Ann E Ehrenhofer-Murray

Summary

Affiliation: University of Duisburg-Essen
Country: Germany

Publications

  1. pmc Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling
    Maria Becker
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, 45117 Essen, Germany
    Nucleic Acids Res 40:11648-58. 2012
  2. pmc Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange
    Franziska Heise
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, Essen, Germany
    Nucleic Acids Res 40:65-74. 2012
  3. pmc Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae
    Jan M Weber
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, 45117 Essen, Germany
    Nucleic Acids Res 38:7991-8000. 2010
  4. doi request reprint Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression: Report from the 43(rd) Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany
    Ann Ehrenhofer-Murray
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Essen, Germany
    Bioessays 35:141-4. 2013
  5. pmc Functional analysis of archaeal MBF1 by complementation studies in yeast
    Jeannette Marrero Coto
    Faculty of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg Essen, Universitätsstr 5, S05 V03 F41, 45141 Essen, Germany
    Biol Direct 6:18. 2011
  6. pmc Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79
    Stefan Ehrentraut
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie ZMB, Universitat Duisburg Essen, D 45141 Essen, Germany
    Genes Dev 25:1835-46. 2011
  7. pmc Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate
    Stefan Ehrentraut
    Abteilung für Genetik and Abteilung für Bioinformatik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, D 45117 Essen, Germany
    Proc Natl Acad Sci U S A 107:5522-7. 2010
  8. pmc Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
    Jan M Weber
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, 45117 Essen, Germany
    BMC Mol Biol 9:100. 2008
  9. doi request reprint Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension
    Jessica Stephan
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Essen, Germany
    Aging Cell 12:574-83. 2013
  10. doi request reprint Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60
    Corinna Schirling
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Universitatsstrasse 5, 45117, Essen, Germany
    Chromosoma 119:99-113. 2010

Collaborators

Detail Information

Publications13

  1. pmc Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling
    Maria Becker
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, 45117 Essen, Germany
    Nucleic Acids Res 40:11648-58. 2012
    ..Taken together, this work reveals a novel connection between nutrient signaling and tRNA methylation that thus may link tRNA methylation to processes downstream of nutrient signaling like ribosome biogenesis and translation initiation...
  2. pmc Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange
    Franziska Heise
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, Essen, Germany
    Nucleic Acids Res 40:65-74. 2012
    ....
  3. pmc Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae
    Jan M Weber
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, 45117 Essen, Germany
    Nucleic Acids Res 38:7991-8000. 2010
    ..Moreover, deletions of SIR1 and DOT1 lead to complete derepression of the HML-SS ΔI silencer. This fully functional, minimal HML-E silencer will therefore be useful to identify novel factors involved in HML silencing...
  4. doi request reprint Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression: Report from the 43(rd) Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany
    Ann Ehrenhofer-Murray
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Essen, Germany
    Bioessays 35:141-4. 2013
    ..Editor's suggested further reading in BioEssays Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology Abstract...
  5. pmc Functional analysis of archaeal MBF1 by complementation studies in yeast
    Jeannette Marrero Coto
    Faculty of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg Essen, Universitätsstr 5, S05 V03 F41, 45141 Essen, Germany
    Biol Direct 6:18. 2011
    ..To study the function and therefore the evolutionary conservation of MBF1 and its single domains complementation studies in yeast (mbf1Δ) as well as domain swap experiments between aMBF1 and yMbf1 were performed...
  6. pmc Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79
    Stefan Ehrentraut
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie ZMB, Universitat Duisburg Essen, D 45141 Essen, Germany
    Genes Dev 25:1835-46. 2011
    ..In summary, the unique folding of this conserved Sir3 AAA(+) domain generates novel surface regions that mediate Sir3-Sir4 and Sir3-nucleosome interactions, both being required for the proper assembly of heterochromatin in living cells...
  7. pmc Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate
    Stefan Ehrentraut
    Abteilung für Genetik and Abteilung für Bioinformatik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, D 45117 Essen, Germany
    Proc Natl Acad Sci U S A 107:5522-7. 2010
    ..In essence, OAADPR therefore is unavailable for binding to Sir3, preventing SIR propagation...
  8. pmc Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
    Jan M Weber
    Zentrum für Medizinische Biotechnologie, Abteilung Genetik, Universitat Duisburg Essen, 45117 Essen, Germany
    BMC Mol Biol 9:100. 2008
    ..Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1...
  9. doi request reprint Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension
    Jessica Stephan
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Essen, Germany
    Aging Cell 12:574-83. 2013
    ..Taken together, these results reveal unanticipated anti-aging activities for several phytochemicals and open up opportunities for the development of novel anti-aging therapies...
  10. doi request reprint Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60
    Corinna Schirling
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Universitatsstrasse 5, 45117, Essen, Germany
    Chromosoma 119:99-113. 2010
    ....
  11. pmc Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation
    Anke Samel
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, D 45141 Essen, Germany
    Proc Natl Acad Sci U S A 109:9029-34. 2012
    ..Altogether, our data identify a unique regulatory principle on centromeric chromatin by posttranslational modification of the amino terminus of CenH3...
  12. doi request reprint Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1
    Jacqueline Franke
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Universitätsstr 5, 45117 Essen, Germany
    J Cell Sci 121:3553-60. 2008
    ..Furthermore, tgs1Delta cells displayed a shortened replicative lifespan, suggesting that the loss of the m(3)G cap of TLC1 causes premature aging...
  13. pmc A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer
    Gesine Hoffmann
    From the Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, 45117 Essen, Germany
    J Biol Chem 289:5208-16. 2014
    ..These compounds thus provide a good opportunity for lead optimization and drug development to target p53-proficient cancers...