Osman El-Maarri


Affiliation: University of Bonn
Country: Germany


  1. Pezeshkpoor B, Pavlova A, Oldenburg J, El Maarri O. F8 genetic analysis strategies when standard approaches fail. Hamostaseologie. 2014;34:167-73 pubmed publisher
    ..In this review, we present the experiences with molecular diagnosis of such cases and approaches to be applied for mutation negative patients. ..
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    El Maarri O, Becker T, Junen J, Manzoor S, Diaz Lacava A, Schwaab R, et al. Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. Hum Genet. 2007;122:505-14 pubmed
    ..This observed difference could be due to the process of X chromosome inactivation or merely to the presence of an additional X chromosome in female cells or could be a result of downstream effects of sex determination. ..
  3. El Maarri O, Walier M, Behne F, van Üüm J, Singer H, Diaz Lacava A, et al. Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles. PLoS ONE. 2011;6:e16252 pubmed publisher
    ..In conclusion, neither natural cycle of hormones nor age has a detectable effect on the LINE-1 methylation in peripheral blood cells, while gender remains an important factor. ..
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    El Maarri O, Singer H, Klein C, Watzka M, Herbiniaux U, Brackmann H, et al. Lack of F8 mRNA: a novel mechanism leading to hemophilia A. Blood. 2006;107:2759-65 pubmed
    ..These findings strongly suggest that the cause of HA in this patient is either absence or rapid degradation of the F8 mRNA, which points to a novel mechanism leading to HA. ..
  5. El Maarri O, Kareta M, Mikeska T, Becker T, Diaz Lacava A, Junen J, et al. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. Hum Mol Genet. 2009;18:1755-68 pubmed publisher