Kai Uwe Eckardt

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Kidney disease: improving global outcomes
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Nat Rev Nephrol 5:650-7. 2009
  2. ncbi request reprint Evolving importance of kidney disease: from subspecialty to global health burden
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Lancet 382:158-69. 2013
  3. doi request reprint The German Chronic Kidney Disease (GCKD) study: design and methods
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 27:1454-60. 2012
  4. pmc Hemoglobin variability does not predict mortality in European hemodialysis patients
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Soc Nephrol 21:1765-75. 2010
  5. doi request reprint Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    Agnes Machnik
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 55:755-61. 2010
  6. doi request reprint Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
    Jonathan Jantsch
    Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Leukoc Biol 90:551-62. 2011
  7. ncbi request reprint Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 47:1101-7. 2006
  8. doi request reprint The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 26:3458-65. 2011
  9. doi request reprint Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    Tina Gimm
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 24:4443-58. 2010
  10. ncbi request reprint Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats
    Markus Schafflhuber
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Am J Physiol Renal Physiol 292:F1490-500. 2007

Detail Information

Publications53

  1. ncbi request reprint Kidney disease: improving global outcomes
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Nat Rev Nephrol 5:650-7. 2009
    ..International conferences organized by KDIGO support the coordination of guideline development, assess the suitability of guideline topics and help to establish global consensus on definitions and policies...
  2. ncbi request reprint Evolving importance of kidney disease: from subspecialty to global health burden
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Lancet 382:158-69. 2013
    ..Collaboration across general and specialised health-care professionals is needed to fully address the challenge of prevention of acute and chronic kidney disease and improve outcomes. ..
  3. doi request reprint The German Chronic Kidney Disease (GCKD) study: design and methods
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 27:1454-60. 2012
    ....
  4. pmc Hemoglobin variability does not predict mortality in European hemodialysis patients
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Soc Nephrol 21:1765-75. 2010
    ..34; 95% CI: 1.24 to 4.41 and RR 1.74; 95% CI: 1.00 to 3.04, respectively). In conclusion, although Hb variability is common in European HD patients, it does not independently predict mortality...
  5. doi request reprint Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    Agnes Machnik
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 55:755-61. 2010
    ..Failure of this physiological extrarenal regulatory mechanism leads to a salt-sensitive blood pressure response...
  6. doi request reprint Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
    Jonathan Jantsch
    Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Leukoc Biol 90:551-62. 2011
    ..Thus, TLR activation and hypoxia stabilize HIF1A via distinct signaling pathways, resulting in differential HIF1A-dependent gene expression...
  7. ncbi request reprint Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 47:1101-7. 2006
    ..Extrarenal Na+ and volume balance seem to play an important role in long-term volume and MAP control...
  8. doi request reprint The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 26:3458-65. 2011
    ..Moreover, although relative cyst volume was decreased, total kidney-to-body weight ratio was not significantly reduced by PLX5568. Further analyses revealed a 2-fold increase of renal and hepatic fibrosis in animals treated with PLX5568...
  9. doi request reprint Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    Tina Gimm
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 24:4443-58. 2010
    ..HIG2 could be detected in atherosclerotic arteries and fatty liver disease, suggesting that this ubiquitously inducible HIF-1 target gene may play an important functional role in diseases associated with pathological lipid accumulation...
  10. ncbi request reprint Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats
    Markus Schafflhuber
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Am J Physiol Renal Physiol 292:F1490-500. 2007
    ....
  11. ncbi request reprint Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  12. doi request reprint Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  13. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
    ..These results highlight the importance of the thick ascending limb in the pathogenesis of AKI and suggest that pharmacologically targeting the HIF system may have potential to prevent and mitigate AKI...
  14. pmc BK viremia and polyomavirus nephropathy in 352 kidney transplants; risk factors and potential role of mTOR inhibition
    Johannes Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    BMC Nephrol 14:207. 2013
    ..Polyomavirus BK nephropathy (PyVAN) remains an important cause of early graft dysfunction and graft loss in kidney transplantation...
  15. ncbi request reprint Organ protection by hypoxia and hypoxia-inducible factors
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Methods Enzymol 435:221-45. 2007
    ..Oxygen-independent activation of HIF is therefore a promising therapeutic strategy for the prevention of organ injury and failure...
  16. doi request reprint Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
    ....
  17. doi request reprint The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment
    Zhendi Wang
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 27:929-36. 2012
    ..It is also unknown whether HIF activation after the onset of ischaemia (postconditioning) is still able to protect the kidney...
  18. pmc HIF activation protects from acute kidney injury
    Alexander Weidemann
    Medical Clinic 4, Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    J Am Soc Nephrol 19:486-94. 2008
    ..Therefore, development of pharmacologic agents to induce renal HIF might provide a new approach to ameliorate cisplatin-induced nephrotoxicity...
  19. ncbi request reprint Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 180:4697-705. 2008
    ..Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen...
  20. ncbi request reprint Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction
    Alexander Weidemann
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Biochem J 409:233-42. 2008
    ..Induction of BNP may therefore contribute to the potential benefits of pharmacological HIF inducers in the treatment of ischaemic heart disease and heart failure...
  21. pmc A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
    Bernward Hinkes
    Department of Pediatrics, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    BMC Nephrol 13:27. 2012
    ..Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy...
  22. pmc The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    Ruth Schietke
    Interdisciplinary Centre for Clinical Research, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 285:6658-69. 2010
    ..Lysyl oxidases could be an attractive molecular target for cancers of epithelial origin, in particular because they are partly extracellular...
  23. pmc Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 21:2151-6. 2010
    ..These data demonstrate that pharmacologic manipulation of the HIF system can stimulate endogenous EPO production. Furthermore, the data indicate that deranged oxygen sensing--not a loss of EPO production capacity--causes renal anemia...
  24. pmc Involvement of hypoxia-inducible transcription factors in polycystic kidney disease
    Wanja Michael Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Am J Pathol 170:830-42. 2007
    ..In conclusion, HIF accumulation in human and rat PKD seems to be responsible for increased EPO production and pericystic hypervascularity and may have an impact on progression of PKD...
  25. ncbi request reprint Renal replacement therapy in the treatment of acute renal failure-intermittent and continuous
    Stefan John
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Semin Dial 19:455-64. 2006
    ..Moreover, it will be discussed whether patients with sepsis and septic shock benefit from early RRT initiation, the use of increased RRT doses, and increased removal of inflammatory mediators by RRT...
  26. ncbi request reprint Inconsistent effects of acidosis on HIF-alpha protein and its target genes
    Carsten Willam
    Department of Nephrology and Hypertension, Medizinische Klinik IV, University of Erlangen Nuremberg, Germany
    Pflugers Arch 451:534-43. 2006
    ....
  27. doi request reprint The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia
    Thomas Hackenbeck
    University of Erlangen Nuremberg, Erlangen, Germany
    Biochim Biophys Acta 1813:1-13. 2011
    ..Furthermore, our study implicates that cellular transport pathways play a role in oxygen homeostasis. Hypoxia-induced Rab20 may influence tissue homeostasis and repair during and after hypoxic stress...
  28. pmc Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts
    Ruth E Schietke
    Interdisciplinary Centre for Clinical Research, University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e31034. 2012
    ..However, HIF-2α overexpression alone is insufficient to induce tumors. Thus, our data bear implications for renal tumorigenesis, epithelial differentiation and renal repair mechanisms...
  29. ncbi request reprint Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats
    Agata Ziomber
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Glückstr 6, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 295:F1752-63. 2008
    ..We conclude that excessive cellular electrolyte redistribution and/or intracellular Na(+) or Cl(-) accumulation may play an important role in the pathogenesis of salt-sensitive hypertension...
  30. doi request reprint (23)Na magnetic resonance imaging of tissue sodium
    Christoph Kopp
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Hypertension 59:167-72. 2012
    ..We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible...
  31. ncbi request reprint Hypoxia-inducible transcription factors and their role in renal disease
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuernberg, Erlangen, Germany
    Semin Nephrol 27:363-72. 2007
    ..On the other hand, continuous activation of the HIF system occurs in kidney cancer and potentially promotes tumor growth. HIF therefore also is explored as a target for anticancer therapy...
  32. pmc Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors
    Melanie Volke
    Department of Nephrology and Hypertension, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 4:e7875. 2009
    ..Hypoxia and chemical stabilizers of the hypoxia-inducible transcription factor (HIF) have been shown to suppress hepcidin expression. We therefore investigated the role of HIF in hepcidin regulation...
  33. ncbi request reprint Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia
    Michael S Wiesener
    Interdisciplinary Centre for Clinical Research IZKF, Friedrich Alexander University of Erlangen Nuremburg, Erlangen, Germany
    Int J Cancer 121:2434-42. 2007
    ..Further to the reported expression of EPO receptors in tumour tissues, the finding of widespread expression of EPO in RCC supports the recent notion of an involvement of this system in paracrine or autocrine effects of tumour cells...
  34. pmc Severe metabolic alkalosis and recurrent acute on chronic kidney injury in a patient with Crohn's disease
    Johannes Jacobi
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    BMC Nephrol 11:6. 2010
    ..Diarrhea is common in patients with Crohn's disease and may be accompanied by acid base disorders, most commonly metabolic acidosis due to intestinal loss of bicarbonate...
  35. doi request reprint Physiological basis for the use of erythropoietin in critically ill patients at risk for acute kidney injury
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Curr Opin Crit Care 14:621-6. 2008
    ..The present review summarizes recent evidence for the use of erythropoietin as a promising candidate to provide protection from AKI...
  36. ncbi request reprint The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
    Christina Warnecke
    Department of Nephrology and Hypertension, University Clinic Erlangen, Germany
    Exp Cell Res 314:2016-27. 2008
    ..Thus, HIF-2alpha effects are modulated by a number of intrinsic and extrinsic factors which may be most relevant in tumour cells...
  37. doi request reprint Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression
    Michael S Wiesener
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 87:871-7. 2009
    ..Unraveling the complex role of VHL in renal epithelial cells is likely to shed further insight into mechanism of epithelial growth control, epithelial-mesenchymal transformation, and tumor development...
  38. pmc Left ventricular geometry predicts cardiovascular outcomes associated with anemia correction in CKD
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Am Soc Nephrol 20:2651-60. 2009
    ..Complete anemia correction may aggravate the adverse prognosis of eccentric LVH...
  39. pmc HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells
    Alexander Weidemann
    Department of Nephrology and Hypertension, Universitatsklinikum Erlangen, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Cell Commun Signal 11:80. 2013
    ..To investigate this important aspect of PHD-inhibition, we used a spheroid-on-matrix cell culture model...
  40. ncbi request reprint Renal replacement strategies in the ICU
    Stefan John
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Chest 132:1379-88. 2007
    ....
  41. pmc From red to white urine: a patient's nightmare with a rather benign outcome
    Benjamin Knier
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    BMC Nephrol 13:7. 2012
    ..Non-parasitic chyluria, however, is a very rare finding...
  42. ncbi request reprint Safety, immunogenicity and efficacy of subcutaneous biosimilar epoetin-α (HX575) in non-dialysis patients with renal anemia: a multi-center, randomized, double-blind study
    Marianne Haag-Weber
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Nephrol 77:8-17. 2012
    ..Here we report data from a study of anemic pre-dialysis patients to assess the safety, immunogenicity and efficacy of subcutaneous (s.c.) administration of HX575 vs. Erypo®/Eprex® (Ortho Biotech, Neuss, Germany)...
  43. ncbi request reprint The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction
    Tetsuhiro Tanaka
    Department of Nephrology and Hypertension, University Clinic Erlangen, Loschgestrasse 8, D 91054 Erlangen, Germany
    Biochem J 424:143-51. 2009
    ..These findings shed light on a novel aspect of HIF-3alpha as a HIF-1 target gene and point to a possible role as a modulator of hypoxic gene induction...
  44. ncbi request reprint Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 85:1058-67. 2014
    ..Knockdown of ANO1 by morpholino analogs also attenuated embryonic cyst growth. Thus, calcium-activated chloride secretion by anoctamin 1 appears to be a crucial component of renal cyst growth. ..
  45. ncbi request reprint Managing a fateful alliance: anaemia and cardiovascular outcomes
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurember, Germany
    Nephrol Dial Transplant 20:vi16-20. 2005
    ..The Cardiovascular risk Reduction by Early Anaemia Treatment with Epoetin beta (CREATE) study is investigating whether this approach is associated with a measurable reduction in cardiovascular risk...
  46. doi request reprint Treatment of acquired thrombotic thrombocytopenic purpura (TTP) with plasma infusion plus rituximab
    Stefan Hagel
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Thromb Haemost 100:151-3. 2008
  47. doi request reprint Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion
    Bjoern Buchholz
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 89:251-61. 2011
    ..In conclusion, we provide in vitro evidence for the ability of principal rather than intercalated cells to form cysts, based on a synergism of cAMP and ATP signaling in enhancing apical fluid secretion...
  48. pmc HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Pathol 174:1663-74. 2009
    ..These results implicate the non-uniform expression of HIF-regulating enzymes that modify the hypoxic response in the kidney under both regional and temporal conditions...
  49. doi request reprint Lethal varicella-zoster virus reactivation without skin lesions following renal transplantation
    Jonathan Jantsch
    Microbiology Institute, Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 26:365-8. 2011
    ..Approaches towards risk assessment pre-transplantation and prophylactic regimens for the prevention of VZV recurrence are needed...
  50. doi request reprint Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism
    Agnes Machnik
    Department of Nephrology and Hypertension, and Nikolaus Fiebiger Centre for Molecular Medicine, University Clinic and Friedrich Alexander University of Erlangen Nuremberg, Germany
    Nat Med 15:545-52. 2009
    ....
  51. ncbi request reprint Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Immunol Methods 337:71-7. 2008
    ..This new approach is superior to lipofection regarding detrimental effects of lipid-based transfection agents on BM-DC immunobiology...
  52. doi request reprint An unusual case of hyponatraemia
    Johannes Jacobi
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 25:998-1001. 2010
    ..To date, tuberculosis remains a frequent cause of adrenal insufficiency although the pathophysiology of adrenal tropism is poorly understood...
  53. ncbi request reprint HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
    Thomas Hackenbeck
    Interdisciplinary Centre for Clinical Research IZKF, University of Erlangen Nuremberg, Erlangen, Germany
    Cell Cycle 8:1386-95. 2009
    ..Importantly, recent approaches to stabilize HIFalpha in normoxia could have deleterious effects on proliferating tissues...