Falk Fahrenholz

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
  2. ncbi request reprint Alpha-secretase as a therapeutic target
    Falk Fahrenholz
    Institute of Biochemistry, University of Mainz, Becherweg 30, 55099, Mainz, Germany
    Curr Alzheimer Res 4:412-7. 2007
  3. ncbi request reprint Alpha-secretase activation--an approach to Alzheimer's disease therapy
    Falk Fahrenholz
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    Neurodegener Dis 3:255-61. 2006
  4. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
  5. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
  6. ncbi request reprint Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Germany
    FEBS J 272:5808-20. 2005
  7. doi request reprint Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg University, Mainz, Germany
    FEBS J 277:1585-96. 2010
  8. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
  9. doi request reprint Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein
    David Holthoewer
    Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 10:224-8. 2012
  10. doi request reprint Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009

Collaborators

Detail Information

Publications31

  1. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
    ..Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology...
  2. ncbi request reprint Alpha-secretase as a therapeutic target
    Falk Fahrenholz
    Institute of Biochemistry, University of Mainz, Becherweg 30, 55099, Mainz, Germany
    Curr Alzheimer Res 4:412-7. 2007
    ..Activation of the PAC1 receptor by the neuropeptide PACAP was identified as an approach for upregulation of the alpha-secretase pathway...
  3. ncbi request reprint Alpha-secretase activation--an approach to Alzheimer's disease therapy
    Falk Fahrenholz
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    Neurodegener Dis 3:255-61. 2006
    ..Our results suggest medications and dietary regiments which enhance the nonamyloidogenic pathway of APP processing to be a valuable approach to Alzheimer's disease therapy...
  4. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
    ..Our results indicate that inhibition of cholesterol biosynthesis by a low lovastatin concentration is sufficient for alpha-secretase activation...
  5. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
    ..Our findings provide evidence for a role of the neuropeptide PACAP in stimulation of the nonamyloidogenic pathway, which might be related to its neuroprotective properties...
  6. ncbi request reprint Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Germany
    FEBS J 272:5808-20. 2005
    ..Retinoic acid treatment of two neuroblastoma cell lines upregulated the expression of both APLP2 and ADAM10, thus leading to an increased release of soluble APLP2...
  7. doi request reprint Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg University, Mainz, Germany
    FEBS J 277:1585-96. 2010
    ..The present review summarizes our knowledge about the structure and function of ADAM10 and highlights the opportunities for enhancing the expression and/or activity of the alpha-secretase as a therapeutic target...
  8. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
    ..Thus, nasal application of PACAP was effective, and our results indicate that PACAP could be of therapeutic value in treating AD...
  9. doi request reprint Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein
    David Holthoewer
    Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 10:224-8. 2012
    ..Enhancement of ADAM10's gene expression may therefore present a valuable therapeutic approach for the treatment of Alzheimer's disease (AD), where Aβ peptides are severely involved in the pathogenesis...
  10. doi request reprint Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009
    ..This indicates that overexpression of ADAM10 rather influences the amount of the cellular prion protein than its processing in vivo...
  11. doi request reprint Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease
    Anja Schroeder
    Central Laboratory Animal Facility ZVTE, Johannes Gutenberg University Mainz, Mainz, Germany
    J Alzheimers Dis 16:309-14. 2009
    ..Stimulation of alpha-secretase activity might thus be a suitable approach to study treatment strategies of Alzheimer's disease...
  12. doi request reprint Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases
    Ling Zhang
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, Mainz D 55099, Germany
    J Biol Chem 283:35507-16. 2008
    ..Identification of these novel mechanisms involved in regulating the availability of cell surface-located RAGE and its soluble ectodomain may influence further research in RAGE-mediated processes in cell biology and pathophysiology...
  13. doi request reprint Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
    Frank Tippmann
    Institute of Biochemistry, University of Mainz, Becherweg 30, D 55099 Mainz, Germany
    FASEB J 23:1643-54. 2009
    ..The results of this study may have clinical relevance because acitretin has been approved for the treatment of psoriasis since 1997 and found generally safe for long-term use in humans...
  14. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    ....
  15. doi request reprint The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
    Christian Freese
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FEBS J 276:1568-80. 2009
    ..Adverse reactions of an ADAM10-based therapy of Alzheimer's disease due to neuregulin-1 cleavage are therefore unlikely...
  16. doi request reprint Retinoids as a perspective in treatment of Alzheimer's disease
    Falk Fahrenholz
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 7:190-2. 2010
    ..Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis...
  17. ncbi request reprint The non-amyloidogenic pathway: structure and function of alpha-secretases
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Subcell Biochem 38:105-27. 2005
    ..We also discuss the pharmacological up-regulation of alpha-secretases as a possible therapeutic treatment for AD...
  18. ncbi request reprint Genomic structure and functional characterization of the human ADAM10 promoter
    Claudia Prinzen
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    FASEB J 19:1522-4. 2005
    ..This finding suggests that pharmacologic targeting of RA receptors may increase the expression of the alpha-secretase ADAM10 with beneficial effects on AD pathology...
  19. ncbi request reprint Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein
    Volker Wiegand
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Germany
    FASEB J 17:782-4. 2003
    ..Our data show that NPC1 has an essential role in the distribution of plasma membrane-derived cholesterol by maintaining the small size of cholesterol-containing lipid droplets in the cell...
  20. ncbi request reprint Cholesterol as stabilizer of the oxytocin receptor
    Gerald Gimpl
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, D 55099, Mainz, Germany
    Biochim Biophys Acta 1564:384-92. 2002
    ..Moreover, in the presence of cholesterol, the oxytocin receptor is significantly more stable against alterations of pH value (pH 4-12). The results show that cholesterol acts as a general stabilizer of the oxytocin receptor...
  21. ncbi request reprint Cholesterol and steroid hormones: modulators of oxytocin receptor function
    Gerald Gimpl
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, D 55099 Mainz, Germany
    Prog Brain Res 139:43-55. 2002
    ..Non-genomic effects of progesterone and estradiol with respect to receptor signaling as well as the influence of cholesterol on signal transduction will be discussed in more detail...
  22. ncbi request reprint Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice
    Ulrich Schmitt
    Department of Psychiatry, Johannes Gutenberg University, 55101 Mainz, Germany
    Behav Brain Res 175:278-84. 2006
    ..Nevertheless, it could be concluded that both, ADAM10 and ADAM10-dn mice are suitable control mice for the assessment of alpha-secretase-related effects in animal models of Alzheimer's disease...
  23. ncbi request reprint A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin
    Angela Valeva
    Institute of Medical Microbiology and Hygiene, University of Mainz, D55101 Mainz, Germany
    J Biol Chem 279:25143-8. 2004
    ..Although many microbial toxins are activated by furin, this is the first evidence for processing by a cellular metalloproteinase. We identified ADAM-17 as a potent activator of pro-VCC...
  24. ncbi request reprint Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
    ....
  25. ncbi request reprint Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin
    Gerald Gimpl
    Institut fur Biochemie, Becherweg 30, 55099 Mainz, Germany
    Eur J Pharmacol 510:9-16. 2005
    ..Overall, the data supported the concept of a central pocket site within the oxytocin receptor...
  26. ncbi request reprint The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
    Christian Hundhausen
    Institute for Biochemistry, Christian Albrechts University, Kiel, Germany
    Blood 102:1186-95. 2003
    ..Our data demonstrate that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX3CL1-expressing cell layers...
  27. ncbi request reprint A closer look at the cholesterol sensor
    Gerald Gimpl
    Trends Biochem Sci 27:596-9. 2002
  28. pmc Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
    Claus Werner Franzke
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    EMBO J 21:5026-35. 2002
    ..Functionally, release of the ectodomain of collagen XVII from the cell surface was associated with altered keratinocyte motility in vitro...
  29. ncbi request reprint Gradient-echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I x ADAM10-dn mouse model
    Cornelius Faber
    Department of Experimental Physics 5, University of Wurzburg, Wurzburg, Germany
    Magn Reson Med 57:696-703. 2007
    ..For future detection of plaques in patients, such bright-contrast visualization protocols may be of particular value when contrast agents that allow labeling of early plaques with iron oxide nanoparticles become available...
  30. ncbi request reprint Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane
    Werner Kramer
    Aventis Pharma Deutschland GmbH, DG Metabolic Diseases, Industriepark Höchst Gebäude G 879, D 65926 Frankfurt am Main, Germany
    Biochim Biophys Acta 1633:13-26. 2003
    ....
  31. ncbi request reprint ADAM-10 over-expression increases cortical synaptogenesis
    Karen F S Bell
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Neurobiol Aging 29:554-65. 2008
    ..These results are the first to demonstrate an in vivo influence of ADAM-10 on neurotransmitter-specific cortical synaptic plasticity and further confirm the neurotrophic influence of sAPP alpha on cortical synaptogenesis...