Research Topics
Species | Ahmet H ElmaagacliSummaryAffiliation: University of Essen Country: Germany Publications
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Detail Information
Publications
Molecular methods used for detection of minimal residual disease following hematopoietic stem cell transplantation in myeloid disordersAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Methods Mol Med 134:161-78. 2007....- Estimating the relapse stage in chronic myeloid leukaemia patients after allogeneic stem cell transplantation by the amount of BCR-ABL fusion transcripts detected using a new real-time polymerase chain reaction methodA H Elmaagacli
Department of Bone Marrow Transplantation and Internal Medicine Cancer Research, University Hospital of Essen, Essen, Germany
Br J Haematol 113:1072-5. 2001..06% (range 0.001-1.55%), 3.2% (range 1.4-5.6%) and 21.5% (range 6.8 -827%) in 17 patients with a molecular relapse, in eight patients with a cytogenetic relapse and in 10 patients with a haematological relapse respectively... - Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantationAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Transplantation 81:247-54. 2006.... - Reduced risk for molecular disease in patients with chronic myeloid leukemia after transplantation from a KIR-mismatched donorAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Transplantation 79:1741-7. 2005.... - WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cellsAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
Haematologica 90:326-34. 2005..Furthermore, we wanted to evaluate whether the additional use of BCR-ABL siRNA could increase the anti-leukemic effects of WT1 siRNA in chronic myeloid leukemia (CML) cells... - Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rateAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Br J Haematol 136:212-9. 2007..Our data indicate that GFI1B plays a major role in AML-M6 and AML-M7 and qualifies as a target for anti-leukaemic strategies in these malignancies... - Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid lAhmet H Elmaagacli
Department of Bone Marrow Transplantation and the Institute of Immunology, University Hospital of Essen, Germany
Blood 101:446-53. 2003..01; and CD34-PBSCT versus PBSCT, P <.03). Transplantation of CD34(+)-PBSCs with T-cell add-back for patients with CML in first chronic phase seems to be safe and is an encouraging alternative transplant procedure to BMT or PBSCT... - Improved disease-free-survival after transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical unrelated donors in patients with first chronic phase chronic myeloid leukemiaAhmet H Elmaagacli
Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Germany
Blood 99:1130-5. 2002..03). Overall survival 1000 days after receiving the transplant was 66% after BMT and 94% after PBSCT (P <.02). In the multivariate analysis, only acute GVHD significantly influenced TRM (P <.01)... - Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemiasDietrich W Beelen
Department of Bone Marrow Transplantation, Institute of Immunology, University Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Blood 105:2594-600. 2005..In conclusion, unmodified allogeneic HSCT from KIR ligand-incompatible donors provides a superior long-term antileukemic efficacy in patients with myeloid malignancies... 
Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinibMichael Koldehoff
Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital of Duisburg Essen, Hufelandstr 55 45122 Essen, Germany
Haematologica 95:388-97. 2010..We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those resistant to imatinib and particularly those with the T315I mutation...- T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donorsMarkus Ditschkowski
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Haematologica 92:558-61. 2007..The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP... - Use of the activating gene mutation of the tyrosine kinase (VAL617Phe) JAK2 as a minimal residual disease marker in patients with myelofibrosis and myeloid metaplasia after allogeneic stem cell transplantationNina K Steckel
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Transplantation 83:1518-20. 2007..Our presented data shows the feasibility of the detection of JAK2 gene mutation by real-time PCR as a minimal residual disease marker after transplant... 
Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cellsMichael Koldehoff
Department of Bone Marrow Transplantation, University Hospital of Duisburg Essen, Essen, Germany
Int J Hematol 87:39-47. 2008..Our data indicate that Gfi-1B signalling is important for commitment and maturation of hematopoietic cell populations...- Donor cell reaction to OKT3 as predictor of chronic graft-vs-host disease in hematopoietic stem cell recipientsMonika Lindemann
Institute of Immunology, University Hospital, Essen, Germany
Exp Hematol 34:1753-8. 2006..02 and p = 0.0007, respectively). CONCLUSION: The proliferative capacity of G-CSF-mobilized donor cells appears as a graft factor that determines the future incidence of cGVHD in the corresponding recipient... - Quantitative analysis of chimerism after allogeneic stem cell transplantation by real-time polymerase chain reaction with single nucleotide polymorphisms, standard tandem repeats, and Y-chromosome-specific sequencesMichael Koldehoff
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Am J Hematol 81:735-46. 2006..0, P < 0.0001). We conclude that the use of real-time SNP or Y-PCR may be superior to the STR-PCR or interphase XY-FISH methods in detecting patients who are at high risk for relapse after transplant... - Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patientsAhmet H Elmaagacli
Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany
Blood 118:1402-12. 2011..0001). This is the first report that demonstrates an independent and substantial reduction of the leukemic relapse risk after early replicative HCMV infection in a homogeneous population of adult acute myeloid leukemia patients... - Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myelomaMichael Koldehoff
Department of Bone Marrow Transplantation, University Hospital of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
J Leukoc Biol 84:561-76. 2008.... - Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosisMarkus Ditschkowski
Department of Bone Marrow Transplantation, WTZ, University Hospital of Essen, Essen, Germany
Haematologica 97:1574-81. 2012..The aim of this study was to assess disease-specific and transplant-related risk factors that influence post-transplant outcome in patients with myelofibrosis... - Improvement of inflammatory bowel disease after allogeneic stem-cell transplantationMarkus Ditschkowski
, , Essen, Germany
Transplantation 75:1745-7. 2003..It may be influenced by the implementation of a new allogeneic immune system resulting from the transplantation of hematopoietic stem cells... - Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cellsMichael Koldehoff
Department of Bone Marrow Transplantation, West German Cancer Center, Medical School of University of Duisburg Essen, University Hospital of Duisburg Essen, Essen, Germany
J Leukoc Biol 90:1017-26. 2011..Rejection of allogeneic skin grafts was delayed in female mice receiving hCG. We conclude that hCG may be useful for the induction of immune tolerance in solid organ transplantation... - Therapeutic targeting of gene expression by siRNAs directed against BCR-ABL transcripts in a patient with imatinib-resistant chronic myeloid leukemiaMichael Koldehoff
Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
Methods Mol Biol 487:451-66. 2009..Our findings imply that the clinical application of synthetic siRNA is feasible, safe and has real potential for genetic-based therapies using synthetic nonviral carriers... - Real-time PCR for monitoring minimal residual disease and chimerism in patients after allogeneic transplantationAhmet H Elmaagacli
Department of Bone Marrow Transplantation, University Hospital Essen, Germany
Int J Hematol 76:204-5. 2002..All in all, new real-time PCR methods offer a fast, reliable and very sensitive method to evaluate MRD and chimerism in patients after allogeneic SCT and therefore, to help to identify patients who are at high risk for leukemic relapse... - Quantitative TP73 transcript analysis in hepatocellular carcinomasThorsten Stiewe
Center for Cancer Research and Cancer Therapy, Institute of Molecular Biology, University of Essen Medical School, Essen, Germany
Clin Cancer Res 10:626-33. 2004..The purpose of our study was to elucidate the origin of DeltaTA-p73 isoforms in hepatocellular carcinomas... - No influence of V617F mutation in JAK2 on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for myelofibrosisMarkus Ditschkowski
Biol Blood Marrow Transplant 12:1350-1. 2006