Matthias Edinger

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. doi request reprint Regulatory T cells for the prevention of graft-versus-host disease: professionals defeat amateurs
    Matthias Edinger
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 39:2966-8. 2009
  2. doi request reprint Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
    Matthias Edinger
    Department of Hematology and Oncology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Curr Opin Immunol 23:679-84. 2011
  3. ncbi request reprint Evaluation of effector cell fate and function by in vivo bioluminescence imaging
    Matthias Edinger
    Department of Hematology and Oncology, University of Regensburg, 93042 Regensburg, Germany
    Methods 31:172-9. 2003
  4. ncbi request reprint Isolation of CD4+CD25+ regulatory T cells for clinical trials
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Biol Blood Marrow Transplant 12:267-74. 2006
  5. doi request reprint Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 39:1088-97. 2009
  6. doi request reprint Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg
    Christian Schmidl
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 41:1491-8. 2011
  7. doi request reprint Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression
    Leo Hansmann
    Department of Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany
    J Immunol 188:1275-82. 2012
  8. doi request reprint Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease
    Marina Kreutz
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 132:179-87. 2012
  9. ncbi request reprint Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    Petra Hoffmann
    Institute of Immunology, Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Blood 108:4260-7. 2006
  10. ncbi request reprint Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells
    Petra Hoffmann
    Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany
    Microbes Infect 7:1066-72. 2005

Collaborators

Detail Information

Publications26

  1. doi request reprint Regulatory T cells for the prevention of graft-versus-host disease: professionals defeat amateurs
    Matthias Edinger
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 39:2966-8. 2009
    ..Thus, the stability of induced Treg is of major concern as discussed in this Commentary...
  2. doi request reprint Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
    Matthias Edinger
    Department of Hematology and Oncology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Curr Opin Immunol 23:679-84. 2011
    ....
  3. ncbi request reprint Evaluation of effector cell fate and function by in vivo bioluminescence imaging
    Matthias Edinger
    Department of Hematology and Oncology, University of Regensburg, 93042 Regensburg, Germany
    Methods 31:172-9. 2003
    ..Here, we highlight one of the newer modalities, in vivo bioluminescence imaging, as a method for evaluating effector T cell proliferation, migration, and function in model systems of malignant and non-malignant diseases...
  4. ncbi request reprint Isolation of CD4+CD25+ regulatory T cells for clinical trials
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Biol Blood Marrow Transplant 12:267-74. 2006
    ....
  5. doi request reprint Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 39:1088-97. 2009
    ..Thus, Treg cell lineage differentiation does not seem to represent a final fate decision, as natural Treg can lose their cell-type-specific characteristics after repetitive TCR stimulation...
  6. doi request reprint Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg
    Christian Schmidl
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Eur J Immunol 41:1491-8. 2011
    ..These findings are highly relevant for the generation of therapeutic Treg products...
  7. doi request reprint Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression
    Leo Hansmann
    Department of Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany
    J Immunol 188:1275-82. 2012
    ..Thus, our studies identify Th2 differentiation as the default developmental program of human Treg after downregulation of FOXP3...
  8. doi request reprint Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease
    Marina Kreutz
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 132:179-87. 2012
    ..Our results strongly suggest that prophylactic UVB irradiation post transplant is safe and should be further explored as a clinical strategy to prevent acute (skin) GvHD...
  9. ncbi request reprint Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    Petra Hoffmann
    Institute of Immunology, Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Blood 108:4260-7. 2006
    ..Based on these unexpected findings, we suggest that isolation and expansion of CD45RA+ naive CD4+ CD25high T cells is the best strategy for adoptive regulatory T (Treg)-cell therapies...
  10. ncbi request reprint Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells
    Petra Hoffmann
    Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany
    Microbes Infect 7:1066-72. 2005
    ..Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT...
  11. ncbi request reprint Inhibitory effect of tumor cell-derived lactic acid on human T cells
    Karin Fischer
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Blood 109:3812-9. 2007
    ..These findings suggest that targeting this metabolic pathway in tumors is a promising strategy to enhance tumor immunogenicity...
  12. pmc Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
    Christian Schmidl
    Department of Hematology, University Hospital Regensburg, 93042 Regensburg, Germany
    Genome Res 19:1165-74. 2009
    ....
  13. ncbi request reprint CD4+CD25+ regulatory T cells and graft-versus-host disease
    Petra Hoffmann
    Institute of Immunology and the Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Semin Hematol 43:62-9. 2006
    ..Here we summarize recent results regarding protection from graft-versus-host disease (GVHD) by adoptively transferred CD4+CD25+ T cells in mice and discuss early findings from clinical studies in HSCT...
  14. doi request reprint Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase
    Karin Landfried
    Department of Haematology Oncology, University Medical Center, Regensburg, Germany
    Blood 118:6971-4. 2011
    ..GVHD-dependent induction of IDO was further suggested by increased expression of IDO mRNA in intestinal biopsies from patients with severe GVHD. Our data indicate reactive release of kynurenines in GVHD-associated inflammation...
  15. doi request reprint Polyclonal expansion of human CD4(+)CD25(+) regulatory T cells
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Methods Mol Biol 677:15-30. 2011
    ..Here, we provide detailed instructions for their identification, isolation, expansion, and functional characterization...
  16. doi request reprint The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection
    Inken Hilgendorf
    Department of Hematology, Oncology, Palliative Care, University of Rostock, Rostock, Germany
    Transpl Int 25:87-96. 2012
    ..Our data underline the close association of diminished B cell counts with cGVHD and the onset of severe infections. The lack of IgM(+) memory B cells in patients with cGVHD may indicate functional asplenia...
  17. doi request reprint Regulatory mechanisms in graft-versus-host responses
    Matthias Edinger
    Department of Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany
    Biol Blood Marrow Transplant 15:2-6. 2009
    ....
  18. ncbi request reprint Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
    Petra Hoffmann
    Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
    Blood 104:895-903. 2004
    ....
  19. ncbi request reprint Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    Joerg Ermann
    Division of Immunology and Rheumatology, The Department of Medicine, Stanford University School of Medicine, CCSR Bldg, Rm 2215 C, 300 Pasteur Dr, Stanford, CA 94305 5166, USA
    Blood 105:2220-6. 2005
    ..The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD...
  20. ncbi request reprint Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells
    Michael R Verneris
    Department of Pediatrics, Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 11:4561-70. 2005
    ..To identify novel treatments for pediatric solid tumors and/or for malignancies with low-level Her2/neu expression...
  21. ncbi request reprint Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging
    Matthias Edinger
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, CA, USA
    Blood 101:640-8. 2003
    ..The complex cellular processes in bone marrow transplantation and antitumor immunotherapy, previously inaccessible to investigation, can now be revealed in real time in living animals...
  22. ncbi request reprint Understanding immune cell trafficking patterns via in vivo bioluminescence imaging
    Stefanie Mandl
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Cell Biochem Suppl 39:239-48. 2002
    ..Such rapid assays that reveal cell fates in vivo will increase our basic understanding of the molecular signals that control these migratory pathways and will substantially speed up the development and evaluation of therapies...
  23. ncbi request reprint CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    Matthias Edinger
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nat Med 9:1144-50. 2003
    ..Thus, CD4+CD25+ T cells are potent regulatory cells that can separate GVHD from GVT activity mediated by conventional donor T cells...
  24. ncbi request reprint DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Eur J Immunol 37:2378-89. 2007
    ..We conclude that FOXP3 DNA demethylation constitutes the most reliable criterion for natural Treg available at present...
  25. ncbi request reprint A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma
    Thomas Leemhuis
    Division of Bone Marrow Transplantation, Stanford University Medical Center, California, USA
    Biol Blood Marrow Transplant 11:181-7. 2005
    ....
  26. ncbi request reprint Studies of ex vivo activated and expanded CD8+ NK-T cells in humans and mice
    Michael R Verneris
    Division of Pediatric Hematology Oncology, and Bone Marrow Transplantation, Stanford, California 94305, USA
    J Clin Immunol 22:131-6. 2002
    ..We conclude that expanded CD8+ NK-T cells are a promising form of cellular therapy in the allogeneic setting...