M Famulok

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Molecular biology. RNAs turn on in tandem
    Michael Famulok
    Kekule Institut fur Organische Chemie und Biochemie, D 53121 Bonn, Germany
    Science 306:233-4. 2004
  2. ncbi request reprint A novel family of structurally stable double stranded DNA catenanes
    Finn Lohmann
    Universitat Bonn, LIMES Life and Medical Science Institut, Program Unit Chemical Biology and Medicinal Chemistry, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chem Commun (Camb) 50:6091-3. 2014
  3. pmc Conformational changes in the expression domain of the Escherichia coli thiM riboswitch
    Andrea Rentmeister
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Nucleic Acids Res 35:3713-22. 2007
  4. pmc Reversible light switch for macrocycle mobility in a DNA rotaxane
    Finn Lohmann
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, c o Kekulé Institute of Organic Chemistry and Biochemistry, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    J Am Chem Soc 134:11884-7. 2012
  5. pmc Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells
    Anke Bill
    Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences LIMES Institute, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    PLoS ONE 7:e41179. 2012
  6. pmc Input-dependent induction of oligonucleotide structural motifs for performing molecular logic
    Tao Li
    Life and Medical Science Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Gerhard Domagk Str 1, 53121 Bonn, Germany
    J Am Chem Soc 134:3508-16. 2012
  7. pmc Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology
    Damian Ackermann
    Chemical Biology and Medicinal Chemistry Unit, LIMES Institute, c o Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Nucleic Acids Res 41:4729-39. 2013
  8. ncbi request reprint Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy
    Michael Famulok
    LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chem Rev 107:3715-43. 2007
  9. ncbi request reprint In vivo-applied functional RNAs as tools in proteomics and genomics research
    Michael Famulok
    Institut fur Biochemie, Rheinische Friedrich Wilhelms Universitat Bonn, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Trends Biotechnol 20:462-6. 2002
  10. doi request reprint A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe
    Barbara Albertoni
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
    Chem Commun (Camb) 48:1272-4. 2012

Collaborators

  • Jörg S Hartig
  • Alexander Heckel
  • Gunter Mayer
  • Tao Li
  • M R Green
  • J Davies
  • Anton Schmitz
  • Sandeep Verma
  • Stefan Jäger
  • Andrew D Ellington
  • Annette G Beck-Sickinger
  • James S Nowick
  • P Cramer
  • Damian Ackermann
  • S Hani Najafi-Shoushtari
  • Finn Lohmann
  • Seergazhi G Srivatsan
  • Andrea Rentmeister
  • Björn Niebel
  • Goran Rasched
  • Thorsten L Schmidt
  • Markus Hafner
  • Stefan Fusz
  • Barbara Albertoni
  • Anke Bill
  • Alexander Eisenführ
  • Tina Wahle
  • Daniela Proske
  • H Schürer
  • Jeffrey S Hannam
  • Imke Grüne
  • N Piganeau
  • Jochen Walter
  • Hubert Kettenberger
  • Waldemar Kolanus
  • Kang ding Gu
  • Mirko G Theis
  • Heike Betat
  • Julián Valero
  • A Jenne
  • U Hahn
  • G Sengle
  • Lukas C Heukamp
  • Katharina König
  • ALAN L MUELLER
  • Benjamin Weiche
  • Dean Y Li
  • Nora Karnowski
  • Monika Pofahl
  • Achim Hoerauf
  • Kenneth M Pfarr
  • Christian Lentz
  • Christian Gloeckner
  • Laura Marchetti
  • Elena Vianini
  • Peter Broekmann
  • Bernd Brutschy
  • Partha P Parui
  • Nicole Kuhn
  • Chayan K Nandi
  • Mirko Theis
  • Inga Bauer
  • Dietmar R Thal
  • Florian Brueckner
  • Bianca Paul
  • Elisabeth Kremmer
  • Magdalena Sastre
  • Nenad Bogdanovic
  • Thomas Quast
  • Michael T Heneka
  • Jörg Moelleken
  • Alexander Knorre
  • Bettina Kellersch
  • Felix Wieland
  • Stefan Vogel
  • Peter Welzel
  • Marc Struhalla
  • Paramjit S Arora
  • Hans Heinrich Förster
  • Gerhard Sengle
  • Leo R Takaoka
  • Ulrich Hahn
  • Hermann M Schatzl
  • Ernst L Winnacker
  • Martin Höfliger
  • Sabine Gilch
  • Richard M Soll
  • Franziska Wopfner
  • D A Samarsky
  • P Welzei

Detail Information

Publications57

  1. ncbi request reprint Molecular biology. RNAs turn on in tandem
    Michael Famulok
    Kekule Institut fur Organische Chemie und Biochemie, D 53121 Bonn, Germany
    Science 306:233-4. 2004
  2. ncbi request reprint A novel family of structurally stable double stranded DNA catenanes
    Finn Lohmann
    Universitat Bonn, LIMES Life and Medical Science Institut, Program Unit Chemical Biology and Medicinal Chemistry, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chem Commun (Camb) 50:6091-3. 2014
    ..Reversible and quantitative on/off switching of the mobility of the rings was demonstrated as a proof-of-concept for the employment of these catenanes as dynamic DNA-nanostructures. ..
  3. pmc Conformational changes in the expression domain of the Escherichia coli thiM riboswitch
    Andrea Rentmeister
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Nucleic Acids Res 35:3713-22. 2007
    ..Furthermore, structural probing provides an explanation for the lack of genetic control exerted by a riboswitch variant with mutations in the expression domain that still binds TPP...
  4. pmc Reversible light switch for macrocycle mobility in a DNA rotaxane
    Finn Lohmann
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, c o Kekulé Institute of Organic Chemistry and Biochemistry, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    J Am Chem Soc 134:11884-7. 2012
    ..The ability to reversibly operate mechanical motion in an interlocked DNA nanostructure opens exciting new avenues in DNA nanotechnology...
  5. pmc Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells
    Anke Bill
    Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences LIMES Institute, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    PLoS ONE 7:e41179. 2012
    ..Our data suggest that targeting the EGFR indirectly by inhibiting its cytoplasmic activators, the cytohesins, has the potential to improve the treatment of primarily EGFR-TKI resistant lung cancers...
  6. pmc Input-dependent induction of oligonucleotide structural motifs for performing molecular logic
    Tao Li
    Life and Medical Science Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Gerhard Domagk Str 1, 53121 Bonn, Germany
    J Am Chem Soc 134:3508-16. 2012
    ..Depending on the nature of the respective peroxidase substrate, distinct output signals can be generated, allowing one to operate multiple logic gates such as NOR, INH, or AND...
  7. pmc Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology
    Damian Ackermann
    Chemical Biology and Medicinal Chemistry Unit, LIMES Institute, c o Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Nucleic Acids Res 41:4729-39. 2013
    ..pcPNAs can potentially be combined with light- and toehold-based switches, thus broadening the toolbox of orthogonal switching approaches for DNA architectures that open up new avenues in dynamic DNA nanotechnology...
  8. ncbi request reprint Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy
    Michael Famulok
    LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chem Rev 107:3715-43. 2007
  9. ncbi request reprint In vivo-applied functional RNAs as tools in proteomics and genomics research
    Michael Famulok
    Institut fur Biochemie, Rheinische Friedrich Wilhelms Universitat Bonn, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Trends Biotechnol 20:462-6. 2002
    ....
  10. doi request reprint A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe
    Barbara Albertoni
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
    Chem Commun (Camb) 48:1272-4. 2012
    ..The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples...
  11. ncbi request reprint Intramers and aptamers: applications in protein-function analyses and potential for drug screening
    Michael Famulok
    Rheinische Friedrich Wilhelms Universitat Bonn, Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chembiochem 6:19-26. 2005
  12. ncbi request reprint Allosteric aptamers and aptazymes as probes for screening approaches
    Michael Famulok
    Rheinische Friedrich Wilhelms Universitat Bonn, Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, Bonn 53121, Germany
    Curr Opin Mol Ther 7:137-43. 2005
    ..The interacting molecules trigger a response in the allosteric nucleic acid, which can be used for purposes such as real-time monitoring, high-throughput screening or gene expression control...
  13. ncbi request reprint Intramers as promising new tools in functional proteomics
    M Famulok
    Kekulé Institut für Organische und Biochimie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Chem Biol 8:931-9. 2001
    ..Thus, intramer-based technologies offer many promising applications in functional genomics, proteomics and drug discovery...
  14. ncbi request reprint Nucleic acid aptamers-from selection in vitro to applications in vivo
    M Famulok
    Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Acc Chem Res 33:591-9. 2000
    ..Using these approaches, one can quickly obtain highly specific research reagents that act on defined intracellular targets in the context of the living cell...
  15. ncbi request reprint Aptamers that bind to the antibiotic moenomycin A
    H Schürer
    Universitat Leipzig, Institut fur Biochemie, Talstr 33, D 04103, Leipzig, Germany
    Bioorg Med Chem 9:2557-63. 2001
    ..The results offer the opportunity of setting up a selective and sensitive assay for identifying moenomycin biosynthetic precursors...
  16. ncbi request reprint Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology
    A Jenne
    Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Str 1, 35121, Bonn, Germany
    Nat Biotechnol 19:56-61. 2001
    ..This approach allows the rapid, reliable, and convenient identification and characterization of ribozyme modulators leading to insights difficult to obtain by classical methodology...
  17. ncbi request reprint Oligonucleotide libraries--variatio delectat
    M Famulok
    Institut fur Biochemie, LMU Munchen, Germany
    Curr Opin Chem Biol 2:320-7. 1998
    ..The current state of aptamer and ribozyme technology is such that it establishes itself as a means of obtaining useful tools for molecular biology, diagnostics, molecular medicine and bio-organic chemistry...
  18. pmc Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers
    G Mayer
    , , Gerhard-Domagk Strasse 1, D-53121 Bonn, Germany
    Proc Natl Acad Sci U S A 98:4961-5. 2001
    ..These highly specific cellular effects suggest that the ARF-GEF activity of cytohesin 1 plays an important role in cytoskeletal remodeling events of lymphoid cells...
  19. pmc Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector
    S Hani Najafi-Shoushtari
    Kekule Institut fur Organische Chemie und Biochemie, University of Bonn, 53121 Bonn, Germany
    RNA 11:1514-20. 2005
    ....
  20. ncbi request reprint Novel RNA catalysts for the Michael reaction
    G Sengle
    , , Germany
    Chem Biol 8:459-73. 2001
    ..Therefore, previously unforeseen RNA-evolution pathways can be considered, for example the formation of dTMP from dUMP. The substrate specificity of this ribozyme may also render it useful in organic syntheses...
  21. pmc Sensing complex regulatory networks by conformationally controlled hairpin ribozymes
    S Hani Najafi-Shoushtari
    Kekule Institut fur Organische Chemie und Biochemie, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Nucleic Acids Res 32:3212-9. 2004
    ..This approach allows to precisely sense the activity status of a protein controlled by its metabolite molecule...
  22. ncbi request reprint [Nucleic acids in the drug discovery process: aptamers as therapeutic and as active ingredients for drugs]
    Gunter Mayer
    Rheinische Friedrich Wilhelms Universitat Bonn, LIMES Institut, Programmeinheit Chemische Biologie und Medizinische Chemie, c o Kekulé Institut für Org Chemie und Biochemie, Gerhard Domagk Str 1, 53121 Bonn
    Pharm Unserer Zeit 36:432-6. 2007
    ..Die Aptamertechnologie eröffnet vielfältige Applikationsmöglichkeiten und neuere Arbeiten zeigen, dass sie auch bei der Identifikation niedermolekularer Wirkstoffe einen wertvollen Beitrag leisten kann...
  23. ncbi request reprint In vitro selection of allosteric ribozymes: theory and experimental validation
    N Piganeau
    , , Gerhard-Domagk-Strasse 1, Bonn, 53121, Germany
    J Mol Biol 312:1177-90. 2001
    ..It can thus be used to determine the optimal conditions for an in vitro selection of an allosteric ribozyme with a desired dissociation constant and cleavage rate for a given application...
  24. ncbi request reprint RNA ligands that distinguish metabolite-induced conformations in the TPP riboswitch
    Gunter Mayer
    Life and Medical Sciences LIMES, Program Unit Chemical Biology and Medicinal Chemistry c o Kekulé Institut für Organische Chemie und Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Angew Chem Int Ed Engl 46:557-60. 2007
  25. pmc RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro
    Andrea Rentmeister
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, Universitat Bonn, 53121 Bonn, Germany
    RNA 12:1650-60. 2006
    ..Because phosphorylation and GGA1 binding to B1-CT regulate BACE1 transport, these RNA inhibitors could be applied to investigate B1-CT activity without affecting the subcellular localization of BACE1...
  26. doi request reprint ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling
    Björn Niebel
    Life and Medical Sciences LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chemistry 16:11100-7. 2010
    ..With full automation and the use of commercially available plate readers, we estimate that the ADLOC-based assay described here could be used to screen at least 100,000 compounds per day...
  27. ncbi request reprint Functional nucleic acids in high throughput screening and drug discovery
    Seergazhi G Srivatsan
    LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie und Biochemie, Gerhard Domagk Str 1, D 53121 Bonn, Germany
    Comb Chem High Throughput Screen 10:698-705. 2007
    ..Here we summarize the development of different types of signaling nucleic acids, and approaches that have been implemented in the screening format...
  28. ncbi request reprint Reporter ribozymes for real-time analysis of domain-specific interactions in biomolecules: HIV-1 reverse transcriptase and the primer-template complex
    Jörg S Hartig
    Kekulé Institut für Organische Chemie und Biochemie Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Angew Chem Int Ed Engl 41:4263-6. 2002
  29. ncbi request reprint Aptamers that recognize the lipid moiety of the antibiotic moenomycin A
    Heike Betat
    Universitat Hamburg, Abteilung Biochemie und Molekularbiologie, Martin Luther King Platz 6, D 20146 Hamburg, Germany
    Biol Chem 384:1497-500. 2003
    ..These results suggest that the evolution of hydrophobic binding pockets in RNA molecules may be much more common than previously assumed...
  30. ncbi request reprint Fluorescence correlation spectroscopy as a new method for the investigation of aptamer/target interactions
    H Schürer
    Universitat Leipzig, Institut fur Biochemie, Germany
    Biol Chem 382:479-81. 2001
    ..The formation of RNA-moenomycin complexes was studied by fluorescence correlation spectroscopy with a tetramethylrhodamine-labeled derivative of moenomycin...
  31. ncbi request reprint Protein-dependent ribozymes report molecular interactions in real time
    Jörg S Hartig
    Kekule Institut fur Organische Chemie und Biochemie, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Nat Biotechnol 20:717-22. 2002
    ..The rapid identification of interactions between proteins or of compounds that disrupt such interactions should have substantial utility for the drug-discovery process...
  32. doi request reprint Photocleavable initiator nucleotide substrates for an aldolase ribozyme
    Stefan Fusz
    LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Str 1, 53121 Bonn, Germany
    J Org Chem 73:5069-77. 2008
    ....
  33. ncbi request reprint A ribozyme for the aldol reaction
    Stefan Fusz
    Universitat Bonn, Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chem Biol 12:941-50. 2005
    ....
  34. ncbi request reprint A ribozyme with michaelase activity: synthesis of the substrate precursors
    Alexander Eisenführ
    Kekule Institut fur Organische Chemie und Biochemie, Rheinische Friedrich Wilhelms Universitat Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Bioorg Med Chem 11:235-49. 2003
    ..We show that the thiol group of the cysteine nucleophile is essential for the reaction to proceed. When substituted for a thiomethyl group, no reaction takes place...
  35. ncbi request reprint Functional tuning of nucleic acids by chemical modifications: tailored oligonucleotides as drugs, devices, and diagnostics
    Sandeep Verma
    Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Gerhard Domagk Str 1, D 53121 Bonn, Germany
    Chem Rec 3:51-60. 2003
    ..This review deals with representative chemical modifications in the nucleobases, sugars, and the phosphate ester backbone and their application from novel catalytic RNA selection to nucleic acid-based biosensors...
  36. ncbi request reprint Sequence-specific detection of MicroRNAs by signal-amplifying ribozymes
    Jörg S Hartig
    Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    J Am Chem Soc 126:722-3. 2004
    ..These probes may be useful in applications that require direct detection of minute amounts of small DNAs or RNAs...
  37. doi request reprint Construction of DNA architectures with RNA hairpins
    Gunter Mayer
    Universitat Bonn, LIMES Life and Medical Science Institut, Programmeinheit Chemische Biologie und Medizinische Chemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Angew Chem Int Ed Engl 47:971-3. 2008
  38. ncbi request reprint DNA aptamer-mediated regulation of the hairpin ribozyme by human alpha-thrombin
    S Hani Najafi-Shoushtari
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Blood Cells Mol Dis 38:19-24. 2007
    ..Protein-responsive allosteric ribozymes are proposed to act as tools with potential applications in medicine where fast detection of clinically relevant targets is required...
  39. ncbi request reprint High-throughput-compatible assay for glmS riboswitch metabolite dependence
    Gunter Mayer
    Universitat Bonn, Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chembiochem 7:602-4. 2006
  40. ncbi request reprint Chemical biology: green fluorescent RNA
    Michael Famulok
    Nature 430:976-7. 2004
  41. doi request reprint Modular reporter hairpin ribozymes for analyzing molecular interactions
    S Hani Najafi-Shoushtari
    Kekulé Institute, University of Bonn, Bonn, Germany
    Methods Mol Biol 429:237-50. 2008
    ..These reporter systems thus represent a general way to obtain signal-amplifying sensors for diverse applications in molecular profiling...
  42. doi request reprint A luminescent oxygen channeling biosensor that measures small GTPase activation
    Björn Niebel
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
    Chem Commun (Camb) 47:7521-3. 2011
    ..The study will provide guidelines for determining activation states of diverse GTPases in various biological contexts...
  43. ncbi request reprint DNA minicircles with gaps for versatile functionalization
    Goran Rasched
    Universitat Bonn, LIMES Life and Medical Science, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Angew Chem Int Ed Engl 47:967-70. 2008
  44. ncbi request reprint A Y2 receptor mimetic aptamer directed against neuropeptide Y
    Daniela Proske
    Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Germany
    J Biol Chem 277:11416-22. 2002
    ..These results indicate that the aptamer mimics the binding of NPY to the Y2 receptor more closely than to the Y1 and Y5 receptors...
  45. ncbi request reprint Polyamide struts for DNA architectures
    Thorsten L Schmidt
    University of Bonn, LIMES Life and Medical Sciences, c o Kekulé Institute, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Angew Chem Int Ed Engl 46:4382-4. 2007
  46. doi request reprint Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates
    Damian Ackermann
    LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
    Chem Commun (Camb) 46:4154-6. 2010
    ..Branched ODNs ligated to single-stranded (ss) gap regions of dsDNA nanocircles led to defined, dumbbell-shaped architectures. ODNs containing an aromatic intercalator yielded oligomeric aggregates...
  47. pmc Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2
    Mirko G Theis
    Kekule Institut fur Organische Chemie und Biochemie, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Proc Natl Acad Sci U S A 101:11221-6. 2004
    ..Our results indicate that intramer technology can be used not only for assigning novel biological functions to proteins or protein domains but also to prove nonredundancy of highly homologous proteins...
  48. doi request reprint Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization
    Markus Hafner
    Program Unit Chemical Biology and Medicinal Chemistry, LIMES Institute, c o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Nat Protoc 3:579-87. 2008
    ..We provide the step-by-step protocol to screen for antagonists of the cytohesin class of small guanosine exchange factors...
  49. ncbi request reprint GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide
    Tina Wahle
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:12838-46. 2006
    ..Thus, GGA proteins might be involved in the pathogenesis of AD...
  50. ncbi request reprint [In vitro selection of specific aptamers against microcystin-LR]
    Kang ding Gu
    Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Yu Fang Yi Xue Za Zhi 38:369-73. 2004
    ..In vitro selection of specific RNA aptamers against microcystin-LR from a random RNA pool...
  51. ncbi request reprint Turning aptamers into anticoagulants
    Michael Famulok
    Nat Biotechnol 22:1373-4. 2004
  52. ncbi request reprint Bringing picomolar protein detection into proximity
    Michael Famulok
    Nat Biotechnol 20:448-9. 2002
  53. ncbi request reprint Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs
    Hubert Kettenberger
    Gene Center, University of Munich, Department of Chemistry and Biochemistry, Feodor Lynen Str 25, 81377 Munich, Germany
    Nat Struct Mol Biol 13:44-8. 2006
    ..The structure also indicates that A-form RNA could interact with Pol II similarly to a B-form DNA promoter, as suggested for the bacterial transcription inhibitor 6S RNA...
  54. ncbi request reprint Prion-protein-specific aptamer reduces PrPSc formation
    Daniela Proske
    Institut fur Biochemie, Genzentrum der LMU München, Feodor Lynen Strasse 25, 81377 München Germany
    Chembiochem 3:717-25. 2002
    ..These findings may open the door towards a rational development of a new class of drugs for the therapy or prophylaxis of prion diseases...
  55. doi request reprint Building objects from nucleic acids for a nanometer world
    Alexander Heckel
    University of Frankfurt, Cluster of Excellence Macromolecular Complexes, c o Institute of Organic Chemistry and Chemical Biology, Max von Laue Str 7, 60438 Frankfurt am Main, Germany
    Biochimie 90:1096-107. 2008
    ..First examples for applications are discussed...
  56. doi request reprint Screening of molecular interactions using reporter hammerhead ribozymes
    Jörg S Hartig
    Department of Chemistry, University of Konstanz, Konstanz, Germany
    Methods Mol Biol 429:251-63. 2008
    ..The assay can be utilized to sense a broad variety of biomolecular interactions, and is very sensitive due to signal amplification by the ribozyme reaction...
  57. ncbi request reprint Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
    Markus Hafner
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, c o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Germany
    Nature 444:941-4. 2006
    ..Because insulin resistance is among the earliest pathological changes in type 2 diabetes, our results show the potential of chemical biology for dissecting the molecular pathogenesis of this disease...