M Flesch

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Na+ channel activators as positive inotropic agents for the treatment of chronic heart failure
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Cardiovasc Drugs Ther 15:379-86. 2001
  2. ncbi request reprint Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Cologne, Germany
    Hypertension 30:383-91. 1997
  3. ncbi request reprint Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite
    M Flesch
    Klinik III fur Innere Medizin, der Universität zu Köln, Germany
    J Am Coll Cardiol 33:1062-70. 1999
  4. ncbi request reprint Alcohol and the risk of myocardial infarction
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Basic Res Cardiol 96:128-35. 2001
  5. ncbi request reprint Differential effects of carvedilol and metoprolol on isoprenaline-induced changes in beta-adrenoceptor density and systolic function in rat cardiac myocytes
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Cardiovasc Res 49:371-80. 2001
  6. ncbi request reprint Beta-adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy
    M Bohm
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Cardiovasc Res 40:146-55. 1998
  7. ncbi request reprint Effects of angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition on cardiac beta-adrenergic signal transduction
    M Bohm
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Hypertension 31:747-54. 1998
  8. pmc Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium
    C Maack
    Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Br J Pharmacol 130:1131-9. 2000
  9. ncbi request reprint Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
    M Flesch
    Klinik III fur Innere Medizin, Universitat Koln, Germany
    J Mol Med (Berl) 74:321-32. 1996
  10. ncbi request reprint Cardiac myocytes of hearts from patients with end-stage dilated cardiomyopathy do not contain Borrelia burgdorferi DNA
    M Suedkamp
    Clinic for Cardiac Surgery, University of Goettinger, Cologne, Germany
    Am Heart J 138:269-72. 1999

Detail Information

Publications15

  1. ncbi request reprint Na+ channel activators as positive inotropic agents for the treatment of chronic heart failure
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Cardiovasc Drugs Ther 15:379-86. 2001
    ..These side effects might limit the clinical use of Na+ channel agonists and demand future development of Na+ channel modulators without significant arrhythmogenic effects...
  2. ncbi request reprint Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Cologne, Germany
    Hypertension 30:383-91. 1997
    ....
  3. ncbi request reprint Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite
    M Flesch
    Klinik III fur Innere Medizin, der Universität zu Köln, Germany
    J Am Coll Cardiol 33:1062-70. 1999
    ..This study examined the effects of endotoxin on cardiac contractility in human myocardium...
  4. ncbi request reprint Alcohol and the risk of myocardial infarction
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Basic Res Cardiol 96:128-35. 2001
    ..Identification and characterization of the pharmacologically active substances might provide the stage for the development of new substances to be used in the prevention of coronary artery disease and myocardial infarction...
  5. ncbi request reprint Differential effects of carvedilol and metoprolol on isoprenaline-induced changes in beta-adrenoceptor density and systolic function in rat cardiac myocytes
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Cardiovasc Res 49:371-80. 2001
    ..Differences between agents might be important for the development of more specific therapeutical approaches. This study investigated whether metoprolol or carvedilol alter beta-adrenergic signaling differently...
  6. ncbi request reprint Beta-adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy
    M Bohm
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Cardiovasc Res 40:146-55. 1998
    ....
  7. ncbi request reprint Effects of angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition on cardiac beta-adrenergic signal transduction
    M Bohm
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Hypertension 31:747-54. 1998
    ..The data support the concept that pharmacological interventions in the myocardial renin-angiotensin system significantly reverse local sympathetic neuroeffector defects. This could be important for the beneficial effects of these agents...
  8. pmc Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium
    C Maack
    Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Br J Pharmacol 130:1131-9. 2000
    ..8. Differences in intrinsic activity may contribute to differences in beta-adrenoceptor regulation and possibly to differences in tolerability and outcomes of patients with heart failure...
  9. ncbi request reprint Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
    M Flesch
    Klinik III fur Innere Medizin, Universitat Koln, Germany
    J Mol Med (Berl) 74:321-32. 1996
    ..The observed alterations are not dependent on the underlying cause of end-stage heart failure...
  10. ncbi request reprint Cardiac myocytes of hearts from patients with end-stage dilated cardiomyopathy do not contain Borrelia burgdorferi DNA
    M Suedkamp
    Clinic for Cardiac Surgery, University of Goettinger, Cologne, Germany
    Am Heart J 138:269-72. 1999
    ..Patients originated from endemic areas for Lyme disease (Bavaria, Lower Saxony, Germany)...
  11. ncbi request reprint Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy
    A T Bäumer
    Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Strasse 9, Koln, D 50924, Germany
    J Mol Cell Cardiol 32:121-30. 2000
    ..Direct reactive oxygen species mediated damage was not detected by the methods applied...
  12. ncbi request reprint [Which cardiac patients may be allowed to travel by air?]
    M Flesch
    Klinik III für Innere Medizin der Universität zu Köln
    MMW Fortschr Med 147:38-40. 2005
    ....
  13. ncbi request reprint Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts
    R H Schwinger
    Universitat zu Koln, Medizinische Klinik III, Germany
    Circulation 92:3220-8. 1995
    ..The aim of the present study was to investigate whether Ca2+ uptake into the sarcoplasmic reticulum (SR) is altered in failing human myocardium resulting from dilated cardiomyopathy...
  14. ncbi request reprint Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading
    M Flesch
    Winters Center for Heart Failure Research, Baylor College of Medicine, VA Medical Center, Houston, Texas, USA
    Circulation 104:2273-6. 2001
    ..These changes in MAPK activity are associated with changes in myocyte hypertrophy and viability, suggesting a potential mechanistic basis for some of the observed salutary changes after LVAD support...
  15. doi request reprint [Severe myocardial infarction due to late and very late stent thrombosis after coronary artery stenting with drug-eluting stents]
    B Krausgrill
    Klinik III fur Innere Medizin, Herzzentrum, Klinikum der Universität zu Köln
    Dtsch Med Wochenschr 133:2014-7. 2008
    ..Clopidogrel had been stopped 10 weeks ago in patient 1 and 18 months ago in patient 2...