Affiliation: University of Erlangen-Nuremberg
Fahlbusch F, Heussner K, Schmid M, Schild R, Ruebner M, Huebner H, et al
. Measurement of amniotic fluid steroids of midgestation via LC-MS/MS. J Steroid Biochem Mol Biol. 2015;152:155-60 pubmed publisher
..The determination of testosterone in amniotic fluid by LC-MS/MS in early pregnancy of healthy subjects can be used to offer a reliable prediction of fetal gender at birth. ..
Heussner K, Ruebner M, Huebner H, Rascher W, Menendez Castro C, Hartner A, et al
. Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS. Placenta. 2016;37:79-84 pubmed publisher
..Consideration of these findings is warranted when transferring results from rodent placental glucocorticoid metabolism into humans. ..
Fahlbusch F, Dawood Y, Hartner A, Menendez Castro C, Nögel S, Tzschoppe A, et al
. Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?. J Matern Fetal Neonatal Med. 2012;25:2209-15 pubmed publisher
..Fbxw8 and Cul7 expression reveals a complex regulation in trophoblastic cells. Our findings suggest that dysregulation of Cul7 and Fbxw8 expression might affect trophoblast turnover in IUGR. ..
Fahlbusch F, Ruebner M, Volkert G, Offergeld R, Hartner A, Menendez Castro C, et al
. Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts. Reprod Biol Endocrinol. 2012;10:80 pubmed publisher
..Intrauterine growth restriction (IUGR) is accompanied by an increase in placental CRH, which could be of pathophysiological relevance for the dysregulation in syncytialisation seen in IUGR placentas...
Fahlbusch F, Ruebner M, Huebner H, Volkert G, Zuern C, Thiel F, et al
. The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration. Placenta. 2013;34:1027-35 pubmed publisher
..Thus, the tumor suppressor GKN1 is expressed in placental EVT and might contribute to the regulation of EVT migration/invasion. ..
Fahlbusch F, Ruebner M, Huebner H, Volkert G, Bartunik H, Winterfeld I, et al
. Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2. Histochem Cell Biol. 2015;144:281-91 pubmed publisher
..Moreover, the specific GKN2 expression in the rodent spongiotrophoblast layer (equivalent to human EVT) might suggest an important role in EVT physiology. ..
Heussner K, Rauh M, Cordasic N, Menendez Castro C, Huebner H, Ruebner M, et al
. Adhesive blood microsampling systems for steroid measurement via LC-MS/MS in the rat. Steroids. 2017;120:1-6 pubmed publisher
..It argues for thorough analysis of chromatographic effects before the use of novel volumetric systems for steroid analysis. ..
Huebner H, Strick R, Wachter D, Kehl S, Strissel P, Schneider Stock R, et al
. Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma. J Exp Clin Cancer Res. 2017;36:165 pubmed publisher
..Based on our analysis, we hypothesize that RARRES1 might exert tumor suppressive functions in multiple cellular processes (e.g. cell cycle regulation, adhesion, invasion and apoptosis). ..
Marek I, Volkert G, Jahn A, Fahlbusch F, Zürn C, Ozcan Z, et al
. Lack of ?8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. BMC Cell Biol. 2010;11:102 pubmed publisher
..This could result in glomerular changes in ?8 integrin-deficient mice, while the vasculature is not affected in these mice. ..