F Fandrich

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint IL-2 antagonists: the European perspective
    K P Platz
    Department of Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 37:1783-4. 2005
  2. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
  3. ncbi request reprint Tolerance-inducing strategies in transplantation surgery-current status and perspectives
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Langenbecks Arch Surg 389:60-6. 2004
  4. ncbi request reprint Overexpression of phosphatidylinositol 3-kinase in human lung cancer
    X Lin
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Langenbecks Arch Surg 386:293-301. 2001
  5. ncbi request reprint Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning
    Fred Fandrich
    Department of General Surgery and Thoracic Surgery, University of Kiel, 24105 Kiel, Germany
    Nat Med 8:171-8. 2002
  6. ncbi request reprint Embryonic stem cells share immune-privileged features relevant for tolerance induction
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    J Mol Med (Berl) 80:343-50. 2002
  7. ncbi request reprint Future strategies for tolerance induction: a comparative study between hematopoietic stem cells and macrophages
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Hum Immunol 63:805-12. 2002
  8. ncbi request reprint Stem cell-mediated tolerance inducing strategies in organ transplantation
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Kiel, Germany
    Kidney Int 65:1548-50. 2004
  9. ncbi request reprint [Stem cells and liver replacement]
    Fred Fandrich
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Med Klin (Munich) 98:18-22. 2003
  10. ncbi request reprint Kinetics and localization of interleukin-2, interleukin-6, heat shock protein 70, and interferon gamma during intestinal-rerfusion injury
    F Braun
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universität Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 36:267-9. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint IL-2 antagonists: the European perspective
    K P Platz
    Department of Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 37:1783-4. 2005
    ..Antilymphocyte preparations do not affect CD4+ CD25+ T cells. Because regulatory CD4+ CD25+ T cells are essential for tolerance induction, protocols attempting tolerance may omit anti-IL-2 antibodies in the future...
  2. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
    ..Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC...
  3. ncbi request reprint Tolerance-inducing strategies in transplantation surgery-current status and perspectives
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Langenbecks Arch Surg 389:60-6. 2004
    ....
  4. ncbi request reprint Overexpression of phosphatidylinositol 3-kinase in human lung cancer
    X Lin
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Langenbecks Arch Surg 386:293-301. 2001
    ..This study was conducted to investigate the expression of phosphatidylinositol 3-kinase (PI3K) and AKT2, a downstream effector, in primary human lung carcinomas of different histological type...
  5. ncbi request reprint Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning
    Fred Fandrich
    Department of General Surgery and Thoracic Surgery, University of Kiel, 24105 Kiel, Germany
    Nat Med 8:171-8. 2002
    ..Our results provide a rationale for using preimplantation-stage stem cells as vehicles in gene therapy and for the induction of long-term graft acceptance...
  6. ncbi request reprint Embryonic stem cells share immune-privileged features relevant for tolerance induction
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    J Mol Med (Berl) 80:343-50. 2002
    ..The field of maternofetal immunobiology has lately emerged as a new scientific branch in immunology which is gathering useful insights for future innovative tolerance strategies to prevent allogeneic graft rejection...
  7. ncbi request reprint Future strategies for tolerance induction: a comparative study between hematopoietic stem cells and macrophages
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Hum Immunol 63:805-12. 2002
    ....
  8. ncbi request reprint Stem cell-mediated tolerance inducing strategies in organ transplantation
    Fred Fandrich
    Department of General and Thoracic Surgery, University of Kiel, Kiel, Germany
    Kidney Int 65:1548-50. 2004
    ....
  9. ncbi request reprint [Stem cells and liver replacement]
    Fred Fandrich
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Med Klin (Munich) 98:18-22. 2003
    ..Successful application of stem cell-associated therapeutics in man will be closely related with ensuing patient risk profiles, stringent indications, long-term patient outcomes and will be determined by cost-benefit efficacy...
  10. ncbi request reprint Kinetics and localization of interleukin-2, interleukin-6, heat shock protein 70, and interferon gamma during intestinal-rerfusion injury
    F Braun
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universität Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 36:267-9. 2004
    ..IL-2, IL-6, HSP70, and INF-gamma are mediators of the inflammatory process. Therefore, we investigated their kinetics and localization during intestinal IRI...
  11. ncbi request reprint Isolated adult intestinal transplantation using portal venous drainage
    K P Platz
    Department of Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 36:305-8. 2004
    ..Furthermore, donor and recipient vessels are well matched for size. Using microsurgical techniques, vascular complications may be avoided...
  12. ncbi request reprint Adult stem cells--perspectives in treatment of metabolic diseases
    M Schulze
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel
    Acta Gastroenterol Belg 68:461-5. 2005
    ....
  13. ncbi request reprint [Long-term survival of curatively operated gastric cancer: influence of the gender and splenectomy]
    C Schafmayer
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7
    Zentralbl Chir 132:515-22. 2007
    ..Thus, the question arises as to how far gender and splenectomy influence the long time-survival after curative gastric cancer surgery...
  14. ncbi request reprint Immunosuppression following intestinal transplantation
    A R Mueller
    Department of Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 36:325-8. 2004
    ..Immunosuppression-associated complications, including infections, were in an acceptable range. However, even late after transplantation, reduction in immunosuppression may lead to severe rejection without major clinical symptoms...
  15. ncbi request reprint Migration and activation pattern of specialized dendritic cells after heterotopic small bowel transplantation in a graft-versus-host model of the rat
    F Fandrich
    Dept of General and Thoracic Surgery, Universitiy of Kiel, Arnold Heller Str 7, 24105 Kiel, Germany
    Front Biosci 2:b1-11. 1997
    ..Based on the immunosuppressive efficacy of 15-deoxyspergualin on the survival and function of SLCs and FDCs, an unaltered development of germinal centers and B cell proliferation within mesenteric lymph nodes and spleen was maintained..
  16. ncbi request reprint Long-term culture and differentiation of rat embryonic stem cell-like cells into neuronal, glial, endothelial, and hepatic lineages
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital of Kiel, Germany
    Stem Cells 21:428-36. 2003
    ..We were able to culture RESCs under stable, long-term conditions and to initiate programmed differentiation of RESCs to endothelial, neuronal, glial, and hepatic lineages in the rat species...
  17. ncbi request reprint Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination
    N Zavazava
    Institute of Immunology and Department of General and Thoracic Surgery, University of Kiel, Germany
    J Leukoc Biol 67:793-800. 2000
    ..Thus, peptide 56-80 appears to represent a dominant epitope that can be exploited for establishing tolerance in this transplantation strain combination...
  18. doi request reprint Markers of operational immune tolerance after pediatric liver transplantation in patients under immunosuppression
    S Schulz-Juergensen
    Department of General Pediatrics, University Hospital Schleswig Holstein, Arnold Heller Strasse 3, Kiel, Germany
    Pediatr Transplant 17:348-54. 2013
    ..This suggests that operational tolerance is a dynamic process, with uncertain prediction by Vδ1/Vδ2-γδ-T-cell ratio and/or Tregs under immunosuppression...
  19. ncbi request reprint Multipotent cells of monocytic origin improve damaged heart function
    B Dresske
    Department of General and Thoracic Surgery, University of Schleswig Holstein, Campus Kiel, Germany
    Am J Transplant 6:947-58. 2006
    ..Successful generation of PCMO in access numbers allows their autologous use as a new additive treatment for early restoration of cardiac function after MI...
  20. ncbi request reprint Audit of a series of 40 gastrointestinal stromal tumour cases
    S Hinz
    Clinic of General Surgery and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Eur J Surg Oncol 32:1125-9. 2006
    ..To analyze prognostic factors influencing survival and tumour recurrence after resection of gastrointestinal stromal tumours...
  21. ncbi request reprint Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function
    B Schniewind
    Department of General Surgery and Thoracic Surgery, UKSH, Campus Kiel, Kiel, Germany
    Oncogene 26:4850-62. 2007
    ..These results suggest a causal, dominant role for the endogenous Smad2/3 signaling pathway in the tumor suppressor and prometastatic activities of TGF-beta in pancreatic tumor cells...
  22. ncbi request reprint [Modification of the liver resection technique with radiofrequency coagulation]
    J Tepel
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Chirurg 75:66-9. 2004
    ..Radiofrequency energy-an established technique for in situ ablation-was used to facilitate liver resection by creating a nearly bloodless tissue plane...
  23. ncbi request reprint Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs
    F Braun
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universität Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplant Proc 36:265-6. 2004
    ..Interaction of leukocytes and endothelial cells mediated by E-selectin appears to be a key step for disturbed microcirculation. Therefore we studied gene and protein expression as well as localization of E-selectin during intestinal IRI...