Research Topics
Species | Matthias EdingerSummaryAffiliation: University of Regensburg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Regulatory T cells for the prevention of graft-versus-host disease: professionals defeat amateursMatthias Edinger
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Eur J Immunol 39:2966-8. 2009..Thus, the stability of induced Treg is of major concern as discussed in this Commentary...- Regulatory T cells in stem cell transplantation: strategies and first clinical experiencesMatthias Edinger
Department of Hematology and Oncology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
Curr Opin Immunol 23:679-84. 2011.... 
Evaluation of effector cell fate and function by in vivo bioluminescence imagingMatthias Edinger
Department of Hematology and Oncology, University of Regensburg, 93042 Regensburg, Germany
Methods 31:172-9. 2003..Here, we highlight one of the newer modalities, in vivo bioluminescence imaging, as a method for evaluating effector T cell proliferation, migration, and function in model systems of malignant and non-malignant diseases...- Isolation of CD4+CD25+ regulatory T cells for clinical trialsPetra Hoffmann
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Biol Blood Marrow Transplant 12:267-74. 2006.... - Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulationPetra Hoffmann
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Eur J Immunol 39:1088-97. 2009..Thus, Treg cell lineage differentiation does not seem to represent a final fate decision, as natural Treg can lose their cell-type-specific characteristics after repetitive TCR stimulation... - Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve TregChristian Schmidl
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Eur J Immunol 41:1491-8. 2011..These findings are highly relevant for the generation of therapeutic Treg products... - Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expressionLeo Hansmann
Department of Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany
J Immunol 188:1275-82. 2012..Thus, our studies identify Th2 differentiation as the default developmental program of human Treg after downregulation of FOXP3... - Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host diseaseMarina Kreutz
Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
J Invest Dermatol 132:179-87. 2012..Our results strongly suggest that prophylactic UVB irradiation post transplant is safe and should be further explored as a clinical strategy to prevent acute (skin) GvHD... - Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansionPetra Hoffmann
Institute of Immunology, Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Blood 108:4260-7. 2006..Based on these unexpected findings, we suggest that isolation and expansion of CD45RA+ naive CD4+ CD25high T cells is the best strategy for adoptive regulatory T (Treg)-cell therapies... - Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cellsPetra Hoffmann
Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany
Microbes Infect 7:1066-72. 2005..Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT... - Inhibitory effect of tumor cell-derived lactic acid on human T cellsKarin Fischer
Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Blood 109:3812-9. 2007..These findings suggest that targeting this metabolic pathway in tumors is a promising strategy to enhance tumor immunogenicity... 
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activityChristian Schmidl
Department of Hematology, University Hospital Regensburg, 93042 Regensburg, Germany
Genome Res 19:1165-74. 2009....- CD4+CD25+ regulatory T cells and graft-versus-host diseasePetra Hoffmann
Institute of Immunology and the Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Semin Hematol 43:62-9. 2006..Here we summarize recent results regarding protection from graft-versus-host disease (GVHD) by adoptively transferred CD4+CD25+ T cells in mice and discuss early findings from clinical studies in HSCT... - Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenaseKarin Landfried
Department of Haematology Oncology, University Medical Center, Regensburg, Germany
Blood 118:6971-4. 2011..GVHD-dependent induction of IDO was further suggested by increased expression of IDO mRNA in intestinal biopsies from patients with severe GVHD. Our data indicate reactive release of kynurenines in GVHD-associated inflammation... - Polyclonal expansion of human CD4(+)CD25(+) regulatory T cellsPetra Hoffmann
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Methods Mol Biol 677:15-30. 2011..Here, we provide detailed instructions for their identification, isolation, expansion, and functional characterization... - The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infectionInken Hilgendorf
Department of Hematology, Oncology, Palliative Care, University of Rostock, Rostock, Germany
Transpl Int 25:87-96. 2012..Our data underline the close association of diminished B cell counts with cGVHD and the onset of severe infections. The lack of IgM(+) memory B cells in patients with cGVHD may indicate functional asplenia... - Regulatory mechanisms in graft-versus-host responsesMatthias Edinger
Department of Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany
Biol Blood Marrow Transplant 15:2-6. 2009.... - Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cellsPetra Hoffmann
Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
Blood 104:895-903. 2004.... - Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHDJoerg Ermann
Division of Immunology and Rheumatology, The Department of Medicine, Stanford University School of Medicine, CCSR Bldg, Rm 2215-C, 300 Pasteur Dr, Stanford, CA 94305-5166, USA
Blood 105:2220-6. 2005..The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD... - Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cellsMichael R Verneris
Department of Pediatrics, Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 11:4561-70. 2005..To identify novel treatments for pediatric solid tumors and/or for malignancies with low-level Her2/neu expression... - Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imagingMatthias Edinger
Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, CA, USA
Blood 101:640-8. 2003..The complex cellular processes in bone marrow transplantation and antitumor immunotherapy, previously inaccessible to investigation, can now be revealed in real time in living animals... - Understanding immune cell trafficking patterns via in vivo bioluminescence imagingStefanie Mandl
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
J Cell Biochem Suppl 39:239-48. 2002..Such rapid assays that reveal cell fates in vivo will increase our basic understanding of the molecular signals that control these migratory pathways and will substantially speed up the development and evaluation of therapies... - CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationMatthias Edinger
Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Nat Med 9:1144-50. 2003..Thus, CD4+CD25+ T cells are potent regulatory cells that can separate GVHD from GVT activity mediated by conventional donor T cells... - DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cellsUdo Baron
Epiontis GmbH, Berlin, Germany
Eur J Immunol 37:2378-89. 2007..We conclude that FOXP3 DNA demethylation constitutes the most reliable criterion for natural Treg available at present... - A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphomaThomas Leemhuis
Division of Bone Marrow Transplantation, Stanford University Medical Center, California, USA
Biol Blood Marrow Transplant 11:181-7. 2005.... - Studies of ex vivo activated and expanded CD8+ NK-T cells in humans and miceMichael R Verneris
Division of Pediatric Hematology Oncology, and Bone Marrow Transplantation, Stanford, California 94305, USA
J Clin Immunol 22:131-6. 2002..We conclude that expanded CD8+ NK-T cells are a promising form of cellular therapy in the allogeneic setting...