Affiliation: University of Heidelberg
Freund I, Buhl D, Boutin S, Kötter A, Pichot F, Marchand V, et al
. 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. RNA. 2019;: pubmed publisher
Freund I, Eigenbrod T, Helm M, Dalpke A. RNA Modifications Modulate Activation of Innate Toll-Like Receptors. Genes (Basel). 2019;10: pubmed publisher
..This review will discuss new findings and developments in the field of immune-modulatory RNA modifications. ..
Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke A. TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes. J Immunol. 2015;195:1092-9 pubmed publisher
..Bacterial RNA within streptococci was also a dominant stimulus for murine immune cells, highlighting the physiological relevance of RNA sensing in defense of infections. ..
Eigenbrod T, Dalpke A. Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses. J Immunol. 2015;195:411-8 pubmed publisher
..RNA modifications differ between eukaryotes and prokaryotes; thus, they can serve to define the innate pattern that is recognized. In this regard, we discuss the role of ribose 2'-O-methylation as a potential immune-escape mechanism. ..
Eigenbrod T, Franchi L, Muñoz Planillo R, Kirschning C, Freudenberg M, Nunez G, et al
. Bacterial RNA mediates activation of caspase-1 and IL-1? release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B. J Immunol. 2012;189:328-36 pubmed publisher
..Thus, our data indicate the presence of a yet unidentified intracellular nucleic acid receptor involved in bacterial RNA-induced inflammasome activation and release of IL-1?. ..
Eigenbrod T, Bode K, Dalpke A. Early inhibition of IL-1? expression by IFN-? is mediated by impaired binding of NF-?B to the IL-1? promoter but is independent of nitric oxide. J Immunol. 2013;190:6533-41 pubmed publisher
..The findings provide evidence for a rapid immune-modulating effect of IFN-? independent of NO...