. ncbi Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
    Charlotte M Niemeyer
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Nat Genet 42:794-800. 2010
    ....
  3. ncbi Is childhood MDS an epigenetic disease?
    Christian Flotho
    Leuk Res 31:743. 2007
  4. ncbi A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia
    Christian Flotho
    Departments of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 110:1271-7. 2007
    ..Incorporation of the expression levels of these genes into existing strategies of risk classification could improve clinical management...
  5. ncbi Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11
    C Flotho
    Division of Pediatric Hematology Oncology, University of Freiburg, Freiburg, Germany
    Oncogene 26:5816-21. 2007
    ....
  6. ncbi The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    C Flotho
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Leukemia 23:1019-28. 2009
    ....
  7. ncbi Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization
    Klaus Hämmerle
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, University Children s Hospital, Germany
    Cancer Genet Cytogenet 142:149-52. 2003
    ..We found no consistent pattern of differential expression between patients and healthy donors. We conclude that aberrant regulation of NACA or ANX2 does not play a relevant role in JMML pathogenesis...
  8. ncbi Stem cell transplantation for paroxysmal nocturnal haemoglobinuria in childhood
    Christian Flotho
    Children's Hospital, University of Freiburg, Freiburg, Germany
    Br J Haematol 118:124-7. 2002
    ..Indications and techniques of SCT in childhood PNH are discussed and an overview of the literature is given...
  9. ncbi Genomic assessment of pediatric acute leukemia
    Charles G Mullighan
    Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    Cancer J 11:268-82. 2005
    ..This review provides an overview of these techniques in clinical practice and as research tools to develop new therapeutic approaches in pediatric leukemia...