Volkmar Falk

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Facilitated MIDCAB using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 79:691-3. 2005
  2. ncbi request reprint Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
  3. ncbi request reprint Developments in robotic cardiac surgery
    V Falk
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Curr Opin Cardiol 15:378-87. 2000
  4. ncbi request reprint Robotic coronary artery bypass grafting (CABG)--the Leipzig experience
    Volkmar Falk
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Surg Clin North Am 83:1381-6, ix. 2003
  5. doi request reprint New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
  6. ncbi request reprint Facilitated endoscopic beating heart coronary artery bypass grafting using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 126:1575-9. 2003
  7. ncbi request reprint Manual control and tracking--a human factor analysis relevant for beating heart surgery
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 74:624-8. 2002
  8. ncbi request reprint Cardio navigation: planning, simulation, and augmented reality in robotic assisted endoscopic bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 79:2040-7. 2005
  9. ncbi request reprint Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury
    V Falk
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Cardiothorac Surg 22:53-8. 2002
  10. ncbi request reprint Invited commentary
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Ann Thorac Surg 82:628-9. 2006

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Facilitated MIDCAB using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 79:691-3. 2005
    ..Postoperative angiogram demonstrated excellent patency and flow...
  2. ncbi request reprint Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
    ..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF...
  3. ncbi request reprint Developments in robotic cardiac surgery
    V Falk
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Curr Opin Cardiol 15:378-87. 2000
    ..Further refinements in telemanipulator technology as well as integration of image-based navigation systems may expand the use of computer-enhanced instrumentation systems in the near future...
  4. ncbi request reprint Robotic coronary artery bypass grafting (CABG)--the Leipzig experience
    Volkmar Falk
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Surg Clin North Am 83:1381-6, ix. 2003
    ..The development of anastomotic devices, and further refinements in telemanipulator technology, optical systems, and image-guided augmented-reality scenarios will greatly facilitate endoscopic bypass grafting in the future...
  5. doi request reprint New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  6. ncbi request reprint Facilitated endoscopic beating heart coronary artery bypass grafting using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 126:1575-9. 2003
    ..The potential benefits of the endoscopic Magnetic Vascular Positioner device (Ventrica, Inc, Fremont, Calif) to facilitate construction of a coronary anastomosis in a closed chest environment were evaluated...
  7. ncbi request reprint Manual control and tracking--a human factor analysis relevant for beating heart surgery
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 74:624-8. 2002
    ..This review provides a brief analysis of factors that are relevant for targeted motions. Knowing and accepting the limitations of human performance may help to optimize performance in off-pump surgery...
  8. ncbi request reprint Cardio navigation: planning, simulation, and augmented reality in robotic assisted endoscopic bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 79:2040-7. 2005
    ..The aim of this study is to optimize the set-up and port placement in robotic surgery and enhance intraoperative orientation by video overlay of the angiographic coronary tree...
  9. ncbi request reprint Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury
    V Falk
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Cardiothorac Surg 22:53-8. 2002
    ..Metalloproteinases (MMPs) regulate extracellular matrix turnover and degrade basal lamina. Aim of the study was to examine the regulation of MMPs and the effect of an MMP inhibitor in transplant related ischemia/reperfusion injury...
  10. ncbi request reprint Invited commentary
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Ann Thorac Surg 82:628-9. 2006
  11. ncbi request reprint Anastomotic devices for coronary artery bypass grafting
    Volkmar Falk
    Universität Leipzig Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Expert Rev Med Devices 2:223-33. 2005
    ..This review collects the available preclinical and clinical data for some of the devices, with special regard as to surgical outcome, patency rate and the need for additional perioperative anticoagulation treatment...
  12. ncbi request reprint Influence of three-dimensional vision on surgical telemanipulator performance
    V Falk
    Department of Cardiothoracic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    Surg Endosc 15:1282-8. 2001
    ..Different viewing conditions (two- and three-dimensional National Television Standard Committee [2D-NTSC and 3D-NTSC] and two-dimensional high-definition television [2D-HDTV]) on telemanipulator performance were evaluated...
  13. ncbi request reprint Endoscopic coronary artery bypass grafting on the beating heart using a computer enhanced telemanipulation system
    V Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Heart Surg Forum 2:199-205. 1999
    ..To develop a technique for computer enhanced endoscopic arterial bypass grafting on the beating heart in an experimental canine model...
  14. ncbi request reprint [Arterial revascularization of coronary vessels]
    Volkmar Falk
    Klinik fur Herzchirurgie, Herzzentrum Leipzig
    Herz 27:426-34. 2002
    ..Recent studies have also demonstrated a survival benefit of double over single ITA graft use. Especially in younger patients bilateral ITA grafting is recommended...
  15. doi request reprint Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  16. doi request reprint Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement
    Jörg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany
    Eur Heart J 29:2382-7. 2008
    ..This study was designed to evaluate the feasibility and haemodynamic performance of transcatheter valve-in-a-valve (VinV) implantation for failed mitral xenografts using a minimally invasive, transatrial, off-pump approach...
  17. doi request reprint Is chronic total coronary occlusion a risk factor for long-term outcome after minimally invasive bypass grafting of the left anterior descending artery?
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 89:1496-501. 2010
    ..It is unclear whether CTO is also a negative predictor for long-term outcome in minimally invasive bypass grafting...
  18. doi request reprint Minimally invasive hybrid coronary artery revascularization
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1856-60. 2008
    ..Here we report the short- and long-term results of a minimally invasive hybrid approach in 117 patients...
  19. ncbi request reprint Predictors of delirium after cardiac surgery delirium: effect of beating-heart (off-pump) surgery
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 127:57-64. 2004
    ..Despite improved outcomes after cardiac operations, postoperative delirium remains a common complication that is associated with increased morbidity and prolonged hospital stay...
  20. ncbi request reprint Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation
    Thomas Walther
    Klinik fur Herzchirurgie, Leipzig, Germany
    J Am Coll Cardiol 50:56-60. 2007
    ..This study sought to evaluate the feasibility of minimally invasive transapical repeat valve-in-a-valve (VinV) implantation...
  21. ncbi request reprint Prospectively randomized evaluation of stented xenograft hemodynamic function in the aortic position
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Germany
    Circulation 110:II74-8. 2004
    ..Standard stented aortic xenograft valves have not yet been compared regarding their hemodynamic function using a stratified intraoperative randomization protocol...
  22. ncbi request reprint Mid-term results after Epic xenograft implantation for aortic, mitral, and double valve replacement
    Sven Lehmann
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Heart Valve Dis 16:641-8; discussion 648. 2007
    ..The study aim was to evaluate the mid-term results after implantation of the stented porcine xenograft (Epic valve with Linx anticalcification treatment) in elderly patients...
  23. doi request reprint Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair
    Joerg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 35:965-9; discussion 969. 2009
    ....
  24. doi request reprint Distal aortic reinterventions after root surgery in Marfan patients
    Evaldas Girdauskas
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1815-9. 2008
    ..Distal aortic disease may evolve in Marfan patients after aortic root surgery. The aim of this study was to analyze the results of distal aortic reoperations in Marfan patients after proximal aortic surgery...
  25. doi request reprint Aortic valve replacement in octogenarians: utility of risk stratification with EuroSCORE
    Sergey Leontyev
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 87:1440-5. 2009
    ..We evaluated characteristics and outcomes of elderly patients undergoing isolated AVR with a particular focus on the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk stratification...
  26. ncbi request reprint Augmented reality for intraoperative guidance in endoscopic coronary artery bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Surg Technol Int 14:231-5. 2005
    ..Qualitative and quantitative analysis demonstrate the potential value during total endoscopic coronary artery bypass grafting...
  27. doi request reprint Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  28. doi request reprint Minimal invasive mitral valve repair for mitral regurgitation: results of 1339 consecutive patients
    Joerg Seeburger
    Department of Cardiac Surgery, Heartcenter, Leipzig University, Struempelstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 34:760-5. 2008
    ..Some have expressed concern that minimal invasive mitral valve (MV) repair may not meet the standard of open surgical techniques. We therefore reviewed our results for minimal invasive MV repair for mitral regurgitation (MR)...
  29. doi request reprint Eight-year follow-up after prospectively randomized implantation of different mechanical aortic valves
    Sven Lehmann
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Struempellstr 39, 04289 Leipzig, Germany
    Clin Res Cardiol 97:376-82. 2008
    ..The aim of this prospectively randomized study was to evaluate the hemodynamic and functional outcomes after aortic valve replacement with three different bileaflet mechanical valves...
  30. doi request reprint Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial
    Evaldas Girdauskas
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 140:1117-24.e2. 2010
    ..In a randomized clinical trial, we evaluated effects of thromboelastometrically guided algorithm on transfusion requirements...
  31. doi request reprint Transapical aortic valve implantation in patients requiring redo surgery
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 36:231-4; discussion 234-5. 2009
    ..To evaluate the results of minimally invasive transapical aortic valve implantation (TA-AVI) in patients requiring redo surgery...
  32. ncbi request reprint Midterm results after stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Circulation 108:II85-9. 2003
    ..To analyze the midterm clinical results after stentless mitral valve (SMV) replacement...
  33. ncbi request reprint [Off-pump coronary artery bypass grafting. State of the art 2006 and results in comparison with conventional coronary artery bypass strategies]
    Ardawan Julian Rastan
    Klinik fur Herzchirurgie, Herzzentrum Leipzig, Universitat Leipzig, Leipzig
    Herz 31:384-95. 2006
    ....
  34. ncbi request reprint Emergency coronary artery bypass graft surgery for acute coronary syndrome: beating heart versus conventional cardioplegic cardiac arrest strategies
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Circulation 114:I477-85. 2006
    ..Aim of this study was to compare the outcome of beating heart versus conventional coronary artery bypass graft (CABG) strategies in acute coronary syndromes for emergency indications...
  35. doi request reprint Is the SYNTAX score a predictor of long-term outcome after coronary artery bypass surgery?
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Heart Surg Forum 13:E143-8. 2010
    ..Although a high SYNTAX score is indicative of a worse long-term outcome after percutaneous coronary intervention (PCI), it remains unclear whether it is also true for coronary artery bypass grafting (CABG)...
  36. ncbi request reprint Clinical experience with stentless mitral valve replacement
    Friedrich W Mohr
    Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:772-5. 2005
    ..Our aim is to describe the clinical experience with stentless mitral valve (SMV) replacement with special focus on the functionality of the SMV...
  37. doi request reprint How does the use of polytetrafluoroethylene neochordae for posterior mitral valve prolapse (loop technique) compare with leaflet resection? A prospective randomized trial
    Volkmar Falk
    Heart Center Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 136:1205; discussion 1205-6. 2008
    ..The aim of this prospectively randomized trial was to determine how preservation of leaflet structure in combination with premeasured neochordae compares with the widely adopted technique of leaflet resection...
  38. ncbi request reprint Reverse remodeling of cardiac collagen protein expression after surgical therapy for experimental aortic stenosis
    Thomas Walther
    University of Leipzig, Heart Center, Clinic for Heart Surgery, Leipzig, Germany
    J Heart Valve Dis 15:651-6. 2006
    ..Reversal of myocardial collagen gene expression was examined in parallel to left ventricular reverse remodeling after surgical correction of experimental aortic stenosis...
  39. ncbi request reprint Six-month angiographic follow-up of the PAS-Port II clinical trial
    Jan F Gummert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 81:90-6. 2006
    ..The PAS-Port device (Cardica, Redwood City, CA) allows the rapid deployment of a clampless proximal anastomosis between a vein graft and the aorta...
  40. ncbi request reprint Early results with stentless mitral valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Heart Valve Dis 13:766-770; discussion 770-1. 2004
    ..Implantation of a chordally supported stentless mitral valve (SMV) may be the strategy of choice for patients with severe degenerative mitral valve disease. Herein, the early clinical results of this surgical technique were analyzed...
  41. doi request reprint Randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus-eluting stenting in isolated proximal left anterior descending coronary artery stenosis
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 53:2324-31. 2009
    ....
  42. ncbi request reprint Minimally invasive transapical beating heart aortic valve implantation--proof of concept
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 31:9-15. 2007
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  43. doi request reprint Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 139:302-11, 311.e1. 2010
    ..5% to 1.5% of cases. Risk factors influencing early or long-term outcome after extracorporeal membrane oxygenation implantation are not well described...
  44. doi request reprint Value of augmented reality-enhanced transesophageal echocardiography (TEE) for determining optimal annuloplasty ring size during mitral valve repair
    Joerg Ender
    Department of Anesthesiology and Intensive Care Medicine II, Leipzig Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1473-8. 2008
    ..This study compared augmented reality-enhanced three-dimensional (3D) transesophageal echocardiography (TEE) for determining MV annuloplasty size with conventional surgical sizing...
  45. ncbi request reprint Hemodynamic evaluation of stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Germany
    Artif Organs 26:847-50. 2002
    ..TEE and TTE are extremely useful to assist SMV implantation as well as for regular follow-up evaluation. The hemodynamic function after SMV implantation with preservation of the annulo-ventricular continuity is promising...
  46. doi request reprint Mitral valve surgical procedures in the elderly
    Joerg Seeburger
    Department of Cardiac Surgery, University Heart Center Leipzig, Germany
    Ann Thorac Surg 94:1999-2003. 2012
    ..We report our experience and results for MV surgical procedures in the elderly, especially with regard to the influence of comorbidities...
  47. doi request reprint Early and mid-term results of mitral valve repair using premeasured Gore-Tex loops ('loop technique')
    Thomas Kuntze
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 33:566-72. 2008
    ..Mitral valve (MV) repair with premeasured Gore-Tex loops (the 'loop technique') was introduced in 1999. We assessed the early- and mid-term outcomes for the loop technique in patients with MV prolapse...
  48. doi request reprint Minimally invasive mitral valve surgery after previous sternotomy: experience in 181 patients
    Joerg Seeburger
    Heart Center, Leipzig University, Leipzig, Germany
    Ann Thorac Surg 87:709-14. 2009
    ..This study evaluated the results for minimally invasive mitral valve (MV) surgery in patients who had undergone previous cardiac operations through a sternotomy...
  49. ncbi request reprint Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  50. ncbi request reprint [Coronary artery bypass grafting on the beating heart in high-risk patients]
    Ardawan Julian Rastan
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany
    Herz 32:483-90. 2007
    ..In conclusion, beating-heart coronary artery bypass grafting seems to be advantageous in various risk populations and should be considered for patients with more than average risks for cardiopulmonary bypass and cardioplegic arrest...
  51. doi request reprint Comparison of outcomes of minimally invasive mitral valve surgery for posterior, anterior and bileaflet prolapse
    Joerg Seeburger
    Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 36:532-8. 2009
    ..We sought to compare the outcomes of minimally invasive mitral valve (MV) surgery for anterior (anterior mitral leaflet, AML), posterior (posterior mitral leaflet, PML) or bileaflet (BL) MV prolapse...
  52. ncbi request reprint Stentless versus conventional xenograft aortic valve replacement: midterm results of a prospectively randomized trial
    Sven Lehmann
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 84:467-72. 2007
    ..The purpose of this study was to analyze the 5- to 8-year clinical results after prospectively randomized stentless versus conventional aortic valve replacement...
  53. doi request reprint Chordae replacement versus resection for repair of isolated posterior mitral leaflet prolapse: à ègalité
    Joerg Seeburger
    Heart Center, Leipzig University, Leipzig, Germany
    Ann Thorac Surg 87:1715-20. 2009
    ..The aim of this study was to assess the medium-term results of the loop technique in comparison with the widely adopted leaflet resection technique for repair of isolated PML prolapse...
  54. ncbi request reprint A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery
    Thomas Walther
    Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Thorac Cardiovasc Surg 129:359-63. 2005
    ..Reoperations are associated with an increased surgical risk due to adhesions. We prospectively evaluated a bioresorbable membrane after surgery for congenital heart defects over a 3.5-year period...
  55. ncbi request reprint On-pump versus off-pump coronary artery bypass grafting: impact on postoperative renal failure requiring renal replacement therapy
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 77:1250-6. 2004
    ..Despite refinements in perioperative patient management postoperative renal failure requiring hemofiltration or dialysis is still a common complication after coronary artery bypass grafting associated with impaired patient outcome...
  56. ncbi request reprint Restitution of sinus rhythm plus stentless mitral valve replacement at three years
    Sven Lehmann
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    J Heart Valve Dis 13:410-3. 2004
    ..The study aim was to examine results after stentless mitral valve (SMV) replacement (Quattro) and restitution of physiological cardiac rhythm by intraoperative left atrial ablation therapy...
  57. ncbi request reprint [Mid-term results after stentless mitral valve replacement. Comparison to conventional mitral valve replacement and mitral valve repair]
    Sven Lehmann
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Strumpellstrasse 39, 04289, Leipzig, Germany
    Herz 32:499-505. 2007
    ..To evaluate the clinical results after stentless (SMV) in comparison to mitral valve repair (MV-rep) and conventional mitral valve replacement (MVR) at 5 years...
  58. ncbi request reprint Stentless mitral valve replacement by conventional and minimally invasive techniques
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Surg Technol Int 14:236-40. 2005
    ..SMV implantation by way of a sternotomy or lateral minithoracotomy leads to preservation of the annulo-ventricular continuity and similar to physiological hemodynamics. However, long-term durability remains to be proven...
  59. doi request reprint Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from single center enrolment in the SYNTAX study
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center Leipzig, Struempellstrasse 39, Leipzig, Germany
    Eur J Cardiothorac Surg 34:376-82; discussion 382-3. 2008
    ....
  60. ncbi request reprint Surgical atrial septal defect closure after interventional occluder placement: incidence and outcome
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Thorac Cardiovasc Surg 134:731-7. 2007
    ..Closure of ostium secundum atrial septal defects is generally performed by using an interventional approach. We evaluated the outcome of patients requiring secondary surgical therapy...
  61. ncbi request reprint Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
    ..To evaluate initial multicenter results with minimally invasive transapical aortic valve implantation (TAP-AVI) for high risk patients with aortic stenosis...
  62. doi request reprint Does reasonable incomplete surgical revascularization affect early or long-term survival in patients with multivessel coronary artery disease receiving left internal mammary artery bypass to left anterior descending artery?
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Circulation 120:S70-7. 2009
    ....
  63. doi request reprint Human minimally invasive off-pump valve-in-a-valve implantation
    Thomas Walther
    Department of Cardiac Surgery, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 85:1072-3. 2008
    ..Hemodynamic function was excellent and the patient had a fast and uneventful recovery...
  64. ncbi request reprint Predictors of prolonged ICU stay after on-pump versus off-pump coronary artery bypass grafting
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Intensive Care Med 30:88-95. 2004
    ..To define predictors for prolonged ICU stay in order to improve patient outcome and reduce costs...
  65. ncbi request reprint Comparison of stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    Anno Diegeler
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    N Engl J Med 347:561-6. 2002
    ..Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these two procedures...
  66. ncbi request reprint Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Am Coll Cardiol 42:861-8. 2003
    ..The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF)...
  67. doi request reprint The utility of trans-catheter aortic valve replacement after commercialization: does the European experience provide a glimpse into the future use of this technology in the United States?
    Axel Linke
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Catheter Cardiovasc Interv 75:511-8. 2010
    ..Despite of the progress in this field, we are still lacking an optimal transcatheter heart valve. Once it is available, we can take the plunge to compare transcatheter valve implantation with convention surgery in severe aortic stenosis!..
  68. ncbi request reprint Exercise and the coronary circulation-alterations and adaptations in coronary artery disease
    Axel Linke
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Prog Cardiovasc Dis 48:270-84. 2006
    ....
  69. ncbi request reprint Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
    ..This analysis was conducted, to evaluate the effects of ET on left ventricular function and haemodynamics in patients with advanced CHF (NYHA class III) fulfilling the inclusion criteria of the COPERNICUS trial...
  70. ncbi request reprint Effects of exercise training on mortality in patients with coronary heart disease
    Sandra Erbs
    Department of Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Coron Artery Dis 17:219-25. 2006
    ....
  71. ncbi request reprint Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  72. doi request reprint Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 30:346-55. 2009
    ..This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs)...
  73. ncbi request reprint Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  74. ncbi request reprint Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Am Heart J 145:E3. 2003
    ..The aim of this consecutive study was to assess whether a home-based exercise program with reduced average training duration can sustain previously achieved effects on coronary endothelial function...
  75. ncbi request reprint Five years of less invasive mitral valve surgery: from experimental to routine approach
    Joerg Friedrich Onnasch
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Heart Surg Forum 5:132-5. 2002
    ..In the last five years, mitral valve surgery has changed fundamentally. This study reviews our experience in less invasive mitral valve surgery (LIMS) during that time...
  76. doi request reprint Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  77. doi request reprint Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training
    Volker Adams
    Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:293-9. 2008
    ..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx...
  78. ncbi request reprint Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
    Rainer Hambrecht
    University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
    J Am Coll Cardiol 39:1175-81. 2002
    ..We sought to assess the role of insulin-like growth factor-I (IGF-I) in muscle wasting in chronic heart failure (CHF), serum concentrations and local muscular IGF-I expression were determined in patients with severe CHF...
  79. doi request reprint How to improve endothelial repair mechanisms: the lifestyle approach
    Sven Mobius-Winkler
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Expert Rev Cardiovasc Ther 8:573-80. 2010
    ..This review focuses on lifestyle interventions to correct endothelial dysfunction in different cardiovascular diseases...
  80. doi request reprint Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  81. ncbi request reprint Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase
    Volker Adams
    Clinic of Cardiology, Leipzig Heart Center, University Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:273-7. 2003
    ..The aim of this study was to assess whether NF-kappaB is activated in skeletal muscle of patients with CHF and linked to the expression of iNOS...
  82. doi request reprint Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 55:2201-9. 2010
    ....
  83. doi request reprint Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....
  84. doi request reprint Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Circulation 121:759-67. 2010
    ..Regular exercise training (ET) slows the progression of atherosclerotic lesions, reduces oxidative stress, and increases nitric oxide bioavailability, all of which may be expected to improve degenerative aortic valve disease...
  85. ncbi request reprint Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study
    Volker Adams
    University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
    Cardiovasc Res 54:95-104. 2002
    ..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression...
  86. doi request reprint Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners
    Volker Adams
    Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:602-7. 2008
    ..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners...
  87. doi request reprint Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model
    Karsten Lenk
    Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur J Heart Fail 11:342-8. 2009
    ..This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha)...
  88. ncbi request reprint Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Am Heart J 146:280-5. 2003
    ..It remains unclear, however, whether the degree of endothelial dysfunction caused by oxidative stress differs between CAD and CHF because of ischemic (ICM) or dilated cardiomyopathy (DCM)...
  89. doi request reprint Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice
    Volker Adams
    Heart Center Leipzig, University Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    J Mol Biol 384:48-59. 2008
    ..However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known...
  90. doi request reprint Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease
    Claudia Walther
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:107-12. 2008
    ..We investigated the impact of 2 years regular ET versus percutaneous intervention (PCI) on chronic inflammation and cardiovascular events...
  91. ncbi request reprint Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 28:1433-9. 2007
    ..Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations...
  92. ncbi request reprint Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
    ..The aim of this study was to investigate morphological, functional and electromyographical parameters of the skeletal muscle in CHF...
  93. ncbi request reprint Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  94. ncbi request reprint Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
    ..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF...
  95. ncbi request reprint Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infa
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Circulation 116:366-74. 2007
    ....
  96. ncbi request reprint Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
    ..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF...
  97. ncbi request reprint Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
    ..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha...
  98. ncbi request reprint Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  99. ncbi request reprint Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
    ..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)...
  100. ncbi request reprint Effects of exercise training upon endothelial function in patients with cardiovascular disease
    Axel Linke
    University of Leipzig, Heart Center, Department of Cardiology, Leipzig, Germany
    Front Biosci 13:424-32. 2008
    ..Given the prognostic value of endothelial function further studies are necessary to elucidate whether the ET-induced correction of vasomotion is the key mechanism responsible for the decline in mortality in patients with CVD...
  101. ncbi request reprint Experimental evaluation and early clinical results of a new low-profile bileaflet aortic valve
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Artif Organs 26:416-9. 2002
    ..2 +/- 0.4 m/s) and low pressure gradients (20 +/- 6 mm Hg) postoperatively and at 6 months follow-up. In vitro testing and early clinical results are promising; however, long-term performance has to be proven...