Research Topics
Species | G FatkenheuerSummaryAffiliation: University of Cologne Country: Germany Publications
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Publications
Infectious diseases publications in leading medical journals--a comparative analysisG Fatkenheuer
Klinik 1 für Innere Medizin, Universitätsklinik Köln, Kerpener Str 62, 50937 Koln, Germany
Eur J Clin Microbiol Infect Dis 31:2585-91. 2012..6 % in NEJM, 73.6 % in JAMA), while the majority of papers in The Lancet originated from non-US residents (76.5 %). This study underlines the importance of infectious diseases as a medical discipline in clinical research...
Lipid profiles for etravirine versus efavirenz in treatment-naive patients in the randomized, double-blind SENSE trialG Fatkenheuer
First Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany
J Antimicrob Chemother 67:685-90. 2012..Efavirenz has been associated with greater increases in serum lipids compared with other non-nucleosides in randomized trials of first-line treatment...- Long-term outcome and quality of care of patients with Staphylococcus aureus bacteremiaG Fatkenheuer
Department of Internal Medicine, University of Cologne, 50924 Cologne, Germany
Eur J Clin Microbiol Infect Dis 23:157-62. 2004..In order to reduce the considerable mortality associated with SAB and to improve short- and long-term outcome, efforts should be made to increase adherence to recommendations... - [New kinds of AIDS drugs inhibit HIV entry into the cell. Entry inhibitors soon for oral administration]G Fatkenheuer
Klinik I für Innere Medizin Infektio logie, Universitäts klinikum Köln
MMW Fortschr Med 147:46-8. 2005..At the moment, the prospective importance of substances possessing other mechanisms of action (attachment inhibitors, CXCR4 inhibitors) can not yet be predicted... - Subgroup analyses of maraviroc in previously treated R5 HIV-1 infectionGerd Fatkenheuer
Universitätsklinik Köln, Cologne, Germany
N Engl J Med 359:1442-55. 2008.... - Short-term administration of the CCR5 antagonist vicriviroc to patients with HIV and HCV coinfection is safe and tolerableGerd Fatkenheuer
Department I of Internal Medicine, University of Cologne, Cologne, Germany
J Acquir Immune Defic Syndr 53:78-85. 2010..The CCR5 receptor is also present on CD8(+) cells involved in clearing hepatitis C virus (HCV). The goal of the present study was to examine the short-term safety of a CCR5 antagonist, vicriviroc, in patients with HIV/HCV coinfection... - Spontaneous regression of HIV associated T-cell non-Hodgkin's lymphoma with highly active antiretroviral therapyG Fatkenheuer
Klinik I fur Innere Medizin, Universitat zu Koln, D 50924 Koln, Germany
Eur J Med Res 5:236-40. 2000..This hypothesis is supported by parallels to EBV associated polyclonal lymphoproliferation in allogeneic transplantat recipients where regression of lymphoma can be induced by reducing immunosuppressive therapy... - [Cystic form of Pneumocystis carinii pneumonia]G Fatkenheuer
Klinik I fur Innere Medizin, Universitat zu Koln
Dtsch Med Wochenschr 122:1441-6. 1997..The correct diagnosis is often missed. An analysis of a large cohort of patients with PCP was undertaken to determine the incidence and clinical manifestations of this form of the disease... - Central venous catheter (CVC)-related infections in neutropenic patients--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)Gerd Fatkenheuer
Klinik 1 für Innere Medizin, Klinikum der Universität zu Köln, 50924, Koln, Germany
Ann Hematol 82:S149-57. 2003..In the future, the rate of catheter-related infections in neutropenic patients may be reduced by the use of catheters coated with antimicrobial agents... 
Invasive amoebiasis in two patients with AIDS and cytomegalovirus colitisG Fatkenheuer
Department of Internal Medicine I, University of Cologne, Germany
J Clin Microbiol 35:2168-9. 1997..We report two patients with AIDS and cytomegalovirus colitis in whom invasive amoebiasis was histologically diagnosed. It is concluded that E. histolytica has to be considered in HIV-infected patients with colitis...- Polymerase chain reaction for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patientsC Franzen
Department of Internal Medicine I, University of Cologne, Germany
AIDS 10:F23-7. 1996..To study the accuracy of polymerase chain reaction (PCR) for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patients for the diagnosis of intestinal microsporidiosis... - Polymerase chain reaction for diagnosis and species differentiation of microsporidiaC Franzen
Department of Internal Medicine I, University of Cologne, Germany
Folia Parasitol (Praha) 45:140-8. 1998..PCR can be used further for species differentiation of microsporidia, even between species which cannot be differentiated by light and/or electron microscopy... - Genetic evidence for latent Septata intestinalis infection in human immunodeficiency virus-infected patients with intestinal microsporidiosisC Franzen
Department of Internal Medicine I, University of Cologne, Germany
J Infect Dis 173:1038-40. 1996..intestinalis. Thus, S. intestinalis seems to occur more frequently in the form of latent infections and the true prevalence of the parasites may be much higher than previously reported... - Randomized controlled monocentric comparison of once daily ceftriaxone with tobramycin and cefotaxime three times daily with tobramycin in neutropenic feverO A Cornely
Department of Internal Medicine I, University Hospital of Cologne, 50924 Cologne, Germany
Ann Hematol 80:103-8. 2001..7% and 80%, respectively. No significant difference in toxicity was observed. Once-daily ceftriaxone plus tobramycin was not inferior to cefotaxime t.i.d. plus tobramycin qd in the empirical treatment of neutropenic fever... - A powerful DNA extraction method and PCR for detection of microsporidia in clinical stool specimensA Muller
Department of Internal Medicine I, University of Cologne, D 50924 Cologne, Germany
Clin Diagn Lab Immunol 6:243-6. 1999..intestinalis was diagnosed by PCR, whereas light microscopy showed only E. bieneusi infection. PCR testing of stool specimens is useful for diagnosis and species differentiation of intestinal microsporidiosis in HIV patients... - Clinical efficacy of protease inhibitor based antiretroviral combination therapy--a prospective cohort studyB Salzberger
Klinik I fur Innere Medizin, Universitätsklinik Köln, D 50924 Koln, Germany
Eur J Med Res 4:449-55. 1999..To analyze virological and clinical efficacy of protease inhibitor based antiretroviral regimens in a cohort of unselected HIV-infected patients... - Virological efficacy and plasma drug concentrations of nelfinavir plus saquinavir as salvage therapy in HIV-infected patients refractory to standard triple therapyM Reiser
First Department of Internal Medicine, University Hospital Koeln, Joseph Stelzmann Str 9, D 50924 Koeln, Germany
Eur J Med Res 4:54-8. 1999..During short observation time a beneficial effect on CD4-count was observed... - Detection of microsporidia (Enterocytozoon bieneusi) in intestinal biopsy specimens from human immunodeficiency virus-infected patients by PCRC Franzen
Department of Internal Medicine I, University of Cologne, Germany
J Clin Microbiol 33:2294-6. 1995..gondii. The results suggest that PCR testing of intestinal biopsy specimens may be a useful approach to diagnosing microsporidiosis in HIV-infected patients... - Bioelectrical impedance analysis in HIV-infected patients treated with triple antiretroviral treatmentA Schwenk
Department of Internal Medicine, University of Cologne, Germany
Am J Clin Nutr 70:867-73. 1999..However, fat redistribution (lipodystrophy) was recognized recently as a metabolic side effect of PIs... - Tissue diagnosis of intestinal microsporidiosis using a fluorescent stain with Uvitex 2BC Franzen
Department of Internal Medicine I, University of Cologne, Germany
J Clin Pathol 48:1009-10. 1995..To detect intestinal microsporidiosis in paraffin wax embedded biopsy specimens using a fluorescence technique incorporating optical brighteners... - Long-term beneficial effect of protease inhibitors on the intrinsic apoptosis of peripheral blood mononuclear cells in HIV-infected patientsN Jung
First Department of Internal Medicine, Medical Hospital of the University of Cologne, Cologne, Germany
HIV Med 13:469-78. 2012..Long-term clinical effects of PI-based ART on mitochondrial toxicity and lymphocyte apoptosis beyond viral suppression have not been exploited to date... - Limited value of PCR for detection of Toxoplasma gondii in blood from human immunodeficiency virus-infected patientsC Franzen
Department of Internal Medicine I, University of Cologne, Germany
J Clin Microbiol 35:2639-41. 1997..The sensitivity was only 25%, but the specificity was very high (100%), so this technique may be useful for discriminating between cerebral toxoplasmosis and other brain diseases which may be mistaken for toxoplasmosis... - Liver involvement in HIV-infected patients diagnosed with syphilisN Jung
First Department of Internal Medicine, Medical Hospital of the University of Cologne, Cologne, Germany
Infection 40:543-7. 2012..Th aim of this study was to assess hepatic involvement of HIV-infected patients diagnosed with syphilis... - Asymptomatic pneumatosis intestinalis and free abdominal air in a patient with AIDSP Hegener
Department of Internal Medicine I, University of Cologne, Joseph Stelzmann Str 9, D 50924 Koln, Germany
Eur J Med Res 3:265-7. 1998.... - Taxonomic position of the human intestinal protozoan parasite Isospora belli as based on ribosomal RNA sequencesC Franzen
Department of Internal Medicine I, University of Cologne, Germany
Parasitol Res 86:669-76. 2000..We suggest that the genus Isospora should be removed from the family Eimeriidae and placed into the family Sarcocystidae within the suborder Eimeriina... - Necrotizing pneumonia caused by Panton-Valentine leucocidin-producing Staphylococcus aureus originating from a Bartholin's abscessN Jung
Department I of Internal Medicine, University of Cologne, 50935 Cologne, Germany
Infect Dis Obstet Gynecol 2008:491401. 2008..Sporadic severe infectious complications after incision of Bartholin's abcesses have been described but involvement of S. aureus is rare... - Body weight changes with protease inhibitor treatment in undernourished HIV-infected patientsA Schwenk
Department of Internal Medicine, University of Cologne, Germany
Nutrition 15:453-7. 1999..Drug side effects may have counteracted any positive effects. The metabolic and nutritional impact of effective antiviral treatment merits further study... - A randomized monocentric trial in febrile neutropenic patients: ceftriaxone and gentamicin vs cefepime and gentamicinO A Cornely
Department of Internal Medicine I, University Hospital of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
Ann Hematol 81:37-43. 2002..5% vs 17%), while nausea/vomiting was less (12.1% vs 5%). Once-daily ceftriaxone plus gentamicin was not inferior to cefepime t.i.d. plus gentamicin q.d. in the empirical treatment of neutropenic fever... - [Update in infectious diseases. Part I: epidemiology]B Salzberger
Klinik I fur Innere Medizin, Universitätsklinik Köln
Med Klin (Munich) 95:314-20. 2000..The extent of this new epidemic is not yet clear. These trends from the last years clearly indicate, that further new infections and infectious agents will be detected in the future... - [HIV infection: a chronic disease with new challenges]N Jung
Klinik I fur Innere Medizin, Uniklinik Köln, Kerpener Str 62, 50937 Koln
Dtsch Med Wochenschr 136:1581-3. 2011..Controversy exists about the best time point of initiation of antiretroviral therapy. Recently, data indicate that an earlier start could reduce HIV transmission... - Fatal case due to methicillin-resistant Staphylococcus aureus small colony variants in an AIDS patientH Seifert
University of Cologne, Germany
Emerg Infect Dis 5:450-3. 1999..Recovered from three blood cultures as well as from a deep hip abscess, these variants may have resulted from long-term antimicrobial therapy with trimethoprim/sulfamethoxazole for prophylaxis of Pneumocystis carinii pneumonia... - AIDS-related progressive multifocal leukoencephalopathy in the era of HAART: report of two cases and review of the literatureC Wyen
University of Cologne, Cologne, Germany
AIDS Patient Care STDS 19:486-94. 2005..Thus, PML will remain a relevant cause of morbidity and mortality in HIV- 1-infected patients. Here we report two cases of PML, along with a concise review of the literature on this important disease... - Rapid improvement of liver function in a patient with HIV and hepatitis B coinfection treated with lamivudine and tenofovirC Lehmann
Department of Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, 50924, Koln, Germany
Infection 34:234-5. 2006..In addition, combination therapy for chronic hepatitis B might be more effective than monotherapy. Future studies need to clarify the value of combination treatment for patients with chronic hepatitis B... - Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patientsN Jung
First Department of Internal Medicine, Medical Hospital of the University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
Infection 41:379-85. 2013..Here, we tested whether OCT1 and OCT2 contribute to the uptake of lamivudine into native CD4 cells of human immunodeficiency virus (HIV)-infected individuals... - Intestinal colonisation and blood stream infections due to vancomycin-resistant enterococci (VRE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBLE) in patients with haematological and oncological malignanciesB J Liss
1st Department of Internal Medicine, University of Cologne, Cologne, Germany
Infection 40:613-9. 2012.... - Preferential upregulation of interferon-alpha subtype 2 expression in HIV-1 patientsC Lehmann
First Department of Internal Medicine, University of Cologne, Cologne, Germany
AIDS Res Hum Retroviruses 25:577-81. 2009..Our results demonstrate that distinct IFN-alpha subtypes are sequentially activated during HIV-1 infection, which may be predictive of disease progression... - Avascular necrosis of both femoral heads in an HIV-infected patient receiving protease inhibitorsC Franzen
Department of Internal Medicine I, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
Eur J Med Res 6:83-4. 2001..We report a further case of avascular necrosis of both femoral heads in an HIV-infected patient treated with protease inhibitor containing antiretroviral therapy... - Treatment of spondylodiscitis in human immunodeficiency virus-infected patients: a comparison of conservative and operative therapyR Sobottke
Department of Orthopaedic Surgery, University of Cologne, Cologne, Germany
Spine (Phila Pa 1976) 34:E452-8. 2009..Multicenter retrospective case series... - [Epidemiology, course and prognosis of Staphylococcus aureus bacteremia--Preliminary results from the INSTINCT (INvasive STaphylococcus aureus INfection CohorT) cohort]H Seifert
Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln, Germany
Dtsch Med Wochenschr 133:340-5. 2008..aureus bacteremia (SAB) is one of the most severe infections acquired in hospital or in the community. The epidemiology and prognosis of this infection in Germany is not fully understood because of the lack of prospective data... - A randomized, placebo-controlled study of the use of filgrastim in non neutropenic patients with nosocomial pneumoniaPia Hartmann
Department of Internal Medicine I, Division of Infectious Diseases, D 93042 Regensburg, Germany
Eur J Med Res 10:29-35. 2005..Filgrastim is safe in non-neutropenic ICU patients with nosocomial pneumonia. A benefit of filgrastim with regard to clinical endpoints could not be observed, while there was a trend toward reduced sepsis rate... - [Infectiology update. II: Diagnosis and therapy]B Salzberger
Klinik I fur Innere Medizin, Universitätsklinik Köln
Med Klin (Munich) 95:568-77. 2000..A number of new antibiotic agents for the treatment of these infections have been developed and licensed... - [A 41 year-old male patient with fever of unknown origin and bacteremia with actinobacillus actinomycetemcomitans]S Rosenkranz
Klinik III fur Innere Medizin, Universitat zu Koln, Germany
Internist (Berl) 44:1180-5. 2003..Despite negative TEE, the diagnosis "infective endocarditis" should not be rejected, and blood cultures should be grown for up to 30 days... - [Vaccination against rabies: how and when?]T Kümmerle
Klinik 1 für Innere Medizin, Universitätsklinik Köln
Dtsch Med Wochenschr 137:789-92. 2012..The mode and intensity of exposure determine the choice of regimen (wound treatment, active and passive vaccination)... - Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patientsC Wyen
Department of Internal Medicine, Hospital of the University of Cologne, Koln, Germany
Clin Pharmacol Ther 84:75-82. 2008..In conclusion, CYP3A, CYP2D6, and P-glycoprotein are profoundly inhibited in patients receiving ritonavir boosted lopinavir. The covariates investigated are not useful for a priori dose selection... - Successful administration of aggressive chemotherapy concomitant to tuberculostatic and highly active antiretroviral therapy in a patient with AIDS-related Burkitt's lymphomaC Lehmann
Department of Internal Medicine, University of Cologne, Cologne, Germany
HIV Med 6:51-3. 2005..This case report provides some useful observations on the successful application of intensive chemotherapy in addition to tuberculostatic therapy and HAART in HIV-infected patients... - Clinical management of catheter-related infectionsG Fatkenheuer
Department of Internal Medicine, University of Cologne, Germany Department of Microbiology, Hygiene and Medical Immunology, University of Cologne, Germany
Clin Microbiol Infect 8:545-50. 2002..In addition to systemic antimicrobial therapy, antibiotic lock therapy may be applied, especially in patients with implanted long-term catheters if catheter salvage is attempted... - Phagocytosis and killing of Mycobacterium avium complex by human neutrophilsP Hartmann
Department of Internal Medicine I, University of Cologne, Germany
J Leukoc Biol 69:397-404. 2001..The newly established flow cytometry method should be useful in further studies of neutrophil function and of the role of G-CSF and other cytokines in MAC disease... - Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin BA Rothe
, , Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany
Ann Hematol 83:394-7. 2004..The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality... - Detection of microsporidia in travelers with diarrheaA Muller
Department of Pediatrics, University of Cologne, Cologne, Germany
J Clin Microbiol 39:1630-2. 2001..Some cases were diagnosed only by PCR, indicating that the true prevalence has to be determined by highly sensitive techniques, such as PCR...