Genomes and Genes


Michael Ewers


Affiliation: University of Munich
Country: Germany


  1. Suárez Calvet M, Kleinberger G, Araque Caballero M, Brendel M, Rominger A, Alcolea D, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Mol Med. 2016;8:466-76 pubmed publisher
    ..Our data demonstrate that CSF sTREM2 levels are increased in the early symptomatic phase of AD, probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration. ..
  2. Franzmeier N, Ren J, Damm A, Monté Rubio G, Boada M, Ruiz A, et al. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Mol Psychiatry. 2019;: pubmed publisher
    ..Together these results suggest that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment. ..
  3. Taylor A, Kambeitz Ilankovic L, Gesierich B, Simon Vermot L, Franzmeier N, Araque Caballero M, et al. Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease. Alzheimers Dement. 2017;13:225-235 pubmed publisher
    ..High fiber tract WMH burden is associated with reduced FC in connected areas, thus adding to the effects of amyloid pathology on neuronal network function. ..
  4. Zhang Y, Simon Vermot L, Araque Caballero M, Gesierich B, Taylor A, Duering M, et al. Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI. Neurobiol Aging. 2016;45:43-49 pubmed publisher
    ..In conclusion, increased parahippocampal-prefrontal FC is predictive of impaired episodic memory in aMCI and may reflect a dysfunctional change within the episodic memory-related neural network. ..
  5. Ewers M, Mattsson N, Minthon L, Molinuevo J, Antonell A, Popp J, et al. CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study. Alzheimers Dement. 2015;11:1306-15 pubmed publisher
    ..CSF Aβ1-42 discriminates AD dementia from FTD, but shows significant overlap with other non-AD forms of dementia, possibly reflecting the underlying mixed pathologies. ..
  6. Franzmeier N, Buerger K, Teipel S, Stern Y, Dichgans M, Ewers M. Cognitive reserve moderates the association between functional network anti-correlations and memory in MCI. Neurobiol Aging. 2017;50:152-162 pubmed publisher
    ..In conclusion, lower DAN-DMN cross-talk is associated with lower memory in aMCI, where such effects are buffered by higher CR. ..
  7. Franzmeier N, Hartmann J, Taylor A, Araque Caballero M, Simon Vermot L, Kambeitz Ilankovic L, et al. The left frontal cortex supports reserve in aging by enhancing functional network efficiency. Alzheimers Res Ther. 2018;10:28 pubmed publisher
    ..The present results suggest that higher education-related LFC connectivity to key memory networks during a memory task is associated with higher network efficiency and thus enhanced reserve of memory abilities in aging. ..