Kristina Endres

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
    Regina Augustin
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße, 1, 85764, Munich Neuherberg, Germany
    BMC Med Genet 13:35. 2012
  2. ncbi The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, University Medical Centre Johannes Gutenberg University Mainz, Germany
    Curr Alzheimer Res 9:157-64. 2012
  3. doi Regulation of α-secretase ADAM10 expression and activity
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, University Medical Centre Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Exp Brain Res 217:343-52. 2012
  4. doi Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg University, Mainz, Germany
    FEBS J 277:1585-96. 2010
  5. doi Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
  6. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
  7. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
  8. doi Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein
    David Holthoewer
    Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 10:224-8. 2012
  9. doi Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
    Sven Reinhardt
    1Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    FASEB J 28:978-97. 2014
  10. ncbi Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009

Collaborators

Detail Information

Publications16

  1. pmc Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
    Regina Augustin
    Helmholtz Centre Munich, German Research Centre for Environmental Health GmbH and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße, 1, 85764, Munich Neuherberg, Germany
    BMC Med Genet 13:35. 2012
    ..To predict miRNAs regulating ADAM10 expression concerning AD, we developed a computational approach...
  2. ncbi The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, University Medical Centre Johannes Gutenberg University Mainz, Germany
    Curr Alzheimer Res 9:157-64. 2012
    ..In this review, we report on recent findings concerning shedding of APP-like proteins and resulting functional consequences...
  3. doi Regulation of α-secretase ADAM10 expression and activity
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, University Medical Centre Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Exp Brain Res 217:343-52. 2012
    ....
  4. doi Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
    Kristina Endres
    Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg University, Mainz, Germany
    FEBS J 277:1585-96. 2010
    ..The present review summarizes our knowledge about the structure and function of ADAM10 and highlights the opportunities for enhancing the expression and/or activity of the alpha-secretase as a therapeutic target...
  5. doi Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
    ..Our results indicate that inhibition of cholesterol biosynthesis by a low lovastatin concentration is sufficient for alpha-secretase activation...
  6. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
    ..Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology...
  7. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    ....
  8. doi Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein
    David Holthoewer
    Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 10:224-8. 2012
    ..Enhancement of ADAM10's gene expression may therefore present a valuable therapeutic approach for the treatment of Alzheimer's disease (AD), where Aβ peptides are severely involved in the pathogenesis...
  9. doi Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
    Sven Reinhardt
    1Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    FASEB J 28:978-97. 2014
    ..Our results demonstrate that XBP-1 is a driver of ADAM10 gene expression and that disturbance of this pathway might contribute to development or progression of AD...
  10. ncbi Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009
    ..This indicates that overexpression of ADAM10 rather influences the amount of the cellular prion protein than its processing in vivo...
  11. ncbi Genomic structure and functional characterization of the human ADAM10 promoter
    Claudia Prinzen
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    FASEB J 19:1522-4. 2005
    ..This finding suggests that pharmacologic targeting of RA receptors may increase the expression of the alpha-secretase ADAM10 with beneficial effects on AD pathology...
  12. ncbi The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
    Christian Freese
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FEBS J 276:1568-80. 2009
    ..Adverse reactions of an ADAM10-based therapy of Alzheimer's disease due to neuregulin-1 cleavage are therefore unlikely...
  13. ncbi A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin
    Angela Valeva
    Institute of Medical Microbiology and Hygiene, University of Mainz, D55101 Mainz, Germany
    J Biol Chem 279:25143-8. 2004
    ..Although many microbial toxins are activated by furin, this is the first evidence for processing by a cellular metalloproteinase. We identified ADAM-17 as a potent activator of pro-VCC...
  14. doi Retinoids as a perspective in treatment of Alzheimer's disease
    Falk Fahrenholz
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 7:190-2. 2010
    ..Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis...
  15. pmc A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug
    Christian Freese
    REPAIR Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany
    PLoS ONE 9:e91003. 2014
    ..This bio-assay can easily be adapted to analyze other Alzheimer- or CNS disease-relevant targets in neuronal cells, as their therapeutical potential also depends on the ability to penetrate the BBB...
  16. ncbi Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
    ....