- Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel lociAntonia Flaquer
Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig Maximilians Universitat, Munich, Germany
BMC Genet 14:44. 2013..The occurrence of these apparently discordant clinical phenotypes within one family might hint at a genetic framework common to most types of CHD...
- A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseasesAntonia Flaquer
Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig Maximilians Universität LMU Munich, Germany
BMC Res Notes 5:411. 2012..Using simulations we have investigated the power of parametric and nonparametric linkage statistics (KC-LOD, NPL, LOD and MOD scores), to detect the effect of genes responsible for complex diseases using different pedigree structures...
- Linkage analysis of alcohol dependence using MOD scoresKonstantin Strauch
Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
BMC Genet 6:S162. 2005..A tendency to maternal imprinting was observed at two loci on chromosome 7. Our findings underscore the fact that an adequate modeling of the genotype-phenotype relation is crucial for the genetic mapping of a complex trait...