Oliver T Fackler

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. Baldauf H, Stegmann L, Schwarz S, Ambiel I, Trotard M, Martin M, et al. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017;114:2729-2734 pubmed publisher
    ..These results indicate that Vpx, in addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level of RT that acts independently of dNTP concentrations and is specific to resting CD4 T cells. ..
  2. Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, et al. T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions. Sci Immunol. 2019;4: pubmed publisher
    ..Ca2+-regulated actin polymerization in the nucleus allows CD4+ T cells the rapid conversion of TCR signals into effector functions required for T cell help. ..
  3. Lamas Murua M, Stolp B, Kaw S, Thoma J, Tsopoulidis N, Trautz B, et al. HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. J Immunol. 2018;201:2731-2743 pubmed publisher
    ..These results thus imply the disruption of T lymphocyte polarity via its NAKC binding site as a novel mechanism by which lentiviral Nef proteins alter T lymphocyte migration in vivo. ..
  4. Haller C, Müller B, Fritz J, Lamas Murua M, Stolp B, Pujol F, et al. HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins. J Virol. 2014;88:14241-57 pubmed publisher
    ..These findings have implications for the interpretation of effects detected for these accessory gene products on individual host cell receptors and illustrate the coevolution of Nef and Vpu function. ..
  5. Chase A, Wombacher R, Fackler O. Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef. J Biol Chem. 2018;293:7824-7840 pubmed publisher
  6. Fackler O. Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor. Viruses. 2015;7:6730-8 pubmed publisher
    ..These findings establish SERINC3/5 as restrictions to HIV replication in human cells and define a novel activity for the HIV pathogenesis factor Nef. ..
  7. Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher
  8. Imle A, Abraham L, Tsopoulidis N, Hoflack B, Saksela K, Fackler O. Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio. 2015;6:e01309-15 pubmed publisher
  9. Trotard M, Tsopoulidis N, Tibroni N, Willemsen J, Binder M, Ruggieri A, et al. Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING. J Virol. 2016;90:2064-76 pubmed publisher
    ..These results establish Tzm-bl STING and Tzm-bl STING IRF3.GFP cells as a useful tool for studies of innate recognition of HIV infection. ..

More Information

Publications15

  1. Imle A, Stolp B, Böhmer V, Geyer M, Raz E, Fackler O. D186/D190 is an allele-dependent determinant of HIV-1 Nef function. Virology. 2016;498:44-56 pubmed publisher
    ..These results emphasize differences between Nef alleles regarding the functional role of individual residues and underscore the need for allele-specific structure-function analyses. ..
  2. Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, et al. The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 2017;292:13702-13713 pubmed publisher
  3. Abraham L, Fackler O. HIV-1 Nef: a multifaceted modulator of T cell receptor signaling. Cell Commun Signal. 2012;10:39 pubmed publisher
    ..We also discuss the implications of these alterations in the context of HIV-1 infection and in light of current concepts of TCR signal transduction. ..
  4. Pujol F, Laketa V, Schmidt F, Mukenhirn M, Müller B, Boulant S, et al. HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites. J Virol. 2016;90:6709-6723 pubmed publisher
    ..These results refine our understanding of the molecular mechanisms of CD317/tetherin antagonism and suggest complexes of Vpu with the restriction factor and AP-1 as targets for potential therapeutic intervention. ..
  5. Trautz B, Pierini V, Wombacher R, Stolp B, Chase A, Pizzato M, et al. The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor. J Virol. 2016;90:10915-10927 pubmed publisher
    ..These results suggest that the antagonism of HIV-1 Nef to SERINC5 restriction of virion infectivity is mediated by a dual mechanism that is related to CD4 downregulation. ..
  6. Fackler O, Grosse R. Cell motility through plasma membrane blebbing. J Cell Biol. 2008;181:879-84 pubmed publisher
    ..The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction...