David Ellinghaus

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
  2. pmc Current software for genotype imputation
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Hum Genomics 3:371-80. 2009
  3. pmc Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    Am J Hum Genet 90:636-47. 2012
  4. doi request reprint Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
    Andre Franke
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:292-4. 2010
  5. pmc Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL
    Eva Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    J Invest Dermatol 132:1133-40. 2012
  6. pmc Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
    Gastroenterology 145:339-47. 2013
  7. doi request reprint A comprehensive evaluation of SNP genotype imputation
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany
    Hum Genet 125:163-71. 2009
  8. doi request reprint Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Hepatology 58:1074-83. 2013
  9. pmc From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software
    Michael Forster
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    Nucleic Acids Res 41:e16. 2013
  10. doi request reprint A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
    Annegret Fischer
    Christian Albrechts University, Institute of Clinical Molecular Biology, Schittenhelmstrasse 12, Kiel, Germany
    Am J Respir Crit Care Med 186:877-85. 2012

Detail Information

Publications16

  1. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
    ..A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors...
  2. pmc Current software for genotype imputation
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Hum Genomics 3:371-80. 2009
    ..Each of them has different strengths and weaknesses, however, and none is optimal for all situations...
  3. pmc Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    Am J Hum Genet 90:636-47. 2012
    ..Our results show the usefulness of joint analyses of clinically distinct immune-mediated diseases and enlarge the map of shared genetic risk loci...
  4. doi request reprint Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
    Andre Franke
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:292-4. 2010
    ..81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively)...
  5. pmc Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL
    Eva Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    J Invest Dermatol 132:1133-40. 2012
    ..We hypothesize that c-Rel, as a member of the Rel/NF-κB family, is associated with PsA in the context of disease pathways that involve other identified PsA and PsV susceptibility genes including TNIP1, TNFAIP3, and NFκBIA...
  6. pmc Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
    Gastroenterology 145:339-47. 2013
    ..We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies...
  7. doi request reprint A comprehensive evaluation of SNP genotype imputation
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany
    Hum Genet 125:163-71. 2009
    ..We nevertheless recommend either MACH or BEAGLE for practical use because these two programs are more user-friendly and generally require less memory than IMPUTE...
  8. doi request reprint Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Hepatology 58:1074-83. 2013
    ..GPR35 shows associations in both UC and PSC, whereas TCF4 represents a PSC risk locus not associated with UC. Both loci may represent previously unexplored aspects of PSC pathogenesis...
  9. pmc From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software
    Michael Forster
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    Nucleic Acids Res 41:e16. 2013
    ..This comparison tool also solves the problem of detecting allelic imbalance within heterozygous SNVs in copy number variation loci, or in heterogeneous tumor sequences...
  10. doi request reprint A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
    Annegret Fischer
    Christian Albrechts University, Institute of Clinical Molecular Biology, Schittenhelmstrasse 12, Kiel, Germany
    Am J Respir Crit Care Med 186:877-85. 2012
    ..Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known...
  11. pmc Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
    Eva Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:991-5. 2010
    ..TRAF3IP2 encodes a protein involved in IL-17 signaling and which interacts with members of the Rel/NF-κB transcription factor family...
  12. ncbi request reprint A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
    Almut Nebel
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Mech Ageing Dev 132:324-30. 2011
    ..A recent GWAS in Dutch LLI independently confirmed the APOE-longevity association, thus strengthening the conclusion that this locus is a very, if not the most, important genetic factor influencing longevity...
  13. ncbi request reprint Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample
    Jurgita Skieceviciene
    Institute for Digestive Research and Department of Gastroenterology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany Center of Hepatology, Gastroenterology and Dietetics, Vilnius University, Vilnius, Lithuania Digestive Diseases Centre GASTRO, Riga, Latvia Departments of Children Diseases and Health Management, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark Internal Disease Department, Riga Stradins University, Riga, Latvia and Department of Surgery, Academy of Medicine, Lithuanian University of Health Science, Kaunas, Lithuania
    Inflamm Bowel Dis 19:2349-55. 2013
    ....
  14. pmc High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
    Nat Genet 45:808-12. 2013
    ..This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis. ..
  15. pmc Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    Andre Franke
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    Nat Genet 42:1118-25. 2010
    ..Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease...
  16. doi request reprint Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel 24105, Germany
    Nat Genet 40:1319-23. 2008
    ..17 (1.01-1.34)). IL10 is an immunosuppressive cytokine that has long been proposed to influence IBD pathophysiology. Our findings strongly suggest that defective IL10 function is central to the pathogenesis of the UC subtype of IBD...