Affiliation: University of Freiburg
Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, et al
. Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain. Neuron. 2014;84:41-54 pubmed publisher
..These results provide a unique resource and detailed contextual data sets for the analysis of native AMPAR complexes and their role in excitatory neurotransmission. ..
Berkefeld H, Fakler B, Schulte U. Ca2+-activated K+ channels: from protein complexes to function. Physiol Rev. 2010;90:1437-59 pubmed publisher
..Finally, the results are related to their significance for the function of K(Ca) channels under cellular conditions. ..
Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, et al
. Auxiliary GABAB receptor subunits uncouple G protein ?? subunits from effector channels to induce desensitization. Neuron. 2014;82:1032-44 pubmed publisher
..Accordingly, genetic ablation of KCTD12 specifically alters GABAB responses in the brain. Our results show that GABAB receptors are endowed with fast and reversible desensitization by harnessing KCTD12 that intercepts G?? signaling. ..
Bettler B, Fakler B. Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes. Curr Opin Neurobiol. 2017;45:16-23 pubmed publisher
..We also highlight progress in unraveling the role of unexpected protein components for receptor physiology. ..
Fakler B, Adelman J. Control of K(Ca) channels by calcium nano/microdomains. Neuron. 2008;59:873-81 pubmed publisher
..The results may serve as a model for other processes operated by local Ca(2+) domains. ..
Boudkkazi S, Brechet A, Schwenk J, Fakler B. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron. 2014;82:848-58 pubmed publisher
..These results identify CNIH2 as the molecular distinction between slow and fast EPSC phenotypes and show that CNIH2 influences the time course and, hence, the efficacy of excitatory synaptic transmission. ..
Constantin C, Müller C, Leitner M, Bildl W, Schulte U, Oliver D, et al
. Identification of Cav2-PKC? and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling. Proc Natl Acad Sci U S A. 2017;114:5707-5712 pubmed publisher
..Our results establish Cav2-enzyme complexes as molecular entities for fast electrochemical coupling that reliably convert brief membrane depolarization into precisely timed intracellular signaling events in the mammalian brain. ..
Schmidt N, Kollewe A, Constantin C, Henrich S, Ritzau Jost A, Bildl W, et al
. Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance. Neuron. 2017;96:827-838.e9 pubmed publisher
..Together, these results establish neuroplastin and basigin as obligatory auxiliary subunits of native PMCAs and key regulators of intracellular Ca2+ concentration. ..