U Ernsberger

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Neural Dev 3:28. 2008
  2. doi request reprint Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia
    Uwe Ernsberger
    Interdisciplinary Center for Neurosciences IZN, INF 307, University of Heidelberg, 69120, Heidelberg, Germany
    Cell Tissue Res 336:349-84. 2009
  3. ncbi request reprint The development of postganglionic sympathetic neurons: coordinating neuronal differentiation and diversification
    U Ernsberger
    Interdisziplinäres Zentrum für Neurowissenschaften, Institut für Anatomie und Zellbiologie III, Heidelberg, Germany
    Auton Neurosci 94:1-13. 2001
  4. ncbi request reprint Evidence for an evolutionary conserved role of bone morphogenetic protein growth factors and phox2 transcription factors during noradrenergic differentiation of sympathetic neurons. Induction of a putative synexpression group of neurotransmitter-synthesiz
    U Ernsberger
    Institut für Neuroanatomie, Anatomie und Zellbiologie, Interdisziplinäres Zentrum für Neurowissenschaften, Heidelberg, Germany
    Eur J Biochem 267:6976-81. 2000
  5. ncbi request reprint The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development
    U Ernsberger
    Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, D 60528, Frankfurt, Germany
    Mech Dev 92:169-77. 2000
  6. pmc The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons
    Uwe Ernsberger
    Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Cell Tissue Res 333:353-71. 2008
  7. ncbi request reprint Expression of neuronal markers suggests heterogeneity of chick sympathoadrenal cells prior to invasion of the adrenal anlagen
    Uwe Ernsberger
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, 69120 Heidelberg, Germany
    Cell Tissue Res 319:1-13. 2005
  8. ncbi request reprint Development of chromaffin cells depends on MASH1 function
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Development 129:4729-38. 2002
  9. ncbi request reprint Cholinergic differentiation occurs early in mouse sympathetic neurons and requires Phox2b
    K Huber
    Institut für Anatomie und Zellbiologie III, Interdisziplindäres Zentrum für Neurowissenschaften, Ruprecht Karls Universitat Heidelberg, Imn Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Gene Expr 13:133-9. 2006
  10. ncbi request reprint Reduction of endogenous TGF-beta does not affect phenotypic development of sympathoadrenal progenitors into adrenal chromaffin cells
    S E Combs
    Neuroanatomy and Interdisciplinary Center for Neurosciences (IZN, University of Heidelberg, Im Neuenheimer Feld 307, 69120, Heidelberg, Germany
    Mech Dev 109:295-302. 2001

Collaborators

Detail Information

Publications18

  1. pmc Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Neural Dev 3:28. 2008
    ..Bone morphogenetic proteins (BMPs) emanating from the dorsal aorta are important signals for the induction of a sympathoadrenal catecholaminergic cell fate...
  2. doi request reprint Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia
    Uwe Ernsberger
    Interdisciplinary Center for Neurosciences IZN, INF 307, University of Heidelberg, 69120, Heidelberg, Germany
    Cell Tissue Res 336:349-84. 2009
    ..In vivo analysis is required to show the degree to which NT signalling regulates these sympathetic neuron properties in developing embryos and postnatally...
  3. ncbi request reprint The development of postganglionic sympathetic neurons: coordinating neuronal differentiation and diversification
    U Ernsberger
    Interdisziplinäres Zentrum für Neurowissenschaften, Institut für Anatomie und Zellbiologie III, Heidelberg, Germany
    Auton Neurosci 94:1-13. 2001
    ....
  4. ncbi request reprint Evidence for an evolutionary conserved role of bone morphogenetic protein growth factors and phox2 transcription factors during noradrenergic differentiation of sympathetic neurons. Induction of a putative synexpression group of neurotransmitter-synthesiz
    U Ernsberger
    Institut für Neuroanatomie, Anatomie und Zellbiologie, Interdisziplinäres Zentrum für Neurowissenschaften, Heidelberg, Germany
    Eur J Biochem 267:6976-81. 2000
    ....
  5. ncbi request reprint The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development
    U Ernsberger
    Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, D 60528, Frankfurt, Germany
    Mech Dev 92:169-77. 2000
    ..The time course of Phox2a and 2b expression suggests an evolutionary conserved role in noradrenergic induction. In addition, Phox2a, Phox2b, and c-ret may be involved in the differentiation of cholinergic sympathetic neurons...
  6. pmc The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons
    Uwe Ernsberger
    Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Cell Tissue Res 333:353-71. 2008
    ..In order to comprehend this process fully, the role of individual GFLs, the transduction of the GFL signals, and the interplay of GFL signalling with other regulatory pathways need to be deciphered...
  7. ncbi request reprint Expression of neuronal markers suggests heterogeneity of chick sympathoadrenal cells prior to invasion of the adrenal anlagen
    Uwe Ernsberger
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, 69120 Heidelberg, Germany
    Cell Tissue Res 319:1-13. 2005
    ....
  8. ncbi request reprint Development of chromaffin cells depends on MASH1 function
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Development 129:4729-38. 2002
    ..Together, these findings suggest that the development of chromaffin cells does depend on MASH1 function not only for catecholaminergic differentiation but also for general chromaffin cell differentiation...
  9. ncbi request reprint Cholinergic differentiation occurs early in mouse sympathetic neurons and requires Phox2b
    K Huber
    Institut für Anatomie und Zellbiologie III, Interdisziplindäres Zentrum für Neurowissenschaften, Ruprecht Karls Universitat Heidelberg, Imn Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Gene Expr 13:133-9. 2006
    ..Phox2b is required for development of cholinergic neurons but does not suffice to support cholinergic properties in chromaffin cells...
  10. ncbi request reprint Reduction of endogenous TGF-beta does not affect phenotypic development of sympathoadrenal progenitors into adrenal chromaffin cells
    S E Combs
    Neuroanatomy and Interdisciplinary Center for Neurosciences (IZN, University of Heidelberg, Im Neuenheimer Feld 307, 69120, Heidelberg, Germany
    Mech Dev 109:295-302. 2001
    ..We therefore conclude that neutralization of endogenous TGF-beta influences chromaffin cell proliferation, but does not interfere with the development of the typical chromaffin cell phenotype...
  11. ncbi request reprint Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells
    Philipp Gut
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Development 132:4611-9. 2005
    ..Our results suggest that cortical cues are not essential for determining chromaffin cell fate, but may be required for proper migration of SA progenitors to and/or colonization of the adrenal anlage...
  12. ncbi request reprint Generation of neuroendocrine chromaffin cells from sympathoadrenal progenitors: beyond the glucocorticoid hypothesis
    Katrin Huber
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany
    Ann N Y Acad Sci 971:554-9. 2002
    ..Together, our data suggest that TGF-betas and BMP-4 do not seem to be essential for chromaffin cell differentiation. In contrast with previous reports, however, MASH-1 apparently plays a crucial role in chromaffin cell development...
  13. ncbi request reprint c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice
    K Burau
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 20:353-62. 2004
    ..Our data suggest that c-ret signalling is necessary for the maturation of cholinergic sympathetic neurons but dispensable for de novo induction of ChAT and VAChT expression...
  14. ncbi request reprint Expression of neurexin Ialpha splice variants in sympathetic neurons: selective changes during differentiation and in response to neurotrophins
    H Patzke
    Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, Frankfurt, D 60528, Germany
    Mol Cell Neurosci 15:561-72. 2000
    ..Our data suggest that changes in neurexin splice variants contribute to alterations of neuronal cell surface properties during target innervation...
  15. ncbi request reprint The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells
    U Ernsberger
    Max Planck Institut für Hirnforschung, Frankfurt, Germany
    Mech Dev 52:125-36. 1995
    ..Cash-1 is detected significantly earlier, suggesting that its expression is induced by a separate event...
  16. ncbi request reprint The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling
    M Geissen
    Max Planck Institut für Hirnforschung, Abt Neurochemie, Deutschordenstr 46, Germany
    Development 125:4791-801. 1998
    ..These results reveal a physiological role of neuropoietic cytokines for the control of VIP expression during the development of cholinergic sympathetic neurons...
  17. ncbi request reprint Development of the cholinergic neurotransmitter phenotype in postganglionic sympathetic neurons
    U Ernsberger
    Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, D 60528 Frankfurt
    Cell Tissue Res 297:339-61. 1999
    ....
  18. ncbi request reprint The role of Phox2B in chromaffin cell development
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Dev Biol 279:501-8. 2005
    ..5. We conclude that Phox2B regulates very early events in the differentiation of adrenal chromaffin cells distinct to steps, which essentially require MASH-1...