Hugo Murua Escobar

Summary

Affiliation: University of Veterinary Medicine Hannover
Location: Hannover, Germany
Publications:
Willenbrock S, Braun O, Baumgart J, Lange S, Junghanß C, Heisterkamp A, Nolte I, Bullerdiek J, Murua Escobar H.
TNF-α stimulation triggers release of high mobility group box 1 (HMGB1) protein in mammary cells (MTH53A) of epithelial origin.
Cytokine, 2011 Dec 6. [Epub ahead of print]

Durán MC, Willenbrock S, Barchanski A, Müller JM, Maiolini A, Soller JT, Barcikowski S, Nolte I, Feige K, Murua Escobar H.
Comparison of nanoparticle-mediated transfection methods for DNA expression plasmids – efficiency and cytotoxicity
J Nanobiotechnol. 2011 Oct 20;9:47

Sterenczak KA, Kleinschmidt S, Wefstaedt P, Eberle N, Hewicker-Trautwein M, Bullerdiek J, Nolte I, Murua Escobar H.
Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (Malignant Histiocytosis)
Anticancer Res. 2011; 31(5):1541-8

Reimann-Berg N, Murua Escobar H, Kiefer Y, Mischke R, Willenbrock S, Eberle N, Nolte I, Bullerdiek J.
Cytogenetic analysis of CpG-oligonucleotide DSP30 plus interleukin-2 stimulated canine B-cell-lymphoma cells reveals the loss of one X chromosome as sole abnormality
Cytogenet Genome Res. 2011 Jul 28. [Epub ahead of print]



Fitting J, Killian D, Junghanss C, Willenbrock S, Murua Escobar H, Lange S, Nolte I, Barth S, Tur MK.
Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology.
Vet Comp Oncol. 2011 Sep; 9(3):183-9

Reimann-Berg N, Willenbrock S, Murua Escobar H, Eberle N, Gerhauser I, Mischke R, Bullerdiek J, Nolte I.
Two new cases of polysomy 13 in canine prostate cancer.
Cytogenet Genome Res. 2011; 132(1-2):16-21

Sterenczak KA, Joetzke A, Willenbrock S, Eberle N, Lange S, Junghanss C, Nolte I, Bullerdiek J, Simon D, Murua Escobar H.
Expression of the high mobility group B1 (HMGB1) and receptor for advanced glycation end products (RAGE) in canine lymphoma.
Anticancer Res. 2010; 30(12):5043-8

Joetzke AE, Sterenczak KA, Eberle N, Wagner S, Soller JT, Nolte I, Bullerdiek J, Murua Escobar H, Simon D.
Expression of the high mobility group A1 (HMGA1) and A2 (HMGA2) genes in canine lymphoma: Analysis of 23 cases and comparison to control cases.
Veterinary Comparative Oncology. 2010; 8(2):87-95

Petersen S, Soller JT, Wagner S, Richter A, Bullerdiek J, Nolte I, Barcikowski S, Murua Escobar H.
Co-transfection of plasmid DNA and laser generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein.
Journal of Nanobiotechnology 2009; 24;7:6



Sterenczak KA, Willenbrock S, Barann M, Klemke M, Soller JT, Eberle N, Nolte I, Bullerdiek J, Murua Escobar H.
Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms.
Gene. 2009; 1;434(1-2):35-42.

Richter A, Hauschild G, Murua Escobar H, Nolte I, Bullerdiek J.
Application of High-mobility-group-A (HMGA) proteins increases the proliferative activity of chondrocytes in vitro.
Tissue Eng Part A. 2009; 15(3):473-7.

Fork M, Murua Escobar H, Soller JT, Sterenczak KA, Willenbrock S, Reimann-Berg N, Winkler S, Dorsch M, Hedrich HJ, Bullerdiek J, Nolte I.
Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258.
BMC Cancer. 2008; 15;8:240.

Altmann S, Lange S, Pommerencke J, Murua Escobar H, Bullerdiek J, Nolte I, Freund M, Junghanss C.
High Mobility Group Box 1-Protein expression in canine haematopoietic cells and influence on canine peripheral blood mononuclear cell proliferative activity.
Vet Immunol Immunopathol. 2008; 15;126(3-4):367-72.

Beuing C, Soller JT, Muth M, Wagner S, Dolf G, Schelling C, Richter A, Willenbrock S, Reimann-Berg N, Winkler S, Nolte I, Bullerdiek J, Murua Escobar. H
Genomic Characterisation, Chromosomal Assignment and in vivo Localisation of the Canine High Mobility Group A1 (HMGA1) Gene.
BMC Genet. 2008; 23;9(1):49

Soller JT, Beuing C, Murua Escobar H, Winkler S, Reimann-Berg N, Drieschner N, Dolf G, Schelling C, Nolte I, Bullerdiek J.
Chromosomal assignment of canine THADA gene to CFA 10q25.
Mol Cytogenet. 2008; 3;1(1):11



Reimann-Berg N, Murua Escobar H, Nolte I, Bullerdiek J.
Testicular tumor in an XXY dog.
Cancer Genet Cytogenet. 2008; 183(2):114-6.

Baumgart J, Bintig W, Ngezahayo A, Willenbrock S, Murua Escobar H, Ertmer W, Lubatschowski H, Heisterkamp A.
Quantified femtosecond laser based opto-perforation of living GFSHR-17 and MTH53 a cells.
Opt Express. 2008; 3;16(5):3021-31.

Meyer B, Krisponeit D, Junghanss C, Murua Escobar H, Bullerdiek J.
Quantitative expression analysis in peripheral blood of patients with chronic myeloid leukaemia: correlation between HMGA2 expression and white blood cell count.
Leuk Lymphoma. 2007; 48(10):2008-13.

Winkler S, Murua Escobar H, Meyer B, Simon D, Eberle N, Baumgartner W, Loeschke S, Nolte I, Bullerdiek J.
HMGA2 expression in a canine model of prostate cancer.
Cancer Genet Cytogenet. 2007; 177(2):98-102.

Soller JT, Murua-Escobar H, Willenbrock S, Janssen M, Eberle N, Bullerdiek J, Nolte I.
Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.
J Hered. 2007; 98(5):485-90. Epub 2007 Jun 15.

Jensen J, Simon D, Murua Escobar H, Soller JT, Bullerdiek J, Beelitz P, Pfister K, Nolte I.
Anaplasma phagocytophilum in dogs in Germany.
Zoonoses Public Health. 2007;54(2):94-101. Erratum in: Zoonoses Public Health. 2007; 54(3-4):169



Murua Escobar H, Soller JT, Sterenczak KA, Sperveslage JD, Schlueter C, Burchardt B, Eberle N, Fork M, Nimzyk R, Winkler S, Nolte I, Bullerdiek J.
Cloning and characterization of the canine receptor for advanced glycation end products.
Gene. 2006; 15;369:45-52.

Soller JT, Murua Escobar H, Janssen M, Fork M, Bullerdiek J, Nolte I
Cytokine Single Nucleotide Polymorphism (SNP) screening analyses in canine malignant histiocytosis
Anticancer Research 2006; 26(5A):3417-20

Winker S, Reimann-Berg N, Murua Escobar H, Höinghaus R, Eberle N, Bullerdiek J, and Nolte I
Polysomy 13 in a Canine Prostate Carcinoma Underlining its Significance in the Development of Prostate Cancer
Cancer Genet Cytogenet.2006; 169(2):154-8.

Hauke S, Leopold S, Schlueter C, Flohr AM, Murua Escobar H, Rogalla P, Bullerdiek J.
Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene.
Biochim Biophys Acta. 2005; 25;1729(1):24-31.

Murua Escobar H, Soller JT, Richter A, Meyer B, Winkler S, Bullerdiek J, Nolte I.
"Best Friends" Sharing the HMGA1 Gene: Comparison of the Human and Canine HMGA1 to Orthologous Other Species.
J Hered. 2005; 96(7):777-81.

Richter A, Murua Escobar H, Gunther K, Soller JT, Winkler S, Nolte I, Bullerdiek J.
RAS Gene Hot-Spot Mutations in Canine Neoplasias.
J Hered. 2005; 96(7):764-5.






Winkler S, Murua Escobar H, Eberle N, Reimann-Berg N, Nolte I, Bullerdiek J.
Establishment of a cell line derived from a canine prostate carcinoma with a highly rearranged karyotype.
J Hered. 2005; 96(7):782-5.

Winkler S, Murua Escobar H, Reimann-Berg N, Bullerdiek J, Nolte I.
Cytogenetic investigations in four canine lymphomas.
Anticancer Res. 2005; 25(6B):3995-8.

Murua Escobar H, Günther K, Richter A, Soller JT, Winkler S, Nolte I, Bullerdiek J
Absence of ras-gene hotspot mutations in canine fibrosarcomas and melanomas
Anticancer Res. 2004; 24(5A):3027-8.

Meyer B, Murua Escobar H, Winkler S, Richter A, Schelling C, Dolf G, Nolte I, Bullerdiek J
Molecular characterization and mapping of the canine Cyclin D1 (CCND1) gene
Anim Genet. 2004; 35(5):413

Meyer J, Murua Escobar H, Winkler S, Schelling C, Dolf G, Nolte I, Bullerdiek J
The FAS-activated serine/threonine kinase (FASTK) gene maps to canine chromosome 16
Anim Genet. 2004; 35(6):497

Murua Escobar H, Meyer J, Winkler S, Schelling C, Dolf G, Nolte I Bullerdiek J
The protein kinase B, gamma (AKT3) gene maps to canine chromosome 7
Anim Genet. 2004; 35(4):354-5

Richter A, Murua Escobar H, Günther K, Meyer B, Winkler S, Dolf G, Schelling C, Nolte I Bullerdiek J
The canine NRAS gene maps to CFA 17
Anim Genet. 2004; 35(4):355-6



Winkler S, Murua Escobar H, Günther K, Richter A, Dolf G, Schelling C, Bullerdiek J, Nolte I
The canine KRAS2 gene maps to CFA 22
Anim Genet. 2004; 35(4):350-1

Meiboom M, Murua Escobar H, Winkler S, Nolte I, Bullerdiek J
Molecular characterization and mapping of the canine KRAB zinc finger gene ZNF331
Anim Genet. 2004; 35(3):262-3

Meyer B, Murua Escobar H, Hauke S, Richter A, Winkler S, Rogalla P, Flohr AM, Bullerdiek J, Nolte I
Expression pattern of the HMGB1 gene in sarcomas of the dog
Anticancer Res. 2004; 24(2B):707-10

Goldmann T, Flohr AM, Murua Escobar H, Gerstmayer B, Janssen U, Bosio A, Loeschke S, Vollmer E, Bullerdiek J
The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues
Pathol Res Prac. 2004; 200:511-5

Murua Escobar H, Soller JT, Richter A, Meyer B, Winkler S, Flohr AM, Nolte I, Bullerdiek J.
The canine HMGA1
Gene. 2004; 14(330):93-9

Santos SE, Murua Escobar H, Sider LH, Winkler S, Aoki SM, Milazzotto MP, Campagnari F, Vannucchi CI, Bullerdiek J, Nolte I, Garcia JF.
DNA sequence, polymorphism, and mapping of luteinizing hormone receptor fragment (LHCGR) gene in Great Dane dogs
Anim Genet. 2004; 35(1):74-5

Meiboom M, Murua Escobar H, Pentimalli F, Fusco A, Belge G, Bullerdiek J.
A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas
Cytogenet Genome Res. 2003; 101(2):113-7


Murua Escobar H, Meyer B, Richter A, Becker K, Flohr AM, Bullerdiek J, Nolte I.
Molecular characterization of the canine HMGB1
Cytogenet Genome Res. 2003; 101(1):33-8

Rippe V, Drieschner N, Meiboom M, Murua Escobar H, Bonk U, Belge G,
Bullerdiek J.
Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas
Oncogene. 2003; 22(38):6111-4

Becker K, Murua Escobar H, Richter A, Meyer B, Nolte I, Bullerdiek J.
The canine HMGA1 gene maps to CFA 23.
Anim Genet. 2003; 34(1):68-9

Murua Escobar H, Becker K, Bullerdiek J, Nolte I
The canine ERBB2 gene maps to a chromosome region frequently affected by aberrations in tumors of the dog (Canis familiaris)
Cytogenet Cell Genet. 2001; 94(3-4):194-5

Publications

  1. pmc Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258
    Melani A M Fork
    Small Animal Clinic, University of Veterinary Medicine Hanover, Hanover, Germany
    BMC Cancer 8:240. 2008
  2. pmc Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein
    Svea Petersen
    Laser Zentrum Hannover e, V, Hannover, Germany
    J Nanobiotechnology 7:6. 2009
  3. doi request reprint Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology
    J Fitting
    Experimental Medicine and Immunotherapy, Department of Applied Medical Engineering, Helmholtz Institute for Biomedical Engineering, University Hospital RWTH Aachen, Aachen, Germany
    Vet Comp Oncol 9:183-95. 2011
  4. doi request reprint Testicular tumor in an XXY dog
    Nicola Reimann-Berg
    Center for Human Genetics, University of Bremen, Leobener Str ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 183:114-6. 2008
  5. ncbi request reprint HMGA2 expression in a canine model of prostate cancer
    Susanne Winkler
    Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 177:98-102. 2007
  6. ncbi request reprint Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians
    Jan T Soller
    Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, 30137 Hanover, Germany
    J Hered 98:485-90. 2007
  7. ncbi request reprint Anaplasma phagocytophilum in dogs in Germany
    J Jensen
    Small Animal Clinic, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Zoonoses Public Health 54:94-101. 2007
  8. ncbi request reprint Polysomy 13 in a canine prostate carcinoma underlining its significance in the development of prostate cancer
    Susanne Winkler
    Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 169:154-8. 2006
  9. ncbi request reprint Cloning and characterization of the canine receptor for advanced glycation end products
    Hugo Murua Escobar
    Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Gene 369:45-52. 2006
  10. pmc Chromosomal assignment of canine THADA gene to CFA 10q25
    Jan T Soller
    Centre for Human Genetics, University of Bremen, Leobener Straße ZHG, 28359 Bremen, Germany
    Mol Cytogenet 1:11. 2008

Collaborators

Detail Information

Publications41

  1. pmc Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258
    Melani A M Fork
    Small Animal Clinic, University of Veterinary Medicine Hanover, Hanover, Germany
    BMC Cancer 8:240. 2008
    ..Thus, it was the aim of the present study to determine whether the formerly established prostate carcinoma cell line CT1258 is a suitable tool for in vivo testing, and to distinguish the growth pattern of the induced tumours...
  2. pmc Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein
    Svea Petersen
    Laser Zentrum Hannover e, V, Hannover, Germany
    J Nanobiotechnology 7:6. 2009
    ..In conclusion, our data indicate that laser-generated AuNPs present a good alternative to chemically synthesized nanoparticles for use in biomedical applications...
  3. doi request reprint Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology
    J Fitting
    Experimental Medicine and Immunotherapy, Department of Applied Medical Engineering, Helmholtz Institute for Biomedical Engineering, University Hospital RWTH Aachen, Aachen, Germany
    Vet Comp Oncol 9:183-95. 2011
    ..This provides the basis for an antibody-based method for the immunological detection and manipulation of DCs and for monitoring antigen-specific immune responses...
  4. doi request reprint Testicular tumor in an XXY dog
    Nicola Reimann-Berg
    Center for Human Genetics, University of Bremen, Leobener Str ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 183:114-6. 2008
    ..In the present case, however, the dog was only 5 years old, allowing the conclusion that the XXY constitution may have promoted the early onset of testicular tumor disease...
  5. ncbi request reprint HMGA2 expression in a canine model of prostate cancer
    Susanne Winkler
    Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 177:98-102. 2007
    ..Thus, canine prostate cancer represents a spontaneously occurring model to test therapeutic effects resulting from reduced expression of HMGA2...
  6. ncbi request reprint Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians
    Jan T Soller
    Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, 30137 Hanover, Germany
    J Hered 98:485-90. 2007
    ..Additionally, based on the canine genome sequence, we derived in silico the complete mRNA structures of the IL-1alpha and IL-1beta mRNAs...
  7. ncbi request reprint Anaplasma phagocytophilum in dogs in Germany
    J Jensen
    Small Animal Clinic, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Zoonoses Public Health 54:94-101. 2007
    ..Results of this study suggest that severe illness solely caused by A. phagocytophilum may be possible although definitive evidence does not exist. Very high antibody titres (>1:1024) may be associated with clinical anaplasmosis...
  8. ncbi request reprint Polysomy 13 in a canine prostate carcinoma underlining its significance in the development of prostate cancer
    Susanne Winkler
    Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Cancer Genet Cytogenet 169:154-8. 2006
    ..Along with the known homology between canine chromosome 13 and human chromosome 8 these findings suggest that a homologous area on both chromosomes plays a crucial role in subsets of prostate cancer in both species...
  9. ncbi request reprint Cloning and characterization of the canine receptor for advanced glycation end products
    Hugo Murua Escobar
    Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Gene 369:45-52. 2006
    ..Furthermore we compared the CDS of six different canine breeds and screened them for single nucleotide polymorphisms...
  10. pmc Chromosomal assignment of canine THADA gene to CFA 10q25
    Jan T Soller
    Centre for Human Genetics, University of Bremen, Leobener Straße ZHG, 28359 Bremen, Germany
    Mol Cytogenet 1:11. 2008
    ..Ten well spread metaphases were examined indicating a signal on canine chromosome 10 on both chromatids. A detailed fine mapping was performed indicating the canine THADA gene locus on the q-arm of chromosome 10...
  11. ncbi request reprint Quantified femtosecond laser based opto-perforation of living GFSHR-17 and MTH53 a cells
    J Baumgart
    Laser Zentrum Hannover e V, Hollerithallee 8, Hannover, Germany
    Opt Express 16:3021-31. 2008
    ..Additionally, this method offers new high efficient possibilities for critical transfection approaches involving special cell types, e.g. primary and stem cells...
  12. pmc Genomic characterisation, chromosomal assignment and in vivo localisation of the canine high mobility group A1 (HMGA1) gene
    Claudia Beuing
    Clinic for Small Animals and Research Cluster of Excellence REBIRTH, University of Veterinary Medicine Hanover, Bischofsholer Damm 15, 30173 Hanover, Germany
    BMC Genet 9:49. 2008
    ..Accordingly, the canine genome was sequenced completely twice but unfortunately this could not solve the structure of canine HMGA1 gene...
  13. doi request reprint High Mobility Group Box 1-Protein expression in canine haematopoietic cells and influence on canine peripheral blood mononuclear cell proliferative activity
    S Altmann
    Division of Medicine, Department of Haematology Oncology, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Vet Immunol Immunopathol 126:367-72. 2008
    ..However, in higher concentrations HMGB1 lost its stimulative effect. In conclusion, HMGB1 is broadly expressed in canine haematopoietic cells with highest levels in haematopoietic stem cells. HMGB1 induced directly PBMC proliferation...
  14. doi request reprint Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms
    Katharina A Sterenczak
    Small Animal Clinic and Research Cluster of Excellence REBIRTH, University of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Gene 434:35-42. 2009
    ..Interestingly, the healthy and the neoplastic tissue samples showed in majority RAGE transcripts coding for the complete receptor and transcripts showing insertions of intron 1...
  15. doi request reprint Expression of the high mobility group A1 (HMGA1) and A2 (HMGA2) genes in canine lymphoma: analysis of 23 cases and comparison to control cases
    A E Joetzke
    Small Animal Clinic and Research Cluster of Excellence REBIRTH, University of Veterinary Medicine Hannover, Hannover, Germany
    Vet Comp Oncol 8:87-95. 2010
    ..The present findings indicate a role of HMGA genes in canine lymphoma. This study represents the basis for future veterinary and comparative studies dealing with their diagnostic, prognostic and therapeutic values...
  16. doi request reprint Two new cases of polysomy 13 in canine prostate cancer
    N Reimann-Berg
    Small Animal Clinic and Research Cluster REBIRTH, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover, Germany
    Cytogenet Genome Res 132:16-21. 2011
    ..As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species...
  17. ncbi request reprint Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis)
    Katharina A Sterenczak
    Small Animal Clinic, University of Veterinary Medicine Hannover, Germany
    Anticancer Res 31:1541-8. 2011
    ..Thus, deregulation of the expression of these genes could have a major effect on the progression of histiocytic disorders...
  18. ncbi request reprint Cytogenetic investigations in four canine lymphomas
    Susanne Winkler
    Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Anticancer Res 25:3995-8. 2005
    ..Case four showed a single trisomy 2. Comparing these results with human hematopoietic malignancies, there are notable similarities between both species...
  19. ncbi request reprint RAS gene hot-spot mutations in canine neoplasias
    A Richter
    Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    J Hered 96:764-5. 2005
    ..The results were compared to the already existing data from other studies about these tumors in dogs...
  20. ncbi request reprint Establishment of a cell line derived from a canine prostate carcinoma with a highly rearranged karyotype
    S Winkler
    Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    J Hered 96:782-5. 2005
    ..The cell line grew very well and showed evidence of being spontaneously immortalized when it crossed the 20th passage...
  21. pmc Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton
    M Jonsson
    Department of Oncology, University of Lund, Sweden
    Br J Cancer 78:430-8. 1998
    ..However, the cancer cell lines treated with cytochalasin D showed no changes in cell morphology or Wnt5a induction, suggesting disruption of this regulatory pathway in cancer...
  22. ncbi request reprint The canine ERBB2 gene maps to a chromosome region frequently affected by aberrations in tumors of the dog (Canis familiaris)
    H Murua Escobar
    Center for Human Genetics, University of Bremen, Germany
    Cytogenet Cell Genet 94:194-5. 2001
    ..By fluorescence in situ hybridization (FISH), we have mapped the canine ERBB2 to 1q13.1. Cytogenetic studies of canine tumors revealed that this region is very often affected by clonal chromosome aberrations in tumors of the dog...
  23. ncbi request reprint [Comment on the contribution by A. Hauschild et al.: "Safety margins in excision of primary malignant melanoma"]
    M Möhrle
    Hautarzt 53:291-2. 2002
  24. ncbi request reprint Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas
    Volkhard Rippe
    Center for Human Genetics, University of Bremen, Leobener Str ZHG, D 28359 Bremen, Germany
    Oncogene 22:6111-4. 2003
    ..The THADA gene spans roughly 365 kbp and, based on preliminary results, encodes a death receptor-interacting protein...
  25. ncbi request reprint Molecular characterization of the canine HMGB1
    H Murua Escobar
    Center for Human Genetics, University of Bremen, Bremen, Germany
    Cytogenet Genome Res 101:33-8. 2003
    ..In this study we characterized the molecular structure of the canine HMGB1 gene on genomic and cDNA levels, its predicted protein, the gene locus and a basic expression pattern...
  26. ncbi request reprint A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas
    M Meiboom
    Center for Human Genetics, University of Bremen, Bremen, Germany
    Cytogenet Genome Res 101:113-7. 2003
    ..Herein, unique expression of a 3.4-kbp transcript is described in thyroid adenoma cell lines with 19q13 aberrations, which was not detected either in normal tissues or in thyroid carcinoma cell lines...
  27. ncbi request reprint DNA sequence, polymorphism, and mapping of luteinizing hormone receptor fragment (LHCGR) gene in Great Dane dogs
    S E C Santos
    Department of Animal Health and Production, Sao Paulo State University, Aracatuba, Brazil
    Anim Genet 35:74-5. 2004
  28. ncbi request reprint The canine HMGA1
    Hugo Murua Escobar
    Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, D 28359 Bremen, Germany
    Gene 330:93-9. 2004
    ..Furthermore, we compared the coding sequence(s) (CDS) of both splice variants for 12 different breeds, screened them for single nucleotide polymorphisms (SNPs) and characterised a basic expression pattern...
  29. ncbi request reprint Molecular characterization and mapping of the canine KRAB zinc finger gene ZNF331
    M Meiboom
    Center for Human Genetics, University of Bremen, Bremen, Germany
    Anim Genet 35:262-3. 2004
  30. ncbi request reprint Expression pattern of the HMGB1 gene in sarcomas of the dog
    Britta Meyer
    alcedo biotech GmbH, Leobener Strasse ZHG, D 28359 Bremen, Germany
    Anticancer Res 24:707-10. 2004
    ..The human high mobility group protein B1 (HMGB1) has attracted considerable interest among oncologists because it sensitises cancer cells to the anticancer drug cisplatin by shielding cisplatin-DNA adducts from nucleotide excision repair...
  31. ncbi request reprint The protein kinase B, gamma (AKT3) gene maps to canine chromosome 7
    H Murua Escobar
    Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
    Anim Genet 35:354-5. 2004
  32. ncbi request reprint The canine NRAS gene maps to CFA 17
    A Richter
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Anim Genet 35:355-6. 2004
  33. ncbi request reprint Molecular characterization and mapping of the canine cyclin D1 (CCND1) gene
    B Meyer
    Center for Human Genetics, University of Bremen, Germany
    Anim Genet 35:413. 2004
  34. ncbi request reprint The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues
    Torsten Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Parkallee 3, 23845 Borstel, Germany
    Pathol Res Pract 200:511-5. 2004
    ..In addition, by detecting GAPDH and high mobility group protein gene B1 (HMGB1)-specific transcripts, we were able to demonstrate that RNA from HOPE-fixed tissue can also be used for Northern blot hybridization...
  35. ncbi request reprint [Chronic myeloid leukemia]
    Miklos Udvardy
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Általános Orvostudományi Kar, Belgyógyászati Intézet, II Belgyógyászati Klinika, Haematológia Tanszék
    Orv Hetil 146:243-7. 2005
    ..With the advent of these new drugs the therapeutic algorithm of chronic myeloid leukaemia and allogenous bone marrow transplantation seems to be reconsidered, too...
  36. ncbi request reprint "Best friends" sharing the HMGA1 gene: comparison of the human and canine HMGA1 to orthologous other species
    H Murua Escobar
    Small Animal Clinic, School of Veterinary Medicine, Bischofsholer Damm 15, 30137 Hanover, Germany
    J Hered 96:777-81. 2005
    ..Additionally, we compared the known human, canine, murine, rat, hamster, bovine, pig, Xenopus, and chicken HMGA1 transcripts...
  37. ncbi request reprint Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene
    Sven Hauke
    ZytoVision GmbH, Fischkai 1, D 27572 Bremerhaven, Germany
    Biochim Biophys Acta 1729:24-31. 2005
    ..It is hypothesized that HMGA2-dependent tumorigenesis is caused by a disturbed equilibrium in the co-expression of the HMGA2 splice variants leading to aberrant cell proliferation and/or malignant transformation of cells...
  38. pmc Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer
    Katharina A Sterenczak
    University of Veterinary Medicine Hannover, Hannover, Germany
    BMC Cancer 12:284. 2012
    ..In this experimental study, we labelled prostate cancer cells with MnCl2 or SPIOs in vitro and used 1 T MRI for tracing labelled cells in-vitro and 7 T MRI for tracking in an in-vivo animal model...
  39. ncbi request reprint Genetic characterization of dogs via chromosomal analysis and array-based comparative genomic hybridization (aCGH)
    M H Muller
    Klinik für Kleintiere, Stiftung Tierarztliche Hochschule Hannover, Bünteweg 9, 30559 Hannover
    Tierarztl Prax Ausg K Kleintiere Heimtiere 40:55-8. 2012
    ..Complemented with traditional methods like karyotyping and fluorescence in situ hybridization (FISH) analyses, the aCGH is able to provide new insights into the underlying causes of canine carcinogenesis...
  40. ncbi request reprint In vivo MRI of intraspinally injected SPIO-labelled human CD34+ cells in a transgenic mouse model of ALS
    S Willenbrock
    Small Animal Clinic, Research Cluster of Excellence REBIRTH, University for Veterinary Medicine, Buenteweg 9, D 30559 Hannover, Germany
    In Vivo 26:31-8. 2012
    ....
  41. ncbi request reprint High-mobility group B1 (HMGB1) and receptor for advanced glycation end-products (RAGE) expression in canine lymphoma
    Katharina A Sterenczak
    Small Animal Clinic and the German Research Foundation SFB Transregio 37, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    Anticancer Res 30:5043-8. 2010
    ..HMGB1 and RAGE are strongly associated with tumour progression and vascularisation. Consequently, deregulated RAGE and HMGB1 may play an important role in the mechanisms involved in lymphoma progression...