Research Topics
Species | S A EmingSummaryAffiliation: University of Cologne Country: Germany Publications
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Detail Information
Publications
Efficacy and safety of the freeze-dried cultured human keratinocyte lysate, LyphoDerm 0.9%, in the treatment of hard-to-heal venous leg ulcersKeith G Harding
Department of Surgery, Wound Healing Research Unit, University of Wales, College of Medicine, Cardiff, United Kingdom
Wound Repair Regen 13:138-47. 2005....
Extracellular matrix in angiogenesis: dynamic structures with translational potentialSabine A Eming
Department of Dermatology, University of Cologne, Koln, Germany
Exp Dermatol 20:605-13. 2011..Finally, this article will provide a rationale for targeting the ECM-morphogen interplay for therapeutic angiogenesis...- Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic woundsSabine A Eming
Department of Dermatology, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Institute for Oral and Musculoskeletal Biology, University of Cologne, Cologne, Germany
J Proteome Res 9:4758-66. 2010..This analysis therefore represents an important basis for the search for potential biomarkers, which give rise to a better understanding and monitoring of disease progression in chronic wounds... - Interrelation of immunity and tissue repair or regenerationSabine A Eming
Department of Dermatology, University of Cologne, Germany
Semin Cell Dev Biol 20:517-27. 2009..Finally, we report on new mechanistic insights on how these inflammatory pathways impair healing under pathological conditions and discuss therapeutic implications... - Regulation of angiogenesis: wound healing as a modelSabine A Eming
Department of Dermatology, University of Cologne, Joseph Stelzmann Street 9, 50931 Koln, Germany
Prog Histochem Cytochem 42:115-70. 2007..The article provides a rationale for targeting the angiogenic response in order to modulate the outcome of the healing response... - [Chronic wounds. Novel approaches in research and therapy]S A Eming
Klinik und Poliklinik fur Dermatologie und Venerologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
Hautarzt 58:939-44. 2007..This review focuses on new developments in wound healing research and the resulting non-operative therapeutic implications... - Inflammation in wound repair: molecular and cellular mechanismsSabine A Eming
Department of Dermatology, University of Cologne, Cologne, Germany
J Invest Dermatol 127:514-25. 2007..In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response... 
Accelerated wound closure in mice deficient for interleukin-10Sabine A Eming
Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
Am J Pathol 170:188-202. 2007..These results show for the first time that IL-10 can impede wound repair...- Molecular mechanisms of VEGF-A action during tissue repairSabine A Eming
Department of Dermatology, University of Cologne, Cologne, Germany
J Investig Dermatol Symp Proc 11:79-86. 2006..These observations support the concept that VEGF-A and VEGF-A receptors are important mediators in tissue repair. Further, our data provide mechanisms how VEGF-A-mediated interactions are disturbed during impaired healing... - Increased expression of VEGF in glomeruloid reactive angioendotheliomatosisSabine A Eming
Department of Dermatology, University of Cologne, Cologne, Germany
Dermatology 207:398-401. 2003..This case suggests a possible role of epidermally derived VEGF in endothelial cell proliferation in RAE... - Gene transfer in tissue repair: status, challenges and future directionsSabine A Eming
University of Cologne, Department of Dermatology, Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
Expert Opin Biol Ther 4:1373-86. 2004..This article summarises repair mechanisms and their failure, and gives an overview of techniques and studies applied to gene transfer in tissue repair. It also provides perspectives on potential targets for gene transfer technology... - Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repairDetlev Roth
Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
Am J Pathol 168:670-84. 2006..Inactivation of the plasmin cleavage site Arg110/Ala111 may preserve the biological function of VEGF165 in therapeutic angiogenesis under conditions in which proteases are highly active, such as wound repair and inflammation... - Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage siteGereon Lauer
Department of Dermatology, University of Cologne, Cologne, Germany
FEBS Lett 531:309-13. 2002..These results suggest that the plasmin cleavage site Arg110/Ala111 and the carboxyl-terminal domain play an important role in the mitogenic activity of VEGF165... - [Autoinflammatory diseases as cause of wound healing defects]R Lohrer
Klinik und Poliklinik fur Dermatologie und Venerologie, Universitat zu Koln, Kerpenerstr 62, 50937, Koln, Deutschland
Hautarzt 62:524-33. 2011..Furthermore, the article will be complemented by an overview of those inflammatory diseases that are associated with non-ulcerative cutaneous manifestations... - Treatment of chronic wounds: state of the art and future conceptsSabine A Eming
Department of Dermatology, University of Cologne, Germany
Cells Tissues Organs 172:105-17. 2002.... - Differential roles of macrophages in diverse phases of skin repairTina Lucas
Department of Dermatology, University of Cologne, Cologne, Germany
J Immunol 184:3964-77. 2010..These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events... - Alternative proteolytic processing of hepatocyte growth factor during wound repairNils Buchstein
Professor of Dermatology, Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
Am J Pathol 174:2116-28. 2009.... - Gene therapy and wound healingSabine A Eming
Department of Dermatology, University of Cologne, D 50937 Cologne, Germany
Clin Dermatol 25:79-92. 2007..We have summarized the molecular and cellular basis of repair mechanisms and their failure, and we give an overview of techniques and studies applied to gene transfer in tissue repair... - A novel property of povidon-iodine: inhibition of excessive protease levels in chronic non-healing woundsSabine A Eming
J Invest Dermatol 126:2731-3. 2006 - Particle-mediated gene therapy of woundsJeffrey M Davidson
Department of Pathology, Vanderbilt University School of Medicine, Department of Veterans Affairs Medical Center, Nashville, TN, USA
Methods Mol Med 78:433-52. 2003 - The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanismsAthanasios N Athanasopoulos
Experimental Immunology Branch, NCI, NIH, Center Dr, Rm 4B17, Bethesda, MD 20892, USA
Blood 107:2720-7. 2006..Eap may also serve as a lead compound for new anti-inflammatory and antiangiogenic therapies in several pathologies... - Increased levels of the soluble variant of the vascular endothelial growth factor receptor VEGFR-1 are associated with a poor prognosis in wound healingSabine A Eming
J Invest Dermatol 123:799-802. 2004