Ahmet H Elmaagacli

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Molecular methods used for detection of minimal residual disease following hematopoietic stem cell transplantation in myeloid disorders
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Methods Mol Med 134:161-78. 2007
  2. ncbi request reprint Estimating the relapse stage in chronic myeloid leukaemia patients after allogeneic stem cell transplantation by the amount of BCR-ABL fusion transcripts detected using a new real-time polymerase chain reaction method
    A H Elmaagacli
    Department of Bone Marrow Transplantation and Internal Medicine Cancer Research, University Hospital of Essen, Essen, Germany
    Br J Haematol 113:1072-5. 2001
  3. ncbi request reprint Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Transplantation 81:247-54. 2006
  4. ncbi request reprint Reduced risk for molecular disease in patients with chronic myeloid leukemia after transplantation from a KIR-mismatched donor
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Transplantation 79:1741-7. 2005
  5. ncbi request reprint WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cells
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    Haematologica 90:326-34. 2005
  6. ncbi request reprint Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Br J Haematol 136:212-9. 2007
  7. ncbi request reprint Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid l
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation and the Institute of Immunology, University Hospital of Essen, Germany
    Blood 101:446-53. 2003
  8. ncbi request reprint Improved disease-free-survival after transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical unrelated donors in patients with first chronic phase chronic myeloid leukemia
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Germany
    Blood 99:1130-5. 2002
  9. ncbi request reprint Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
    Dietrich W Beelen
    Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Blood 105:2594-600. 2005
  10. pmc Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib
    Michael Koldehoff
    Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital of Duisburg Essen, Hufelandstr 55 45122 Essen, Germany
    Haematologica 95:388-97. 2010

Detail Information

Publications25

  1. ncbi request reprint Molecular methods used for detection of minimal residual disease following hematopoietic stem cell transplantation in myeloid disorders
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Methods Mol Med 134:161-78. 2007
    ....
  2. ncbi request reprint Estimating the relapse stage in chronic myeloid leukaemia patients after allogeneic stem cell transplantation by the amount of BCR-ABL fusion transcripts detected using a new real-time polymerase chain reaction method
    A H Elmaagacli
    Department of Bone Marrow Transplantation and Internal Medicine Cancer Research, University Hospital of Essen, Essen, Germany
    Br J Haematol 113:1072-5. 2001
    ..06% (range 0.001-1.55%), 3.2% (range 1.4-5.6%) and 21.5% (range 6.8 -827%) in 17 patients with a molecular relapse, in eight patients with a cytogenetic relapse and in 10 patients with a haematological relapse respectively...
  3. ncbi request reprint Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Transplantation 81:247-54. 2006
    ....
  4. ncbi request reprint Reduced risk for molecular disease in patients with chronic myeloid leukemia after transplantation from a KIR-mismatched donor
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Transplantation 79:1741-7. 2005
    ....
  5. ncbi request reprint WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cells
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    Haematologica 90:326-34. 2005
    ..Furthermore, we wanted to evaluate whether the additional use of BCR-ABL siRNA could increase the anti-leukemic effects of WT1 siRNA in chronic myeloid leukemia (CML) cells...
  6. ncbi request reprint Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Br J Haematol 136:212-9. 2007
    ..Our data indicate that GFI1B plays a major role in AML-M6 and AML-M7 and qualifies as a target for anti-leukaemic strategies in these malignancies...
  7. ncbi request reprint Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid l
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation and the Institute of Immunology, University Hospital of Essen, Germany
    Blood 101:446-53. 2003
    ..01; and CD34-PBSCT versus PBSCT, P <.03). Transplantation of CD34(+)-PBSCs with T-cell add-back for patients with CML in first chronic phase seems to be safe and is an encouraging alternative transplant procedure to BMT or PBSCT...
  8. ncbi request reprint Improved disease-free-survival after transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical unrelated donors in patients with first chronic phase chronic myeloid leukemia
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Germany
    Blood 99:1130-5. 2002
    ..03). Overall survival 1000 days after receiving the transplant was 66% after BMT and 94% after PBSCT (P <.02). In the multivariate analysis, only acute GVHD significantly influenced TRM (P <.01)...
  9. ncbi request reprint Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
    Dietrich W Beelen
    Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Blood 105:2594-600. 2005
    ..In conclusion, unmodified allogeneic HSCT from KIR ligand-incompatible donors provides a superior long-term antileukemic efficacy in patients with myeloid malignancies...
  10. pmc Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib
    Michael Koldehoff
    Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital of Duisburg Essen, Hufelandstr 55 45122 Essen, Germany
    Haematologica 95:388-97. 2010
    ..We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those resistant to imatinib and particularly those with the T315I mutation...
  11. ncbi request reprint T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors
    Markus Ditschkowski
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Haematologica 92:558-61. 2007
    ..The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP...
  12. ncbi request reprint Use of the activating gene mutation of the tyrosine kinase (VAL617Phe) JAK2 as a minimal residual disease marker in patients with myelofibrosis and myeloid metaplasia after allogeneic stem cell transplantation
    Nina K Steckel
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Transplantation 83:1518-20. 2007
    ..Our presented data shows the feasibility of the detection of JAK2 gene mutation by real-time PCR as a minimal residual disease marker after transplant...
  13. doi request reprint Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells
    Michael Koldehoff
    Department of Bone Marrow Transplantation, University Hospital of Duisburg Essen, Essen, Germany
    Int J Hematol 87:39-47. 2008
    ..Our data indicate that Gfi-1B signalling is important for commitment and maturation of hematopoietic cell populations...
  14. ncbi request reprint Donor cell reaction to OKT3 as predictor of chronic graft-vs-host disease in hematopoietic stem cell recipients
    Monika Lindemann
    Institute of Immunology, University Hospital, Essen, Germany
    Exp Hematol 34:1753-8. 2006
    ..In the hematopoietic stem cell transplantation setting, granulocyte colony-stimulating factor (G-CSF) administration can reduce donor cell reactivity in vitro, but the clinical significance of this phenomenon was only sparsely defined...
  15. ncbi request reprint Quantitative analysis of chimerism after allogeneic stem cell transplantation by real-time polymerase chain reaction with single nucleotide polymorphisms, standard tandem repeats, and Y-chromosome-specific sequences
    Michael Koldehoff
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Am J Hematol 81:735-46. 2006
    ..0, P < 0.0001). We conclude that the use of real-time SNP or Y-PCR may be superior to the STR-PCR or interphase XY-FISH methods in detecting patients who are at high risk for relapse after transplant...
  16. pmc Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis
    Markus Ditschkowski
    Department of Bone Marrow Transplantation, WTZ, University Hospital of Essen, Essen, Germany
    Haematologica 97:1574-81. 2012
    ..The aim of this study was to assess disease-specific and transplant-related risk factors that influence post-transplant outcome in patients with myelofibrosis...
  17. ncbi request reprint Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Blood 118:1402-12. 2011
    ..0001). This is the first report that demonstrates an independent and substantial reduction of the leukemic relapse risk after early replicative HCMV infection in a homogeneous population of adult acute myeloid leukemia patients...
  18. doi request reprint Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myeloma
    Michael Koldehoff
    Department of Bone Marrow Transplantation, University Hospital of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    J Leukoc Biol 84:561-76. 2008
    ....
  19. doi request reprint Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cells
    Michael Koldehoff
    Department of Bone Marrow Transplantation, West German Cancer Center, Medical School of University of Duisburg Essen, University Hospital of Duisburg Essen, Essen, Germany
    J Leukoc Biol 90:1017-26. 2011
    ..Rejection of allogeneic skin grafts was delayed in female mice receiving hCG. We conclude that hCG may be useful for the induction of immune tolerance in solid organ transplantation...
  20. ncbi request reprint Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation
    Markus Ditschkowski
    Klinik für Knochenmarktransplantation, Universitatsklinikum Essen, Essen, Germany
    Transplantation 75:1745-7. 2003
    ..It may be influenced by the implementation of a new allogeneic immune system resulting from the transplantation of hematopoietic stem cells...
  21. doi request reprint Maternal molecular features and gene profiling of monocytes during first trimester pregnancy
    Michael Koldehoff
    Department of Bone Marrow Transplantation, West German Cancer Center, Faculty of Medicine, University Duisburg Essen, Essen, Germany Electronic address
    J Reprod Immunol 99:62-8. 2013
    ..Further studies will be needed to elucidate the biological significance of our observation. ..
  22. doi request reprint Therapeutic targeting of gene expression by siRNAs directed against BCR-ABL transcripts in a patient with imatinib-resistant chronic myeloid leukemia
    Michael Koldehoff
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Methods Mol Biol 487:451-66. 2009
    ..Our findings imply that the clinical application of synthetic siRNA is feasible, safe and has real potential for genetic-based therapies using synthetic nonviral carriers...
  23. ncbi request reprint Real-time PCR for monitoring minimal residual disease and chimerism in patients after allogeneic transplantation
    Ahmet H Elmaagacli
    Department of Bone Marrow Transplantation, University Hospital Essen, Germany
    Int J Hematol 76:204-5. 2002
    ..All in all, new real-time PCR methods offer a fast, reliable and very sensitive method to evaluate MRD and chimerism in patients after allogeneic SCT and therefore, to help to identify patients who are at high risk for leukemic relapse...
  24. ncbi request reprint Quantitative TP73 transcript analysis in hepatocellular carcinomas
    Thorsten Stiewe
    Center for Cancer Research and Cancer Therapy, Institute of Molecular Biology, University of Essen Medical School, Essen, Germany
    Clin Cancer Res 10:626-33. 2004
    ..The purpose of our study was to elucidate the origin of DeltaTA-p73 isoforms in hepatocellular carcinomas...
  25. ncbi request reprint No influence of V617F mutation in JAK2 on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for myelofibrosis
    Markus Ditschkowski
    Biol Blood Marrow Transplant 12:1350-1. 2006