Research Topics
Genomes and Genes | Jörg EllingerSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarkerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
BJU Int 104:48-52. 2009..To analyse the diagnostic and prognostic value of cell-free mitochondrial (mt)DNA in patients with testicular cancer, as increased levels of cell-free circulating mtDNA have been reported in patients with cancer...- Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignanciesJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
Urol Oncol 30:509-15. 2012..Cell-free circulating mitochondrial DNA (mtDNA) has been proposed as universal diagnostic and prognostic biomarker in cancer patients... - Global histone H3K27 methylation levels are different in localized and metastatic prostate cancerJörg Ellinger
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
Cancer Invest 30:92-7. 2012..H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis... - Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entityJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Cancer Lett 264:274-80. 2008..011) indicating that the AI is an independent prognostic factor. Thus, cell-free DNA seems to be a useful prognostic marker in patients with BCA... - The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urol Oncol 29:124-9. 2011..The detection of increased DNA levels and tumor-specific DNA sequences may provide diagnostic and prognostic information. The recent findings in the emerging field of cell-free DNA will be discussed... - Global levels of histone modifications predict prostate cancer recurrenceJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
Prostate 70:61-9. 2010..Our study was performed to evaluate histone lysine (H(x)K(y)) and histone acetyl (H(x)Ac) modifications in prostate tissue... - CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancerJörg Ellinger
Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Bonn, Germany
J Urol 182:324-9. 2009..DNA hypermethylation is a common cancer associated alteration. We analyzed methylation patterns of cell-free serum DNA in patients with testicular cancer... - [Circulating cell-free serum DNA: significance as a new biomarker for urological malignancies]J Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Deutschland
Urologe A 49:1131-2, 1134. 2010..Measurement of cell-free DNA allowed sensitive and specific discrimination between cancer patients and those with non-malignant diseases... - Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomyJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
BJU Int 102:628-32. 2008..To investigate the role of circulating mitochondrial DNA (mtDNA) in patients with localized prostate cancer, as recent reports show that patients with advanced cancer have increased levels of mtDNA... - CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urology 71:161-7. 2008..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis... - DNA hypermethylation in papillary renal cell carcinomaJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
BJU Int 107:664-9. 2011..To investigate the pattern of DNA CpG island hypermethylation in papillary renal cell carcinoma (pRCC)... 
Prostate cancer tissue is masked by bicalutamide: a case reportJ Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Eur J Med Res 12:212-5. 2007..Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells...- Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicatorsJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
Int J Cancer 122:138-43. 2008..We suggest that cancer-induced apoptosis of peripheral noncancerous tissues is relevant in many malignancies... - CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Prostate 68:42-9. 2008..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients... - Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
J Urol 179:346-52. 2008..CpG island hypermethylation is a frequent event in bladder carcinogenesis and progression. We investigated the diagnostic and prognostic value of hypermethylation in cell-free serum DNA of patients with bladder cancer... - Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene lociPatrick J Bastian
Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Clin Cancer Res 11:4097-106. 2005..Our study was designed to evaluate promoter CpG island hypermethylation in the diagnosis and prognosis of prostate cancer... - Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinomaJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Int J Cancer 127:2360-6. 2010..Our study on H3K4 methylation supports the concept of global histone modifications as potential cancer prognosis markers... - Cell-free circulating DNA: Diagnostic value in patients with renal cell cancerStefan Hauser
Department of Urology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Anticancer Res 30:2785-9. 2010..To analyse the diagnostic and prognostic value of cell-free DNA in patients with renal cell carcinoma (RCC)... - Analysis of serum microRNAs (miR-26a-2*, miR-191, miR-337-3p and miR-378) as potential biomarkers in renal cell carcinomaStefan Hauser
Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Cancer Epidemiol 36:391-4. 2012..Emerging evidence suggest that microRNAs could serve as non-invasive biomarker for cancer patients. Our study was designed to analyze circulating serum microRNAs in patients with renal cell carcinoma (RCC)... 
Alterations of global histone H4K20 methylation during prostate carcinogenesisTurang E Behbahani
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
BMC Urol 12:5. 2012..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...- Global histone H4K20 trimethylation predicts cancer-specific survival in patients with muscle-invasive bladder cancerAnn Christin Schneider
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
BJU Int 108:E290-6. 2011..To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer... - Global histone acetylation levels: prognostic relevance in patients with renal cell carcinomaDavit Mosashvilli
Department of Urology, University Hospital Bonn, Bonn, Germany
Cancer Sci 101:2664-9. 2010..In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC... - Tyrosine kinase expression profile in clear cell renal cell carcinomaTurang E Behbahani
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
World J Urol 30:559-65. 2012..To profile different tyrosine kinase (TK) expression patterns in clear cell renal carcinoma (ccRCC)... - Decreased levels of histone H3K9me1 indicate poor prognosis in patients with renal cell carcinomaSebastian Rogenhofer
Department of Urology, University Hospital Bonn, Bonn, Germany
Anticancer Res 32:879-86. 2012..To determine the role of global histone H3K9 and H4K20 methylation levels as prognostic parameters in patients with renal cell cancer (RCC)... - Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomyPatrick J Bastian
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
Eur Urol 51:665-74; discussion 674. 2007.... - Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinomaSebastian Rogenhofer
Department of Urology, University of Bonn, Germany
BJU Int 109:459-65. 2012..To evaluate if histone H3 lysine 27 (H3K27) methylation plays a role in renal cell carcinoma (RCC) tissue and whether its expression is a predictor of cancer recurrence in RCC... - Serum DNA hypermethylation in patients with bladder cancer: results of a prospective multicenter studyStefan Hauser
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Anticancer Res 33:779-84. 2013..A few reports indicated that methylated serum DNA in patients with bladder cancer (BCA) is a useful non-invasive biomarker. The purpose of this prospective multicenter study was to validate earlier studies... - Histone methylation defines an epigenetic entity in penile squamous cell carcinomaSebastian Rogenhofer
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
J Urol 189:1117-22. 2013..Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue... - Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhageStefan Hauser
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
Urol Int 88:390-4. 2012..To evaluate the feasibility and safety of thulium:yttrium-aluminium-garnet laser vapoenucleation of the prostate (ThuVEP) in patients with chronic anticoagulation and bleeding disorders... - Cell-free serum DNA in patients with bladder cancer: results of a prospective multicenter studyStefan Hauser
Department of Urology and Paediatric Urology, University Hospital Bonn, Bonn, Germany
Anticancer Res 32:3119-24. 2012..Cell-free DNA may serve as a biomarker for patients with cancer; we designed our study to determine its potential in patients with bladder cancer (BCA)... - Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
J Urol 181:363-71. 2009..Increased levels of cell-free circulating DNA have been described in various malignancies as a diagnostic and prognostic biomarker. We analyzed the significance of cell-free DNA in patients with testicular cancer... - Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignanciesJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urology 68:257-62. 2006..It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation... - Circulating microRNAs (miRNA) in serum of patients with prostate cancerRobert Mahn
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Germany
Urology 77:1265.e9-16. 2011..To analyze circulating microRNAs (miRNA) in serum as non-invasive biomarker in patients with localized prostate cancer (PCA), benign prostate hyperplasia (BPH) and healthy individuals (HI)... - Stem cell marker expression in small cell lung carcinoma and developing lung tissueLin Kristin Koch
Institut of Pathology, University of Bonn, Bonn, Germany
Hum Pathol 39:1597-605. 2008..Taken together, we show that small cell lung cancers and clustered epithelial cells in developing proximal bronchi share the expression of stem cell markers, suggesting a possible histogenetic link... - Saturation biopsy improves preoperative Gleason scoring of prostate cancerPhilip Kahl
Department of Pathology, University Hospital Bonn Medical School, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
Pathol Res Pract 205:259-64. 2009..Both techniques fail to detect insignificant prostate cancer... - Pathological outcomes of men eligible for active surveillance after undergoing radical prostatectomy: are results predictable?Turang Ed Behbahani
Department of Urology, University of Bonn, Bonn, Germany
Clin Genitourin Cancer 10:32-6. 2012..To analyze pathological results in patients with prostate cancer eligible for active surveillance (AS) after radical prostatectomy and available prediction systems... - Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptideVera Hauptstock
Department of Pathology, University Hospital Bonn, Bonn, Germany
Biochem Biophys Res Commun 412:606-11. 2011..Successful therapy requires both, DNA demethylation and activating histone modifications, to induce complete gene expression of epigenetically silenced genes and depsipeptide fulfils both criteria... - Identification of prostaglandin receptors in human uretersMatthias Oll
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
BMC Urol 12:35. 2012..Prostaglandins play an important role in ureteral obstruction, but the detailed expression profiles of the prostaglandin receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR) remain unknown in the different parts of the human ureter... - Evaluation of reference genes for the analysis of serum miRNA in patients with prostate cancer, bladder cancer and renal cell carcinomaImke Sanders
Department of Urology, University Hospital Bonn, Bonn, Germany
Int J Urol 19:1017-25. 2012..To identify an appropriate reference gene for the analysis of circulating micro-ribonucleic acid in patients with urological malignancies... - Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulationZaki Shaikhibrahim
Institute of Pathology, University Hospital Bonn, Bonn, Germany
Int J Mol Med 28:799-807. 2011..Unraveling the dynamics of the ETS-immunity-related genes will provide an invaluable insight into understanding prostate cancer immunology... - Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinomaNicolas Fischer
Department of Urology, University of Bonn, Bonn, Germany
Biochem Biophys Res Commun 417:29-34. 2012..We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals... - Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrencePhilip Kahl
Institute of Pathology, University Hospital Bonn Medical School, Germany
Cancer Res 66:11341-7. 2006..Our present study suggests that LSD1 and nuclear FHL2 may serve as novel biomarkers predictive for prostate cancer with aggressive biology and point to a role of LSD1 and FHL2 in constitutive activation of AR-mediated growth signals... - Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?Sabine Ellinger
Department of Food and Nutrition Sciences Nutrition Physiology, University of Bonn, Endenicher Allee 11 13, 53115 Bonn, Germany
Curr Opin Clin Nutr Metab Care 9:722-7. 2006.... - MicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levelsLena M Wulfken
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
PLoS ONE 6:e25787. 2011..MicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for cancer patients. Our study was designed to analyze circulating serum microRNAs in patients with renal cell carcinoma (RCC)... - First report of an unexpected blind-ending duplication of the ureter as a rare pitfall in kidney transplantationStefan Hauser
Department of Urology, University of Bonn, Bonn, Germany
Transpl Int 21:696-7. 2008..Accuracy should be ensured when exploring the exact anatomy of the donor organ... - Impact of the menstrual cycle on circulating cell-free DNAMartin Pölcher
Department of Gynecology and Obstetrics, Center for Integrated Oncology, Bonn University Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
Anticancer Res 30:2235-40. 2010..To determine serum levels of circulating cell-free DNA (cfDNA) throughout the stages of endometrial proliferation and apoptosis during the menstrual cycle...