Peter Falkai

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
  2. ncbi request reprint [The chances of new atypical substances]
    P Falkai
    Klinik fur Psychiatrie und Psychotherapie, Universitat Bonn
    Fortschr Neurol Psychiatr 68:S32-7. 2000
  3. ncbi request reprint [Structural brain changes in patients with schizophrenic psychoses. From focal pathology to network disorder]
    P Falkai
    Klinik fur Psychiatrie und Psychotherapie, Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, 53127 Bonn
    Nervenarzt 72:331-41. 2001
  4. ncbi request reprint The temporal lobe in schizophrenia from uni- and multiply affected families
    Peter Falkai
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 325:25-8. 2002
  5. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
  6. doi request reprint [Shortage of doctors in psychiatric hospitals--providing for the future by reorganizing medical services]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S16-24. 2011
  7. doi request reprint [Definition of the core area of medical services in the psychiatric-psychotherapeutic field--the prerequisite for any delegation]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S8-15. 2011
  8. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
  9. doi request reprint Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
  10. doi request reprint Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:126-34. 2009

Detail Information

Publications71

  1. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  2. ncbi request reprint [The chances of new atypical substances]
    P Falkai
    Klinik fur Psychiatrie und Psychotherapie, Universitat Bonn
    Fortschr Neurol Psychiatr 68:S32-7. 2000
    ..However, apart from the clear advantage of clozapine in the treatment of otherwise treatment-resistant schizophrenia, differential indications for the different antipsychotics remain to be established...
  3. ncbi request reprint [Structural brain changes in patients with schizophrenic psychoses. From focal pathology to network disorder]
    P Falkai
    Klinik fur Psychiatrie und Psychotherapie, Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, 53127 Bonn
    Nervenarzt 72:331-41. 2001
    ..Present research therefore focuses on testing this theory using functional imaging on a macroscopic level and examination of the neuronal cytoarchitecture on a microscopic level...
  4. ncbi request reprint The temporal lobe in schizophrenia from uni- and multiply affected families
    Peter Falkai
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 325:25-8. 2002
    ..Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia...
  5. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  6. doi request reprint [Shortage of doctors in psychiatric hospitals--providing for the future by reorganizing medical services]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S16-24. 2011
    ..The essential steps and instruments of process optimisation in medical services for a psychiatric clinic are elucidated and discussed in the context of demographic changes, generation change, and a new concept of values...
  7. doi request reprint [Definition of the core area of medical services in the psychiatric-psychotherapeutic field--the prerequisite for any delegation]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S8-15. 2011
    ....
  8. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  9. doi request reprint Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
    ....
  10. doi request reprint Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:126-34. 2009
    ..Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia...
  11. ncbi request reprint Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects
    Hans Joergen Grabe
    Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
    Am J Psychiatry 163:1986-92. 2006
    ..This study compared the familial aggregation of OCD in first-degree relatives of community subjects with never-treated OCD, outpatients with OCD, and comparison subjects...
  12. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  13. pmc Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning
    David Zilles
    Department of Psychiatry, Center for Translational Research in Systems Neuroscience and Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:667-76. 2012
    ....
  14. pmc Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:101-11. 2010
    ..This supports the hypothesis of an abnormal glutamatergic neurotransmission in the right cerebellum in the pathophysiology of schizophrenia...
  15. ncbi request reprint Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:513-7. 2005
    ..Results showed no significant differences between diagnostic groups with respect to the dependent variables, supporting the view that there is no primary alteration of hippocampal gray matter in schizophrenia...
  16. doi request reprint Differential working memory performance as support for the Kraepelinian dichotomy between schizophrenia and bipolar disorder? An experimental neuropsychological study using circuit-specific working memory tasks
    David Zilles
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    World J Biol Psychiatry 14:258-67. 2013
    ..In this study we aimed to further clarify the diagnostic specificity of working memory deficits in schizophrenia and bipolar disorder...
  17. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  18. ncbi request reprint Evidence for specific cognitive deficits in visual information processing in patients with OCD compared to patients with unipolar depression
    Friederike Rampacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, DE 53105 Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:984-91. 2010
    ..As yet, it has not been substantiated whether deficits in visual organization and complex visual memory are also specific to OCD and are not shared by MDD...
  19. ncbi request reprint Volumes of association thalamic nuclei in schizophrenia: a postmortem study
    Peter Danos
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Schizophr Res 60:141-55. 2003
    ..However, the findings of a substantial volume reduction of the THAL suggest that the volumes of additional thalamic nuclei may be also reduced in schizophrenia...
  20. doi request reprint The hippocampus in families with schizophrenia in relation to obstetric complications
    Florian Ebner
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Res 104:71-8. 2008
    ..The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications...
  21. doi request reprint Hippocampal plasticity in response to exercise in schizophrenia
    Frank Gerald Pajonk
    Department of Psychiatry, The Saarland University Hospital, Homburg, Germany
    Arch Gen Psychiatry 67:133-43. 2010
    ..Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal plasticity...
  22. doi request reprint Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 11:243-50. 2010
    ..However, our study sample was small and results of this exploratory study should be verified in a larger sample...
  23. doi request reprint A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires
    Esther K Diekhof
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Goettingen, Germany
    Brain Res 1473:63-77. 2012
    ..Together, these findings support the view of a sexual dimorphism that manifested in the recruitment of gender-specific neural resources during the successful deployment of self-control...
  24. pmc The role of the cerebellum in schizophrenia: from cognition to molecular pathways
    Peyman Yeganeh-Doost
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Clinics (Sao Paulo) 66:71-7. 2011
    ..We discuss the molecular findings in the light of the role of the cerebellum in attention and cognitive deficits in schizophrenia...
  25. doi request reprint The orbitofrontal cortex and its role in the assignment of behavioural significance
    Esther Kristina Diekhof
    Department of Psychiatry, Georg August University, Goettingen, Germany
    Neuropsychologia 49:984-91. 2011
    ..Our findings thus further underscore the putative role of the OFC in the prioritisation of attentional selection and behavioural control...
  26. ncbi request reprint Hippocampal deformities in the unaffected siblings of schizophrenia subjects
    Ralf Tepest
    Department of Psychiatry RT, University of Bonn Medical Center, Bonn, Germany
    Biol Psychiatry 54:1234-40. 2003
    ..The objective of this study was to further elucidate hippocampal deformities as a marker of genetic vulnerability for schizophrenia...
  27. ncbi request reprint Altered cholesterol metabolism in APP695-transfected neuroblastoma cells
    Oliver Wirths
    Department of Psychiatry, Section Neurobiology, University of Goettingen, Von Siebold Str 5, D 37075 Goettingen, Germany
    Brain Res 1152:209-14. 2007
    ....
  28. ncbi request reprint Dynamic interactions between neural systems underlying different components of verbal working memory
    O Gruber
    Department of Psychiatry, Saarland University, Homburg, Germany
    J Neural Transm 114:1047-50. 2007
    ..These activations showed a negative functional coupling with anatomically connected brain regions subserving the non-articulatory maintenance of phonological information, i.e. the "inner ear"...
  29. pmc A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression
    Oliver Gruber
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:179-84. 2011
    ..As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients...
  30. ncbi request reprint Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:519-23. 2005
    ....
  31. ncbi request reprint Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia
    Kai Vogeley
    Research Center Juelich, Institute of Medicine, 52425 Juelich, Germany
    Schizophr Res 62:133-40. 2003
    ..The described automated image analysis method providing cytoarchitectonic profiles can be applied as a fast and observer-independent scanning tool to detect cytoarchitectonic abnormalities in multiple brain regions...
  32. ncbi request reprint S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 264:311-6. 2014
    ..This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology...
  33. ncbi request reprint Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression
    Svenja C Schulze-Rauschenbach
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Br J Psychiatry 186:410-6. 2005
    ....
  34. ncbi request reprint The ventral lateral posterior nucleus of the thalamus in schizophrenia: a post-mortem study
    Peter Danos
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Psychiatry Res 114:1-9. 2002
    ..The present results suggest that the total neuron number of the left VLp is reduced in the schizophrenia group, which may reflect disturbed cerebello-thalamocortical and basal ganglia-thalamocortical circuits in this disease...
  35. doi request reprint Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
    Gerald Stober
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 10:127-55. 2009
    ....
  36. ncbi request reprint Trait characteristic of impaired visuomotor integration during Trail-Making Test B performance in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Neuropsychobiology 48:59-67. 2003
    ..Thus, the abnormalities in the process of TMT-B performance proved to be reliable and stable trait characteristics in schizophrenia...
  37. doi request reprint The power of imagination--how anticipatory mental imagery alters perceptual processing of fearful facial expressions
    Esther K Diekhof
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Goettingen, Germany
    Neuroimage 54:1703-14. 2011
    ..Anticipatory mental imagery may thus represent an effective antecedent strategy through which emotional perception can be significantly altered...
  38. pmc Is brain banking of psychiatric cases valuable for neurobiological research?
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Germany
    Clinics (Sao Paulo) 63:255-66. 2008
    ....
  39. ncbi request reprint The dichotomy of schizophrenia and affective disorders in extended pedigrees
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Schizophr Res 57:259-66. 2002
    ..In relatives, the risk of schizophrenia was maximal in absence of a family history of affective disorder. This constellation holds true even if only families of index cases without any affective syndrome during lifetime are considered...
  40. ncbi request reprint Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  41. doi request reprint [Legal aspects of delegation and reorganisation of medical services in the psychiatric field]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S1-7. 2011
    ..The present paper outlines the legal, organisational and health policy aspects of delegation and the reorganisation of medical activities in the field of psychiatry...
  42. ncbi request reprint Brain mechanisms associated with background monitoring of the environment for potentially significant sensory events
    Oliver Gruber
    Department of Psychiatry, Georg August University, Goettingen, Germany
    Brain Cogn 69:559-64. 2009
    ..This fronto-parietal network may thus play an important role in adaptive responding to potentially significant events outside the current focus of attention...
  43. ncbi request reprint Alexithymia in obsessive-compulsive disorder - results from a family study
    Hans Joergen Grabe
    Department of Psychiatry, University of Greifswald, Greifswald, Germany
    Psychother Psychosom 75:312-8. 2006
    ..This study investigates the hypotheses of an elevated level of alexithymia in subjects with OCD and their first-degree relatives compared to controls and their first-degree relatives...
  44. ncbi request reprint Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, University of the Saarland, 66421 Homburg Saar, Germany
    Exp Gerontol 41:220-4. 2006
    ..Furthermore, statistical analysis revealed a significant negative correlation between plasma cholesterol and brain Abeta42 levels during aging in the mice expressing both APP and PS1...
  45. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  46. ncbi request reprint Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients
    Ute Habel
    Department of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Am J Psychiatry 161:1806-13. 2004
    ..Brain activity was measured during mood induction in patients with schizophrenia and their first-degree nonaffected relatives...
  47. ncbi request reprint Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Psychiatry Res 155:103-12. 2007
    ..Results point to a differentiation between trait and state components in cerebral dysfunctions during emotional olfactory processing in schizophrenia...
  48. doi request reprint Automated gray level index measurements reveal only minor cytoarchitectonic changes of Brodmann area 9 in schizophrenia
    Ralf Tepest
    Department of Psychiatry and Psychotherapy, University of Cologne, Köln Cologne, Germany
    Psychiatry Res 163:183-92. 2008
    ..Since increases in GLI were found only in selected layers (V and VI) of BA9, these findings do not support a generalized neuropil reduction across all cortical layers...
  49. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  50. ncbi request reprint Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
    ..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn...
  51. ncbi request reprint MRI of the brainstem in patients with major depression, bipolar affective disorder and normal controls
    Tillmann Supprian
    Dept of Psychiatry, The Saarland University Hospital, D 66421 Homburg Saar, Germany
    Psychiatry Res 131:269-76. 2004
    ..This finding needs to be replicated in a larger sample with more elaborated MRI techniques (multi-echo sequences) for the determination of T2-relaxation times...
  52. ncbi request reprint Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms
    Andrea Schmitt
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 80:305-13. 2005
    ..Correlations point to the impact of S100B in neuroplasticity and ageing. Post-mortem studies should clarify the presence of altered S100B function in the brain and its relationship to neuroplastic or neurodegenerative processes...
  53. ncbi request reprint Hippocampal complexin proteins and cognitive dysfunction in schizophrenia
    Ken Sawada
    Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
    Arch Gen Psychiatry 62:263-72. 2005
    ..A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II...
  54. ncbi request reprint Developmental abnormalities of the hippocampus in first-episode schizophrenia
    Geoffrey N Smith
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Psychiatry 53:555-61. 2003
    ..The primary purpose of this study was to determine if hippocampal fissures are evident in schizophrenia. A second goal was to assess the association between HF size and premorbid and clinical features of the illness...
  55. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  56. ncbi request reprint Cardiac risk of psychotropic drugs
    David Ames
    Aust N Z J Psychiatry 36:819-20. 2002
  57. ncbi request reprint [Volumetric analysis of gray matter, white matter and cerebrospinal fluid space in schizophrenia]
    Nadja Maric
    Institute of Psychiatry, Clinical Center of Serbia, Belgrade
    Srp Arh Celok Lek 131:26-30. 2003
    ..It was suggested that neuropil reduction i.e. synaptic and dendritic changes were to induce functional abnormalities and the expression of schizophrenia...
  58. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  59. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 6:132-91. 2005
    ....
  60. ncbi request reprint Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses...
  61. ncbi request reprint Obsessive-compulsive disorder and posttraumatic stress disorder
    Hans Joergen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
    Psychopathology 41:129-34. 2008
    ..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD...
  62. doi request reprint Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review
    Mirko Bibl
    Klinik fur Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universitat Duisburg Essen, Essen, Germany
    Dement Geriatr Cogn Disord 25:256-65. 2008
    ..The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (Abeta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD)...
  63. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  64. ncbi request reprint Limitations of current therapies: why do patients switch therapies?
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    Eur Neuropsychopharmacol 18:S135-9. 2008
    ....
  65. pmc Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1181-7. 2008
    ..Despite a number of findings supporting the hypothesis of environmental Cu modulating AD, our results demonstrate that oral Cu intake has neither a detrimental nor a promoting effect on the progression of AD...
  66. ncbi request reprint Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression
    Iris Bertram
    Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:147-56. 2007
    ..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia...
  67. ncbi request reprint Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
    Oliver Gruber
    Cognitive Neuroscience Unit, Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    Neurosci Lett 405:24-8. 2006
    ..The findings provide first evidence that dysfunction of a brain system subserving articulatory rehearsal could represent a biological marker which differentiates between schizophrenia and schizoaffective disorder...
  68. ncbi request reprint Effects of antipsychotics on brain structure
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany
    Curr Opin Psychiatry 19:145-50. 2006
    ..This review highlights the recent findings of different effects of typical and atypical antipsychotics on brain structure...
  69. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 7:5-40. 2006
    ....
  70. ncbi request reprint Clozapine alone versus clozapine and risperidone with refractory schizophrenia
    William G Honer
    Centre for Complex Disorders and the Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
    N Engl J Med 354:472-82. 2006
    ..The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known...
  71. ncbi request reprint Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Cereb Cortex 12:349-56. 2002
    ..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...