Research Topics
Genomes and Genes | G ErhardtSummaryAffiliation: University of Giessen Country: Germany Publications
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Publications
Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burdenGesine Luhken
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstrasse 21b, 35390 Giessen, Germany
Vet Res 42:84. 2011..4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken...
Prion protein allele A136 H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheepG Luhken
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Arch Virol 149:1571-80. 2004..This has to be considered when strategies for the eradication of scrapie in sheep are based on PrP genotypes...
Epidemiological and genetical differences between classical and atypical scrapie casesGesine Luhken
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, 35390 Giessen, Germany
Vet Res 38:65-80. 2007..Furthermore, six atypical scrapie-positive sheep carried the PrP genotype ARR/ARR. The high proportion of sheep flocks affected by atypical scrapie underscores the importance of this scrapie type...
Functional analysis of a single nucleotide polymorphism in a potential binding site for GATA transcription factors in the ovine interleukin 2 geneGesine Luhken
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstrasse 21b, 35390 Giessen, Germany
Vet Immunol Immunopathol 107:51-6. 2005..The obtained results argue against an impact of this polymorphism on the IL2 transcription and the genetic disease resistance in sheep...
Genetic characterization of a sheep-dwarf goat hybridG Luhken
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Cytogenet Genome Res 125:158-61. 2009....
Molecular characterization of bovine CSN1S2*B and extensive distribution of zebu-specific milk protein alleles in European cattleE M Ibeagha-Awemu
Institute of Animal Breeding and Genetics, Justus Liebig University, Ludwigstrasse 21b, D 35390 Giessen, Germany
J Dairy Sci 90:3522-9. 2007....
Molecular genetic characterization of new bovine kappa-casein alleles CSN3F and CSN3G and genotyping by PCR-RFLPE M Prinzenberg
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Anim Genet 27:347-9. 1996..A PCR-restriction fragment length polymorphism (RFLP) genotyping procedure for all currently known CSN3 alleles (CSN3A, CSN3B, CSN3C, CSN3E, CSN3F, CSN3G) was developed...
Analysis of prion protein genotypes in relation to reproduction traits in local and cosmopolitan German sheep breedsS Lipsky
Department of Animal Breeding and Genetics, Justus Liebig University Giessen, Ludwigstrasse 21 b, 35390 Giessen, Germany
Anim Reprod Sci 103:69-77. 2008..In conclusion, breeding for TSE resistant sheep will not lead to a reduction in economically important reproduction traits...
Genetic structure and differentiation of 12 African Bos indicus and Bos taurus cattle breeds, inferred from protein and microsatellite polymorphismsE M Ibeagha-Awemu
, , Giessen, Germany
J Anim Breed Genet 122:12-20. 2005..The first step towards realizing these goals might be to geographically demarcate the breeds...
Polymorphism of the bovine CSN1S1 promoter: linkage mapping, intragenic haplotypes, and effects on milk production traitsE M Prinzenberg
Institute for Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany
J Dairy Sci 86:2696-705. 2003..An effect on milk yield breeding values was indicated for genotype 12, but is probably caused by a linked locus...
Joint analysis of the influence of CYP11B1 and DGAT1 genetic variation on milk production, somatic cell score, conformation, reproduction, and productive lifespan in German Holstein cattleB Kaupe
Institut für Tierzucht und Haustiergenetik der Justus Liebig Universität, 35390 Giessen, Germany
J Anim Sci 85:11-21. 2007..These observations indicate a possible negative influence of DGAT1(K) on maternal nonreturn rate, and thus, on length of productive life...
Genetic variation in the kappa-casein gene (CSN3) of Chinese yak (Bos grunniens) and phylogenetic analysis of CSN3 sequences in the genus BosE M Prinzenberg
Institute of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany
J Dairy Sci 91:1198-203. 2008..This is the first report of polymorphisms in the yak CSN3 gene and may be helpful for future studies on genetic variation within and between yak populations or on associated traits...
Characterization and genetic analysis of bovine alpha S1-casein I variantG Luhken
Department of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany
Anim Genet 40:479-85. 2009..Taken together, we can postulate that the alpha(s1)-casein variant I is caused by a non-synonymous nucleotide substitution in exon 11 of the gene and that it originated within Bos indicus and spread to Bos taurus subsequently...
Caprine kappa-casein (CSN3) polymorphism: new developments in molecular knowledgeE M Prinzenberg
Institut fur Tierzucht und Haustiergenetik, Justus Liebig Universitat, 35390 Giessen, Germany
J Dairy Sci 88:1490-8. 2005....
Rapid communication: amplification and linkage mapping of the ovine microsatellite DYMS1 in German angus cattleC Weimann
Institute of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
J Anim Sci 80:1382-3. 2002
An evaluation of genetic diversity indices of the Red Bororo and White Fulani cattle breeds with different molecular markers and their implications for current and future improvement optionsE M Ibeagha-Awemu
Institute of Animal Breeding and Genetics, Justus-Liebig-University, Giessen, Ludwigstrasse 21b, D-35390 Giessen, Germany
Trop Anim Health Prod 38:431-41. 2006..We propose an improvement scheme with aims to prevent loss of genetic diversity, improve productivity and reduce uncontrolled genetic exchanges between breeds...
Effect and repeatability of Ascaridia galli egg output in cockerels following a single low dose infectionM Gauly
Department of Animal Breeding and Genetics, Justus Liebig University Giessen, Oberer Hardthof 18, D 35398, Giessen, Germany
Vet Parasitol 96:301-7. 2001..55-0.87). This may open a way of genetic selection for A. galli resistance in chickens, which will be of importance for birds kept in alternative and organic farming systems...
SSCP analysis at the bovine CSN3 locus discriminates six alleles corresponding to known protein variants (A, B, C, E, F, G) and three new DNA polymorphisms (H, I, A1)E M Prinzenberg
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Anim Biotechnol 10:49-62. 1999..In CSN3*A1, a silent mutation in the third codon position of Pro150 was found (GenBank accession number AF092513)...
Short communication: Association analysis of microsatellites and Mycobacterium avium subspecies paratuberculosis antibody response in German HolsteinsM Hinger
Justus Liebig University, Department of Animal Breeding and Genetics, Giessen, Germany
J Dairy Sci 90:1957-61. 2007..Fisher's exact and chi2 tests revealed no significant differences in microsatellite allele frequencies between the 2 groups of German Holstein cows testing positive or negative for paratuberculosis...
Influence of Ascaridia galli infections and anthelmintic treatments on the behaviour and social ranks of laying hens (Gallus gallus domesticus)M Gauly
Department of Animal Breeding and Genetics, Georg August University, Albrecht Thaer Weg 3, 37075 Gottingen, Germany
Vet Parasitol 146:271-80. 2007..This study showed that even sub-clinical A. galli infections and their anthelmintic treatment can have an impact on animal behaviour...
Genetic resistance to gastrointestinal nematode parasites in Rhön sheep following natural infectionM Gauly
Department of Animal Breeding and Genetics, Oberer Hardthof 18, Justus Liebig University of Giessen, D 35398 Giessen, Germany
Vet Parasitol 102:253-9. 2001..Teladorsagia spp., Haemonchus contortus and Cooperia spp. are the dominant species. Breeding decisions can be based on one or two samples depending on the mean values and ranges of FEC and haematocrit, respectively...
Differences in recombination rates on chromosome 23 between German Angus and German Simmental and breed specific linkage mappingC Weimann
Department of Animal Breeding and Genetics, Justus Liebig University Giessen, Ludwigstrasse 21b, 35390 Giessen, Germany
Anim Genet 34:229-31. 2003..The length of the map of GA was 90.5 cM in contrast to 117.8 cM for GS. The breed specific linkage maps show differences in length but confirmation of the order of the markers...
Heritability estimates for antibody response to Mycobacterium avium subspecies paratuberculosis in German Holstein cattleM Hinger
Justus Liebig University, Department of Animal Breeding and Genetics, Giessen, Germany
J Dairy Sci 91:3237-44. 2008....
Null allele at the OarAE129 locus and corresponding allele frequencies in German sheep breedsCh Peter
Department of Animal Breeding and Genetics, University of Giessen, 35390 Giessen, Germany
Anim Genet 36:92. 2005
Transmitochondrial differences and varying levels of heteroplasmy in nuclear transfer cloned cattleS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Mol Reprod Dev 54:24-31. 1999..These results suggest that mtDNA type of donor embryos and recipient oocytes used in nuclear transfer cattle cloning should be controlled to obtain true clones with identical nuclear and cytoplasmic genomes...
Association between single nucleotide polymorphisms in the CXCR1 gene and somatic cell score in Holstein dairy cattleI Goertz
Department of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany
J Dairy Sci 92:4018-22. 2009..These results contradict previously published studies...
Polymorphisms in blood proteins of Bos indicus and Bos taurus cattle breeds of Cameroon and Nigeria, and description of new albumin variantsE M Ibeagha-Awemu
Department of Animal Breeding and Genetics, Justus-Liebig-University, Giessen, Germany
Biochem Genet 42:181-97. 2004..5% and 5.7%, respectively. The high resolution of PAG-IEF in screening for polymorphisms within diversity studies was demonstrated...
Estimating genetic differences in natural resistance in Rhön and Merinoland sheep following experimental Haemonchus contortus infectionM Gauly
Department of Animal Breeding and Genetics, Oberer Hardthof 18, Justus Liebig University of Giessen, D 35398 Giessen, Germany
Vet Parasitol 106:55-67. 2002..01). IgG was significantly (P<0.05) and positively correlated with worm burden in male Merinoland and IgL with worm burden in male Rhön sheep...
Mapping of CYP11B and a putative CYHR1 paralogous gene to bovine chromosome 14 by FISHB Kaupe
, , Ludwigstrasse 21b, Giessen, Germany
Anim Genet 35:478-9. 2004
Estimation of genetic and crossbreeding parameters for preweaning traits in German Angus and Simmental beef cattle and the reciprocal crossesH Brandt
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstr 21b, 35390 Giessen, Germany
J Anim Sci 88:80-6. 2010..01). Superior mothering ability of SIM was implicated by greater WWT and ADG of SIM as dam against the reciprocal cross (P < 0.001). The results provide information about the extent of individual heterosis and maternal breed effects...
Genetic variation in monoamine oxidase A and analysis of association with behaviour traits in beef cattleG Luhken
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Giessen, Germany
J Anim Breed Genet 127:411-8. 2010..No significant association was found between this MAOA polymorphism and the behaviour-related scores analysed in the study...
Pattern of Eimeria oocyst output and repeatability in naturally infected suckling Rhön lambsM Gauly
Department of Animal Breeding and Genetics, University of Giessen, Germany
J Vet Med B Infect Dis Vet Public Health 48:665-73. 2001..05 to 0.41. This result provides a starting point for possible genetic selection based on faecal oocyst counts of Rhön sheep for resistance to Eimeria infections...
A chromosome-wide QTL study on BTA29 affecting temperament traits in German Angus beef cattle and mapping of DRD4K Glenske
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstr 21b, 35390 Giessen, Germany
Animal 5:195-7. 2011..During the study one of the sires was detected to be a blood chimera...
Short communication: molecular genetic characterization of ovine alpha(S1)-casein allele H caused by alternative splicingI J Giambra
Department of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany
J Dairy Sci 93:792-5. 2010....
Short communication: bovine kappa-casein variants result in different angiotensin I converting enzyme (ACE) inhibitory peptidesC Weimann
Institute of Animal Breeding and Genetics, Ludwigstr 21b, D 35390 Giessen, Germany
J Dairy Sci 92:1885-8. 2009..6) was detected. Furthermore, the peptides VSP (IC50 = 21.8) and ACHP (IC50 = 360.7) were identified in CSN3*F1 and CSN3*G2, respectively...
The dynamic air bubble trap reduces cerebral microembolism during cardiopulmonary bypassM Schoenburg
Department of Thoracic and Cardiovascular Surgery, Kerckhoff Klinik, Bad Nauheim, Germany
J Thorac Cardiovasc Surg 126:1455-60. 2003..Neuropsychologic disorders are common after coronary artery bypass operations. Air microbubbles are identified as a contributing factor. A dynamic bubble trap might reduce the number of gaseous microemboli...
Genetic diversity and subdivision of 57 European and Middle-Eastern sheep breedsC Peter
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstr 21b, 35390 Giessen, Germany
Anim Genet 38:37-44. 2007..Within the last group, two less-distinct clusters comprised the Merino-type and Alpine breeds respectively. The incomplete demarcations of most clusters probably reflects cross-breeding and/or upgrading...
Genotyping of bovine kappa-casein (kappa-CNA, kappa-CNB, kappa-CNC, kappa-CNE) following DNA sequence amplification and direct sequencing of kappa-CNE PCR productS Schlieben
Institut fur Tierzucht und Haustiergenetik, Justus Liebig Universitat, Giessen, Germany
Anim Genet 22:333-42. 1991..Therefore using PCR followed by Hin dIII or HinfI and Hae III digest allows discrimination between kappa-casein A, B and E directly at the DNA level...
Genetic differences of Ascaridia galli egg output in laying hens following a single dose infectionM Gauly
Department of Animal Breeding and Genetics, Justus Liebig University Giessen, D 35398 Giessen, Germany
Vet Parasitol 103:99-107. 2002..13 and 0.19 for white hens and between 0.0 and 0.10 for brown hens. Thus, it should be possible to select for A. galli resistance in chickens, which will be of importance for birds kept in alternative and organic farming systems...
A complex malformation in a pig: case report and review of the literatureG Reiner
Department of Veterinary Clinical Sciences, Justus Liebig University, 35392 Giessen, Germany
Dtsch Tierarztl Wochenschr 115:194-7. 2008..There have been no further piglets with developmental disorders in the same litter, in a second litter of the same parents and in other twelve litters by the same boar...
Changes in testicular histology and sperm quality in llamas (Lama glama), following exposure to high ambient temperatureA Schwalm
Institute of Animal Breeding and Genetics, University of Giessen, Justus Liebig University Giessen, Ludwigstr 21b, 35390 Giessen, Germany
Theriogenology 67:1316-23. 2007..Our data indicate that in llamas the thermoregulatory ability is not sufficient enough to prevent heat caused damage to the testis at longer acting ambient temperature of 29 degrees C...
Strain typing of German transmissible spongiform encephalopathies field cases in small ruminants by biochemical methodsA Gretzschel
Friedrich-Loeffler-Institut (FLI, Institute for Novel and Emerging Diseases, Insel Riems, Germany
J Vet Med B Infect Dis Vet Public Health 52:55-63. 2005..However, in two cases distinct but BSE-unrelated PrP(Sc) types were found, which alludes to the existence of different scrapie strains in the German sheep population...
Effects of DGAT1 variants on milk production traits in German cattle breedsG Thaller
Lehrstuhl für Tierzucht, Technische Universitat Munchen, 85354 Freising, Germany
J Anim Sci 81:1911-8. 2003..Molecular tests allow for the direct selection among variants; however, the benefits of the alternative alleles depend on economic weights given to the different milk production traits in the breeding goal...
Quantitative trait loci mapping of functional traits in the German Holstein cattle populationCh Kuhn
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, D 18196 Dummerstorf, Germany
J Dairy Sci 86:360-8. 2003..Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required...
Genetic polymorphism of goat kappa-casein (CSN3) in different breeds and characterization at DNA levelA Caroli
Dipartimento di Sanità e Benessere Animale, University of Bari, Strada Provinciale per Casamassima Km 3, Valenzano, Bari, Italy
Anim Genet 32:226-30. 2001..Among the four mutations, only the 44 Gln --> Arg can be revealed by milk protein IEF analysis while at DNA level three further genetic variants should exist in addition to CSN3(A) and CSN3(B)...
Evidence for a geographical cline of casein haplotypes in Portuguese cattle breedsA Beja-Pereira
Centro de Estudos de Ciência Animal CECA UP Campus Agrário de Vairão, Portugal
Anim Genet 33:295-300. 2002..Our data suggest that high genetic similarity among neighbouring Portuguese breeds is mainly caused by gene flow, and that the geographical distribution of particular casein haplotypes may indicate an influence of African cattle...
Mapping of the bovine blood group systems J, N', R', and Z show evidence for oligo-genetic inheritanceH Thomsen
Institut für Tierzucht und Tierhaltung der Christian Albrechts Universität, Kiel, Germany
Anim Genet 33:107-17. 2002..The appearance of a single blood group system might be therefore either dependent on the existence of other blood group systems or because of an interaction between different loci on various chromosomes as is known in humans and in pigs...
Mapping of quantitative trait loci for lactation persistency traits in German Holstein dairy cattleB Harder
, , Kiel, Germany
J Anim Breed Genet 123:89-96. 2006....
A spatial analysis method (SAM) to detect candidate loci for selection: towards a landscape genomics approach to adaptationS Joost
Istituto di Zootecnica, Universita Cattolica del S Cuore, Via E Parmense 84, 29100 Piacenza, Italy
Mol Ecol 16:3955-69. 2007..In the future, such an approach may accelerate the process of hunting for functional genes at the population level...
Characterization of the casein gene complex in West African goats and description of a new alpha(s1)-casein polymorphismA Caroli
Dipartimento di Scienze Biomediche e Biotecnologie, Universita degli Studi di Brescia, Viale Europa 11, 25123 Brescia, Italy
J Dairy Sci 90:2989-96. 2007..Haplotypes providing greater protein and casein content would increase the energy content of milk, thus resulting in more favorable growth and survival of young goats and humans consuming the milk...
Short communication: a polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breedsM Ron
Department of Ruminants and Genetics, Agricultural Research Organization, P O B 6, Bet Dagan 50 250, Israel
J Dairy Sci 89:4921-3. 2006..The detection of ABCG2(C) only in Bos taurus breeds may indicate that ABCG2(A) is the ancestral allele, and that the Y581S substitution occurred after the separation of the Bos indicus and Bos taurus lineages...
Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid testsA Buschmann
Federal Research Centre for Virus Diseases of Animals, Institute for Novel and Emerging Infectious Diseases, Boddenblick 5a, 17493 Greifswald-Insel Riems, Germany
J Virol Methods 117:27-36. 2004..Similar discrepancies have not been observed during rapid testing of cattle for BSE, the disease for which all diagnostic methods applied have been evaluated...
Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR)Anne Buschmann
Federal Research Centre for Virus Diseases of Animals, Institute for Novel and Emerging Infectious Diseases, Boddenblick 5a, 17493 Greifswald Insel Riems, Germany
J Gen Virol 85:2727-33. 2004..SAF immunoblotting also revealed PrPSc deposition in the obex, frontal cortex and brainstem. Transmission experiments to investigate the infectivity of scrapie propagated from these sheep have been initiated...
The DGAT1 K232A mutation is not solely responsible for the milk production quantitative trait locus on the bovine chromosome 14J Bennewitz
Institut für Tierzucht und Tierhaltung, Christian Albrechts Universitat, D 24098 Kiel, Germany
J Dairy Sci 87:431-42. 2004....
Differentiation of European cattle by AFLP fingerprintingR Negrini
Institute of Zootechnics, Catholic University of Sacred Heart, Piacenza, Italy
Anim Genet 38:60-6. 2007..This probably reflects import from the East after the original introduction of domestic cattle into Europe. Our data suggest that Italian cattle breeds are relatively diverse at the DNA sequence level...
Mapping of QTL for Body Conformation and Behavior in CattleS Hiendleder
Institut für Tierzucht und Haustiergenetik der Justus Liebig Universität, D 35390 Giessen, Germany
J Hered 94:496-506. 2003..This study provides the first evidence for QTL involved in behavior of dairy cattle and identifies QTL for udder conformation on chromosome 6 that could form the basis of recently reported QTL for clinical mastitis...
Short communication: Simultaneous identification of five kappa-casein (CSN3) alleles in domestic goat by polymerase chain reaction-single strand conformation polymorphismS Chessa
Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Universita degli Studi di Milano, 20134 Milano, Italy
J Dairy Sci 86:3726-9. 2003..The PCR-SSCP analysis is a powerful tool for the genetic study of CSN3 variability in domestic goats, allowing both the simultaneous identification of different alleles, and the detection of new variants...
Heterosis analysis of Haemonchus contortus resistance and production traits in Rhoen sheep, Merino Land sheep and crossbred lambsA Hielscher
Institute of Animal Breeding and Genetics, University of Giessen, Ludwigstrasse 21, 35398 Giessen, Germany
Vet Parasitol 141:279-84. 2006..These results suggested that crossbreeding Rh to Ml sheep may be a suitable way of producing lambs with improved resistance to H. contortus infection without any negative effects on production traits...
[Use of FAMACHA Scoring System as a diagnostic aid for the registration of distinguishing marks in the breeding program for lambs exposed to an experimental Haemonchus contortus infection]M Gauly
Institut für Tierzucht und Haustiergenetik der Georg August Universität Göttingen
Dtsch Tierarztl Wochenschr 111:430-3. 2004..The estimated correlations have been low. This proofs the limits of the FAMACHA system under a situation of low parasite pressure...
Genetic resistance to Heterakis gallinarum in two chicken layer lines following a single dose infectionM Gauly
Institute of Animal Breeding and Genetics, Georg August University Gottingen, Albrecht Thaerr Weg 3, 37075 Gottingen, Germany
Vet Parasitol 155:74-9. 2008..Based on the estimated heritabilities it is possible to select for H. gallinarum resistance in both genetically distinct chicken breeds. This approach may be of importance for chickens kept in floor husbandry systems...
Isolation and complete primary sequence of a new ovine wild-type beta-lactoglobulin CG Erhardt
Justus Liebig Universitat, Institut fur Tierzucht und Haustiergenetik, Giessen
Biol Chem Hoppe Seyler 370:757-62. 1989....
Influence of sex on the resistance of sheep lambs to an experimental Haemonchus contortus infectionM Gauly
Institute of Animal Breeding and Genetics, University of Gottingen, Germany
Dtsch Tierarztl Wochenschr 113:178-81. 2006..Therefore male breeding values are probably not representative for the whole population...
[Suckling behavior of llamas (Lama glama)]M Gauly
Institut fur Tierzucht und Haustiergenetik, Justus Liebig Universitat Giessen
Dtsch Tierarztl Wochenschr 110:412-6. 2003..But the animals suckled less frequently and spent less total time suckling as they grow older. The age related differences and evidence for a dual function (nutrition, social contact) of suckling behaviour are discussed...
