Matthias Eberl

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi Differentiation of human gamma-delta T cells towards distinct memory phenotypes
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, 35392 Giessen, Germany
    Cell Immunol 218:1-6. 2002
  2. ncbi Microbial isoprenoid biosynthesis and human gammadelta T cell activation
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, Germany
    FEBS Lett 544:4-10. 2003
  3. pmc Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
    Infect Immun 72:4881-3. 2004
  4. ncbi Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
    J Leukoc Biol 77:67-70. 2005
  5. ncbi A novel and sensitive method to monitor helminth infections by faecal sampling
    Matthias Eberl
    Department of Biology, University of York, P O Box 373, York YO10 5YW, UK
    Acta Trop 83:183-7. 2002
  6. pmc Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Giessen, Germany
    Immunology 106:200-11. 2002
  7. pmc Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Immunology 112:364-8. 2004
  8. pmc Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees
    M Eberl
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Infect Immun 69:5352-62. 2001
  9. ncbi Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?
    M Eberl
    Department of Biology, University of York, York, United Kingdom
    J Infect Dis 183:1238-47. 2001
  10. ncbi Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli
    M Hintz
    Jomaa Pharmaka GmbH, Frankfurter Strasse 50, 35392 Giessen, Germany
    FEBS Lett 509:317-22. 2001

Collaborators

Detail Information

Publications27

  1. ncbi Differentiation of human gamma-delta T cells towards distinct memory phenotypes
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, 35392 Giessen, Germany
    Cell Immunol 218:1-6. 2002
    ..In contrast, Vgamma9/Vdelta2 T cells grown with IL-21 differentiated into putative central memory CD45RO(+) T cells that did not produce TNF-alpha, IFN-gamma, or IL-4, and maintained expression of CD62L, CD81, and CCR7...
  2. ncbi Microbial isoprenoid biosynthesis and human gammadelta T cell activation
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, Germany
    FEBS Lett 544:4-10. 2003
    ..Unexpectedly, the intermediate of the MEP pathway, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate) (HMB-PP), turned out to be by far the most potent Vgamma9/Vdelta2 T cell activator known, with an EC(50) of 0.1 nM...
  3. pmc Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
    Infect Immun 72:4881-3. 2004
    ..Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells...
  4. ncbi Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
    J Leukoc Biol 77:67-70. 2005
    ..Moreover, KLRG1 ligation on Vgamma9/Vdelta2 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells...
  5. ncbi A novel and sensitive method to monitor helminth infections by faecal sampling
    Matthias Eberl
    Department of Biology, University of York, P O Box 373, York YO10 5YW, UK
    Acta Trop 83:183-7. 2002
    ..Moreover, the sensitivity of our method allows its use in proposed pre-clinical and clinical vaccine trials in non-human primates and humans, where reliable estimates of faecal egg counts are essential...
  6. pmc Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli
    Matthias Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, Giessen, Germany
    Immunology 106:200-11. 2002
    ....
  7. pmc Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Immunology 112:364-8. 2004
  8. pmc Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees
    M Eberl
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Infect Immun 69:5352-62. 2001
    ..Moreover, vaccinated chimpanzees had a 46% lower level of circulating cathodic antigen and a 38% reduction in fecal egg output, compared to controls, during the chronic phase of infection...
  9. ncbi Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?
    M Eberl
    Department of Biology, University of York, York, United Kingdom
    J Infect Dis 183:1238-47. 2001
    ..Their occurrence in humans might explain the long time required for antischistosome immunity to build up after infection...
  10. ncbi Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli
    M Hintz
    Jomaa Pharmaka GmbH, Frankfurter Strasse 50, 35392 Giessen, Germany
    FEBS Lett 509:317-22. 2001
    ..HMB-PP is 10(4) times more potent in activating human Vgamma9/Vdelta2 T cells than isopentenyl pyrophosphate...
  11. ncbi Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis
    Ann Kristin Kollas
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392, Giessen, Germany
    FEBS Lett 532:432-6. 2002
    ..The maximal specific activity was 0.6 micromol x min(-1) x mg(-1) at pH 7.5 and 55 degrees C. The kcat value was 0.4 s(-1) and the K(m) value for HMBPP 0.42 mM...
  12. pmc Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis
    Marina Zafranskaya
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Germany
    Immunology 121:29-39. 2007
    ..Assessment of T-cell subsets and their reactivity to MOG may represent an important diagnostic tool for monitoring successful immunotherapy in MS...
  13. ncbi IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen
    M Eberl
    Department of Biology, University of York, York, UK
    Vaccine 18:2002-8. 2000
    ....
  14. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  15. ncbi Effect of two complex platinum salts on human sperm motility and acrosome reaction
    M Eberl
    Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 32:303-10. 2000
    ..This stimulatory effect is independent of calcium and seems to be dependent on protein kinase A or C...
  16. ncbi Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis
    B Altincicek
    Jomaa Pharmaka GmbH, Giessen, Germany
    J Immunol 166:3655-8. 2001
    ..coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome...
  17. ncbi Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermia
    A Jung
    Center of Dermatology and Andrology, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Reproduction 121:595-603. 2001
    ..This study shows the importance of genital heat stress as a cofactor in fertility impairment in men and indicates nocturnal scrotal cooling as a therapeutic option...
  18. ncbi LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli
    B Altincicek
    Jomaa Pharmaka GmbH, Giessen, Germany
    FEBS Lett 499:37-40. 2001
    ..Cells deleted for the essential lytB gene were viable only if the medium was supplemented with mevalonate or the cells were complemented with an episomal copy of lytB...
  19. pmc Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis
    M Eberl
    Biochemisches Institut, Justus Liebig Universitat Giessen, 35392 Giessen, Germany
    Infect Immun 67:3383-9. 1999
    ..Further analysis of one particular pool revealed that only one of its constituents stimulated considerable IFN-gamma secretion by CD4(+) T cells and that the expressed antigen is identical to a small fragment of myosin heavy chain...
  20. ncbi The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes
    Maire Begley
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    FEBS Lett 561:99-104. 2004
    ..Vgamma9/Vdelta2 T cell bioactivity is increased in DeltalytB mutants where HMB-PP accumulation is expected, and lost in DeltagcpE mutants which fail to produce HMB-PP...
  21. ncbi A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens
    Matthias Eberl
    Trends Immunol 24:407-9. 2003
  22. ncbi Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism
    Armin Reichenberg
    Jomaa Pharmaka GmbH, Frankfurter Str 50, D 35392 Giessen, Germany
    Bioorg Med Chem Lett 13:1257-60. 2003
    ..However, replacing the pyrophosphate by a P-CH(2)-P function abrogates the bioactivity drastically, with HMB-PCP having a EC(50) of only 5.3 microM...
  23. ncbi Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    J Leukoc Biol 79:663-6. 2006
    ..The phenotypical conversion in men older than 30 years is mirrored by an increased proliferative response of Vgamma9/Vdelta2 T cells and a reduced interferon-gamma secretion upon stimulation with isopentenyl pyrophosphate in vitro...
  24. pmc Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy
    David Vermijlen
    Peter Gorer Department of Immunobiology, Guy s, King s and St Thomas Medical School, King s College London, London, UK
    J Immunol 178:4304-14. 2007
    ....
  25. pmc Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    Francesco Dieli
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Cancer Res 67:7450-7. 2007
    ..Moreover, gammadelta cell phenotypes and possibly serum TRAIL may constitute novel biomarkers of prognosis upon therapy with zoledronate + IL-2 in metastatic carcinoma...
  26. ncbi Don't count your interleukins before they've hatched
    Matthias Eberl
    Trends Immunol 23:341-2. 2002
  27. ncbi gammadelta T cells: novel initiators of adaptive immunity
    Bernhard Moser
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    Immunol Rev 215:89-102. 2007
    ..This unexpected finding is discussed with regards to microbial sensing by human gammadelta T cells and a possible role for these cells in anti-microbial immunity...