S Finotto

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
  2. ncbi [Immunopathogenesis of bronchial asthma]
    S Finotto
    Labor Immunologie I, I Medizinische Klinik der Johannes Gutenberg Universität Mainz
    Pneumologie 54:412-8. 2000
  3. doi T-cell regulation in asthmatic diseases
    Susetta Finotto
    Laboratory of Cellular and Molecular Lung Immunology, First Medical Clinic, Mainz, Germany
    Chem Immunol Allergy 94:83-92. 2008
  4. ncbi Asthmatic changes in mice lacking T-bet are mediated by IL-13
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Mainz, Germany
    Int Immunol 17:993-1007. 2005
  5. ncbi T cell directives for transcriptional regulation in asthma
    Susetta Finotto
    I Medical Clinic, Laboratory of Immunology, Verfügungsgebäude für Forschung und Entwicklung, University of Mainz, Germany
    Springer Semin Immunopathol 25:281-94. 2004
  6. ncbi Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
    Int Immunol 19:685-93. 2007
  7. pmc Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo
    S Finotto
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gut 53:392-400. 2004
  8. pmc Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
    S Finotto
    Laboratory of Immunology, University of Mainz, 55099 Mainz, Germany
    J Exp Med 193:1247-60. 2001
  9. pmc The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 195:1129-43. 2002
  10. pmc The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 115:313-25. 2005

Collaborators

Detail Information

Publications29

  1. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  2. ncbi [Immunopathogenesis of bronchial asthma]
    S Finotto
    Labor Immunologie I, I Medizinische Klinik der Johannes Gutenberg Universität Mainz
    Pneumologie 54:412-8. 2000
    ..However, the clinical value of these novel therapeutic approaches remains to be determined. In particular, long term efficacy and safety of immunomodulatory therapy has to be studied more in detail...
  3. doi T-cell regulation in asthmatic diseases
    Susetta Finotto
    Laboratory of Cellular and Molecular Lung Immunology, First Medical Clinic, Mainz, Germany
    Chem Immunol Allergy 94:83-92. 2008
    ..A better understanding of effector and Treg activation will most likely lead to novel treatment strategies in the near future...
  4. ncbi Asthmatic changes in mice lacking T-bet are mediated by IL-13
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Mainz, Germany
    Int Immunol 17:993-1007. 2005
    ..These data highlight a T-bet-directed function for IL-13 in controlling lung remodeling that is both dependent on and independent of its interaction with TGF-beta in the asthmatic airway...
  5. ncbi T cell directives for transcriptional regulation in asthma
    Susetta Finotto
    I Medical Clinic, Laboratory of Immunology, Verfügungsgebäude für Forschung und Entwicklung, University of Mainz, Germany
    Springer Semin Immunopathol 25:281-94. 2004
    ..Although recent reports suggest that the induction of T-reg cells is under the control of the transcription factor Foxp3, the specific signals that preferentially induce development of T-reg cells instead of Th2 cells are still unclear...
  6. ncbi Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
    Int Immunol 19:685-93. 2007
    ..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells...
  7. pmc Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo
    S Finotto
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gut 53:392-400. 2004
    ..Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells...
  8. pmc Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
    S Finotto
    Laboratory of Immunology, University of Mainz, 55099 Mainz, Germany
    J Exp Med 193:1247-60. 2001
    ..This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine...
  9. pmc The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 195:1129-43. 2002
    ..Specific targeting of this pathway may be a promising novel approach for the treatment of patients with Crohn's disease and other autoimmune diseases mediated by Th1 T lymphocytes...
  10. pmc The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 115:313-25. 2005
    ..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma...
  11. ncbi Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
    ..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma...
  12. ncbi Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
    R Atreya
    Lab of Immunology and Section Pathophysiology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Med 6:583-8. 2000
    ..These data indicate that a pathway of T-cell activation driven by IL-6-sIL-6R contributes to the perpetuation of chronic intestinal inflammation. Specific targeting of this pathway may be a promising new approach for the treatment of CD...
  13. doi Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsiveness
    Peri Caucig
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Int Arch Allergy Immunol 152:303-12. 2010
    ..In the present study, we determined the role of IL-1alpha in other Th2-mediated diseases...
  14. doi Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model
    Roman Karwot
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    J Allergy Clin Immunol 121:992-9.e6. 2008
    ..The transcriptional regulation of cytokines released and controlled by memory T cells is not well understood. Defective IFN-gamma production in allergic asthma correlates in human beings with the risk of wheezing in childhood...
  15. ncbi Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131, Mainz, Germany
    Trends Immunol 22:21-6. 2001
    ..Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD...
  16. ncbi A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
    Eur J Immunol 34:3401-12. 2004
    ....
  17. ncbi IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 181:1917-26. 2008
    ..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans...
  18. ncbi Transgenic models in allergic responses
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
    Curr Drug Targets 9:503-10. 2008
    ..Moreover, the transgenic model provide reliable models for the pre-clinical approval of therapy for allergic asthma to develop more efficient compounds and functional antibodies...
  19. ncbi Pathological role of IL-6 in the experimental allergic bronchial asthma in mice
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Germany
    Clin Rev Allergy Immunol 28:257-70. 2005
    ....
  20. ncbi TGF-beta regulates airway responses via T cells
    Christoph Schramm
    I Medizinische Klinik, Johannes Gutenberg University, Mainz, Germany
    J Immunol 170:1313-9. 2003
    ....
  21. ncbi The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
    ..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium...
  22. doi A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes
    Joachim H Maxeiner
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    Cancer Res 69:3069-76. 2009
    ....
  23. ncbi Mucosal immunoregulation: transcription factors as possible therapeutic targets
    Aysefa Doganci
    Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Curr Drug Targets Inflamm Allergy 4:565-75. 2005
    ..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses...
  24. ncbi Regulation of T cells in asthma: implications for genetic manipulation
    Cornelia Luft
    I Medical Clinic, University of Mainz, Mainz, Germany
    Curr Opin Allergy Clin Immunol 4:69-74. 2004
    ..In this review, we discuss the possibility that the kind and the quantity of infectious agent determines the type of immune response...
  25. ncbi A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators
    Joachim H Maxeiner
    Laboratory of Cellular and Molecular Immunology of the Lung University of Mainz, Mainz, Germany
    Nat Protoc 2:105-12. 2007
    ..This protocol can be completed within 35 min...
  26. ncbi Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells
    Kerstin A Sauer
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Germany
    J Immunol 181:6148-57. 2008
    ..Taken together, these data demonstrate that targeting EBI-3 leads to a T-bet-mediated antitumor CD8(+) T cell responses in the lung...
  27. ncbi The many roads to inflammatory bowel diseases
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Immunity 25:189-91. 2006
  28. ncbi Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lung
    Kerstin A Sauer
    Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Germany
    Nat Protoc 1:2870-5. 2006
    ..This protocol can be completed in approximately 4 h 20 min...
  29. ncbi Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation
    Eva Zindler
    Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, D 55131 Mainz, Germany
    Am J Respir Cell Mol Biol 38:38-46. 2008
    ....