Research Topics
| Jens FiehlerSummaryAffiliation: University of Hamburg Country: Germany Publications
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Detail Information
Publications
Combination of T2*W and FLAIR abnormalities for the prediction of parenchymal hematoma following thrombolytic therapy in 100 stroke patientsJens Fiehler
Department of Neuroradiology, University Medical Care Hamburg Eppendorf, Hamburg, Germany
J Neuroimaging 19:311-6. 2009..The objective of our study was to determine whether the combination of hypointense spots ("cerebral microbleeds," CMBs) with a leukoaraiosis is associated with the risk of parenchymal hematoma (PH) after thrombolytic therapy...- Predictors of periprocedural brain lesions associated with carotid stentingArkadiusz Russjan
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Cerebrovasc Dis 33:30-6. 2012..Carotid stenting carries a risk of periprocedural stroke. We aimed at determining predictors of cerebral ischemic events associated with stenting for symptomatic carotid stenosis... - Older age and greater carotid intima-media thickness predict ischemic events associated with carotid-artery stentingMichael Rosenkranz
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Cerebrovasc Dis 30:567-72. 2010..Carotid-artery stenting (CAS) may be complicated by stroke. We aimed to determine predictors of procedure-related ischemic events... 
Two tales: hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia: MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hoursGotz Thomalla
Neuro Zentrum, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Stroke 38:313-8. 2007..We studied whether perfusion-weighted imaging and diffusion-weighted imaging has the potential to identify patients at risk of severe intracerebral hemorrhage after treatment with intravenous tissue plasminogen activator...- Carotid plaque surface irregularity predicts cerebral embolism during carotid artery stentingMichael Rosenkranz
Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Cerebrovasc Dis 32:163-9. 2011..The procedural risk may vary with plaque characteristics. We aimed at determining the impact of carotid plaque surface irregularity on the risk of cerebral embolism during CAS... - Predictors of apparent diffusion coefficient normalization in stroke patientsJens Fiehler
Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
Stroke 35:514-9. 2004..We sought to describe the frequency of normalization of apparent diffusion coefficient (ADC) values that are decreased in hyperacute stroke and to identify characteristics of tissue demonstrating normalization... - Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic strokeThomas Kucinski
Department of Neuroradiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
Neuroradiology 46:716-22. 2004..78) or rTTP (1.34, p = 0.26). Therefore, the reduction of rCBF determines the severity of the early ischaemic oedema (EIOE) on CT, as well as reduction of the ADC. These findings provide a coherent view on the pathophysiology of the EIOE... - Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational studyGotz Thomalla
Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Ann Neurol 68:435-45. 2010..We tested the hypothesis that acute stroke magnetic resonance imaging (MRI) predicts MMI within 6 hours of stroke onset... - Quantitative t2 values predict time from symptom onset in acute stroke patientsSusanne Siemonsen
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Stroke 40:1612-6. 2009..We measured the increase of qT2 in the infarct core to quantify the correlation between time from symptom onset and change in qT2... - Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation: an MRI study in acute stroke patientsJens Fiehler
Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
Cerebrovasc Dis 19:117-24. 2005..We applied magnetic resonance imaging to analyze the degree of local diffusion and perfusion abnormalities and the status of reperfusion in regions with subsequent hemorrhagic transformation (HT)... - Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?Jens Fiehler
Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Germany
Stroke 35:2099-104. 2004..We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI)... - Macromolecule content influences proton diffusibility in gliomasEinar Goebell
Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg Eppendorf UKE, Martinistrase 52, 20246 Hamburg, Germany
Eur Radiol 21:2626-32. 2011..Different compositions of the extra cellular matrix with changing concentrations of more or less hydrophilic components like proteins may have a major influence on the diffusion phenomena found in gliomas... - Abciximab is a safe rescue therapy in thromboembolic events complicating cerebral aneurysm coil embolization: single center experience in 42 cases and review of the literatureThorsten Ries
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Stroke 40:1750-7. 2009.... 
Dynamics of regional distribution of ischemic lesions in middle cerebral artery trunk occlusion relates to collateral circulationBastian Cheng
Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
J Cereb Blood Flow Metab 31:36-40. 2011..The probability of brain regions being involved in acute diffusion lesions and evolving into or escaping from the final infarct relates to the anatomy of arterial blood supply...- Vascular occlusion sites determine differences in lesion growth from early apparent diffusion coefficient lesion to final infarctJens Fiehler
Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Germany
AJNR Am J Neuroradiol 26:1056-61. 2005..These patients develop considerably large infarctions, suggesting a high potential for infarct growth. This growth might be averted with improved early recanalization of proximal vascular occlusions... - Quantitative measurements of relative fluid-attenuated inversion recovery (FLAIR) signal intensities in acute stroke for the prediction of time from symptom onsetBastian Cheng
Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
J Cereb Blood Flow Metab 33:76-84. 2013..Our results raise doubts whether the prediction of stroke onset time by visual image judgment can be improved by quantitative rSI measurements... - Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - a position paper endorsed by ESMINT and ESNR : part II: methodology of future trialsJens Fiehler
Department of Neuroradiology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Neuroradiology 54:1303-12. 2012..We anticipate that this roadmap will facilitate the setting up and conduct of successful trials in close collaboration with our neighbouring disciplines... - Cerebral blood flow predicts lesion growth in acute stroke patientsJens Fiehler
Department of Neuroradiology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Stroke 33:2421-5. 2002..We sought to study the role of MRI-derived cerebral blood flow (CBF) measurements for the prediction of lesion development in acute stroke patients... - Cerebral embolism during carotid artery stenting: role of carotid plaque echolucencyMichael Rosenkranz
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Cerebrovasc Dis 27:443-9. 2009..A better understanding of specific risk factors could help to improve the procedure and to reduce the overall risk of CAS. We addressed the role of carotid plaque echolucency as potential risk factor for cerebral embolism during CAS... - Local intra-arterial fibrinolysis in acute hemispheric stroke: effect of occlusion type and fibrinolytic agent on recanalization success and neurological outcomeBernd Eckert
Department of Neuroradiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Cerebrovasc Dis 15:258-63. 2003..To evaluate the effect of occlusion type and fibrinolytic agent on recanalization success and clinical outcome in patients undergoing local intra-arterial fibrinolysis (LIF) in acute hemispheric stroke... - Tissue at risk is overestimated in perfusion-weighted imaging: MR imaging in acute stroke patients without vessel recanalizationThomas Kucinski
Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
AJNR Am J Neuroradiol 26:815-9. 2005..The most conclusive inferences can be drawn from CBV images. The site of arterial occlusion also determines progression to infarction... - Persistent hemodynamic changes in ruptured brain arteriovenous malformationsTill Illies
Department of Diagnostic and Interventional Neuroradiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Stroke 43:2910-5. 2012..We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those without these properties... - Clinical applications of quantitative T2 determination: a complementary MRI tool for routine diagnosis of suspected myelination disordersXiao Qi Ding
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Eur J Paediatr Neurol 12:298-308. 2008..We report on the first experiences with evaluation of routine T2 relaxation time measurement as a diagnostic tool in routine imaging of suspected myelination disorders... - Outcome and symptomatic bleeding complications of intravenous thrombolysis within 6 hours in MRI-selected stroke patients: comparison of a German multicenter study with the pooled data of ATLANTIS, ECASS, and NINDS tPA trialsGotz Thomalla
Klinik und Poliklinik fur Neurologie, Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Stroke 37:852-8. 2006.... - T2' imaging predicts infarct growth beyond the acute diffusion-weighted imaging lesion in acute strokeSusanne Siemonsen
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Radiology 248:979-86. 2008.... - MRI abnormalities in normal-appearing brain tissue of treated adult PKU patientsXiao Qi Ding
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Magn Reson Imaging 27:998-1004. 2008.... - Blister-like aneurysms--a diagnostic and therapeutic challengeJan Regelsberger
Universitatsklinikum Hamburg Eppendorf, Neurochirurgische Klinik, Hamburg, Germany
Neurosurg Rev 34:409-16. 2011..If endovascular treatment is not promising, wrapping and revascularization techniques come true to still be an important part of the neurosurgeons toolbox for reconstructing a vessel lumen and preserving a sufficient cerebral blood flow... - Blood-oxygen-level-dependent MRI allows metabolic description of tissue at risk in acute stroke patientsBenjamin S Geisler
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Stroke 37:1778-84. 2006..One candidate is deoxyhemoglobin (deoxy-Hb) as an indicator of the oxygen extraction fraction that can be visualized by T2*-based blood oxygen level-dependent (BOLD) imaging... - Outcome of MRI-based intravenous thrombolysis in carotid-T occlusionChristoph Beck
Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
J Neurol 259:2141-6. 2012..43 %). The proportion of patients with good clinical outcome after intravenous thrombolysis in CTO is small. Moreover, final infarct volume is larger and clinical outcome appears to be worse compared to MCAO... - DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational studyGotz Thomalla
Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Lancet Neurol 10:978-86. 2011.... - Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patientsJens Fiehler
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Stroke 38:2738-44. 2007..Because of this concern, some centers withhold potentially beneficial thrombolytic therapy from these patients... - Reference-based linear curve fitting for bolus arrival time estimation in 4D MRA and MR perfusion-weighted image sequencesNils Daniel Forkert
Department of Medical Informatics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Magn Reson Med 65:289-94. 2011..A major benefit of the method proposed is that no assumption about the underlying distribution of indicator dilution has to be made, as it is implicitly modeled in the reference curve... - Case report: surviving a tiger attackPedram Emami
Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Neurosurg Rev 35:621-4; discussion 624. 2012..This seems to be related to the specific dynamics of the cranial assault and the reduced forces applied to the patient's head demonstrated in a 3D bite simulation... - Rigid 3D-3D registration of TOF MRA integrating vessel segmentation for quantification of recurrence volumes after coiling cerebral aneurysmDennis Säring
Department of Medical Informatics, University Medical Center Hamburg Eppendorf, Bldg W36, Martinistrase 52, 20246, Hamburg, Germany
Neuroradiology 54:171-6. 2012..This paper presents two registration schemes for the semi-automatic quantification of aneurysm recurrence volumes based on baseline and follow-up 3D MRA TOF datasets... - Brain iron deposition fingerprints in Parkinson's disease and progressive supranuclear palsyKai Boelmans
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 27:421-7. 2012..Regional decreases of T2' relaxation times in parts of the basal ganglia reflecting increased brain iron load in these areas are characteristic for progressive supranuclear palsy but not PD patients... - Quantification of recurrence volumes after endovascular treatment of cerebral aneurysm as surrogate endpoint for treatment stabilityThorsten Ries
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Neuroradiology 53:593-8. 2011..We hypothesize that this method allows detecting effects of new materials with reduced sample sizes in comparison to conventional studies with dichotomous endpoints... - Intravenous administration of acetylsalicylic acid during endovascular treatment of cerebral aneurysms reduces the rate of thromboembolic eventsThorsten Ries
Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Stroke 37:1816-21. 2006..ASA seems to be associated with a significant reduction in the rate of thromboembolic events without increase in the rate or severity of intraoperative bleedings... - Diffusion-weighted imaging in acute stroke--a tool of uncertain value?Jens Fiehler
Department of Neuroradiology, University Hospitals of Hamburg Eppendorf, Hamburg, Germany
Cerebrovasc Dis 14:187-96. 2002..MR stroke imaging delivers important information in acute stroke, particularly in defining the 'tissue at risk of infarction'... - Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or lessGotz Thomalla
Department of Neurology, Center for Clinical Neurosciences, University Medical Center Hamburg, Eppendorf, Hamburg, Germany
Ann Neurol 65:724-32. 2009..To evaluate the use of fluid-attenuated inversion recovery (FLAIR) imaging as surrogate marker of lesion age within the first 6 hours of ischemic stroke... - Clinical outcome and imaging follow-up in acute stroke patients with normal perfusion CT and normal CT angiographyBernd Eckert
Department of Neuroradiology, Asklepios Klinik Altona, Abt für Neuroradiologie, Paul Ehrlich Str 1, 22763 Hamburg, Germany
Neuroradiology 53:79-88. 2011..We prospectively evaluated the sensitivity/specificity of MMCT infarct detection and the clinical outcome in patients with normal MMCT findings... - Screening for cerebellopontine angle tumors: is a CISS sufficient?Einar Goebell
Department of Neuroradiology, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
Eur Radiol 15:286-91. 2005.... - Prevention and treatment of thromboembolism during endovascular aneurysm therapyJens Fiehler
Department of Neuroradiology, University Hospital Eppendorf, Hamburg, Germany
Klin Neuroradiol 19:73-81. 2009..Moreover, treatment of thrombotic complications of endovascular therapy of cerebral aneurysms is discussed... - Plea of the defence-critical comments on the interpretation of EVA3S, SPACE and ICSSJens Fiehler
Department of Neuroradiology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Neuroradiology 52:601-10. 2010..Designing a single cooperative European trial that incorporates the lessons learned would be major step forward... - Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic strokeThomas Kucinski
Department of Neuroradiology, University-Hospital Hamburg Eppendorf, Hamburg, Germany. kucinski@ uke.uni-hanburg.de
Stroke 33:1786-91. 2002..The time delay and low value of CT density changes provide a reasonable explanation for the higher sensitivity of MR imaging in ischemic stroke... - Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients: a position paper endorsed by ESMINT and ESNR : part I: Current situation and major research questionsJens Fiehler
Department of Neuroradiology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Neuroradiology 54:1293-301. 2012..In Part 1 of this two part series, we outline the current situation and the major research questions... - Differences in complication rates among the centres in the SPACE studyJens Fiehler
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Neuroradiology 50:1049-53. 2008..We evaluated the treatment risk in stent-protected angioplasty of the carotid versus endarterectomy (SPACE) associated with the specific patient enrollment rates of the centres... - MRI features of pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL)Xiao Qi Ding
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, University of Hamburg, Germany
J Neuroimaging 20:134-40. 2010..We report the magnetic resonance imaging (MRI) characteristics of a recently found autosomal dominantly inherited microangiopathy... - Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imagingEinar Goebell
Department of Neuroradiology, University of Hamburg, Martinistrasse 52, 20251 Hamburg, Germany
Radiology 239:217-22. 2006..To prospectively evaluate whether diffusion-tensor magnetic resonance (MR) imaging depicts differences in World Health Organization (WHO) grade II and III glial brain tumors on the basis of tumor architecture and peritumoral tract invasion... - Intranasal delivery of neural stem/progenitor cells: a noninvasive passage to target intracerebral gliomaMatthias Reitz
Department of Neurosurgery, Medical Center, Eppendorf, Hamburg, Germany
Stem Cells Transl Med 1:866-73. 2012.... - T2 relaxation time correlates of face recognition deficits in temporal lobe epilepsyThomas Bengner
Evangelisches Krankenhaus Alsterdorf gGmbH, Abteilung für Neurologie und Epileptologie, Hamburg, Germany
Epilepsy Behav 13:670-7. 2008..We suggest that long-term face recognition depends on a right hemispheric network encompassing structures outside the temporal lobe... - Factors affecting outcome after endovascular treatment of intracranial aneurysmsJens Fiehler
Department of Neuroradiology, University Medical Center Hamburg, Hamburg, Germany
Curr Opin Neurol 22:103-8. 2009..This brief review highlights some factors affecting the short-term and long-term outcomes after endovascular treatment (EVT) of patients with intracranial aneurysms... - Cerebral microbleeds: old leaks and new haemorrhagesJens Fiehler
Department of Neuroradiology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Int J Stroke 1:122-30. 2006.... - Pathophysiology and treatment of brain AVMsUlrich Grzyska
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Klin Neuroradiol 19:82-90. 2009..Finally, some problems of the current treatment options are mentioned, and future directions in diagnostics and therapy considered... - Severe ADC decreases do not predict irreversible tissue damage in humansJens Fiehler
Department of Neurology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Stroke 33:79-86. 2002..This concept is based on the assumption that diffusion slowing of and decreases in the apparent diffusion coefficient (ADC) serve as indicator of tissue proceeding to infarction. We tested this hypothesis...