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Genomes and Genes | Sandra ErbsSummaryAffiliation: University of Leipzig Country: Germany Publications
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Publications
Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and InfaSandra Erbs
University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
Circulation 116:366-74. 2007....
High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled studySandra Erbs
University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
Int J Cardiol 146:56-63. 2011..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...- Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular functionSandra Erbs
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
Circ Heart Fail 3:486-94. 2010.... - Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failureRainer Hambrecht
Heart Center, Department of Cardiology, University of Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 12:401-6. 2005..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)... - Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscleStephan Gielen
Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 12:393-400. 2005..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF... - Maximal exercise, limb ischemia, and endothelial progenitor cellsMarcus Sandri
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 18:55-64. 2011..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers... - Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction StudyMarcus Sandri
Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
Eur Heart J 33:1758-68. 2012..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)... - Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscleAxel Linke
Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
Circulation 111:1763-70. 2005..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF... - Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studiesMarcus Sandri
Heart Center, Department of Internal Medicine/Cardiology, University of Leipzig, Leipzig, Germany
Circulation 111:3391-9. 2005..However, ischemic and subischemic ET programs affect CXCR4 expression of CPCs, which might lead to an improved CPC integration into endothelial networks... - Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failureStephan Gielen
, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, , 04289 Leipzig, Germany
J Am Coll Cardiol 42:861-8. 2003..These local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression of CHF... - Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery diseaseSandra Erbs
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 13:826-31. 2006.... - Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trialClaudia Walther
Department of Cardiology, University of Leipzig, Heart Center, 4289 Leipzig, Germany
Circulation 120:2251-9. 2009.... - Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training TrialSandra Erbs
, Herzzentrum GmbH, , Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 10:336-44. 2003..CONCLUSIONS: In patients with advanced CHF (NYHA class III), long-term exercise training is associated with an enhanced physical work capacity, an improvement in stroke volume and a reduction in cardiomegaly... - Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary arteryKai Kendziorra
Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
J Nucl Med 49:557-63. 2008.... - Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled studySandra Erbs
Department of Cardiology, Heart, University of Leipzig, Germany
Circ Res 97:756-62. 2005..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium... - Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathySandra Erbs
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany
Am Heart J 146:280-5. 2003..These results suggest that in patients with CHF, factors other than oxidative stress (eg, cytokines) contribute to the pathologic endothelial function... - Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery diseaseEphraim B Beck
Heart Center, Department of Cardiology, University of Leipzig, Struempellstrasse 39, Leipzig, Germany
Eur J Prev Cardiol 19:412-8. 2012..The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD... - Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise trainingVolker Adams
Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 15:293-9. 2008..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx... - Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery diseaseVolker Adams
University Leipzig, Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
Circulation 111:555-62. 2005..7 arbitrary units) mRNA expression. CONCLUSIONS: ET reduces vascular expression of NAD(P)H oxidase and AT1-R, resulting in decreased local ROS generation. These molecular effects converge in a reduced Ang II-mediated vasoconstriction... - Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trialRainer Hambrecht
Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
Circulation 109:1371-8. 2004.... - Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cellsNicolle Krankel
Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
Arterioscler Thromb Vasc Biol 25:698-703. 2005..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function... - Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failureKarsten Lenk
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
Eur J Prev Cardiol 19:404-11. 2012..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome... - Chemerin as a mediator between obesity and vascular inflammation in childrenKathrin Landgraf
Pediatric Research Center, Department of Women s and Child Health, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
J Clin Endocrinol Metab 97:E556-64. 2012..The chemoattractant protein chemerin has recently been shown to be expressed in adipose tissue... - Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runnersVolker Adams
Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 15:602-7. 2008..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners... - Exercise and the coronary circulation-alterations and adaptations in coronary artery diseaseAxel Linke
Department of Cardiology, University of Leipzig-Heart Center, Leipzig, Germany
Prog Cardiovasc Dis 48:270-84. 2006.... - How to improve endothelial repair mechanisms: the lifestyle approachSven Mobius-Winkler
Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
Expert Rev Cardiovasc Ther 8:573-80. 2010..This review focuses on lifestyle interventions to correct endothelial dysfunction in different cardiovascular diseases... - Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expressionNicolle Krankel
Department of Cardiology, Heart Center, University of Leipzig, D 04289 Leipzig, Germany
Mol Genet Metab 80:262-71. 2003..The upregulation of PP2A, an important regulator in intracellular signaling and apoptosis, may be due to an increase of inflammatory cytokines... - Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunctionSandra Erbs
Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
Arterioscler Thromb Vasc Biol 23:1814-9. 2003..Only the promoter polymorphism might have an adverse effect on training-induced improvement in endothelial function... - Effects of exercise training on mortality in patients with coronary heart diseaseSandra Erbs
Department of Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Coron Artery Dis 17:219-25. 2006.... - Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failureP Christian Schulze
Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
Eur J Heart Fail 5:33-40. 2003..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF... - Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusionsHolger Thiele
University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
Int J Cardiol 135:287-95. 2009..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size... - Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-Holger Thiele
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
J Am Coll Cardiol 55:2201-9. 2010.... - Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cellsClaudia Walther
Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 15:416-22. 2008..In the context of primary prevention, the impact of regular physical activity on the amount and function of EPC has not yet been investigated in school children... - Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemiaKarsten Lenk
Department of Cardiology, University of Leipzig Heart Center, , D-04289 Leipzig, Germany
Eur Heart J 26:1903-9. 2005..CONCLUSION: These preliminary data in a small series of patients with CLI without surgical or interventional options indicate that CPC application is safe, feasible, and may improve both functional and clinical indices... - Exercise-induced modulation of endothelial nitric oxide productionStephan Gielen
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrabe 39, 04289 Leipzig, Germany
Curr Pharm Biotechnol 12:1375-84. 2011.... - Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IVHolger Thiele
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
Circulation 118:49-57. 2008..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus... - Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trialSteffen Desch
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
JACC Cardiovasc Interv 4:452-9. 2011.... - Effects of exercise training upon endothelial function in patients with cardiovascular diseaseAxel Linke
University of Leipzig, Heart Center, Department of Cardiology, Leipzig, Germany
Front Biosci 13:424-32. 2008..Given the prognostic value of endothelial function further studies are necessary to elucidate whether the ET-induced correction of vasomotion is the key mechanism responsible for the decline in mortality in patients with CVD... - Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imagingHolger Thiele
Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
Eur Heart J 28:1433-9. 2007..Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations... - Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centreUlrike M Müller
Department of Internal Medicine Cardiology, University of Leipzig, Heart Centre, Strumpellstrasse 39, Leipzig, Germany
Clin Res Cardiol 100:297-309. 2011..We hypothesised that DBT of <30 min can be accomplished for the majority of patients... - Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractilityVolker Adams
University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
Cardiovasc Res 73:120-9. 2007..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha... 
Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trialMadlen Uhlemann
Sports Medicine, University Wuppertal, Wuppertal, Germany
Trials 13:167. 2012..Until now, data demonstrating the positive effect of ET on the collateral blood flow and the functional capacity of the coronary collateral circulation are still lacking...- New predictors of the metabolic syndrome in children--role of adipocytokinesAntje Körner
University Hospital for Children and Adolescents, University of Leipzig, 04317 Leipzig, Germany
Pediatr Res 61:640-5. 2007..Overall factors from the adipose tissue may constitute not only markers but also mediators of metabolic sequelae of obesity... - Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotionStephan Gielen
Department of Internal Medicine/Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Am Heart J 145:E3. 2003..However, acetylcholine-induced increases in CBF were lower after home-based ET, suggesting a relation between daily training duration and improvement of coronary vasomotion... - Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure modelKarsten Lenk
Clinic of Cardiology, University Leipzig Heart Center Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
Eur J Heart Fail 11:342-8. 2009..This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha)... - Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemiaVolker Adams
University Leipzig, Heart Center Leipzig, Germany
Arterioscler Thromb Vasc Biol 24:684-90. 2004..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs... - Intracoronary bone marrow-derived progenitor cells in acute myocardial infarctionVolker Schachinger
Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
N Engl J Med 355:1210-21. 2006..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction... - Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failureP Christian Schulze
Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
Basic Res Cardiol 98:267-74. 2003.... - Flow-mediated vasodilation partially reflects nitric oxide-mediated endothelial functionAxel Linke
University of Leipzig-Heart Center, Department of Cardiology, Germany
J Appl Physiol 99:1622. 2005 - Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trialVolker Schachinger
J W Goethe Universität Frankfurt, Med Klinik III, Abt Kardiologie, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
Eur Heart J 27:2775-83. 2006..To investigate the clinical outcome after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI)... - Spotlight on a young cardiologistIngrid Torjesen
Circulation 114:f120. 2006 - Intracoronary administration of circulating blood-derived progenitor cells after recanalization of chronic coronary artery occlusion improves endothelial functionSandra Erbs
Circ Res 98:e48. 2006 - Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trialHenning Morawietz
Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
Circulation 114:I296-301. 2006....