M Fiege

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint [Malignant hyperthermia--update 2002]
    M Fiege
    klinik und Poliklinik für Anesthesiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:478-82. 2003
  2. ncbi request reprint Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
    M Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    J Clin Anesth 12:123-8. 2000
  3. ncbi request reprint In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine
    Marko Fiege
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 98:944-9. 2003
  4. ncbi request reprint Induction of malignant hyperthermia in susceptible swine by 3,4-methylenedioxymethamphetamine ("ecstasy")
    Marko Fiege
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Anesthesiology 99:1132-6. 2003
  5. ncbi request reprint Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
    M Fiege
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 22:283-8. 2005
  6. ncbi request reprint 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
  7. ncbi request reprint 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
  8. ncbi request reprint Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 94:95-100. 2001
  9. ncbi request reprint Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
  10. ncbi request reprint Dantrolene--a review of its pharmacology, therapeutic use and new developments
    T Krause
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anaesthesia 59:364-73. 2004

Detail Information

Publications28

  1. ncbi request reprint [Malignant hyperthermia--update 2002]
    M Fiege
    klinik und Poliklinik für Anesthesiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:478-82. 2003
  2. ncbi request reprint Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
    M Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    J Clin Anesth 12:123-8. 2000
    ..To study the in vitro effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible (MHS) and normal (MHN) patients...
  3. ncbi request reprint In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine
    Marko Fiege
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 98:944-9. 2003
    ..In this study, the in vitro and in vivo effects of enoximone in MH-normal (MHN) and MH-susceptible (MHS) swine were investigated...
  4. ncbi request reprint Induction of malignant hyperthermia in susceptible swine by 3,4-methylenedioxymethamphetamine ("ecstasy")
    Marko Fiege
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Anesthesiology 99:1132-6. 2003
    ..Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to investigate whether MDMA is a trigger of MH in susceptible swine...
  5. ncbi request reprint Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
    M Fiege
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 22:283-8. 2005
    ..Whether this is a substance specific effect of enoximone or caused by inhibition of PDE-III remained unclear. Therefore, the effects of the PDE-III inhibitor amrinone in porcine MH normal (MHN) and MHS skeletal muscles were investigated...
  6. ncbi request reprint 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
    ..Further studies have to determine the pathophysiological role of the 5-HT system in MH, and whether ritanserin could be an alternative for treatment or prevention of halothane-induced MH...
  7. ncbi request reprint 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
    ..g., insulin, heparin, succinylcholine), and it has been suggested that 4-CmC might trigger malignant hyperthermia. This study was designed to investigate the effects of 4-CmC in vivo and in vitro in the same animals...
  8. ncbi request reprint Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 94:95-100. 2001
    ..To establish an association between ER and susceptibility to MH, the authors determined the MH status in patients with a history of MH-like episodes induced by physical stress...
  9. ncbi request reprint Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
    ..In this study the in vivo effects of DOI on anaesthetized (and thus stress-protected) MHS and MH-normal (MHN) pigs were investigated...
  10. ncbi request reprint Dantrolene--a review of its pharmacology, therapeutic use and new developments
    T Krause
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anaesthesia 59:364-73. 2004
    ..Due to economic considerations, no other similar drugs have been introduced into routine clinical practice...
  11. ncbi request reprint [Malignant neuroleptic syndrome after haloperidol administration]
    M U Gerbershagen
    Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Anaesthesist 50:329-32. 2001
    ..blockade of central receptors, 2. a skeletal muscle target model and 3. sympathoadrenal hyperactivity. The differential diagnosis includes among others malignant hyperthermia and serotonin syndrome...
  12. ncbi request reprint [Dantrolene. Pharmacological and therapeutic aspects]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Anaesthesist 52:238-45. 2003
    ..Since dantrolene is weakly water soluble, the clinical preparation is time and manpower consuming. New agents have been synthesized, but because of economic considerations no registration for clinical usage has been realised...
  13. ncbi request reprint Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:528-36. 2003
    ..This multicentre study was designed to investigate whether an in vitro contracture test with bolus administration of 4-chloro-m-cresol can improve the accuracy of the diagnosis of susceptibility to MH...
  14. ncbi request reprint In vitro effects of 4-chloro-3-ethylphenol in skeletal muscle preparations from malignant hyperthermia susceptible and normal swine
    M U Gerbershagen
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 19:135-40. 2002
    ..0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguishes between malignant hyperthermia-susceptible and malignant hyperthermia-normal subjects with a higher specificity and sensitivity...
  15. ncbi request reprint [The new regulations for the licence to practice medicine. Implementation for the faculty of anesthesiology at the University Clinic Hamburg-Eppendorf]
    G N Schmidt
    Zentrum für Anästhesiologie und Intensivmedizin, Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Anaesthesist 56:691-701. 2007
    ..The basic principle, especially the training in the practical proficiencies, is to achieve a continuous learning process from students through to specialists for anesthesiology...
  16. ncbi request reprint [Is a presymptomatic malignant hyperthermia in-vitro diagnosis with 4-chloro-3-ethyl phenol possible? A study using porcine skeletal preparations]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:81-6. 2004
    ..The pur-pose of this study was to investigate the ability of bolus CEP-applications to distinguish between porcine MHS- and MHN-muscle specimens using the IVCT...
  17. ncbi request reprint [Theophylline induces contractures in porcine skeletal muscle preparations with the disposition to malignant hyperthermia]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:147-52. 2004
    ....
  18. ncbi request reprint [Key performance indicators of OR efficiency. Myths and evidence of key performance indicators in OR management]
    M Schuster
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Deutschland
    Anaesthesist 56:259-71. 2007
    ..The increased transparency due to the free accessibility of diagnosis-related-groups (DRG) cost breakdown data can help to develop tools for economic analysis of OR efficiency...
  19. ncbi request reprint [In-vitro-effects of cocaine in skeletal muscle specimens of patients susceptible to malignant hyperthermia]
    R Weisshorn
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:138-43. 2002
    ..Therefore, aim of this study was to investigate the in-vitro effects of cocaine in skeletal muscle specimens of MH susceptible (MHS) and normal (MHN) patients...
  20. doi request reprint [Further education in anesthesiology. Implementation at the University Hospital Hamburg-Eppendorf]
    G N Schmidt
    Klinik und Poliklinik für Anästhesiologie, Zentrum für Anästhesie und Intensivmedizin, Martinistrasse 52, Hamburg, Germany
    Anaesthesist 60:366-74. 2011
    ....
  21. doi request reprint Influence of resident training on anaesthesia induction times
    M Schuster
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Br J Anaesth 101:640-7. 2008
    ..Comparisons of anaesthesia process times between residents and consultants might be systematically skewed by interactions of anaesthesia technique and patient factors...
  22. ncbi request reprint Cumulative and bolus in vitro contracture testing with 4-chloro-3-ethylphenol in malignant hyperthermia positive and negative human skeletal muscles
    Mark Ulrich Gerbershagen
    Department of Anesthesiology, Hospital Köln Merheim, University Witten Herdecke, Cologne, Germany
    Anesth Analg 101:710-4, table of contents. 2005
    ..The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed...
  23. ncbi request reprint Inhibition of sarcoplasmic Ca2+ adenosine triphosphatase in porcine skeletal muscle samples with cyclopiazonic acid enables in vitro malignant hyperthermia discrimination
    Mark Ulrich Gerbershagen
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 101:1475-7. 2004
  24. ncbi request reprint Ryanodine contracture threshold times for diagnosis of malignant hyperthermia susceptibility: an experimental approach from a single laboratory
    Ralf Weisshorn
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Anesth 16:353-7. 2004
    ..To define threshold times for ryanodine contracture testing (RCT) using skeletal muscle specimens from malignant hyperthermia-susceptible (MHS) and control individuals...
  25. ncbi request reprint Histomorphologic examination of skeletal muscle preparations does not differentiate between malignant hyperthermia-susceptible and -normal patients
    Franziska von Breunig
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 100:789-94. 2004
    ..The purpose of this study was to investigate whether there are characteristic myopathologic changes in skeletal muscles of MH-susceptible (MHS) compared with MH-normal (MHN) patients...
  26. ncbi request reprint Results of contracture tests with halothane, caffeine, and ryanodine depend on different malignant hyperthermia-associated ryanodine receptor gene mutations
    Marko Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 97:345-50. 2002
    ..This study was designed to investigate the effects of different mutations in the RYR1 gene on contracture development in in vitro contracture tests (IVCT) with halothane, caffeine, and ryanodine...
  27. ncbi request reprint Evidence for a spontaneous C1840-T mutation in the RYR1 gene after DNA fingerprinting in a malignant hyperthermia susceptible family
    Markus Steinfath
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Naunyn Schmiedebergs Arch Pharmacol 366:372-5. 2002
    ....
  28. ncbi request reprint Is desflurane a "weak" trigger of malignant hyperthermia?
    Frank Wappler
    Anesth Analg 97:295; author reply 295. 2003