Research Topics
| S FinottoSummaryAffiliation: University of Mainz Country: Germany Publications
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Detail Information
Publications
Development of spontaneous airway changes consistent with human asthma in mice lacking T-betSusetta Finotto
Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 295:336-8. 2002..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...- [Immunopathogenesis of bronchial asthma]S Finotto
Labor Immunologie I, I Medizinische Klinik der Johannes Gutenberg Universität Mainz
Pneumologie 54:412-8. 2000..However, the clinical value of these novel therapeutic approaches remains to be determined. In particular, long term efficacy and safety of immunomodulatory therapy has to be studied more in detail... 
T-cell regulation in asthmatic diseasesSusetta Finotto
Laboratory of Cellular and Molecular Lung Immunology, First Medical Clinic, Mainz, Germany
Chem Immunol Allergy 94:83-92. 2008..A better understanding of effector and Treg activation will most likely lead to novel treatment strategies in the near future...- Asthmatic changes in mice lacking T-bet are mediated by IL-13Susetta Finotto
Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Mainz, Germany
Int Immunol 17:993-1007. 2005..These data highlight a T-bet-directed function for IL-13 in controlling lung remodeling that is both dependent on and independent of its interaction with TGF-beta in the asthmatic airway... - T cell directives for transcriptional regulation in asthmaSusetta Finotto
I Medical Clinic, Laboratory of Immunology, Verfügungsgebäude für Forschung und Entwicklung, University of Mainz, Germany
Springer Semin Immunopathol 25:281-94. 2004..Although recent reports suggest that the induction of T-reg cells is under the control of the transcription factor Foxp3, the specific signals that preferentially induce development of T-reg cells instead of Th2 cells are still unclear... - Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cellsSusetta Finotto
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
Int Immunol 19:685-93. 2007..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells... 
Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivoS Finotto
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Gut 53:392-400. 2004..Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells...- Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expressionS Finotto
Laboratory of Immunology, University of Mainz, 55099 Mainz, Germany
J Exp Med 193:1247-60. 2001..This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine... - The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's diseaseM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
J Exp Med 195:1129-43. 2002..Specific targeting of this pathway may be a promising novel approach for the treatment of patients with Crohn's disease and other autoimmune diseases mediated by Th1 T lymphocytes... - The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 115:313-25. 2005..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma... - Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthmaMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Eur J Immunol 37:1663-77. 2007..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma... - Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivoR Atreya
Lab of Immunology and Section Pathophysiology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
Nat Med 6:583-8. 2000..These data indicate that a pathway of T-cell activation driven by IL-6-sIL-6R contributes to the perpetuation of chronic intestinal inflammation. Specific targeting of this pathway may be a promising new approach for the treatment of CD... - Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsivenessPeri Caucig
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Int Arch Allergy Immunol 152:303-12. 2010..In the present study, we determined the role of IL-1alpha in other Th2-mediated diseases... - Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy modelRoman Karwot
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
J Allergy Clin Immunol 121:992-9.e6. 2008..The transcriptional regulation of cytokines released and controlled by memory T cells is not well understood. Defective IFN-gamma production in allergic asthma correlates in human beings with the risk of wheezing in childhood... - Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal questionM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131, Mainz, Germany
Trends Immunol 22:21-6. 2001..Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD... - A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiationMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
Eur J Immunol 34:3401-12. 2004.... - IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 181:1917-26. 2008..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans... - Transgenic models in allergic responsesMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
Curr Drug Targets 9:503-10. 2008..Moreover, the transgenic model provide reliable models for the pre-clinical approval of therapy for allergic asthma to develop more efficient compounds and functional antibodies... - Pathological role of IL-6 in the experimental allergic bronchial asthma in miceAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Germany
Clin Rev Allergy Immunol 28:257-70. 2005.... - TGF-beta regulates airway responses via T cellsChristoph Schramm
I Medizinische Klinik, Johannes Gutenberg University, Mainz, Germany
J Immunol 170:1313-9. 2003.... - The role of Th1/Th2 polarization in mucosal immunityMarkus F Neurath
Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
Nat Med 8:567-73. 2002..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium... - A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytesJoachim H Maxeiner
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
Cancer Res 69:3069-76. 2009.... - Mucosal immunoregulation: transcription factors as possible therapeutic targetsAysefa Doganci
Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Curr Drug Targets Inflamm Allergy 4:565-75. 2005..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses... - Regulation of T cells in asthma: implications for genetic manipulationCornelia Luft
I Medical Clinic, University of Mainz, Mainz, Germany
Curr Opin Allergy Clin Immunol 4:69-74. 2004..The latter are known to play an important role in downregulating allergic immune responses... - A method to enable the investigation of murine bronchial immune cells, their cytokines and mediatorsJoachim H Maxeiner
Laboratory of Cellular and Molecular Immunology of the Lung University of Mainz, Mainz, Germany
Nat Protoc 2:105-12. 2007..This protocol can be completed within 35 min... - Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cellsKerstin A Sauer
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Germany
J Immunol 181:6148-57. 2008..Taken together, these data demonstrate that targeting EBI-3 leads to a T-bet-mediated antitumor CD8(+) T cell responses in the lung... - The many roads to inflammatory bowel diseasesM F Neurath
Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131 Mainz, Germany
Immunity 25:189-91. 2006 - Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lungKerstin A Sauer
Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Germany
Nat Protoc 1:2870-5. 2006..This protocol can be completed in approximately 4 h 20 min... - Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammationEva Zindler
Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, D 55131 Mainz, Germany
Am J Respir Cell Mol Biol 38:38-46. 2008....