Christian Erbel

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Functional profile of activated dendritic cells in unstable atherosclerotic plaque
    Christian Erbel
    Department of Cardiology, Internal Medical Clinic III University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 102:123-32. 2007
  2. pmc CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages
    Christian A Gleissner
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Circ Res 106:203-11. 2010
  3. ncbi request reprint IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg 69120, Germany
    J Immunol 193:4344-55. 2014
  4. ncbi request reprint High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Germany
    Transpl Int 26:267-72. 2013
  5. pmc PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels
    Christian Erbel
    Department of Cardiology, Angiology and Pneumology, Medical Clinic III, University Hospital Heidelberg, INF 410, 69120 Heidelberg, Germany
    Eur J Med Res 16:367-74. 2011
  6. ncbi request reprint Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Basic Res Cardiol 106:125-34. 2011
  7. ncbi request reprint Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Immunol 183:8167-75. 2009
  8. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
  9. pmc Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1323-8. 2013
  10. pmc Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Germany
    Drug Des Devel Ther 8:447-57. 2014

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Functional profile of activated dendritic cells in unstable atherosclerotic plaque
    Christian Erbel
    Department of Cardiology, Internal Medical Clinic III University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 102:123-32. 2007
    ..This study established a functional profile of plaque-residing dendritic cells (DC) to examine whether they can function as Ag-presenting cells to facilitate in situ T-cell activation...
  2. pmc CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages
    Christian A Gleissner
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Circ Res 106:203-11. 2010
    ..CXCL4 is a platelet-derived chemokine that promotes macrophage differentiation from monocytes. Deletion of the PF4 gene that encodes CXCL4 reduces atherosclerotic lesions in ApoE(-/-) mice...
  3. ncbi request reprint IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg 69120, Germany
    J Immunol 193:4344-55. 2014
    ..The underlying mechanisms involve reduced inflammation and distinct effects of IL-17A on monocyte/macrophage lineage. In addition, translational experiments underline the relevance for the human system. ..
  4. ncbi request reprint High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Germany
    Transpl Int 26:267-72. 2013
    ..90, 95% CI: 0.81-1.00, P = 0.03). Cardiac troponin T concentrations early after transplantation as measured with a highly sensitive assay represent a strong and independent risk predictor of death after heart transplantation...
  5. pmc PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels
    Christian Erbel
    Department of Cardiology, Angiology and Pneumology, Medical Clinic III, University Hospital Heidelberg, INF 410, 69120 Heidelberg, Germany
    Eur J Med Res 16:367-74. 2011
    ..Poly(ADP-ribose) polymerase-1 (PARP), a nuclear enzyme linked to DNA repair, has been shown to be involved in atherogenesis; however, the effects on dendritic cells, T cells and serum auto-antibody levels are not fully understood...
  6. ncbi request reprint Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Basic Res Cardiol 106:125-34. 2011
    ..05), but did not influence IL-17A. The association of IL-17A with ischemic symptoms and vulnerable plaque characteristics suggests that the pro-inflammatory cytokine IL-17A may contribute to atherosclerosis und plaque instability...
  7. ncbi request reprint Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Immunol 183:8167-75. 2009
    ..The present data support a pathogenic role of IL-17A in the development of atherosclerosis by way of its widespread proinflammatory and proapoptotic effects on atherogenic cells...
  8. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
    ....
  9. pmc Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1323-8. 2013
    ..However, long-term data regarding the effects of ivabradine, a novel If channel antagonist, are limited in patients after heart transplantation...
  10. pmc Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Germany
    Drug Des Devel Ther 8:447-57. 2014
    ..Costimulatory molecules and their receptors provide decisive signals for antigen-specific cell activation. The contribution of B7-related pathways to atherosclerosis has hardly been explored...
  11. ncbi request reprint Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen
    Matthias Helmschrott
    Department of Cardiology, Angiology, Pneumology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 8:1307-14. 2014
    ..The use of tacrolimus (TAC) in patients after heart transplantation (HTX) has increased over the last few years...
  12. pmc Conversion to generic cyclosporine A in stable chronic patients after heart transplantation
    Maximilian Kraeuter
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1421-6. 2013
    ..Available CSA products differ in the constitution of their emulsion. To compare intra-individual differences after a conversion to a generic CSA, a retrospective single-center study was initiated...
  13. ncbi request reprint Return to work after heart transplantation: discrepancy with subjective work ability
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 87:1001-5. 2009
    ....
  14. ncbi request reprint CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions
    Mohammadreza Akhavanpoor
    Department of Cardiology, University of Heidelberg, Germany DZHK German Centre for Cardiovascular Research, partner site Heidelberg Mannheim, Germany
    Drug Des Devel Ther 8:2359-71. 2014
    ..In conclusion, modulation of the chemokines CCL19 and CCL21 represents a potent immunoregulatory treatment approach, and thus represents a novel therapeutic target to stabilize atherosclerotic lesions...
  15. ncbi request reprint Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy
    Rasmus Rivinius
    Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 9:93-102. 2015
    ..Special emphasis was placed on the effects of a mammalian target of rapamycin (mTOR) containing immunosuppressive regimen...
  16. pmc Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation
    Ibrahim Gueler
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:297-303. 2013
    ..Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes...
  17. ncbi request reprint Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris
    Mathias H Konstandin
    Dept of Cardiology, Ruprecht Karls University, Heidelberg, Germany
    Basic Res Cardiol 104:341-51. 2009
    ..Beta2-integrin mediated T cell recruitment plays a pivotal role in coronary atherosclerotic plaque rupture. The present study investigates beta2-integrin activation on T cell subsets as a risk marker in UA...
  18. pmc Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg
    Drug Des Devel Ther 6:289-95. 2012
    ..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation...
  19. ncbi request reprint Beneficial effect of omega-3 fatty acids on sirolimus- or everolimus-induced hypertriglyceridemia in heart transplant recipients
    Sultan Celik
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:245-50. 2008
    ..Omega-3 fatty acids (FAs) exert cardioprotective effects supporting a therapeutic role in cardiovascular conditions...
  20. pmc An in vitro model to study heterogeneity of human macrophage differentiation and polarization
    Christian Erbel
    Department of Cardiology, University of Heidelberg
    J Vis Exp . 2013
    ....
  21. pmc Reversible left ventricular dysfunction resembling Takotsubo syndrome after self-injection of adrenaline
    Hans Christian Volz
    Department of Internal Medicine III, University of Heidelberg, INF 410, Heidelberg 69120, Germany
    Can J Cardiol 25:e261-2. 2009
    ..The present case may provide additional evidence to the hypothesis of excess sympathetic activation in LV ballooning syndrome...